Guest guest Posted October 10, 2003 Report Share Posted October 10, 2003 Hi Bunny, The Mannitol study sounds promising. I hope it is successful as many of us may be helped. My pulmonary doctor probably does not know about it as he did not know that The Vest machine was being used for bronchiectasis patients. My cardiologist gave me an article about bronchiectasis from the New England Journal of Medicine about it. I realize that doctors are busy and probably do not have time to read all of the journals. I really appreciate receiving this information and hope that it helps. Thanks. Norma Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 10, 2003 Report Share Posted October 10, 2003 Hi Norma, The mannitol studies are being carried out by the Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia. I'm not sure how advanced the studies are, but I believe they have been promising so far. Here is some info that I copied from the web about the mannitol study: ---------- We have also been investigating a dry powder preparation of mannitol, which can be inhaled as a therapy to enhance clearance of lung secretions. In this study, we found that mannitol was equally as effective as hypertonic saline in clearing the lung. In addition to our success with patients with cystic fibrosis, we found that the beneficial effects of mannitol were most profound in those suffering from bronchiectasis, a chronic stretching of the bronchi with excessive secretions of mucus and chronic infection. In this group of patients, we demonstrated that clearance of the lung secretions could be normalised after a single dose of mannitol. This is a major breakthrough. We now know that clearance of lung secretions is impeded in bronchiectasis by excessive load, rather than any fundamental abnormality of the clearance mechanism. We now plan to carry out a two-week trial using mannitol daily in bronchiectasis patients with excess mucus production. The portable equipment, in the form of a dry powder inhaler, used to administer the mannitol should permit treatment to take place anywhere at anytime, improving the quality of life for many patients. There appears to be more than one mechanism involved whereby mannitol enhances the clearance of mucus. Because it is an osmotic agent, mannitol causes water to move into the airways and this helps to hydrate the sticky mucus. Further, the mannitol appears to break the bonds within the mucus making it less viscous and thus easier to remove by cough and physiotherapy --------- I hope this helps some, perhaps other members will be able to add their knowledge Love Bunny -----Original Message-----From: nor236@... Sent: Saturday, 11 October 2003 2:35 AMTo: bronchiectasis Subject: Re: Pink Disease Bunny,Where is this study being done? As I recall from previous emails, it is in Australia. I live near Austin, Texas (U. S) and have not heard of it except through this group. If anyone has any additional information regarding this study, please let me know. I have learned so much from this group.Take care,Norma Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 10, 2003 Report Share Posted October 10, 2003 --- That is very interesting I am sure we will all be interested in the studies, Thanks Bunny. In bronchiectasis , " Bob & Bunny " <robert_hasforth@s...> wrote: > Hi Norma, > > The mannitol studies are being carried out by the Department of > Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, Australia. > I'm not sure how advanced the studies are, but I believe they have been > promising so far. > > Here is some info that I copied from the web about the mannitol study: > ---------- > We have also been investigating a dry powder preparation of mannitol, > which can be inhaled as a therapy to enhance clearance of lung > secretions. In this study, we found that mannitol was equally as > effective as hypertonic saline in clearing the lung. > > In addition to our success with patients with cystic fibrosis, we found > that the beneficial effects of mannitol were most profound in those > suffering from bronchiectasis, a chronic stretching of the bronchi with > excessive secretions of mucus and chronic infection. In this group of > patients, we demonstrated that clearance of the lung secretions could be > normalised after a single dose of mannitol. This is a major > breakthrough. We now know that clearance of lung secretions is impeded > in bronchiectasis by excessive load, rather than any fundamental > abnormality of the clearance mechanism. We now plan to carry out a > two-week trial using mannitol daily in bronchiectasis patients with > excess mucus production. The portable equipment, in the form of a dry > powder inhaler, used to administer the mannitol should permit treatment > to take place anywhere at anytime, improving the quality of life for > many patients. > > There appears to be more than one mechanism involved whereby mannitol > enhances the clearance of mucus. Because it is an osmotic agent, > mannitol causes water to move into the airways and this helps to hydrate > the sticky mucus. Further, the mannitol appears to break the bonds > within the mucus making it less viscous and thus easier to remove by > cough and physiotherapy > > --------- > > I hope this helps some, perhaps other members will be able to add their > knowledge > > Love Bunny > > > > Re: Pink Disease > > > Bunny, > > Where is this study being done? As I recall from previous emails, it is > in Australia. I live near Austin, Texas (U. S) and have not heard of it > except through this group. If anyone has any additional information > regarding this study, please let me know. I have learned so much from > this group. > > Take care, > > Norma Quote Link to comment Share on other sites More sharing options...
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