Guest guest Posted July 20, 2003 Report Share Posted July 20, 2003 Try eosinophils -- also doing a search on CBC blood test brings up info. From my reading these are elevated by allergies or parrasites. Gaylen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 20, 2003 Report Share Posted July 20, 2003 ---Original Message Follows---- From: " timaryp " <timaryp@...> Subject: esophinils? Date: Sun, 20 Jul 2003 12:42:12 -0000 Hi Timary, Below are several abstracts that discuss eosinophils. Cheryl J Allergy Clin Immunol. 2003 Jul;112(1):45-50. Related Articles, Links Seasonal intestinal inflammation in patients with birch pollen allergy. Magnusson J, Lin XP, Dahlman-Hoglund A, Hanson L La, Telemo E, Magnusson O, Bengtsson U, Ahlstedt S, . Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergy, Department of Clinical Immunology, Occupational and Environmental Medicine, and Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital; Surgical Department, Frolunda Specialist Hospital; and Inst Environmental Medicine, Karolinska Institute. BACKGROUND: The pathophysiologic interactions of inflammatory reactions between the mucosa of the respiratory tract and that of the gastrointestinal tract in individuals with allergy are poorly studied, despite the fact that allergic symptoms in the airways and the gastrointestinal tract might arise in the same patient. OBJECTIVE: The objective of this study was to examine the inflammatory response histologically by enumerating eosinophils, IgE+ cells, and T cells in duodenal biopsy specimens in adult patients with IgE-mediated birch pollen allergy during the birch pollen season and off-season. METHODS: Nine patients with birch pollen allergy verified by skin prick test and serum IgE antibodies were investigated toward the end of the birch pollen season and again 6 months later (off-season). Duodenal biopsy specimens were obtained and studied by immunostaining for the eosinophil major basic protein (MBP), IgE, and CD3+ T cells. RESULTS: Oral allergy syndrome to birch-associated foods was present in all patients as indicated by questionnaire. Duodenal increases of MBP+ eosinophils and IgE-bearing cells were found in the patients during the birch pollen season as compared with off-season. No seasonal differences in the T-cell numbers in these patients were seen. Off-season, there was no significant difference between the patients and the control subjects regarding the intestinal frequencies of MBP+ eosinophils, mucosal IgE+ cells, and T cells. CONCLUSION: Birch pollen exposure triggered a local inflammation with an increase in duodenal eosinophils and IgE-carrying mast cells in patients with allergy. Our study gives evidence for the interplay between immunologically active cells in the airways and the gut. PMID: 12847478 [PubMed - as supplied by publisher] Eur Respir J. 2003 Jun;21(6):925-31. Related Articles, Links Upregulated response to chemokines in oxidative metabolism of eosinophils in asthma and allergic rhinitis. Sannohe S, Adachi T, Hamada K, Honda K, Yamada Y, Saito N, Cui CH, Kayaba H, Ishikawa K, Chihara J. Dept of Clinical and Laboratory Medicine, Akita University School of Medicine, Hondo, Akita, Japan. Reactive oxygen species (ROS) from eosinophils are known to cause tissue damage in allergic inflammation. CC chemokines, especially eotaxin and regulated on activation, normal T-cell expressed and secreted (RANTES), are involved not only in chemotaxis but also in eosinophil activation, such as ROS production. It has been shown that eosinophils from allergic patients are not functionally equivalent to those from normal subjects. In the present study, the characteristics of chemokine-primed ROS production in eosinophils from allergic patients and normal controls were compared. After pretreatment with chemokines, eosinophils were stimulated with calcium ionophore A23187. ROS production by eosinophils was measured using luminol-dependent chemiluminescence. Both RANTES and eotaxin exhibited a priming effect on calcium ionophore-induced ROS production from eosinophils. Despite there being no difference in expression of CC chemokine receptor 3, the priming effect of RANTES and eotaxin was significantly enhanced in eosinophils from the patients. Interleukin-5 further enhanced the priming effect of chemokines in eosinophils from normal subjects, but not those from allergic subjects. The present results suggest an upregulated response to chemokines in eosinophils from allergic patients, and that interleukin-5 can induce a similar phenotype to that found in vivo in allergic patients. PMID: 12797483 [PubMed - in process] Curr Allergy Asthma Rep. 2003 Jan;3(1):79-85. Related Articles, Links Eosinophilic gastroenteritis: a problem of the mucosal immune system? Kweon MN, Kiyono H. Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita City, Osaka 565-0871, Japan. The gastrointestinal immune system is a major component of the mucosal barrier, which provides an appropriate immunologic homeostasis between host and numerous foreign antigens, including microbial and dietary antigens. However, under certain pathological circumstances created by disturbance of the immunologic balance, allergic responses associated with the gastrointestinal tract can be triggered by abnormal immune responses against selected food protein antigens. Among the several types of immune competent cells, eosinophils are generally considered to play a central role for the development of allergic diseases in gastrointestinal tissue. Although most research has been focused on the molecular and cellular understanding of eosinophils in the peripheral tissues and lung, recent studies elucidate the unique trafficking and regulation mechanisms of eosinophils in the gastrointestinal tissues. In this review, we summarize current findings in the regulatory mechanism of gastrointestinal eosinophils. Furthermore, several unique murine models for eosinophilic gastroenteritis, which can be applied for the elucidation of underlying mechanisms of eosinophil-mediated gastrointestinal allergy, and the development of new mucosal immune therapy for the control of food allergy are reviewed. Publication Types: Review Review, Tutorial PMID: 12542999 [PubMed - indexed for MEDLINE] J Pediatr. 2002 Oct;141(4):576-81. Related Articles, Links Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry. Guajardo JR, Plotnick LM, Fende JM, MH, Putnam PE, Rothenberg ME. Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. A world wide web database was established that tracked features of eosinophil-associated gastrointestinal disorders; 80% had coexisting atopic disease, 62% had food sensitization, and 16% had an immediate family member with a similar disorder. Developmental delay, seizure disorders, and congenital anomalies were seen in a proportion of respondents. The world wide web has proven to be an efficient tool to gather patient information, allowing us to define distinguishing features of various eosinophil-associated gastrointestinal disorders and to establish that these disorders have strong genetic and allergic components. PMID: 12378201 [PubMed - indexed for MEDLINE] _________________________________________________________________ The new MSN 8: smart spam protection and 2 months FREE* http://join.msn.com/?page=features/junkmail Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 21, 2003 Report Share Posted July 21, 2003 eosinophils is correct. On Sunday, July 20, 2003, at 01:33 PM, wrote: > Spelled eosiniphils (I hope). --- timaryp <timaryp@...> wrote: >> Please help me, someone. I did a search everywhere >> (www.neuroimmunedr.com, here, ) on " esophinils " >> and can't get a >> hit anywhere. How am I misspelling this? I know my >> son's were kind >> of high and I remember at least one message thread >> on this topic, but >> I can't find anything. >> >> Thanks! >> Timary __________________________________ `````````````````````````````````` Responsibility for the content of this message lies strictly with the original author, and is not necessarily endorsed by or the opinion of the Research Institute. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 21, 2003 Report Share Posted July 21, 2003 HON Allergy Glossary Eosinophil HON Allergy Glossary, Eosinophil: Eosinophils are important in phagocytosis as well as in allergic and inflammatory reactions. ... Eosinophils image. .... http://www.hon.ch/Library/Theme/Allergy/Glossary/eosinophil.html - 11k - Cached - Similar pages Try this link and spelling. Marty Re: esophinils? > Spelled eosiniphils (I hope). > --- timaryp <timaryp@...> wrote: > > Please help me, someone. I did a search everywhere > > (www.neuroimmunedr.com, here, ) on " esophinils " > > and can't get a > > hit anywhere. How am I misspelling this? I know my > > son's were kind > > of high and I remember at least one message thread > > on this topic, but > > I can't find anything. > > > > Thanks! > > Timary __________________________________ `````````````````````````````````` Responsibility for the content of this message lies strictly with the original author, and is not necessarily endorsed by or the opinion of the Research Institute. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 21, 2003 Report Share Posted July 21, 2003 It is spelled eosinophils. m Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2003 Report Share Posted July 23, 2003 This is interesting since Dr. G. told me that eosiniphil counts would not increase due to seasonal-type/ inhalant allergies. He attributed it only to ingested substances. I asked because my son's count went up at the same time his seasonal stuff kicked in. Becky esophinils? > Date: Sun, 20 Jul 2003 12:42:12 -0000 > > Hi Timary, > Below are several abstracts that discuss eosinophils. > Cheryl > > > J Allergy Clin Immunol. 2003 Jul;112(1):45-50. Related Articles, Links > > > Seasonal intestinal inflammation in patients with birch pollen allergy. --------------------------------- > Responsibility for the content of this message lies strictly with > the original author, and is not necessarily endorsed by or the > opinion of the Research Institute. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 23, 2003 Report Share Posted July 23, 2003 After watching this for years with my son I have a personal theory. Maybe eosinphils only relate to food type allergies (and parasites in extreme cases) BUT when the system is doing poorly for other reasons (infections, seasonal allergies etc,) the body seems to have a worse time with the food and the eosinophils go up even eating the same foods. Re: esophinils? This is interesting since Dr. G. told me that eosiniphil counts would not increase due to seasonal-type/ inhalant allergies. He attributed it only to ingested substances. I asked because my son's count went up at the same time his seasonal stuff kicked in. Becky //message thread truncated// ______________________________ `````````````````````````````` Responsibility for the content of this message lies strictly with the original author, and is not necessarily endorsed by or the opinion of the Research Institute. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 24, 2003 Report Share Posted July 24, 2003 , we have noticed too a relationship with increase EOS and doing poorly, but we think its the other way round. I have read somewhere (one of those " what blood cells do " sites I guess) that Eosinophils are cells that " bomb " foreign unwanted objects like parasites and other bugs entering the digestive system . They release a tiny chemical to neutralise the bug/parasite. They mistakenly attack some foods entering too - an allergy response - which is how you get the high EOS count due to some foods. We have noticed too that EOS can go up even if foods and other things ingested don't change - once our son had Giardia, another time Salmonella and also we noticed if we lose control of gut yeast it also goes up. In fact, I have charted Anti-fungal med (ie type used) v's Eos counts and anecdotally we noticed that his EOS is lowest when on Diflucan, and tends to climb when on others. Dr G found this very interesting. We stick with Diflucan and do only a change for a short time now to rest the system. EOS are now usually less than 3% and the lowest absolute of 0.18 we have ever had v's 9-12% highs and absolutes as high as 0.9 - 1.2 when we started treatment or when he has had parasite infections etc. Re: esophinils? After watching this for years with my son I have a personal theory. Maybe eosinphils only relate to food type allergies (and parasites in extreme cases) BUT when the system is doing poorly for other reasons (infections, seasonal allergies etc,) the body seems to have a worse time with the food and the eosinophils go up even eating the same foods. Re: esophinils? This is interesting since Dr. G. told me that eosiniphil counts would not increase due to seasonal-type/ inhalant allergies. He attributed it only to ingested substances. I asked because my son's count went up at the same time his seasonal stuff kicked in. Becky //message thread truncated// ______________________________ `````````````````````````````` Responsibility for the content of this message lies strictly with the original author, and is not necessarily endorsed by or the opinion of the Research Institute. Responsibility for the content of this message lies strictly with the original author, and is not necessarily endorsed by or the opinion of the Research Institute. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 24, 2003 Report Share Posted July 24, 2003 In a message dated 7/23/03 10:59:27 PM Central Daylight Time, thecolemans4@... writes: > . I wanted to know if when eos's were that high, did you > have a food screen run, and if so, did it have a lot > of high readings? > My son was nearly 10% when we ran the last Merridian test and it didn't show many things as a problem at all. Eggs were slightly elevated along with rice and fish being iffy as problems. We had retried milk and cheese a month before that test though so it is possible that his body was so out of balance that he was reacting more to things. I also suspect parrasites as a contributor and certainly a viral thing that was making him much more reactive to everything. He's really been able to branch out his exposures and foods he used to react to much more since starting Famvir. Gaylen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 24, 2003 Report Share Posted July 24, 2003 Hi - Gosh 9-12% is high. Congrats on keeping them down. I wanted to know if when eos's were that high, did you have a food screen run, and if so, did it have a lot of high readings? Thanks for the info- > EOS are now usually less than 3% and the > lowest absolute of 0.18 we > have ever had v's 9-12% highs and absolutes as high > as 0.9 - 1.2 when we > started treatment or when he has had parasite > infections etc. > > > Re: esophinils? > > > After watching this for years with my son I have a > personal theory. > Maybe eosinphils only relate to food type allergies > (and parasites in > extreme cases) BUT when the system is doing poorly > for other reasons > (infections, seasonal allergies etc,) the body > seems to have a worse time > with the food and the eosinophils go up even eating > the same foods. > //message thread truncated// ______________________________ `````````````````````````````` Responsibility for the content of this message lies strictly with the original author, and is not necessarily endorsed by or the opinion of the Research Institute. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 25, 2003 Report Share Posted July 25, 2003 , We have had three Meridian food screens. At the beginning, we had over 23 at the high end of positive - mostly gluten and casein items as well as egg white and yolk, peanuts etc. EOS was around 9% at that time The second time about 18 months later, EOS had dropped and the food screen showed a lot of shifts into equivocal and negative. Last November a further 18 months later again, we had only one food in positive - egg whites, 4 in equivocal and the rest negative - all gluten is now negative. Point is that EOS had hit nearly 12% at that time due to other factors. EOS and food allergy screens do not run parallel, because EOS can be elevated due to parasites, and other viral, bacterial or fungal activity going on in the gut. The overall system has to be in good shape to keep EOS down. We do argue with Dr G on this point - and we have the clinical evidence! Hope this helps, RE: esophinils? Hi - Gosh 9-12% is high. Congrats on keeping them down. I wanted to know if when eos's were that high, did you have a food screen run, and if so, did it have a lot of high readings? Thanks for the info- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 25, 2003 Report Share Posted July 25, 2003 , thank you for this, it gives me hope!! Almost every food is at the high end of positive for us right now. I dream of the day I get a food screen result that is not all full of long black lines. Interestingly enough, the highest our Eos has ever been is 5%, and its currently at 3%, despite all the food problems. This causes me to disagree with Dr. G on this also when he attributes most eos. changes to foods. Becky RE: esophinils? > , > We have had three Meridian food screens. At the beginning, we had over 23 at > the high end of positive - mostly gluten and casein items as well as egg > white and yolk, peanuts etc. EOS was around 9% at that time > The second time about 18 months later, EOS had dropped and the food screen > showed a lot of shifts into equivocal and negative. > Last November a further 18 months later again, we had only one food in > positive - egg whites, 4 in equivocal and the rest negative - all gluten is > now negative. Point is that EOS had hit nearly 12% at that time due to other > factors. > EOS and food allergy screens do not run parallel, because EOS can be > elevated due to parasites, and other viral, bacterial or fungal activity > going on in the gut. The overall system has to be in good shape to keep EOS > down. > We do argue with Dr G on this point - and we have the clinical evidence! > Hope this helps, > > > > Responsibility for the content of this message lies strictly with > the original author, and is not necessarily endorsed by or the > opinion of the Research Institute. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 25, 2003 Report Share Posted July 25, 2003 In a message dated 7/24/03 8:00:19 PM Central Daylight Time, rmwilson@... writes: > Point is that EOS had hit nearly 12% at that time due to other > factors. > EOS and food allergy screens do not run parallel, because EOS can be > elevated due to parasites, and other viral, bacterial or fungal activity > going on in the gut. The overall system has to be in good shape to keep EOS > down. > We do argue with Dr G on this point - and we have the clinical evidence! > I tend to agree with this but it makes sense if you consider the theory that reactions to allergies and pathogens are like a bit pot, the more filled with offenders it is, the more reactive you are going to be. That would also explain why EOS or reactions to food allergies would be larger during inhalant allergy season. Gaylen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 25, 2003 Report Share Posted July 25, 2003 agree totally, Gaylen Re: esophinils? In a message dated 7/24/03 8:00:19 PM Central Daylight Time, rmwilson@... writes: > Point is that EOS had hit nearly 12% at that time due to other > factors. > EOS and food allergy screens do not run parallel, because EOS can be > elevated due to parasites, and other viral, bacterial or fungal activity > going on in the gut. The overall system has to be in good shape to keep EOS > down. > We do argue with Dr G on this point - and we have the clinical evidence! > I tend to agree with this but it makes sense if you consider the theory that reactions to allergies and pathogens are like a bit pot, the more filled with offenders it is, the more reactive you are going to be. That would also explain why EOS or reactions to food allergies would be larger during inhalant allergy season. Gaylen Quote Link to comment Share on other sites More sharing options...
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