Re: Re: Percent of P in MS cream question?

June 8, 2005

The Wiley progesterone is 25% then -- very concentrated. One is trying

to put much more P using a relatively small amount of cream which would

not spread to as large a skin area -- and from what I understand this

would affect the pharmacokinetics of the stuff. I can imagine a more

concentrated P spread over a relatively small area might tend to

oversaturate any given area. Wonder what we could thin it with to make

it spread further to improve its absorption?

Namaste, Liz

> The percent is usually mg per gram - for instance 10% is 100mg per

> gram of cream - now each line is 25mg. but I don't know how to

> convert that to grams? MOST of the various doctors I have read say

> to use P on the thin skinned areas not underlain by fat for best

> immediate absoprtion and only the E should be put where it can get

> into fat.

>

> > Does anyone know what percent P the MS P cream is -- in the

> literature

> > they always talk about progesterone cream in terms of the percent

> of P

> > per unit of cream. I mean a cream might contain 20 mg per 1/2

> teaspoon

> > or the like -- the stuff that Susie formula is extremely

> concentrated

> > -- I think that might have affect the pharamcokinetics of P

> > particularly.

> >

> > Also I was reading up on P cream on the LEF site -- and they made a

> > real point that the area of application should be constantly

> rotated so

> > as not to 'saturate the fat cells.'

> >

> > Also there are a few studies that unlike most have found that

> > percutaneous P cream is antiproliferative on the endometrium in one

> > study " the women were randomly placed on daily 0.625 mg of CEE and

> > twice daily transdermal application of 0%, 1.5%, or 4.0% PC.

> Astraea,

> > Inc. (Portland, Oregon), formulated the cream's concentration of

> > progesterone based on the patient's weight. In addition, the cream

> > contained aloe vera gel and alpha tocopherol

> > acetate. " Sounds like this stuff might be safe enough to eat!

> >

> > Another study that evaluated Pro-gest and found that it produced

> blood

> > levels of progesterone equal to prometrium again stressed that the

> > women were told to rotate the area of application -- in other words

> not

> > to create a so called 'depot.'

> >

> > Oddly enough back when I first started WP my first pharmacist said

> to

> > change the area of application of the hormones -- and I was

> surprised

> > when I first starting reading posts on RL that the instructions

> were to

> > make some kind of depot. Park also said to use areas where

> capillaries

> > were close to the surface such as the wrists, neck, face, etc. I do

> > remember him commenting on the concentration of P -- I thought he

> was

> > worried about the amount, I can see that he was worried about the

> > pharmacokinetics.

> >

> > Back to research

> >

> > Liz M

>

> click here for our webpage http://rhythmicliving.com/

>

> **The group conversation is informational in nature and is not

> intended as medical advice.**

>

June 8, 2005

The percent is usually mg per gram - for instance 10% is 100mg per gram of cream - now each line is 25mg. but I don't know how to convert that to grams? MOST of the various doctors I have read say to use P on the thin skinned areas not underlain by fat for best immediate absoprtion and only the E should be put where it can get into fat.

>>>>>>>>>>>>, we got the 25% P in the WP ((((((((

June 10, 2005