Re: Re: gamma globulin/erythromycin

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From: Barb Katsaros <barbkatsaros@...>

They are very slight so far and just have been offset by an increase in

celexa.

> I am worrying that maybe he has permanent damage which cannot be helped.

Dr. G is

>also considering stattera for him. Maybe if we can get the pandas resolved

>we will get some real

>improvements. He may have to go on keflex for that. Anyone have to go to

>keflex yet and have >any experience with it? Dr. G would like to cont.

>with the emycin, but so far, the improvements >are so slow. He is only down

>to 555 after 9 mos. Barb

Did your son improve on emycin? It helped my son a little but it also

caused symptoms. When he was on an antibiotic that was a good

match......the improvements were obvious with no negative symptoms. We also

saw a drastic change in the immune markers a long with the symptom

improvement.

We have the same problem with ampB and SSRI's. AmpB seems to trigger

symptoms just like the erythromycin type antibiotics. The SSRI's also

trigger symptoms when we try to go above the minimal dose.

I really believe that some of our kids who have PANDAS type problems

(different part of the immune system activated than the ASD related

symptoms) have a more difficult time tolerating some of the meds. Since not

everyone believes this.....it's difficult at times to deal with. Thankfully

I'm also stubborn. Otherwise I'd have a child unable to function

because nothing will over-ride the symptoms from the wrong med or dose.

Due to the pattern we saw when we tried certain meds again......I knew there

had to be something about them in common. Several months ago someone was

posting (on another group) various abstracts about antibiotics. This one

caught my eye because it included both AmpB and Eryth. Stimulating

cytokines might be ok in the purely type 2/ allergic ASD kids if they help

the balance, but a whole other ballgame if a child is dealing with a type 1

autoimmune disorder like PANDAS and they stimulate that side. The SSRI's

also have similar effects on cytokines.

Infection. 1996 Jul-Aug;24(4):275-91.

Immunomodulating effects of antibiotics: literature review.

Van Vlem B, Vanholder R, De Paepe P, Vogelaers D, Ringoir S.

Dept. of Nephrology, University Hospital, Ghent, Belgium.

Antibiotics can interact directly with the immune system. This is a review

of the immunomodulating effects of antibiotics. The Medline database on

CD-ROM was searched for the years 1987 to 1994 using the following search

string: " thesaurus explode antibiotics/all AND (thesaurus explode

immune-system/drug effects OR thesaurus immune-tolerance/drug effects). "

Aspects of the immune system studied were aspects of phagocyte functions:

phagocytosis and killing, and chemotaxis and aspects of lymphocyte

functions: lymphocyte proliferation, cytokine production, antibody

production, delayed hypersensitivity and natural killer-cell activity. In

order to quantify and to compare immunomodulatory properties of antibiotics

we calculated an " immune index, " defined as: number of positive

statements--number of negative statements/total number of statements.

Concerning phagocytosis, positive effects were observed for cefodizime,

imipenem, cefoxitin, amphotericin B and clindamycin and negative effects for

erythromycin, roxithromycin, cefotaxime, tetracycline, ampicillin and

gentamicin. Clindamycin, cefoxition and imipenem induce enhancement of

chemotaxis, whereas cefotazime, rifampicin and teicoplanin decrease

chemotaxis. Regarding lymphocyte proliferation, cefodizime has the strongest

stimulating effect, whereas tetracycline has the strongest negative effect.

Except for erythromycin and amphotericin B the number of statements reported

is too small to be conclusive for the interpretation of effects on cytokine

production.

*********

Erythromycin and amphotericin B appear to stimulate cytokine production.

************

As to antibody production, cefodizime has the strongest positive effect,

whereas josamycin, rifampicin and tetracycline have marked negative effects.

For delayed hypersensitivity and the natural killer-cell activity the number

of statements is too small for any single antibiotic to be conclusive. There

are three markedly immuno-enhancing antibiotics (imipenem, cefodizime and

clindamycin) and eight markedly immuno-depressing antibiotics (erythromycin,

roxithromycin, cefotaxime, tetracycline, rifampicin, gentamicin, teicoplanin

and ampicillin).

PMID: 8875279 [PubMed - indexed for MEDLINE]

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