How long before LDN kicks in?

[Guest guest]

The following statements comes from Dr. Bob Lawrence's packet on LDN and MS.

Hope it's helpful.

1. ...despite the fact that the drug is at a very low dose, the absence of

significant introductory or prolonged side-effects cannot be excluded. The

treatment can only be provided if these conditions are accepted.

2. Side-Effects: When starting this therapy in the treatment of MS, the

possibility of adverse side-effects due to the drug, cannot be entirely

excluded. The likelihood of damaging side-effects is believed to be minimal

however, as the drug is used at such a low dose.

3. Introductory Side-effects: There may be some initial transient, though

temporary, increase in MS symptoms during the adaptive period when the LDN

is first introduced. This usually lasts no more than one week but if

symptoms are severe, or more prolonged, then the initial dose of 3 mg may be

reduced to 2 mg until the anticipated improvements begin to develop.

Introductory symptoms, on starting this treatment, may include such as

disturbed sleep, occasionally with vivid, bizarre and disturbing dreams,

tiredness, fatigue, spasm and pain.

4. Symptoms related to increased endorphins: These may include such as

nausea or constipation. These symptoms diminish naturally as the body

adjusts to the increased endorphin level.

5. Symptoms related to previous Opiate use: On starting LDN the recent use

of opiate analgesics will result in an opiate withdrawal syndrome, with

increased pain, spasm, vomiting and diarrhea. These symptoms may be

prevented by stopping all opiate analgesics at least two weeks before

starting the LDN.

6. Symptoms related to the use of Lactose filler: If lactose filler is used

in the capsules some individuals may be sensitive to this sugar and, usually

after a few weeks of treatment, will develop diffuse but persistent muscle

or joint pain. This may be avoided by using an alternative filler, such as

calcium carbonate.