Guest guest Posted September 15, 2011 Report Share Posted September 15, 2011 That is helpful. Dr Julu worked with Alison Kerr at Quarriers outside Glasgow before moving south and studied abnormalities of brainstem function in Rett syndrome. In Rett's there is an unusual pattern of activation with a reversed valsalva reaction - the hyperventilation that is commonly seen actually seems to calm the brain, reducing abnormal electrical activity where in the rest of us the opposite typically happens. I am not sure if the Rett idea is a red herring here and apologise if it is. Has he been tested for MeCP2 or does he have any features that could be suggestive? There are a number of 'forme fruste' male Rett people reported in the literature and MeCP2 deletions are not unknown in autism. Putting Rett to one side, the ARAS, or whatever other term might be being used, is the system in the brainstem that modulates cortical arousal. Abnormalities can be reflected in altered awareness of what is going on around you - being seemingly unaware or having unusual patterns of hyperfixation, or differences might be seen in circadian patterns like his sleep-wake pattern. Ken Subject: Re: ASBA Test?To: Autism-Biomedical-Europe Date: Thursday, 15 September, 2011, 21:20 Stands for Abnormal Spontaneous Brainstem Activation. Is this Dr Julu's autonomic baseline testing? I understand very little, but the brainstem controls basic (autonomic) functions such as breathng etc. We did this test and was told my son's brainstem is irritated, possibly by virus or allergy. I think the idea is that if you repeat the test after doing a treatment, you can see the asba has improved and so if the treatment is working or not. Sorry not to be more helpful than that! nah > > Im sure I have the name of this test wrong, but its what the DR kept saying to me, my sons ASBA's are really off the scale? does anyone have a clue what this test is all about? Any info would be grateful. > > Kind Regards > Sophie > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 16, 2011 Report Share Posted September 16, 2011 MeCP2 is a gene that has been found to be causative in most Rett syndrome (there are a couple of others which are also sufficient to cause RS), and has been found in a number of both males and females with ASD.KenSubject: Re: ASBA Test?To: Autism-Biomedical-Europe Date: Friday, 16 September, 2011, 16:10 Hi Thank you all for your replies. Its a little clearer to me know, I will ask my Doctor more about it when I speak to him face to face. Does anyone know if there is anything you can do to bring these ASBA's down? Also Ken, what is MEcp2?? Thanks Sophie > > > > > > Im sure I have the name of this test wrong, but its what the DR kept saying to me, my sons ASBA's are really off the scale? does anyone have a clue what this test is all about? Any info would be grateful. > > > > > > Kind Regards > > > Sophie > > > > Quote Link to comment Share on other sites More sharing options...
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