Re: Pre- and Postnatal Immune Dysfunction in Autism

[Guest guest]

Thanks for posting this, it looks interesting but it is difficult to say how useful it will be from the conference abstract - the devil is always in the detail. This is an early ASD cohort who are in the main also developmentally disabled. The earlier Californian work on cord blood spots (see et al 2001) also seemed to predict ASD, but was hard to replicate and looked to be more a reflection of associated developmental problems rather than a predictor of ASD - more able cases were not detected by this method. It would be interesting to match this study's findings against the more recent differences in ASD immune function reviewed by Ashwood and co, and to look at genetic and epigenetic factors that might be

linked. MOBA is starting to show some interesting general links between foetal development and maternal diet during pregnancy and if we were able to be more specific in recommendations based on such early profiling we might really be getting somewhere (e.g. if avoiding fats higher in the precursors to proinflammatory thromboxanes, leukotrienes and prostaglandins had a significant effect in a particular subgroup). The outcome data on ASD from this cohort should be coming through over the next couple of years so fingers crossed.Ken To: "Autism-Biomedical-Europe " <Autism-Biomedical-Europe > Sent: Saturday, 17 March 2012, 15:02 Subject: Pre- and Postnatal Immune Dysfunction in Autism

http://www.medscape.com/viewarticle/760389?src=stfbNovel Finding Variations in several cytokines and chemokines in amniotic fluid and neonatal blood were observed between the ASD children and their control counterparts….… On the basis of the pattern of cytokines and chemokines that he observed, Dr. Abdallah concluded that his findings suggest a proinflammatory intrauterine state during pregnancy in children diagnosed later in life with ASD, compensated for by an anti-inflammatory response. The lower level of neonatal cytokines may indicate postnatal hypoactivity of immune cells, associated with ASD.

[Guest guest]

Full study was actually published back in December http://informahealthcare.com/doi/abs/10.3109/15622975.2011.639803From: KEN AITKEN Reply-To: "Autism-Biomedical-Europe " <Autism-Biomedical-Europe >Date: Sat, 17 Mar 2012 15:56:17 +0000 (GMT)To: "Autism-Biomedical-Europe " <Autism-Biomedical-Europe >Subject: Re: Pre- and Postnatal Immune Dysfunction in Autism

Thanks for posting this, it looks interesting but it is difficult to say how useful it will be from the conference abstract - the devil is always in the detail. This is an early ASD cohort who are in the main also developmentally disabled. The earlier Californian work on cord blood spots (see et al 2001) also seemed to predict ASD, but was hard to replicate and looked to be more a reflection of associated developmental problems rather than a predictor of ASD - more able cases were not detected by this method. It would be interesting to match this study's findings against the more recent differences in ASD immune function reviewed by Ashwood and co, and to look at genetic and epigenetic factors that might be

linked. MOBA is starting to show some interesting general links between foetal development and maternal diet during pregnancy and if we were able to be more specific in recommendations based on such early profiling we might really be getting somewhere (e.g. if avoiding fats higher in the precursors to proinflammatory thromboxanes, leukotrienes and prostaglandins had a significant effect in a particular subgroup). The outcome data on ASD from this cohort should be coming through over the next couple of years so fingers crossed.Ken To: "Autism-Biomedical-Europe " <Autism-Biomedical-Europe > Sent: Saturday, 17 March 2012, 15:02 Subject: Pre- and Postnatal Immune Dysfunction in Autism

http://www.medscape.com/viewarticle/760389?src=stfbNovel Finding Variations in several cytokines and chemokines in amniotic fluid and neonatal blood were observed between the ASD children and their control counterparts….… On the basis of the pattern of cytokines and chemokines that he observed, Dr. Abdallah concluded that his findings suggest a proinflammatory intrauterine state during pregnancy in children diagnosed later in life with ASD, compensated for by an anti-inflammatory response. The lower level of neonatal cytokines may indicate postnatal hypoactivity of immune cells, associated with ASD.