Your cholesterol to high not toxic very safe

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Guggul Clinical Studies

· Cholesterol - Baylor College of Medicine in Houston found

that the guggulsterone, the active ingredient in the Guggul extract,

blocks the activity of a receptor in the liver's cells called

Farnesoid X Receptor (FXR). Later, Dr. Mangelsdorf at

University of Texas Southwestern Medical Center in Dallas confirmed

that the guggul blocked the receptor and affected how cholesterol is

metabolized.

· Cholesterol/ Atherosclerosis - A double-blind placebo-

controlled study of guggul for reducing cholesterol studied 61

individuals for 24 weeks. After following a healthy diet for 12 weeks

the participants were divided into two groups with half of the

participants receiving placebo and the other half receiving guggul

(100 mg of guggulsterones daily). At 24 weeks the results showed that

the treated group had a 11.7% decrease in total cholesterol. Those on

guggul also had a 12.7% decrease in LDL ( " bad " cholesterol), a 12%

decrease in triglycerides, and an 11.1% decrease in the total

cholesterol ratio.

· Cholesterol/ Atherosclerosis - 40 heart disease patients

participated in a 16-week study were given twice daily divided doses

of 4.5 grams of guggul lipid. They experienced a 21.75 percent

decrease in blood fats (including LDL, VLDL, and triglycerides) and a

35 percent increase in " good cholesterol " . Guggul lipid also reduced

platelet stickiness.

· Cholesterol - Another study conducted at Kerala University in

India established that " guggul given to laboratory animals reduced

their blood lipid levels quickly and effectively without side

effects " . They found that improved liver enzyme activity was one of

the ways Guggul reduced the blood cholesterol. Kerala Univ., Indian

J. Exp. Biol. 33, 1995

· Cholesterol/ Atherosclerosis - This study of 228 patients

showed similar results from guggul as were obtained from the standard

drug clofibrate.

· Impotence - South Carolina scientists conducted a study of

more than 3,200 healthy men between the ages of 25 and 83. The men

with total cholesterol over 240 mg/dl had close to double the risk of

penile dysfunction as men with readings of 180 mg/dl. Also those with

HDL readings of 60 mg/dl or greater were less likely to develop

penile dysfunction than the men with less than 30 mg/dl HDL.

· Obesity - In one double-blind study - a combination of

guggul, phosphate salts, hydroxycitrate, and tyrosine (along with

healthy exercise) improved the mood of overweight patients with a

slight tendency to improve weight loss. However, there appeared to be

no effect on thyroid gland function in the people studied.

· Diabetes - Some treatment value for diabetes was noted in one

rodent study. However, more research is needed in this area.

· Acne - In a 1994 study at the Department of Dermatology, in

Bajaj Nagar, Jaipur, India, 20 patients with nodulocystic acne were

randomly given either 500mg of Tetracycline or doses of gugulipid

with 25mg guggulsterone. Both groups produced a progressive reduction

in lesions. Those on tetracycline showed a 65.2% reduction compaired

with a 68% reduction with the gugulipid. The three-month follow-up

showed relapses in 4 cases of tetracycline and 2 cases of the

gugulipid patients.

· Future Studies - The Southern California University of Health

Sciences (SCUHS) in Whittier, Calif., USA, started a study on the

Usefulness of guggul (Commiphora mukul) for osteoarthritis of the

knee in March of 2001