Re: The Search for Improved Treatments for Chronic Hepatitis C

[Guest guest]

Hiya , If I'm not mistakesn a few of the drugs that were listed in Dr Baker's report are new to FDA...like Rebif is for MS...Viramideine is for the flu..I may be mistaken, but if you go to the FDA site they list them that way. Kindly correct me if I'm wrong. Thanks elizabethnv1 wrote: The Search for Improved Treatments for Chronic Hepatitis CBy Baker, PhDDespite the improvement in hepatitis C therapy offered by the pegylated interferons Pegasysand PegIntron, more than half of individuals with chronic hepatitis C do not achieve a sustainedresponse from these treatments, which also are relatively expensive and may produceserious or even life-threatening adverse events. In addition, certain patient

groups experience consistently inferior virological responses tocombination treatment with interferon and ribavirin, including African Americans, personswith genotypes 1 and 4 and HIV-HCV coinfected individuals.There is a pressing need for the development of new therapies to address these and other shortcomings of the currently available treatments. As a result, studies of various experimentaltherapies representing a variety of approaches are moving forward in the research pipeline. The table below provides a snapshot of the new anti-HCV therapies now in clinical developmentin the US. New Anti-HCV Therapies in Development Drug CategoryDescriptionDrug Name and Drug SponsorFDA StatusInterferons Fusion protein Interferon alfa-albuminAlbuferon(Human Genome Sciences)Phase IIPurified multi-subtype human IFN alfaMultiferon

(Viragen)Phase IIPegylated alfacon-1 Peg-alfacon (InterMune)Phase 1Interferon omegaOmega interferon(Biomedicines)Phase IMedusa interferonMedusa Interferon(Flamel Technologies)Phase IIInterferon beta-1aRebif(Ares Serono)Phase IIIOral interferon alfaOral interferon alfa(Amarillo Biosciences)Phase IRibavirin AlternativesAmidine prodrug of ribavirin(nucleoside analogue)Viramidine (Valeant Pharmaceuticals)Phase 3IMPDH inhibitorsMerimepodib [VX-497](Vertex Pharmaceuticals)Phase 2Mycophenolic acidMycophenolic acid(Roche Pharmaceuticals)Phase 1AntiviralAmantadine(Endo Labs, etc)Phase 3ImmunomodulatorsAugmented T-cell functionThymosin alfa-1 [Zadaxin](Sci-Clone)Phase 3Enhanced IFN activation of T and natural killer cellsHistamine dihydrochloride

(Ceplene)(Maxim Pharmaceuticals)Phase 2Therapeutic vaccine(viral E1 protein of HCV)E1 vaccine(Innogenetics)Phase 2Therapeutic vaccineIC-41(Intercell)Phase 2VaccineHCV-MF59 (Chiron)Phase 1Inhibitors of Viral Enzymessynthetic oligonucleotide and selective TLR9 agonistActilon (Coley)Phase 1/2NS3 serine protease inhibitorBILN-2061(Boehringer Ingelheim)Phase 2(on hold)Serine protease inhibitorSch-6 (Schering-Plough)Phase 1NS3-4A protease inhibitorVX-950 (Vertex Pharmaceuticals)Phase 2RdRp inhibitorValopicitabine [NM-283](Idenix Pharmaceuticals)Phase 1/2Polymerase inhibitorJDK-003(Akros Pharmaceuticals)Phase 1Polymerase inhibitorHCV-896(ViriPharma)Phase 1AntifibroticsAntisense oligonucleotideISIS-14803 (Isis Pharmaceuticals)Phase 2Anti-tumor

necrosis factor á (FDA-approved for treatment of arthritis)Enbrel (Wyeth-Ayerst)Phase 1Oral phospholipid antifibroticsIP-501 (Indevus Pharmaceuticals)Phase 3Others Caspase inhibitorsID-6556 (Idun Pharmaceuticals)Phase 2Anti-CD20 mononclonal antibodyRituximab (Genentech)Phase 1/2Monoclonal antibodyXLT-6865 (XTL)Phase 1/2Prodrug of isatoribineANA-971 (Anadys)Phase 1Prodrug of isatoribineANA-245(Anadys)Phase 1/2Anti-phospholipidTarvacin (Peregrine)Phase 1

Yahoo! Personals Single? There's someone we'd like you to meet. Lots of someones, actually. Yahoo! Personals