Guest guest Posted January 1, 2004 Report Share Posted January 1, 2004 Dear Cathrine, I'm very grateful as always. All the very best for 2004 > Dear , > > > I wasn't going to respond to any more email until tonight but I didn't > want to let this wait. You said: > > > <<A belated Merry Christmas and a healthy New Year to you all from > Germany. Hope you will all find your own personal Peace on Earth in > 2004.>> > > > > ** Thank you. I wish you the same. > > You said: > > <<I have another question to the group from one of our new members. He > has been taking Citalopram for 2 weeks and suffers from hypothermia > for about 3-4 hours after taking the tablet with a temperature of > 34.2 °C (approx. 91°F). Has anyone heard of or experienced this > before?>> > > > Psychopharmacology (Berl). 2001 Apr;154(4):429-34. > > > Involvement of 5-HT1A and 5-HT1B receptors for citalopram-induced > hypothermia in the rat. > > Oerther S, Ahlenius S. > > Department of Physiology and Pharmacology, Division of Pharmacology, > Karolinska Institutet, 17177 Stockholm, Sweden. > > OBJECTIVES: To examine the role of 5-HT1A and 5-HT1B receptors for > citalopram-induced hypothermia in the rat. METHODS: Core temperature > measurements were performed in adult male Wistar rats (305-340 g) using a > computer-assisted recording instrument. The temperature readings were > automated and gave a printout when the core temperature had stabilised at > +/- 0.1 degree C for 10 s. RESULTS: Citalopram (6.25-100.0 mumol/kg) > produced a dose-dependent hypothermia. The effect was maximal within 60 min > after administration, and had waned off at 120 min. The 5-HT1B receptor > agonist anpirtoline (0.25-4.0 mumol/kg) produced a dose-dependent decrease > in core temperature. The citalopram-induced hypothermia (25 mumol/kg) was > antagonised by pretreatment with either of the 5-HT1A and the 5-HT1B > receptor antagonists, WAY-100,635 (0.04 mumol/kg) and NAS-181 (1.0 > mumol/kg), respectively, or by the two drugs in combination. Subchronic > treatment with the SSRI zimeldine (100 mumol/kg once daily for 2 weeks) > resulted in tolerance to the hypothermic effect of citalopram (100 > mumol/kg). CONCLUSIONS: The hypothermia produced by acute administration of > the SSRI citalopram is mediated via activation of 5-HT1A, as well as 5-HT1B > receptors, and this effect is subject to the development of tolerance. > > AND > > http://www.ub.rug.nl/eldoc/dis/science/m.m.mensonides.harsema/summary. pdf > > > > Regards, > Quote Link to comment Share on other sites More sharing options...
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