GEO! OT ALS does represent with Scarring/plaques/sclerosis

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Geo would you email me privately and tell me more about PLS? I too had a normal lumbar puncture and MRI, and the neuro doesnt know what I've got really. DO you get worse with heat?Nola

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[low dose naltrexone] Re: OT ALS does represent with Scarring/plaques/sclerosis

Hi great article ,but also there is Primary Lateral Sclerosis . It is also a Motor Neuron Disease . I can say first hand that the the Electro Diagnostics and Lab work show absolutely Nothing abnormal . Im a PLS patient 6 yrs. No Muscle atrophy only ridgity and i can say for myself absolutely no pain ,others talk of spasms and pain ,I had some cramps at the beginning but in the last 2 yrs. none . To test your self to see if your Motor Neurons fire right try to knock on a door really fast,or sit with your hands in our lap and try and flip your hands over and over real fast ,This will show how fast the signal from the Brain gets there .I had a spinal tap also with a clean outcome . I should be a healthy guy GEO >> ALS does have lesions. Amyotrophic lateral sclerosis. Sclerosis = > scarring or hardening. Multiple sclerosis = more than one area of > scarring. ALS is also one of the diseases that is mistaken for ms. > It has similar symptoms and the scarring. Many ALS patients are > initially diagnosed or thought to have ms.> > > And Amyotrophic lateral sclerosis (ALS), often referred to as "Lou > Gehrig's disease," is a progressive neurodegenerative disease that > affects nerve cells in the brain and the spinal cord. Motor neurons > reach from the brain to the spinal cord and from the spinal cord to > the muscles throughout the body. The progressive degeneration of the > motor neurons in ALS eventually lead to their death. When the motor > neurons die, the ability of the brain to initiate and control muscle > movement is lost. With voluntary muscle action progressively > affected, patients in the later stages of the disease may become > totally paralyzed. Yet, through it all, for the vast majority of > people, their minds remain unaffected.> > A-myo-trophic comes from the Greek language. "A" means no or > negative. "Myo" refers to muscle, and "Trophic" means nourishment---> "No muscle nourishment." When a muscle has no nourishment, > it "atrophies" or wastes away. "Lateral" identifies the areas in a > person's spinal cord where portions of the nerve cells that signal > and control the muscles are located. As this area degenerates it > leads to scarring or hardening ("sclerosis") in the region.> > As motor neurons degenerate, they can no longer send impulses to the > muscle fibers that normally result in muscle movement. Early symptoms > of ALS often include increasing muscle weakness, especially involving > the arms and legs, speech, swallowing or breathing. When muscles no > longer receive the messages from the motor neurons that they require > to function, the muscles begin to atrophy (become smaller). Limbs > begin to look "thinner" as muscle tissue atrophies.> > > > > > What Types of Nerves Make Your Body Work Properly? > (from Living with ALS, Manual 1: What's It All About?)> > > The body has many kinds of nerves. There are those involved in > the process of thinking, memory, and of detecting sensations (such as > hot/cold, sharp/dull), and others for vision, hearing, and other > bodily functions. The nerves that are affected when you have ALS are > the motor neurons that provide voluntary movements and muscle power. > Examples of voluntary movements are your making the effort to reach > for the phone or step off a curb; these actions are controlled by the > muscles in the arms and legs.> > > The heart and the digestive system are also made of muscle but > a different kind, and their movements are not under voluntary > control. When your heart beats or a meal is digested, it all happens > automatically. Therefore, the heart and digestive system are not > involved in ALS. Breathing also may seem to be involuntary. Remember, > though, while you cannot stop your heart, you can hold your breath - > so be aware that ALS may eventually have an impact on breathing.> > > > > Although the cause of ALS is not completely understood, the recent > years have brought a wealth of new scientific understanding regarding > the physiology of this disease.> > While there is not a cure or treatment today that halts or reverses > ALS, there is one FDA approved drug, Rilutek®, that modestly slows > the progression of ALS as well as several other drugs in clinical > trials that hold promise.> > > > > > Causes> > ALS is not a disease with a single> cause. Many factors appear to play> important roles in its ultimate> development:> > - familial/genetic: SOD-I and NEFH> > - excess glutamate> > - environmental risk factors> > - immune system abnormalities> > - nerve growth factors: > IGF-I (Myotrophin), > BDNF, GDNF> > > > > > > > Yes I realize other diseases show lesions. ALS is one.> >>