A behavioural pattern analysis of hypoglutamatergic mice-effects of four differe

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J Neural Transm 2001;108(10):1181-96

A behavioural pattern analysis of hypoglutamatergic mice-effects of four

different antipsychotic agents.

Nilsson M, Waters S, Waters N, Carlsson A, Carlsson ML.

Department of Pharmacology, Institute of Physiology and Pharmacology,

Goteborg University, Sweden. marie.nilsson@...

In a hypoglutamatergic rodent model, we have observed certain behaviours

that

might have relevance for the cognitive impairments seen in autism and

schizophrenia. Thus, hypoglutamatergic mice show defective habituation,

impaired attention, a meagre behavioural repertoire and a general

behavioural

primitivization. The aim of the present study was to characterise and

quantify changes in movement pattern in mice rendered hypoglutamatergic by

means of MK-801 treatment, using an automated video tracking system.

Further,

the effects of four different antipsychotic drugs, the classical neuroleptic

haloperidol, the atypical antipsychotic clozapine, the DA D2/5-HT2A

antagonist risperidone and the selective 5-HT2A-receptor antagonist M100907,

were compared with respect to effects on NMDA antagonist-induced movement

pattern alterations. We found that each receptor antagonist had a unique

effect on the MK-801-induced behavioural primitivization. Haloperidol was

unable to affect the monotonous behaviour induced by MK-801, while

risperidone, clozapine and M100907 produced movement patterns of high

intricacy.

PMID: 11725821 [PubMed - in process]