Re: Still's and genes- Fuzzy's take on it

[Guest guest]

This one is from our Tom aka Uncle fuzzy...he's been feeling kinda crummy lately

methinks, so a little hi how are yah would be in order!!!

Cat

----- Forwarded Message ----

To: Stillsdisease

Sent: Sat, January 3, 2009 3:51:01 AM

Subject: Re: Still's and genes- Fuzzy's take on it

IL 18 Genome. interleukin 18 (interferon- gamma-inducing factor)

What I found so far and please read my commentary at the end for my

take on the subject.

============ ========= ========= ========= ========= ========= =========

The protein encoded by this gene is a proinflammatory cytokine. This

cytokine can induce the IFN-gamma production of T cells. The

combination of this cytokine and IL12 has been shown to inhibit IL4

dependent IgE and IgG1 production, and enhance IgG2a production of B

cells. IL-18 binding protein (IL18BP) can specifically interact with

this cytokine, and thus negatively regulate its biological activity.

============ ========= ========= ========= ========= ========= =========

Interleukin- 18 (IL-18) is a cytokine produced by macrophages and

other cells that belongs to the IL-1 superfamily. IL-18 works

together with IL-12 to induce cell-mediated immunity following

infection with microbial products like lipopolysaccharide (LPS).

After stimulation with IL-18, natural killer (NK) cells and certain T

cells release another important cytokine called interferon-ã (IFN-ã)

or type II interferon that plays an important role in activating the

macrophages or other cells. Apart from its physiological role, IL-18

is also able to induce severe inflammatory reactions, which suggests

its role in certain inflammatory disorders. The protein encoded by

this gene is a proinflammatory cytokine. This cytokine can induce the

IFN-gamma production of T cells. The combination of this cytokine and

IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production,

and enhance IgG2a production of B cells. IL-18 binding protein

(IL18BP) can specifically interact with this cytokine, and thus

negatively regulate its biological activity.[1]

[edit] References

^ " Entrez Gene: IL18 interleukin 18 (interferon- gamma-inducing

factor) " . http://www.ncbi. nlm.nih.gov/ sites/entrez?

Db=gene & Cmd= ShowDetailView & TermToSearch= 3606.

============ ========= ========= ========= ========= ========= ========= =

My take on this:

It would seem that most individuals would have this genome and if

lacking then would cause issues in even proper inflammatory responses

of fighting off infections. IgE is related to allergies, so there is

a connection there as well.

The Cytokine cascade is what causes so many of our Stills and similar

auto inflammatory disease problems and these proteins created are all

tied to TNF (tumor necrosis factor), the Interleukins, interferons

and others.

So, the unknown is usually connections to not just a single genome,

but but a combination of them and unique unknown triggers. In other

words, a predisoposition due to possible genetic factors and being in

the wrong place at the wrong time.

Professor Fuzzy

>

> Hi all,

> I get the updates and inquiries posted to the International Still's

Disease website each week and came across this posting. I find it

very interesting and wondered if any of our doctors or anyone else

for that matter have heard of this and can shed some light?

>

>

>

> Is this IL18 information correct I'm wondering and if so where did

it come from? This so peaked my inquiring mind.

>

>

[Guest guest]

Thank you so very much Tom;

Your knowlege and experience is so helpful to me and of course others as well. I

know you've been ill and miss you terribly. We wish you much better days. I

found this research on an arthritis website under some of the journals and

thought it was perhaps something that may be of interest into the future of what

is being studied to help understand if there is genetic studies being done to

find causes. I value your insights as I said.

Best wishes for better days!

Now is the only true moment we have in time.

To: stillsdisease

Date: Tue, 14 Dec 2010 18:49:30 -0800

This one is from our Tom aka Uncle fuzzy...he's been feeling kinda crummy lately

methinks, so a little hi how are yah would be in order!!!

IL 18 Genome. interleukin 18 (interferon- gamma-inducing factor)

What I found so far and please read my commentary at the end for my

take on the subject.

============ ========= ========= ========= ========= ========= =========

The protein encoded by this gene is a proinflammatory cytokine. This

cytokine can induce the IFN-gamma production of T cells. The

combination of this cytokine and IL12 has been shown to inhibit IL4

dependent IgE and IgG1 production, and enhance IgG2a production of B

cells. IL-18 binding protein (IL18BP) can specifically interact with

this cytokine, and thus negatively regulate its biological activity.

============ ========= ========= ========= ========= ========= =========

Interleukin- 18 (IL-18) is a cytokine produced by macrophages and

other cells that belongs to the IL-1 superfamily. My take on this:

It would seem that most individuals would have this genome and if

lacking then would cause issues in even proper inflammatory responses

of fighting off infections. IgE is related to allergies, so there is

a connection there as well.

The Cytokine cascade is what causes so many of our Stills and similar

auto inflammatory disease problems and these proteins created are all

tied to TNF (tumor necrosis factor), the Interleukins, interferons

and others.

So, the unknown is usually connections to not just a single genome,

but but a combination of them and unique unknown triggers. In other

words, a predisoposition due to possible genetic factors and being in

the wrong place at the wrong time.

Professor Fuzzy