Re: Sort of new member w/PCT and HCV and TBI

[Guest guest]

It's probably the IDEAL study.

There are two kinds of Pegulated interferons on the market for

hepatitis C and both are used in combination with Ribavirin/Copegus.

Roche's is called Pegasys and is a larger molecule....stays in the

system for 6 weeks, one dose for all. Schering's is called

PegIntron....smaller molecule, stays in the system a week.....closer

to 6 days actually...and the dose is weight based.

The IDEAL study was supposed to be a comparison between the two

products to see which one is better (though I feel the comparison is

not trully fair since Schering can use higher dose of Riba).

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough

to get people to clear.

At 12 weeks, if you get at least a 2 log drop then you are allowed to

continue......but if you don't then you will be terminated from the

study. What's a 2 log drop? let's say that you start with a viral

load of 1,000,000 then a 2 log drop....you remove the last two zeros

and that leaves 10,000.

You really need to know this things when you enroll in a study...then

you can make an informed decision.

Let me know if you have any questions.

Silvia

> > Hello everyone,

> > I am relatively new to the group (signed up just a couple of

weeks

> ago

> > or less.) I do not really remember and that is another issue I

> will

> > explain later. The postings have been so helpful and informative

> to

> > explain some of the issues I am dealing (trying to) with. The

> reason

> > for my delay is that I had a horse accident the end of May and

have

> > traumatic brain injury and three broken ribs. This group has been

> most

> > helpful in sorting out some of the issues related to HCV so that

I

> can

> > know which are more TBI related. Apologizies in advance if I may

> send

> > info that does not make sense or I repeat info. Please keep up

the

> > good work of providing helpful information and places to research

> so

> > that we may come to our own conclusions in an informed manner.

> Thank

> > you all again! Sorry we are here, but glad to be in such good

> > company! Kathy in SC

> >

> >

> >

> >

> > It's a pleasure having you join in our conversations. We hope you

> have found the support you need with us.

> >

> > If you are using email for your posts, for easy access to our

> group, just click the link--

> http://groups.yahoo.com/group/Hepatitis_C_Central/

> >

> > Happy Posting

> >

> >

> >

> >

[Guest guest]

It's probably the IDEAL study.

There are two kinds of Pegulated interferons on the market for

hepatitis C and both are used in combination with Ribavirin/Copegus.

Roche's is called Pegasys and is a larger molecule....stays in the

system for 6 weeks, one dose for all. Schering's is called

PegIntron....smaller molecule, stays in the system a week.....closer

to 6 days actually...and the dose is weight based.

The IDEAL study was supposed to be a comparison between the two

products to see which one is better (though I feel the comparison is

not trully fair since Schering can use higher dose of Riba).

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough

to get people to clear.

At 12 weeks, if you get at least a 2 log drop then you are allowed to

continue......but if you don't then you will be terminated from the

study. What's a 2 log drop? let's say that you start with a viral

load of 1,000,000 then a 2 log drop....you remove the last two zeros

and that leaves 10,000.

You really need to know this things when you enroll in a study...then

you can make an informed decision.

Let me know if you have any questions.

Silvia

> > Hello everyone,

> > I am relatively new to the group (signed up just a couple of

weeks

> ago

> > or less.) I do not really remember and that is another issue I

> will

> > explain later. The postings have been so helpful and informative

> to

> > explain some of the issues I am dealing (trying to) with. The

> reason

> > for my delay is that I had a horse accident the end of May and

have

> > traumatic brain injury and three broken ribs. This group has been

> most

> > helpful in sorting out some of the issues related to HCV so that

I

> can

> > know which are more TBI related. Apologizies in advance if I may

> send

> > info that does not make sense or I repeat info. Please keep up

the

> > good work of providing helpful information and places to research

> so

> > that we may come to our own conclusions in an informed manner.

> Thank

> > you all again! Sorry we are here, but glad to be in such good

> > company! Kathy in SC

> >

> >

> >

> >

> > It's a pleasure having you join in our conversations. We hope you

> have found the support you need with us.

> >

> > If you are using email for your posts, for easy access to our

> group, just click the link--

> http://groups.yahoo.com/group/Hepatitis_C_Central/

> >

> > Happy Posting

> >

> >

> >

> >

[Guest guest]

It's probably the IDEAL study.

There are two kinds of Pegulated interferons on the market for

hepatitis C and both are used in combination with Ribavirin/Copegus.

Roche's is called Pegasys and is a larger molecule....stays in the

system for 6 weeks, one dose for all. Schering's is called

PegIntron....smaller molecule, stays in the system a week.....closer

to 6 days actually...and the dose is weight based.

The IDEAL study was supposed to be a comparison between the two

products to see which one is better (though I feel the comparison is

not trully fair since Schering can use higher dose of Riba).

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough

to get people to clear.

At 12 weeks, if you get at least a 2 log drop then you are allowed to

continue......but if you don't then you will be terminated from the

study. What's a 2 log drop? let's say that you start with a viral

load of 1,000,000 then a 2 log drop....you remove the last two zeros

and that leaves 10,000.

You really need to know this things when you enroll in a study...then

you can make an informed decision.

Let me know if you have any questions.

Silvia

> > Hello everyone,

> > I am relatively new to the group (signed up just a couple of

weeks

> ago

> > or less.) I do not really remember and that is another issue I

> will

> > explain later. The postings have been so helpful and informative

> to

> > explain some of the issues I am dealing (trying to) with. The

> reason

> > for my delay is that I had a horse accident the end of May and

have

> > traumatic brain injury and three broken ribs. This group has been

> most

> > helpful in sorting out some of the issues related to HCV so that

I

> can

> > know which are more TBI related. Apologizies in advance if I may

> send

> > info that does not make sense or I repeat info. Please keep up

the

> > good work of providing helpful information and places to research

> so

> > that we may come to our own conclusions in an informed manner.

> Thank

> > you all again! Sorry we are here, but glad to be in such good

> > company! Kathy in SC

> >

> >

> >

> >

> > It's a pleasure having you join in our conversations. We hope you

> have found the support you need with us.

> >

> > If you are using email for your posts, for easy access to our

> group, just click the link--

> http://groups.yahoo.com/group/Hepatitis_C_Central/

> >

> > Happy Posting

> >

> >

> >

> >

[Guest guest]

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough to get

people to clear.

THAT should be illegal, to put someone through this tx without enough INF to

help them clear.. What are they thinking?

silvianursey wrote:

It's probably the IDEAL study.

There are two kinds of Pegulated interferons on the market for

hepatitis C and both are used in combination with Ribavirin/Copegus.

Roche's is called Pegasys and is a larger molecule....stays in the

system for 6 weeks, one dose for all. Schering's is called

PegIntron....smaller molecule, stays in the system a week.....closer

to 6 days actually...and the dose is weight based.

The IDEAL study was supposed to be a comparison between the two

products to see which one is better (though I feel the comparison is

not trully fair since Schering can use higher dose of Riba).

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough

to get people to clear.

At 12 weeks, if you get at least a 2 log drop then you are allowed to

continue......but if you don't then you will be terminated from the

study. What's a 2 log drop? let's say that you start with a viral

load of 1,000,000 then a 2 log drop....you remove the last two zeros

and that leaves 10,000.

You really need to know this things when you enroll in a study...then

you can make an informed decision.

Let me know if you have any questions.

Silvia

> > Hello everyone,

> > I am relatively new to the group (signed up just a couple of

weeks

> ago

> > or less.) I do not really remember and that is another issue I

> will

> > explain later. The postings have been so helpful and informative

> to

> > explain some of the issues I am dealing (trying to) with. The

> reason

> > for my delay is that I had a horse accident the end of May and

have

> > traumatic brain injury and three broken ribs. This group has been

> most

> > helpful in sorting out some of the issues related to HCV so that

I

> can

> > know which are more TBI related. Apologizies in advance if I may

> send

> > info that does not make sense or I repeat info. Please keep up

the

> > good work of providing helpful information and places to research

> so

> > that we may come to our own conclusions in an informed manner.

> Thank

> > you all again! Sorry we are here, but glad to be in such good

> > company! Kathy in SC

> >

> >

> >

> >

> > It's a pleasure having you join in our conversations. We hope you

> have found the support you need with us.

> >

> > If you are using email for your posts, for easy access to our

> group, just click the link--

> http://groups.yahoo.com/group/Hepatitis_C_Central/

> >

> > Happy Posting

> >

> >

> >

> >

[Guest guest]

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough to get

people to clear.

THAT should be illegal, to put someone through this tx without enough INF to

help them clear.. What are they thinking?

silvianursey wrote:

It's probably the IDEAL study.

There are two kinds of Pegulated interferons on the market for

hepatitis C and both are used in combination with Ribavirin/Copegus.

Roche's is called Pegasys and is a larger molecule....stays in the

system for 6 weeks, one dose for all. Schering's is called

PegIntron....smaller molecule, stays in the system a week.....closer

to 6 days actually...and the dose is weight based.

The IDEAL study was supposed to be a comparison between the two

products to see which one is better (though I feel the comparison is

not trully fair since Schering can use higher dose of Riba).

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough

to get people to clear.

At 12 weeks, if you get at least a 2 log drop then you are allowed to

continue......but if you don't then you will be terminated from the

study. What's a 2 log drop? let's say that you start with a viral

load of 1,000,000 then a 2 log drop....you remove the last two zeros

and that leaves 10,000.

You really need to know this things when you enroll in a study...then

you can make an informed decision.

Let me know if you have any questions.

Silvia

> > Hello everyone,

> > I am relatively new to the group (signed up just a couple of

weeks

> ago

> > or less.) I do not really remember and that is another issue I

> will

> > explain later. The postings have been so helpful and informative

> to

> > explain some of the issues I am dealing (trying to) with. The

> reason

> > for my delay is that I had a horse accident the end of May and

have

> > traumatic brain injury and three broken ribs. This group has been

> most

> > helpful in sorting out some of the issues related to HCV so that

I

> can

> > know which are more TBI related. Apologizies in advance if I may

> send

> > info that does not make sense or I repeat info. Please keep up

the

> > good work of providing helpful information and places to research

> so

> > that we may come to our own conclusions in an informed manner.

> Thank

> > you all again! Sorry we are here, but glad to be in such good

> > company! Kathy in SC

> >

> >

> >

> >

> > It's a pleasure having you join in our conversations. We hope you

> have found the support you need with us.

> >

> > If you are using email for your posts, for easy access to our

> group, just click the link--

> http://groups.yahoo.com/group/Hepatitis_C_Central/

> >

> > Happy Posting

> >

> >

> >

> >

[Guest guest]

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough to get

people to clear.

THAT should be illegal, to put someone through this tx without enough INF to

help them clear.. What are they thinking?

silvianursey wrote:

It's probably the IDEAL study.

There are two kinds of Pegulated interferons on the market for

hepatitis C and both are used in combination with Ribavirin/Copegus.

Roche's is called Pegasys and is a larger molecule....stays in the

system for 6 weeks, one dose for all. Schering's is called

PegIntron....smaller molecule, stays in the system a week.....closer

to 6 days actually...and the dose is weight based.

The IDEAL study was supposed to be a comparison between the two

products to see which one is better (though I feel the comparison is

not trully fair since Schering can use higher dose of Riba).

HOWEVER.....and this is the thing I wnat you to be aware of....the

FDA also requested that another arm be added to the study to compare

2 doses of PegIntron.....that means that out of the people wqho get

PegIntron, some will get what is considered the optimal dose of

1.5mg/Kg and another group will get 1.0mg/Kg which may not be enough

to get people to clear.

At 12 weeks, if you get at least a 2 log drop then you are allowed to

continue......but if you don't then you will be terminated from the

study. What's a 2 log drop? let's say that you start with a viral

load of 1,000,000 then a 2 log drop....you remove the last two zeros

and that leaves 10,000.

You really need to know this things when you enroll in a study...then

you can make an informed decision.

Let me know if you have any questions.

Silvia

> > Hello everyone,

> > I am relatively new to the group (signed up just a couple of

weeks

> ago

> > or less.) I do not really remember and that is another issue I

> will

> > explain later. The postings have been so helpful and informative

> to

> > explain some of the issues I am dealing (trying to) with. The

> reason

> > for my delay is that I had a horse accident the end of May and

have

> > traumatic brain injury and three broken ribs. This group has been

> most

> > helpful in sorting out some of the issues related to HCV so that

I

> can

> > know which are more TBI related. Apologizies in advance if I may

> send

> > info that does not make sense or I repeat info. Please keep up

the

> > good work of providing helpful information and places to research

> so

> > that we may come to our own conclusions in an informed manner.

> Thank

> > you all again! Sorry we are here, but glad to be in such good

> > company! Kathy in SC

> >

> >

> >

> >

> > It's a pleasure having you join in our conversations. We hope you

> have found the support you need with us.

> >

> > If you are using email for your posts, for easy access to our

> group, just click the link--

> http://groups.yahoo.com/group/Hepatitis_C_Central/

> >

> > Happy Posting

> >

> >

> >

> >

[Guest guest]

Ok I got the idea,, lol,,,

silvianursey wrote:

Well...the first thing is .....I won't give her vermex...did you know

it's used to kill fleas, worms and larvae?

> > > Hello everyone,

> > > I am relatively new to the group (signed up just a couple of

> weeks

> > ago

> > > or less.) I do not really remember and that is another issue I

> > will

> > > explain later. The postings have been so helpful and

informative

> > to

> > > explain some of the issues I am dealing (trying to) with. The

> > reason

> > > for my delay is that I had a horse accident the end of May and

> have

> > > traumatic brain injury and three broken ribs. This group has

been

> > most

> > > helpful in sorting out some of the issues related to HCV so

that

> I

> > can

> > > know which are more TBI related. Apologizies in advance if I

may

> > send

> > > info that does not make sense or I repeat info. Please keep up

> the

> > > good work of providing helpful information and places to

research

> > so

> > > that we may come to our own conclusions in an informed manner.

> > Thank

> > > you all again! Sorry we are here, but glad to be in such good

> > > company! Kathy in SC

> > >

> > >

> > >

> > >

> > > It's a pleasure having you join in our conversations. We hope

you

> > have found the support you need with us.

> > >

> > > If you are using email for your posts, for easy access to our

> > group, just click the link--

> > http://groups.yahoo.com/group/Hepatitis_C_Central/

> > >

> > > Happy Posting

> > >

> > >

> > >

> > >

[Guest guest]

Ok I got the idea,, lol,,,

silvianursey wrote:

Well...the first thing is .....I won't give her vermex...did you know

it's used to kill fleas, worms and larvae?

> > > Hello everyone,

> > > I am relatively new to the group (signed up just a couple of

> weeks

> > ago

> > > or less.) I do not really remember and that is another issue I

> > will

> > > explain later. The postings have been so helpful and

informative

> > to

> > > explain some of the issues I am dealing (trying to) with. The

> > reason

> > > for my delay is that I had a horse accident the end of May and

> have

> > > traumatic brain injury and three broken ribs. This group has

been

> > most

> > > helpful in sorting out some of the issues related to HCV so

that

> I

> > can

> > > know which are more TBI related. Apologizies in advance if I

may

> > send

> > > info that does not make sense or I repeat info. Please keep up

> the

> > > good work of providing helpful information and places to

research

> > so

> > > that we may come to our own conclusions in an informed manner.

> > Thank

> > > you all again! Sorry we are here, but glad to be in such good

> > > company! Kathy in SC

> > >

> > >

> > >

> > >

> > > It's a pleasure having you join in our conversations. We hope

you

> > have found the support you need with us.

> > >

> > > If you are using email for your posts, for easy access to our

> > group, just click the link--

> > http://groups.yahoo.com/group/Hepatitis_C_Central/

> > >

> > > Happy Posting

> > >

> > >

> > >

> > >

[Guest guest]

Come on Jackie....it's done all the time. How about all the studies

that have placebo. It's a comparison study. It is up to us to ask

questions.

Silvia

> > > Hello everyone,

> > > I am relatively new to the group (signed up just a couple of

> weeks

> > ago

> > > or less.) I do not really remember and that is another issue I

> > will

> > > explain later. The postings have been so helpful and

informative

> > to

> > > explain some of the issues I am dealing (trying to) with. The

> > reason

> > > for my delay is that I had a horse accident the end of May and

> have

> > > traumatic brain injury and three broken ribs. This group has

been

> > most

> > > helpful in sorting out some of the issues related to HCV so

that

> I

> > can

> > > know which are more TBI related. Apologizies in advance if I

may

> > send

> > > info that does not make sense or I repeat info. Please keep up

> the

> > > good work of providing helpful information and places to

research

> > so

> > > that we may come to our own conclusions in an informed manner.

> > Thank

> > > you all again! Sorry we are here, but glad to be in such good

> > > company! Kathy in SC

> > >

> > >

> > >

> > >

> > > It's a pleasure having you join in our conversations. We hope

you

> > have found the support you need with us.

> > >

> > > If you are using email for your posts, for easy access to our

> > group, just click the link--

> > http://groups.yahoo.com/group/Hepatitis_C_Central/

> > >

> > > Happy Posting

> > >

> > >

> > >

> > >