Response to my question from ldninfo.org

[Guest guest]

Wow, what a wonderful resource! Here is the response I received:

Dear Jon,

People who are affected with autoimmune disorders are not generally

known

to spontaneously revert to having adequate immune systems, with or

without

the use of LDN. In fact, as people age, it is very likely that their

immune systems gradually degrade.

Over the almost 20-year history of LDN's being used in patient

treatment,

we are unaware of any manifestation of spontaneous reversion to

" normalcy "

of immune status in the absence of daily LDN use. Thus, without

research

to the contrary, one must surmise that LDN treatment on a chronic

basis

is

necessary.

You wrote:<Can the object responsible for the deficiency in

production

heal itself if given an adequate amount of time and therapy on LDN?>

My best guess at this time is that people either are born with the

proclivity to developing an autoimmune disease or they are not --

and

one

hallmark of that is an abnormally low level of endorphins. That

tendency

is not going to disappear -- once LDN is removed, they will slip

back

to

their former status.

You may be interested in the following scientific report abstract:

Ann. N.Y. Acad. Sci. 1051: 255–262 (2005). © 2005 New York Academy of

Sciences.

Premature Immunosenescence in Rheumatoid Arthritis and Multiple

Sclerosis

Patients

BY:MARIELLE THEWISSEN, LOES LINSEN, VEERLE SOMERS, PIET GEUSENS,JEF

RAUS,

AND PIET STINISSEN

Biomedisch Onderzoeksinstituut, Limburgs Universitair Centrum and

School of Life Sciences, Transnational University Limburg,

Universitary Campus, Diepenbeek, Belgium

ABSTRACT: Patients with T-cell-mediated autoimmune diseases show

immune

system abnormalities that resemble the typical characteristics of

autoimmune dysfunction described in the elderly. In addition, the

incidence of autoimmune disease increases with advancing age. To

evaluate

whether patients with rheumatoid arthritis (RA) and multiple

sclerosis

(MS) have premature immunosenescence, we measured two indicators of

aging:

the number of T-cell-receptor excision circles (TRECs) and the

percentage

of CD4+CD28null T cells. We studied them in the peripheral blood

mononuclear cells (PBMCs) of 60 RA patients, 32 MS patients, and 40

healthy controls (HCs). We found that TREC numbers were lower in RA

and

MS

patients than in age-matched HCs, indicating premature thymic

involution.

Moreover, a subset of these patients contained age-inappropriate high

frequencies of CD4+CD28null T cells.

This study provides evidence of premature immune system

senescence

in

both RA and MS patients. Premature aging could be a risk factor for

developing autoimmune disorders in genetically predisposed

individuals in a susceptible environment.

Wishing you a Healthy New Year!

Website Editor [DG]

Aren't we lucky to have such thoughful people as a resource?