castor oil and DMSO

[Guest guest]

You're right, Jim. I forgot about people taking drugs. These folks

make your argument with scientific discovery...Chemical Enhancement of

Skin Absorption

www.chiactivate.com/scientific-journals/skin-absorption.shtml

My mistake...I thought you were specifically referring to Castor Oil

which has long record of internal use. DMSO has not been used

internally quite as long as Castor Oil to my knowledge, but it too has

been deemed non-toxic. While one never knows what will happen when

combining two substances deemed " safe " the body will normally create a

reaction if it is not. I guess it might be hard to tell with Castor Oil

since bowel urgency is one of it's effects. How do you tell if DMSO

increases that urgency and if it's toxic or just increasing the normal

action of Castor Oil? Kind of like ingesting too many lobelia plants;

what's too many? The body will tell you long before you're dead. Same

rationale for caffeine: you'll vomit or get diarrhea before it hurts

you...and it might help the prostate on the way thru' the system.

ly, I rarely use DMSO to increase the bioavailability of something

else. DMSO has a host of benefits all by itself. Most of my

combinations have to do with mitigating the stink than making another

substance work better.

Janet says DMSO cannot transport anything larger than 1000 daltons.

While I don't understand that measurement, I do know that it correlates

with the molecular weight = DMSO MW 78.13. Because I don't understand

it, I do research the molecular weight of substances that I suspect have

the potential to be toxic.

Are you sure about B12? I've read so many docs who use DMSO-B12

topically that I'd be surprised if taking the mixture internally would

be any more beneficial than B12 by itself since it doesn't play nice

with stomach acid. At the same time, I wonder if topical application of

dmso/B12 produces more than a placebo effect since the B12 molecule is

so very large. Wonder what part of the molecule dissolves in the DMSO

for dermal transport and of what benefit that component is to the body.

Saralou

------------------------------------------------------------------------

Caffeine

* Molecular Formula : C8H10N4O2

* Molecular weight : 194.19

* Chemical name : 1,3,7-trimethylxanthine

References consulted

/journal.scconline.org/pdf/cc1968/cc019n02/p00119-p00127.pdf

//jacoblab.com/dmso_protocols.htm

<https://jacoblab.com/dmso_protocols.htm> copied by slp Thu Jun 09 2011

11:08:11 GMT-0400 (Eastern Daylight Time)* Physical charcteristics:*

DMSO is a clear, colorless, essentially odorless liquid at room

temperature. It has the empirical formula of C_2 H_6 O_2 S, and a

molecular weight of 78.13. CAS number: 67-68-5.

//www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0 & N5=Product%20No.|BRAND_KEY & \

N4=07-4872|SAJ & N25=0 & QS=ON & F=SPEC

://www.beyondveg.com/billings-t/comp-anat/comp-anat-7b.shtml

<http://www.beyondveg.com/billings-t/comp-anat/comp-anat-7b.shtml>

copied by slp Thu Jun 09 2011 11:14:27 GMT-0400 (Eastern Daylight Time)

Note that the term vitamin B-12 does not refer just to one specific

molecule; instead the term is applied to a number of biologically active

compounds (though not the biologically inactive B-12 " analogues " ), an

/approximate/ average molecular weight for which is 1350 [schneider and

Stroinski 1987, pp. 56-59]. These slight variations in molecular weight

between different active B-12 compounds account for the approximate

nature of the conversion ratio between the two measures pmol/L and pg/ml.

Pharmacology of DMSO

http://www.dmso.org/articles/information/herschler.htm copied by slp Thu

Jun 09 2011 12:07:45 GMT-0400 (Eastern Daylight Time) Nonionized

*molecules of low molecular wight are transported through the skin with

DMSO*. Substance of high molecular weight such as insulin do not pass

through the skin to any significant extent. Studies in our laboratory

have revealed that a 90% concentration of DMSO is optimal for the

passage of morphine sulfate dissoved in DMSO...................the

possibility should always be considered that when DMSO is combined with

another substance a new compound results which can then exert a greater

or lesser influence on a given process.

//api.ning.com/files/n5748T7-nM-p7VUtNv5uSgLVpUfpjMn2JavHI5aC49SSUKWZUoTGGK7BIvR\

2hf1Zzuk5cb6sB3eHDXKtIvN5AQ2FELvNXtJj/AbsorptionofDrugs.ppt

<http://api.ning.com/files/n5748T7-nM-p7VUtNv5uSgLVpUfpjMn2JavHI5aC49SSUKWZUoTGG\

K7BIvR2hf1Zzuk5cb6sB3eHDXKtIvN5AQ2FELvNXtJj/AbsorptionofDrugs.ppt>.

www.nature.com/jid/journal/v56/n1/abs/5618086a.html

//www.racoon.com/dcforum/DCForumID7/221.html

//users.rcn.com/jkimball.ma.ultranet/BiologyPages/M/Mole.html

There is a distinction between what DMSO will dissolve or mix with, and

what it will transport through the skin. The 1000 dalton limit is the

limit of size that is imposed by the reverse osmosis membrane pore size

of the epidermis ( skin ). Thus although DMSO may dissolve compounds of

huge size (such as plastics), they will be unable to penetrate the

skin. Care should still be given on open wounds, where the skin is no

longer a barrier to large molecules. For this reason, I would never use

DMSO gel on an open wound Marshall Dudley Thu, 20 Aug 2009 10:40:

personal message to me post Silverlist conversation

DimethylSulfoxide-DMSO RE: DMSO and aspirin

Mon, 20 Jul 2009 08:49:48 -0500

Re:

DMSO and Colloidal Silver Thu, 09 Dec 2010 20:45:

------------------------------------------------------------------------

--- Re: castor oil and DMSO

Date: Thu, 09 Jun 2011 09:44:12 -0000

To: DimethylSulfoxide-DMSO

I have a problem with your basic premise; " If its good enough to eat,

its good to mix with DMSO. " (Paraphrasing)One of the reasons to use DMSO

is to increase " Bioavailability " .Because when you ingest a substance,

some of it is 'consumed' by stomach acid, some by enzymes and bacteria

in the stomach, and then ALL the blood from the intestines goes to the

liver for 'first pass', where a significant amount of the substance is

'Metabolised' into a biologically inert substance.

All well and good, if you want to get more " Bang for the buck " from Vit.

B12, for instance.But, depending on the quantity, there are many

substances I would ingest, that might be harmful if taken with DMSO.

Caffien, perhaps Some medications? At least thats my thinking.Jim

>

> >

> >

> > wonder if its safe to use DMSO in combination with castor oil in

topical

> > application, had a broken leg with pins and plate, and use castor

oil on my

> > liver for general overall health as advised by Dr. david Jubb.

> >

> > But am worried if any of the compounds in castor oil would be toxic

drawn

> > in by DMSO??

> >

> > Thx