Looking for activist for HDL studies and other studies.

[Guest guest]

Dear Fellow Activist:

There is an urgent need to come up with better treatments for

raising HDL Cholesterol. After doing some research, I have

discovered that Hoffman LaRouche is looking for investigators for JTT-

705, a drug that raises HDL Cholesterol by 33%. If you know of a

Cardiologist or Endocrinologist, or other practitioner with metabolic

experience, please have then sign up to be an investigator on

Rouche's website at http://www.rocheinvestigators.com JTT-705 has

mainly been studied in Europe, but is ready to enter Phase III

expanded access in the US>

I have been looking at Actos (Pioglitazone) for another HDL study

and I believe that a lot more research needs to be done with this

drug in hiv patients -- particularly with hiv patients who are not

diabetic, have low HDL, or elevated C-Reactive Protein. Currently

Actos is approved for treatment of Diabetes in the US, but it has

been studied all over the world for preventing and reversing

peripheral artery disease, raising HDL and lowering C-Reactive

Protein. One of the main effects of this drug is to significantly

raise Blood Serum Adiponectin. Yet inspite of this fact, there is no

standardized test for Blood Serum Adiponectin. Most physicians won't

prescribe the drug unless you have diabetes. This is almost criminal

since protease reduces Blood Serum Adiponectin.

I would like to see a study for hiv patients that uses low doses of

Actos for raising HDL and/or lowering C-Reactive Protein and I would

like to see a secondary objective of the study for developing a

standardized test for Blood Serum Adiponectin. Although Actos can

prevent and reverse cardio problems, it can also cause some problems

in some cases. There seems to be some evidence that this might be

due to overdosing. A review of the citations on medline seems to

indicate that those people who developed problems with the drug were

those who were taking insulin concurrently or who already had a heart

problem. However, both French, Australians, and Taiwan have shown

the drug is safe when used appropriately. I don't think most

practitioners know how to use this drug and I am wondering if a

standardized test for Adiponectin would increase its safety? Most

doctors want to see more studies. There have been some studies in

the US for treating advanced peripheral artery disease and the

studies look good so far.

I have done some calling to the manufacturer of the drug and they

appear to be simpathetic to my concerns. Their marketing agent

Takeda appears to be willing to sponsor a study, but they need

someone to write a draft of a proposal and submit it to them. I have

done some digging around and there is a slight possibility that Dr.

Grunfeld in the Bay Area might be willing to be an investigator. I

was hoping to find people on here who have low HDL who might be

willing to talk to Dr. Grunfeld and help find others doctors to be

investigators. We need someone willing to write a proposed draft.

Any interested activist should contact me with their e-mail and

phone and I could provide them with some contact information for Dr.

Grunfeld. I think Dr. Grunfeld might be our best chance at getting

someone who is proactive, knowledgeable and willing to write a

study. Lilly wants a very safe study. I was thinking of two study

arms -- one with Actos and one with Actos and Th9507 for raising

HDL. I could elaborate further on some of the other guidelines. New

data shows that a lot of hiv patients -- particularly men are low in

human growth hormone. Different from other forms of human growth

hormone, Th9507 doesn't appear to have some of the glucose toxicities

we have seen with other treatments. In addition, there is data to

show that human growth hormone also has one or more immune components

as it relates to hiv treatment.

I have been busy these past few days at trying to find other

treatments to stay alive. I have developed high level resistance to

everything -- including drugs I have never taken. In addition, I

have dangerously low HDL Cholesterol. It is currently being propped

up with 1000mg/day of Niacin, but this prevents me from taking 3TC.

I tried to get into a gene therapy study, but the manufacture

couldn't find a drug that would kill the virus in vitro. About two

years ago I recall reading a blurb sent to me by Diane Cenko that

indicated that T-Cells can now be created outside of the body from

stem cells. The author of the article, Zuñiga-Pflücker,

is affiliated with a Canadian Institution and I have sent him an

inquiry to see where the current research on T-Cells is and whether

or not these manufactured T-Cells could be infused with the gene

therapy product.

Also, for those of you who would like to participate in a clinical

trial, IL-7 is recruiting at the National Institute of Health.

ZCorker

[Guest guest]

If you want to lower your C-Reactive Protein to nomal, look no

further than Benicar - either 20 mg or 40 mg per day.

Although marketed as a angiotensin-2 receptor blocker to lower high

blood pressure, the primary effect of Benicar is to dramatically

reduce inflammation in the cardio-vascular system. Made by Daiichi-

Sankyo.

>

> Dear Fellow Activist:

>

> There is an urgent need to come up with better treatments for

> raising HDL Cholesterol. After doing some research, I have

> discovered that Hoffman LaRouche is looking for investigators for

JTT-

> 705, a drug that raises HDL Cholesterol by 33%. If you know of a

> Cardiologist or Endocrinologist, or other practitioner with

metabolic

> experience, please have then sign up to be an investigator on

> Rouche's website at http://www.rocheinvestigators.com JTT-705 has

> mainly been studied in Europe, but is ready to enter Phase III

> expanded access in the US>

>

> I have been looking at Actos (Pioglitazone) for another HDL

study

> and I believe that a lot more research needs to be done with this

> drug in hiv patients -- particularly with hiv patients who are not

> diabetic, have low HDL, or elevated C-Reactive Protein. Currently

> Actos is approved for treatment of Diabetes in the US, but it has

> been studied all over the world for preventing and reversing

> peripheral artery disease, raising HDL and lowering C-Reactive

> Protein. One of the main effects of this drug is to significantly

> raise Blood Serum Adiponectin. Yet inspite of this fact, there is

no

> standardized test for Blood Serum Adiponectin. Most physicians

won't

> prescribe the drug unless you have diabetes. This is almost

criminal

> since protease reduces Blood Serum Adiponectin.

>

> I would like to see a study for hiv patients that uses low doses

of

> Actos for raising HDL and/or lowering C-Reactive Protein and I

would

> like to see a secondary objective of the study for developing a

> standardized test for Blood Serum Adiponectin. Although Actos can

> prevent and reverse cardio problems, it can also cause some

problems

> in some cases. There seems to be some evidence that this might be

> due to overdosing. A review of the citations on medline seems to

> indicate that those people who developed problems with the drug

were

> those who were taking insulin concurrently or who already had a

heart

> problem. However, both French, Australians, and Taiwan have shown

> the drug is safe when used appropriately. I don't think most

> practitioners know how to use this drug and I am wondering if a

> standardized test for Adiponectin would increase its safety? Most

> doctors want to see more studies. There have been some studies in

> the US for treating advanced peripheral artery disease and the

> studies look good so far.

>

> I have done some calling to the manufacturer of the drug and

they

> appear to be simpathetic to my concerns. Their marketing agent

> Takeda appears to be willing to sponsor a study, but they need

> someone to write a draft of a proposal and submit it to them. I

have

> done some digging around and there is a slight possibility that

Dr.

> Grunfeld in the Bay Area might be willing to be an investigator.

I

> was hoping to find people on here who have low HDL who might be

> willing to talk to Dr. Grunfeld and help find others doctors to be

> investigators. We need someone willing to write a proposed draft.

>

> Any interested activist should contact me with their e-mail and

> phone and I could provide them with some contact information for

Dr.

> Grunfeld. I think Dr. Grunfeld might be our best chance at

getting

> someone who is proactive, knowledgeable and willing to write a

> study. Lilly wants a very safe study. I was thinking of two

study

> arms -- one with Actos and one with Actos and Th9507 for raising

> HDL. I could elaborate further on some of the other guidelines.

New

> data shows that a lot of hiv patients -- particularly men are low

in

> human growth hormone. Different from other forms of human growth

> hormone, Th9507 doesn't appear to have some of the glucose

toxicities

> we have seen with other treatments. In addition, there is data to

> show that human growth hormone also has one or more immune

components

> as it relates to hiv treatment.

>

> I have been busy these past few days at trying to find other

> treatments to stay alive. I have developed high level resistance

to

> everything -- including drugs I have never taken. In addition, I

> have dangerously low HDL Cholesterol. It is currently being

propped

> up with 1000mg/day of Niacin, but this prevents me from taking 3TC.

>

> I tried to get into a gene therapy study, but the manufacture

> couldn't find a drug that would kill the virus in vitro. About

two

> years ago I recall reading a blurb sent to me by Diane Cenko that

> indicated that T-Cells can now be created outside of the body from

> stem cells. The author of the article, Zuñiga-

Pflücker,

> is affiliated with a Canadian Institution and I have sent him an

> inquiry to see where the current research on T-Cells is and

whether

> or not these manufactured T-Cells could be infused with the gene

> therapy product.

>

> Also, for those of you who would like to participate in a

clinical

> trial, IL-7 is recruiting at the National Institute of Health.

>

> ZCorker

>

>