sodium cocoyol isethionate safety

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Final report on the safety assessment of sodium cocoyl isethionate.

Authors: <A

HREF= " http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?./temp/~ezi8rS:@and+@au+@te\

rm+COSMET+INGREDIENT+REV+EXPERT+PANEL++USA " >COSMET INGREDIENT REV EXPERT PANEL

USA </A>

Author Address: 1101 17th St. NW, Suite 310, Washington, DC 20036, USA.

Source: JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY; 12 (5 SPEC. ISSUE).

1993. 459-479.

Abstract: BIOSIS COPYRIGHT: BIOL ABS. Sodium Cocoyl Isethionate is used as a

surfactant-cleansing agent in cosmetic formulations. Sodium Cocoyl Isethionate

is slightly to practically nontoxic, with an oral LD50 of \4.33 g/kg for

rats. Dermal application of 1.0-36.0% w/w aqueous Sodium Cocoyl Isethionate to

rats for 28 days did not produce any significant toxic effects. The ocular

irritation produced by Sodium Cocoyl Isethionate was concentration dependent,

ranging from a mild reaction at a test concentration of 2.5% to a primary ocular

irritant at test concentrations of 49%. Sodium Cocoyl Isethionate is neither a

sensitizer nor phototoxic compound. Sodium Cocoyl Isethionate was nonmutagenic

in an in vitro chromosomal aberration assay and did not produce a positive

response in an S. typhimurium reverse mutation assay. Based on the concentration

of test cited in this report, it is concluded that Sodium Cocoyl Isethionate is

safe for use in cosmetic formulations at 50% in rinse-off products and at 17%

in leav ...