A point,Ravin.

[Guest guest]

Hi,

When,I first started using Dorzolamide,way back in 1999,I had seen only 2-3

cases of frank SJ Syndrome,prior to that,during and after my PG.(The first was

when we were asked to see a case in the dermatology dept,in Medicine wards,of

our college,headed by one Dr.Sharma,AND THE PATIENT WAS A FULL BLOWN CASE,and I

as an HO, then would go twice daily,to sweep the fornix with a sterile glass

rod to prevent Symblepheron.The patient however died,later due to systemic

complications.

In 2000,we had one patient and in 2002,we had another,who had no prior history

of allergy to Sulfa,and came to us after avg 2weeks of using monotherapy from

outside,with frank inferior conjuctival redness,and small blister like

lesions,taking me by surprise.Then,my fellow senior consultant,decided to stop

the drug,call over the local representative and seek their views.They

photographed,had it sent to their company and their panel of experts from

US,and,I think,also from Switzerland reviewed and said,probaly,it was

A. Preservative induced bullous pemphigoid ,early stage

B. Preservative induced Toxic conjunctivitis.

Blister reports were normal.Patient recovered after 15days,with mild fibrosis of

inferior conjunctiva.

The second had a less severe reaction.In both cases,we felt it was early

SJ,contrary to what they made us feel.

I still use it in cases after laser iridotomy,ALT,and it gives me good

results,without BETA-BLOCKER,induced side effects.

Now,with Xalatan, too having entered the scene,most older regimes have gone into

disuse.

Bye.

Shyam( 1984)

Re: Hi,Ravin,did u....

Dear Shyam,

Yes, it was a cocktail dinner. But the Cipla people chose the wrong day,

Saturday, because most of the private consultants here do not get over their

clinics till well after 9 PM.

So the program started at around 9:45 PM. We had our JDOS session first,

followed by the Cipla product launch session, the two together took about 45

minutes...

It was a cocktail dinner, Hotel Satya Ashoka is an excellent place,

exhaustive cuisine, etc.

We have been using Dorzolamide in the form of Cosopt/Trusopt (MNC's) for the

last 3 years, but not as a stand alone (monotherapy), that is what Cipla

have launched in the form of Dorzox.

Personally I feel Dorzolamide 2% eye drops in the form of monotherapy is

valueless (since the pressure reduction lies between that of timolol and

betaxolol).

In the launch literature I read that no cases of SJ syndrome have been

reported so far (world-wide), so I am surprised that you came across two. We

have not had any experiences so far, at least with adjunctive dorzolamide.

But now, with the launch of stand-alone dorzolamide, lets see!

Ravin '82

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Website: www.mgims.org

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[Guest guest]

Dear Shyam,

Thanks for the update!

Ravin '82