Re: Methotrexate (MTX) Questions

[Guest guest]

,

I've had the same problem. When I told my Rheumy, he suggested I take the

mtx on Mon nights--that way I'd at least have the weekend to rest up on when

the effectiveness was wearing off. Also, I take Enbrel on Tues & Fri in

hopes of getting a bit more energy for the weekend. I have to admit,

though, that I'm not able to get much done on weekends. I usually spend at

least one full day in bed.

I've never asked about taking the mtx more frequently. I'll ask when I see

the Rheumy next week.

Hope you have a good day!

Teri

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[Guest guest]

,

I've had the same problem. When I told my Rheumy, he suggested I take the

mtx on Mon nights--that way I'd at least have the weekend to rest up on when

the effectiveness was wearing off. Also, I take Enbrel on Tues & Fri in

hopes of getting a bit more energy for the weekend. I have to admit,

though, that I'm not able to get much done on weekends. I usually spend at

least one full day in bed.

I've never asked about taking the mtx more frequently. I'll ask when I see

the Rheumy next week.

Hope you have a good day!

Teri

_________________________________________________________________

Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp

[Guest guest]

,

I've had the same problem. When I told my Rheumy, he suggested I take the

mtx on Mon nights--that way I'd at least have the weekend to rest up on when

the effectiveness was wearing off. Also, I take Enbrel on Tues & Fri in

hopes of getting a bit more energy for the weekend. I have to admit,

though, that I'm not able to get much done on weekends. I usually spend at

least one full day in bed.

I've never asked about taking the mtx more frequently. I'll ask when I see

the Rheumy next week.

Hope you have a good day!

Teri

_________________________________________________________________

Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp

[Guest guest]

, I dont know of any studies, but I have read in individual cases of

people with RA taking their mtx shots twice a week, on a schedule

similar to the enbrel schedule of every 96 hours. It can be done, it's

just basically up to your rheumy, and how well your labs are and such.

RANGERS LEAD THE WAY

[Guest guest]

, I dont know of any studies, but I have read in individual cases of

people with RA taking their mtx shots twice a week, on a schedule

similar to the enbrel schedule of every 96 hours. It can be done, it's

just basically up to your rheumy, and how well your labs are and such.

RANGERS LEAD THE WAY

[Guest guest]

, I dont know of any studies, but I have read in individual cases of

people with RA taking their mtx shots twice a week, on a schedule

similar to the enbrel schedule of every 96 hours. It can be done, it's

just basically up to your rheumy, and how well your labs are and such.

RANGERS LEAD THE WAY

[Guest guest]

Hi ,

Very good questions! Are you taking the pill form?? (I thought you

were..but??)

I take the MTX via the pills once a week, and have wondered the same thing,

but thought it was probably because there would be more possible side

effects

if taken more than once a week.

Would it make any difference if this is injected or taken as a tablet..I

wonder?

Interesting.

Tricia

Methotrexate (MTX) Questions

> Hi all - -

>

> I have been taking MTX for about 6 months. My subjective experience is

that the drug " wears out " toward the end of the week. That is, I feel best

for the first few days after I take my weekly dose, and then I feel not so

good later in the dose week. I asked my Rheumie why MTX is taken in a

weekly dose rather than more frequently, and he said that there really was

not any good data to support this practice. He said that, way back when

they first started using MTX to treat Psoriasis, there was some data that

suggested that there were less negative side effects from the drug when it

was taken weekly than when it was taken more frequently. He thinks that

doctors just generalized this finding to their use of MTX with Rheumatoid

Arthritis and then with all the other conditions that MTX is now prescribed

for.

>

> Now my questions:

>

> 1. Does anyone else have the feeling that their MTX is wearing off before

the dose week is over?

>

> 2. Does anyone know of any research studies that address the question of

the relationship between MTX side effects and frequency of dosing?

>

> Thanks, Cannon johncann@... Front Royal, VA, USA

>

>

>

[Guest guest]

Hi ,

Very good questions! Are you taking the pill form?? (I thought you

were..but??)

I take the MTX via the pills once a week, and have wondered the same thing,

but thought it was probably because there would be more possible side

effects

if taken more than once a week.

Would it make any difference if this is injected or taken as a tablet..I

wonder?

Interesting.

Tricia

Methotrexate (MTX) Questions

> Hi all - -

>

> I have been taking MTX for about 6 months. My subjective experience is

that the drug " wears out " toward the end of the week. That is, I feel best

for the first few days after I take my weekly dose, and then I feel not so

good later in the dose week. I asked my Rheumie why MTX is taken in a

weekly dose rather than more frequently, and he said that there really was

not any good data to support this practice. He said that, way back when

they first started using MTX to treat Psoriasis, there was some data that

suggested that there were less negative side effects from the drug when it

was taken weekly than when it was taken more frequently. He thinks that

doctors just generalized this finding to their use of MTX with Rheumatoid

Arthritis and then with all the other conditions that MTX is now prescribed

for.

>

> Now my questions:

>

> 1. Does anyone else have the feeling that their MTX is wearing off before

the dose week is over?

>

> 2. Does anyone know of any research studies that address the question of

the relationship between MTX side effects and frequency of dosing?

>

> Thanks, Cannon johncann@... Front Royal, VA, USA

>

>

>

[Guest guest]

Hi ,

Very good questions! Are you taking the pill form?? (I thought you

were..but??)

I take the MTX via the pills once a week, and have wondered the same thing,

but thought it was probably because there would be more possible side

effects

if taken more than once a week.

Would it make any difference if this is injected or taken as a tablet..I

wonder?

Interesting.

Tricia

Methotrexate (MTX) Questions

> Hi all - -

>

> I have been taking MTX for about 6 months. My subjective experience is

that the drug " wears out " toward the end of the week. That is, I feel best

for the first few days after I take my weekly dose, and then I feel not so

good later in the dose week. I asked my Rheumie why MTX is taken in a

weekly dose rather than more frequently, and he said that there really was

not any good data to support this practice. He said that, way back when

they first started using MTX to treat Psoriasis, there was some data that

suggested that there were less negative side effects from the drug when it

was taken weekly than when it was taken more frequently. He thinks that

doctors just generalized this finding to their use of MTX with Rheumatoid

Arthritis and then with all the other conditions that MTX is now prescribed

for.

>

> Now my questions:

>

> 1. Does anyone else have the feeling that their MTX is wearing off before

the dose week is over?

>

> 2. Does anyone know of any research studies that address the question of

the relationship between MTX side effects and frequency of dosing?

>

> Thanks, Cannon johncann@... Front Royal, VA, USA

>

>

>

[Guest guest]

Dear -

I'm sorry my answers won't help, but I don't experience any " wearing off "

from the MTX. Also, have never known of any research. I do remember a very

long time ago asking the doc I had who prescribed it about the once a week

dose, and he said it was safer for the liver than doing it more frequently.

Marcia

[Guest guest]

Hello all we do have a taper off about the last two to three days of the week

and at the frist of the week for two days or so we sleep most of the time and

that is at a low dose so what fun we are sleep two days feel good two days and a

big old grouchy bear the rest of the time please nobody take this wrong but the

wife says that living with me know is like having a period every four days or so

buy if that is how it is I feel for you women as I can be a real @#$%* & and to

you guys if your wife has stills and you stay with her good God you must like

pain or they tell the truth LOVE IS BLIND and we will and numbing LOL o well

later and pain free to me and you

Marty G.

Re: Methotrexate (MTX) Questions

Dear -

I'm sorry my answers won't help, but I don't experience any " wearing off "

from the MTX. Also, have never known of any research. I do remember a very

long time ago asking the doc I had who prescribed it about the once a week

dose, and he said it was safer for the liver than doing it more frequently.

Marcia

[Guest guest]

Marty....maybe it's in the wheaties! Just kidding...I know from experience

how *crabby* (mild word here) meds can make a person too! It's like a

Dr. Jekyl & Mr. Hyde thingy. I was on much Codeine for a whole year,

back in 1989 due to very severe right shoulder pain (shoulder has since

been replaced) the Codeine along with the steroids, and whatever else

I was taking then turned me into the wicked witch..with a B. Our youngest

son was 14 at that time, and he and my dear hubby still remember the horror

of that time! I think it took all the will power they had to not dump me off

somewhere or smother me with a pillow when I finally did sleep! Yes, the

spouses, and the rest of the family deserve a special thanks for all they go

through...and still stay with us. The disease does one of two things with

the

family...either it brings them closer together..or (sadly) it breaks them

apart.

Your friend.. & 's too!

Tricia

Re: Methotrexate (MTX) Questions

>

> Dear -

>

> I'm sorry my answers won't help, but I don't experience any " wearing off "

> from the MTX. Also, have never known of any research. I do remember a very

> long time ago asking the doc I had who prescribed it about the once a

week

> dose, and he said it was safer for the liver than doing it more

frequently.

>

> Marcia

>

>

>