SSRI

[Guest guest]

Hi Lori,

The database and files section have a lot of info, with more being added.

(thanks to Timary who's spent countless hours-database & Cyn and Marc-files

section)

/database

/files/

I've included links below to some items that may be helpful. The article

from Yale discusses serotonin and SSRI use. Others discuss the protective

effects of serotonin, depletion of serotonin from immune activation, etc.

The abstracts below discuss the immune system and serotonin, a viral model

of autism and serotonin, SSRI use and immune system, serotonin, etc.

Hope that helps

If you need references not in the database yet, a message search using

1raptor will bring up most of my research posts.

Cheryl

The references from the recent genetic study on autism

/message/17224

discusses autism and serotonin

http://info.med.yale.edu/chldstdy/plomdevelop/genetics/02decgen.htm

antidepressants and Neuroprotection

/message/10776

Sustained Use Of Anti-Depressants Increases Cell Growth And Protects Cells

In The Brain

/message/7824

Tryptophan, Serotonin, Immunologic, Neuropsychiatric, Infections, etc.

/message/17652

Serotonin, some antidepressants can fight fungus

/message/14520

Brain Res. 2002 Jul 19;944(1-2):108-23. Related Articles, Links

Effects of genetic background on neonatal Borna disease virus

infection-induced neurodevelopmental damage. II. Neurochemical alterations

and responses to pharmacological treatments.

Pletnikov MV, Rubin SA, Vogel MW, Moran TH, Carbone KM.

Department of Psychiatry and Behavioral Sciences, The s Hopkins

University School of Medicine, Baltimore, MD 21205, USA.

pletnikov@...

The gene-environment interplay is thought to determine variability in

clinical conditions and responses to therapy in human neurodevelopmental

disorders. Studying abnormal brain and behavior development in inbred

strains of rodents can help in the identification of the complex pathogenic

mechanisms of the host-environment interaction. This paper is the second one

in a series of the two reports of the use of the Borna disease virus (BDV)

infection model of neurodevelopmental damage to characterize effects of

genetic background on virus-induced neurodevelopmental damage in inbred rat

strains, and Fisher344. The present data demonstrate that neonatal BDV

infection produced regional and strain-related alterations in levels of

serotonin, norepinephrine and in levels of serotonin turnover at postnatal

day 120. Neonatal BDV infection also induced upregulation of hippocampal

5-HT(1a) and cortical 5-HT(2a) receptors in rats and downregulation of

cortical 5-HT(2a) receptors in Fisher344 rats. BDV-associated regional

downregulation of D(2) receptors and dopamine transporter sites were noted

in Fisher344 rats. In addition to the neurochemical disturbances, neonatal

BDV infection induced differential responses to serotonin compounds. While

8-OH-DPAT suppressed virus-enhanced ambulation in BDV-infected Fisher344,

fluoxetine inhibited virus-induced hyperactivity in BDV-infected rats

only. The present data provide new insights into the pathogenic events that

lead to differential responses to pharmacological treatments in genetically

different animals following exposure to the same environmental challenge.

PMID: 12106671 [PubMed - indexed for MEDLINE]

Brain Res. 2002 Jul 19;944(1-2):97-107. Related Articles, Links

Effects of genetic background on neonatal Borna disease virus

infection-induced neurodevelopmental damage. I. Brain pathology and

behavioral deficits.

Pletnikov MV, Rubin SA, Vogel MW, Moran TH, Carbone KM.

Psychiatry and Behavioral Sciences, The s Hopkins University School of

Medicine, Baltimore, MD 21205, USA. pletnikov@...

The pathogenic mechanisms of gene-environment interactions determining

variability of human neurodevelopmental disorders remain unclear. In the two

consecutive papers, we used the neonatal Borna disease virus (BDV) infection

rat model of neurodevelopmental damage to evaluate brain pathology,

monoamine alterations, behavioral deficits, and responses to pharmacological

treatments in two inbred rat strains, and Fisher344. The first paper

reports that despite comparable virus replication and distribution in the

brain of both rat strains, neonatal BDV infection produced significantly

greater thinning of the neocortex in BDV-infected Fisher344 rats compared to

BDV-infected rats, while no strain-related differences were found in

BDV-induced granule cell loss in the dentate gyrus of the hippocampus and

cerebellar hypoplasia. Unlike BDV-infected rats, more severe

BDV-induced brain pathology in Fisher344 rats was associated with (1)

greater locomotor activity to novelty and (2) impairment of habituation and

prepulse inhibition of the acoustic startle response. The present data

demonstrate that the same environmental insult can produce differential

neuroanatomical and behavioral abnormalities in genetically different inbred

rat strains.

PMID: 12106670 [PubMed - indexed for MEDLINE]

Physiol Behav. 2002 Mar;75(3):403-10. Related Articles, Links

Behavioral and magnetic resonance spectroscopic studies in the rat

hyperserotonemic model of autism.

Kahne D, Tudorica A, Borella A, Shapiro L, stone F, Huang W,

Whitaker-Azmitia PM.

Department of Psychology, SUNY at Stony Brook, 11794-2500, USA.

Autism is classified as a pervasive developmental disorder, with several

cardinal features including sensory disturbances, obsessive-compulsive-like

behavior, lack of bonding to caregivers and motor disturbances. To date,

there is a lack of an animal model of the disease. The current work is aimed

at producing such a model by treating developing rat pups with a

serotonergic agonist, 5-methoxytryptamine (5-MT; 1 mg/kg) during development

(from gestational age 12 days to postnatal day 20), thus mimicking one of

the hallmark neurochemical features of the illness-increases in the

neurotransmitter, serotonin. Animals were then tested in behavioral

paradigms that may resemble the human illness. Treated rat pups were found

to be overreactive to auditory or tactile sensory stimuli, to display

changes in the negative geotaxic test of motor development, to show lack of

separation-induced vocalizations when their dam was removed and to show

decreased alternation in the spontaneous alternation task. As well, the

animals showed metabolic abnormalities in the brain using in vivo proton

magnetic resonance spectroscopy, which are consistent with those observed in

autistic children. In summary, the model we are proposing shows some of the

behavioral and metabolic features of autism, as well as being produced

through alteration of a neurochemical system known to be altered in autism.

PMID: 11897268 [PubMed - indexed for MEDLINE]

Cell Mol Neurobiol. 2002 Dec;22(5-6):797-804. Related Articles, Links

Serotonin transporter modulation in blood lymphocytes from patients with

major depression.

Lima L, Urbina M.

Laboratorio de Neuroquimica, Centro de Biofisica y Bioquimica, Instituto

Venezolano de Investigaciones Cientificas, Caracas, Venezuela.

llima@...

1. Serotonin is a neurotransmitter in the central nervous system which has

been implicated in the aetiology and pathogenesis of affective disorders.

The serononergic system also plays several roles in the immune system

through the expression of a number of its receptor subtypes in the immune

cells. 2. Following release serotonin is inactivated by reuptake into

neurons and other cells by a specific serotonin sodium and

chloride-dependent transporter molecule, whose structure has been

elucidated. 3. Measurement [3H]paroxetine binding showed that human

lymphocytes contain a high-affinity serotonin transporter. 4. To assess the

serotonin function in major depression, we investigated serotonin

transporter density in blood lymphocytes from patients with this disorder

and selected according to the interview of the American Psychiatric

Association. 5. Patients were divided into two groups and treated with two

different antidepressant drugs, one group receiving fluoxetine, a selective

serotonin reuptake inhibitor, and another mirtazapine, an antagonist of

alpha2-adrenergic auto and heteroreceptors, for a period of 6 weeks. 6.

Blood samples were obtained before and after the treatment, lymphocytes were

isolated by Ficoll/Hypaque gradient, subjected to differential adhesion to

plastic, and cell membranes were prepared for binding assay of

[3H]paroxetine. 7. Lymphocytes serotonin transporter number was

significantly reduced, while the affinity was unchanged, in patients with

major depression disorder as compare to controls. 8. In addition, there was

a partial recovery in lymphocytes serotonin (5HT) transporter number in the

period posterior to the antidepressants administration, accompanied with

clinical and depression rating scales improvement. Serotonin was determined

in platelet-poor plasma and in lymphocytes before and after drugs

administration, showing a significant decrease in the patients treated

compared to untreated and controls. 9. These results are evidence of the

potential interaction between the nervous and immune systems. The mechanisms

underlying this interaction are under study, and might be related to

modifications in the expression or function of the serotonin transporters in

lymphocytes of depressed patients.

PMID: 12585696 [PubMed - indexed for MEDLINE]

Brain Behav Immun. 2002 Aug;16(4):333-50. Related Articles, Links

Altered expression of autonomic neurotransmitter receptors and proliferative

responses in lymphocytes from a chronic mild stress model of depression:

effects of fluoxetine.

Edgar VA, Cremaschi GA, Sterin-Borda L, Genaro AM.

CEFYBO-CONICET, Serrano 669, Buenos Aires, 1414, Argentina.

We studied beta-adrenergic and muscarinic cholinergic receptor (MR)

expression and proliferative response in lymphocytes from animals under

chronic mild stress (CMS) model of depression (CMS animals). Animals were

subjected to CMS (periods of food or water deprivation, changes in lighting

conditions, tilted cage, etc.) for 12 weeks. CMS lymphocytes showed an

altered mitogen-induced proliferation. CMS-B and -T lymphocytes showed an

increment on beta-adrenoceptor number and on intracellular responses to a

beta-agonist. CMS-T cells showed higher MR expression and lower cGMP

responses than normal lymphocytes. MR were not detectable in normal B cells

while CMS-B cells showed both MR expression and cGMP response. Beta and

muscarinic stimulation influenced lymphocyte proliferative responses, in

accordance with cAMP and cGMP responses. After 12 weeks of the CMS

procedure, animals were treated with fluoxetine while the CMS procedure

continued. Fluoxetine treatment reverted the alterations induced by CMS.

These findings suggest a possible mechanism for the immune alterations found

in depressive disorders and for the effect of fluoxetine treatment on immune

response. Copyright 2001 Elsevier Science (USA).

PMID: 12096882 [PubMed - indexed for MEDLINE]

_________________________________________________________________

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[Guest guest]

My son started on a similar route. We did Paxil first, about two months into

treatment. Then moved to Celexa since the Paxil increase from the original dose

didn't work out (hyper, tantrums, etc). After about three months on Celexa he

was doing okay- no bad reactions but nothing amazingly positive with periods of

marked zoniness- Dr. G wanted to try Zoloft to see if it would help better.

I was scared to switch since the Paxil DID NOT agree with him and I still had

the memory of the worst meltdown ever in the middle of the mall during the

holidays (had to call my parents for them to come help me).

But Zoloft worked wonders!

It was last summer, just before he turned five. Within the first week there

were noticeable improvements. He transitioned into a new school (teacher and

all) last summer for a six week program with no hassles. He started staying in

his chair and on task for up to twenty minutes when before he could only sit for

a few minutes in a classroom setting. And his language really started taking

off.

Zoloft has diffidently had the quickest and most recognizable improvements of

anything else we've done except the removal of dairy products. (We never had

major die-off symptoms from antifungals/antivirals or immediate marked

improvements after using them.) Everything else has been, and still is, slow

and steady with a few bumps along the way.

- in AL

Reality lies beyond the horizon...

Wonderwegian

[Guest guest]

Thank you, for your response re: Zoloft.

Did you ever discuss with Dr G about removing SSRI and altogether at

any point and what was his reaction.

JA

> My son started on a similar route. We did Paxil first, about two

months into treatment. Then moved to Celexa since the Paxil

increase from the original dose didn't work out (hyper, tantrums,

etc). After about three months on Celexa he was doing okay- no bad

reactions but nothing amazingly positive with periods of marked

zoniness- Dr. G wanted to try Zoloft to see if it would help better.

>

> I was scared to switch since the Paxil DID NOT agree with him and

I still had the memory of the worst meltdown ever in the middle of

the mall during the holidays (had to call my parents for them to

come help me).

>

> But Zoloft worked wonders!

>

> It was last summer, just before he turned five. Within the first

week there were noticeable improvements. He transitioned into a new

school (teacher and all) last summer for a six week program with no

hassles. He started staying in his chair and on task for up to

twenty minutes when before he could only sit for a few minutes in a

classroom setting. And his language really started taking off.

>

> Zoloft has diffidently had the quickest and most recognizable

improvements of anything else we've done except the removal of dairy

products. (We never had major die-off symptoms from

antifungals/antivirals or immediate marked improvements after using

them.) Everything else has been, and still is, slow and steady with

a few bumps along the way.

>

> - in AL

>

>

> Reality lies beyond the horizon...

> Wonderwegian

>

>

[Guest guest]

Thank you, for your response re: Zoloft.

Did you ever discuss with Dr G about removing SSRI and altogether at

any point and what was his reaction.

JA

> My son started on a similar route. We did Paxil first, about two

months into treatment. Then moved to Celexa since the Paxil

increase from the original dose didn't work out (hyper, tantrums,

etc). After about three months on Celexa he was doing okay- no bad

reactions but nothing amazingly positive with periods of marked

zoniness- Dr. G wanted to try Zoloft to see if it would help better.

>

> I was scared to switch since the Paxil DID NOT agree with him and

I still had the memory of the worst meltdown ever in the middle of

the mall during the holidays (had to call my parents for them to

come help me).

>

> But Zoloft worked wonders!

>

> It was last summer, just before he turned five. Within the first

week there were noticeable improvements. He transitioned into a new

school (teacher and all) last summer for a six week program with no

hassles. He started staying in his chair and on task for up to

twenty minutes when before he could only sit for a few minutes in a

classroom setting. And his language really started taking off.

>

> Zoloft has diffidently had the quickest and most recognizable

improvements of anything else we've done except the removal of dairy

products. (We never had major die-off symptoms from

antifungals/antivirals or immediate marked improvements after using

them.) Everything else has been, and still is, slow and steady with

a few bumps along the way.

>

> - in AL

>

>

> Reality lies beyond the horizon...

> Wonderwegian

>

>

[Guest guest]

No, we never did discuss the removal of SSRI with Dr. G.

I've never been " big " on medication- one of those people who don't like to take

an OTC pill for even a headache- but I've personally had to go on a SSRI several

different times in my life and I do understand the need to " increase blood flow "

in the brain (though my son did not receive a Neurospect.) Zoloft has worked

for me in the past and hearing that sometimes if a SSRI works well for an

immediate family member there is a chance that it would work better for that

individual helped ease a little of the worry over trying yet a third SSRI on my

then four year old son.

I do think that if Zoloft hadn't worked and we saw negative problems I'd have

been resistant to risk a trial of a different SSRI.

-

Reality lies beyond the horizon...

Wonderwegian

[Guest guest]

Hi Everyone,

Dr. G. has just put my 4 year old on an SSRI (Zoloft). He has been on an

Famvir since Nonmember and Nizoral for almost three weeks. He also takes

nighttime triaminic for allergies. Although Dr. G. said triaminic was fine it

says right on the bottle do not take with certain depression medicine. I was

hoping someone could give me some insight? We are seeing positive movement but

no dramatic changes like some of you report. Having been on the protocol

for only 4 months I was surprised Dr. G. started an SSRI.

Any thought would be great.

Thank you

[Guest guest]

Thank you.

I have read so many things about SSRI's. Some good some bad! I have not

gotten the dramatic results so many have reported so I just want to be

prepared. I have read that Zoloft can take up to two weeks for any results to

appear. Has anyone had experience with Zoloft? I have to remind myself that

progress is progress even if very slow. I just hope for one of these drugs to

make

a big jump.

As always thank you for any information.

[Guest guest]

Hi

When my son was 3 1/2 Dr G put him on Celexa and it was 6 months

into the protocol and I thought it was fast....so I know what you

mean. But in our experience, it helped the blood flowing in the

brain, and we saw quick improvement in motor planning issues.

> Hi Everyone,

>

> Dr. G. has just put my 4 year old on an SSRI (Zoloft). He has

been on an

> Famvir since Nonmember and Nizoral for almost three weeks. He

also takes

> nighttime triaminic for allergies. Although Dr. G. said

triaminic was fine it

> says right on the bottle do not take with certain depression

medicine. I was

> hoping someone could give me some insight? We are seeing

positive movement but

> no dramatic changes like some of you report. Having been on the

protocol

> for only 4 months I was surprised Dr. G. started an SSRI.

>

> Any thought would be great.

>

> Thank you

>

>

>

>

[Guest guest]

Hi -

It is fine for you to give Zoloft & Triaminic

Nighttime together - per two different pediatricians.

I believe (but I don't have the bottle in front of me)

that it is MAOI inhibitors - a very different class of

meds that Dr G is not likely to use on any of our

kids. If your child were to be on that type of med,

you would know about it, as there are MANY limitations

w/ MAOIs that you would be thoroughly well-lectured

on.

No med interactions there. In fact, there are very

few potential interactions with most of the meds we

take, and Dr G is aware of all these. In one case of

a particular antibiotic vs antifungals, he is aware

but not very concerned of one recently discussed

potential interaction but has used it for so many

years that he is comfortable with it. I trust him on

that - we were on that combo and had no problem.

Hope that rests your mind.

--- dazseaton@... wrote:

> Hi Everyone,

>

> Dr. G. has just put my 4 year old on an SSRI

> (Zoloft). He has been on an

> Famvir since Nonmember and Nizoral for almost three

> weeks. He also takes

> nighttime triaminic for allergies. Although Dr. G.

> said triaminic was fine it

> says right on the bottle do not take with certain

> depression medicine. I was

> hoping someone could give me some insight? We are

> seeing positive movement but

> no dramatic changes like some of you report.

> Having been on the protocol

> for only 4 months I was surprised Dr. G. started

> an SSRI.

>

> Any thought would be great.

>

> Thank you

>

>

>

> [Non-text portions of this message have been

> removed]

>

>

__________________________________

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[Guest guest]

Hello everyone,

I was wondering if anyone could tell me if they have had success with

SSRI's? Things seem to be going well with my son since Dr. G up his SSRI.

However, we have had the plenty of downs and I would love to hear any positives

that

stayed. I have been investigating chelation but, since my son is on the up

swing I hate to change anything. I think I will have the test done before I

decide. I know Dr. G is dead against it. So many decisions. I really was

starting to question SSRI's myself. I don't want him to be on them to long

but since he is doing well right now I don't want to take him off and I would

have to for chelation. Can anyone tell me how long these children need the

SSRIs?

Any thought as always are wonderful.

Thanks

[Guest guest]

We recently started on SSRI's too. First Zoloft, which was horrible, no sleep,

regression, then we moved to Paxil, and it's been wonderful. I have a background

in neurobiology so I understand how that each SSRI treats a different chem in

the brain. I'm very positive about it. I also have a brother w/ severe

depression and have seen the amazing things that SSRI's have done for him. If

you are having good results, it probably means that it's helping the brain

function in a way it cannot w/o it. Good luck,

Joie

dazseaton@... wrote:

Hello everyone,

I was wondering if anyone could tell me if they have had success with

SSRI's? Things seem to be going well with my son since Dr. G up his SSRI.

However, we have had the plenty of downs and I would love to hear any positives

that

stayed. I have been investigating chelation but, since my son is on the up

swing I hate to change anything. I think I will have the test done before I

decide. I know Dr. G is dead against it. So many decisions. I really was

starting to question SSRI's myself. I don't want him to be on them to long

but since he is doing well right now I don't want to take him off and I would

have to for chelation. Can anyone tell me how long these children need the

SSRIs?

Any thought as always are wonderful.

Thanks

[Guest guest]

Does anyone know if there is a way to determine which

ssri is the best for someone? I seem to remember

hearing about a dna or blood test which could

determine whether or not a med. is a good fit or not.

So far, I think we have tried them all on my oldest,

except maybe some of the newer ones, and nothing

seems to do what it really needs to.

--- Joie Rightmier <joiesports@...> wrote:

> We recently started on SSRI's too. First Zoloft,

> which was horrible, no sleep, regression, then we

> moved to Paxil, and it's been wonderful. I have a

> background in neurobiology so I understand how that

> each SSRI treats a different chem in the brain. I'm

> very positive about it. I also have a brother w/

> severe depression and have seen the amazing things

> that SSRI's have done for him. If you are having

> good results, it probably means that it's helping

> the brain function in a way it cannot w/o it. Good

> luck,

>

> Joie

>

> dazseaton@... wrote:

> Hello everyone,

>

> I was wondering if anyone could tell me if they have

> had success with

> SSRI's? Things seem to be going well with my son

> since Dr. G up his SSRI.

> However, we have had the plenty of downs and I would

> love to hear any positives that

> stayed. I have been investigating chelation but,

> since my son is on the up

> swing I hate to change anything. I think I will

> have the test done before I

> decide. I know Dr. G is dead against it. So many

> decisions. I really was

> starting to question SSRI's myself. I don't want

> him to be on them to long

> but since he is doing well right now I don't want

> to take him off and I would

> have to for chelation. Can anyone tell me how long

> these children need the

> SSRIs?

>

> Any thought as always are wonderful.

> Thanks

>

>

>

> [Non-text portions of this message have been

> removed]

>

>

>

> Responsibility for the content of this message lies

> strictly with

> the original author(s), and is not necessarily

> endorsed by or the

> opinion of the Research Institute.

>

>

>

>

> ---------------------------------

>