Guest guest Posted June 28, 2003 Report Share Posted June 28, 2003 This phrase was used once before. I think I asked then what it was but forgot the reply. So, what are " PANDAS? " Thank you. msherrett. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 6, 2003 Report Share Posted November 6, 2003 Hi! I need to know anyone that has information on PANDAS. Please e-mail me privity if you would like. Thank you, Lois Lois Noland President Washington county ASA 721 Georgia Ave Hagerstown Md 21740 240-420-3692 jlois@... Add this card to your address book Digest Number 1796 > > > Responsibility for the content of this message lies strictly with > the original author, and is not necessarily endorsed by or the > opinion of the Research Institute. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 7, 2003 Report Share Posted November 7, 2003 My son has been checked for PANDAS, he has many of the symptoms and improved on Antibiotics. I wish I knew more about it however I am just learning of it. I belong to the Gulf Coast chapter ASA and I first heard of PANDAS at a meeting from another parent. My husband and I often wonder what hit us. My son was 51/2 when diagnosed with PDD-NOS and it presented in him with extreme OCD it would improve and then get worse. In February at our monthly meeting one of the moms was describing something similar and that it may be PANDAS, so I asked our pedi about it and he said his throat looks fine and then our family doctor said the same. I couldn't get anyone to do a simple throat test. Finally in June I found a pedi who knew something about PANDAS he tested my son and sure enough no temp no redness but swollen tonsils and lots of strepp. It amazed us we didn't expect it. My sons immune system is definitely not what it should be. I found some good info on the internet only when I spelled out PANDAS. I hope this is of some help to you. Good luck. Dawn Lois Nolan <jlois@...> wrote: Hi! I need to know anyone that has information on PANDAS. Please e-mail me privity if you would like. Thank you, Lois Lois Noland President Washington county ASA 721 Georgia Ave Hagerstown Md 21740 240-420-3692 jlois@... Add this card to your address book Digest Number 1796 > > > Responsibility for the content of this message lies strictly with > the original author, and is not necessarily endorsed by or the > opinion of the Research Institute. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 7, 2003 Report Share Posted November 7, 2003 My son has been checked for PANDAS, he has many of the symptoms and improved on Antibiotics. I wish I knew more about it however I am just learning of it. I belong to the Gulf Coast chapter ASA and I first heard of PANDAS at a meeting from another parent. My husband and I often wonder what hit us. My son was 51/2 when diagnosed with PDD-NOS and it presented in him with extreme OCD it would improve and then get worse. In February at our monthly meeting one of the moms was describing something similar and that it may be PANDAS, so I asked our pedi about it and he said his throat looks fine and then our family doctor said the same. I couldn't get anyone to do a simple throat test. Finally in June I found a pedi who knew something about PANDAS he tested my son and sure enough no temp no redness but swollen tonsils and lots of strepp. It amazed us we didn't expect it. My sons immune system is definitely not what it should be. I found some good info on the internet only when I spelled out PANDAS. I hope this is of some help to you. Good luck. Dawn Lois Nolan <jlois@...> wrote: Hi! I need to know anyone that has information on PANDAS. Please e-mail me privity if you would like. Thank you, Lois Lois Noland President Washington county ASA 721 Georgia Ave Hagerstown Md 21740 240-420-3692 jlois@... Add this card to your address book Digest Number 1796 > > > Responsibility for the content of this message lies strictly with > the original author, and is not necessarily endorsed by or the > opinion of the Research Institute. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 7, 2003 Report Share Posted November 7, 2003 Does anyone know if Dr. Golberg do testing for PANDAS? Re: PANDAS My son has been checked for PANDAS, he has many of the symptoms and improved on Antibiotics. I wish I knew more about it however I am just learning of it. I belong to the Gulf Coast chapter ASA and I first heard of PANDAS at a meeting from another parent. My husband and I often wonder what hit us. My son was 51/2 when diagnosed with PDD-NOS and it presented in him with extreme OCD it would improve and then get worse. In February at our monthly meeting one of the moms was describing something similar and that it may be PANDAS, so I asked our pedi about it and he said his throat looks fine and then our family doctor said the same. I couldn't get anyone to do a simple throat test. Finally in June I found a pedi who knew something about PANDAS he tested my son and sure enough no temp no redness but swollen tonsils and lots of strepp. It amazed us we didn't expect it. My sons immune system is definitely not what it should be. I found some good info on the internet only when I spelled out PANDAS. I hope this is of some help to you. Good luck. Dawn Lois Nolan <jlois@...> wrote: Hi! I need to know anyone that has information on PANDAS. Please e-mail me privity if you would like. Thank you, Lois Lois Noland President Washington county ASA 721 Georgia Ave Hagerstown Md 21740 240-420-3692 jlois@... Responsibility for the content of this message lies strictly with the original author, and is not necessarily endorsed by or the opinion of the Research Institute. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 7, 2003 Report Share Posted November 7, 2003 Here's some info that may help. Cheryl Is obsessive-compulsive an autoimmune disorder? http://www.cmaj.ca/cgi/reprint/165/10/1353.pdf http://info.med.yale.edu/chldstdy/plomdevelop/genetics/01julgen.htm http://info.med.yale.edu/chldstdy/plomdevelop/genetics/01auggen.htm http://info.med.yale.edu/chldstdy/plomdevelop/genetics/01octgen.htm http://info.med.yale.edu/chldstdy/plomdevelop/genetics/01novgen.htm http://info.med.yale.edu/chldstdy/plomdevelop/genetics/01decgen.htm http://info.med.yale.edu/chldstdy/plomdevelop/genetics/02jangen.htm http://info.med.yale.edu/chldstdy/plomdevelop/genetics/02febgen.htm _________________________________________________________________ MSN Messenger with backgrounds, emoticons and more. http://www.msnmessenger-download.com/tracking/cdp_customize Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 8, 2003 Report Share Posted November 8, 2003 Does anyone know if Dr. Golberg do testing for PANDAS? Yes, he does. He ordered an ASO blood test for my son because of some OCD-like symptoms that I reported. (It was negative in my son's case). Donna Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2004 Report Share Posted February 18, 2004 ----Original Message Follows---- From: " Candi DAVIS " <cdavis642@...> Hello Everyone, We have been seeing Dr.Goldberg for over 2 years now we just got the ASO test back and it was a little high...233.....so we are thinking maybe PANDAS ...we will retest in about a month .......I don't know much about this ...but I have been reading some posts about Tic with Pandas....what is that ? Just wondering ...thanks candi Hi Candi, Any type of infection can aggravate . If your child has PANDAS on top of the normal symptoms.......it's pretty hard to miss. The symptoms come on fairly quickly and are pretty unique. What I've found interesting is that after years of telling Dr. G. about the urinary problems that appeared each time we had an OCD flair.......it was finally validated in a publication in 2002. This is one article that I could really relate to. Although my son's is triggered by some other type of infection, his response to antibiotics like Bactrim and Augmentin have been just as dramatic as described in this article. He already had ASD symptoms. Then at age seven (2nd grade) he began the handwashing, extreme nighttime fear/rituals, irrational terrible moodswings, meltdowns, panic attack meltdowns, deterioration in motor, handwriting, math, etc. that made it impossible to leave him at school. There was also a dramatic increase in sensory problems like the sock thing mentioned. (also light, sound, motion) His third grade teacher has a lot of notes about his sock complaints and all his willfull " behavioral " problems and who I'm sure thought I was nuts and making excuses for what was happening. http://ajp.psychiatryonline.org/cgi/content/full/155/11/1592 We've experienced pretty much every symtom during a flair. Without the right antibiotic we lived an increasing nightmare from about Oct til sometime in Spring. Then we'd be back to the normal problems until we'd have another flair in early Fall. Cheryl " The OCD behaviors exhibited included hand washing and preoccupation with germs, but daytime urinary urgency and frequency without dysuria, fever, or incontinence were the most notable symptoms in our series (58% of patients). Symptoms disappeared at night. " (Abstract below) " The children's symptom onset was acute and dramatic, typically triggered by GABHS infections at a very early age (mean=6.3 years, SD=2.7, for tics; mean=7.4 years, SD=2.7, for OCD). The PANDAS clinical course was characterized by a relapsing-remitting symptom pattern with significant psychiatric comorbidity accompanying the exacerbations; emotional lability, separation anxiety, nighttime fears and bedtime rituals, cognitive deficits, oppositional behaviors, and motoric hyperactivity were particularly common " . Biol Psychiatry. 2004 Jan 1;55(1):61-8. Detecting pediatric autoimmune neuropsychiatric disorders associated with streptococcus in children with obsessive-compulsive disorder and tics. TK, Sajid M, Soto O, Shapira N, Edge P, Yang M, MH, Goodman WK. Department of Psychiatry, University of Florida, Gainesville, Florida 32610-0256, USA. BACKGROUND: A subgroup of children with obsessive-compulsive and tic disorders are proposed to have an infectious trigger. The purpose of this study was to investigate the relationship between group A streptococcal titers and symptom fluctuations in children with a clinical course resembling that described for pediatric autoimmune neuropsychiatric disorders associated with streptococcus. METHODS: Twenty-five children with obsessive-compulsive disorder and/or tic disorder were evaluated for neuropsychiatric severity and group A streptococcal antibody titers (streptolysin O, deoxyribonuclease B, and carbohydrate A) at 6-week intervals for > or = six consecutive evaluations (total visits=277). RESULTS: Children with large symptom fluctuations (n=15) were compared with children without dramatic fluctuations (n=10). Co-movements of obsessive-compulsive/tic severity and group A streptococcal antibodies were assessed. In subjects with large symptom changes, positive correlations were found between streptococcal titers and obsessive-compulsive severity rating changes (p=.0130). These subjects were also more likely to have elevated group A streptococcal titers during the majority of observations (p=.001). Tic symptom exacerbations occurred more often in the fall/winter months than spring/summer months (p=.03). CONCLUSIONS: Patients with marked obsessive-compulsive/tic symptom changes may be characterized by streptococcal titer elevations and exhibit evidence of seasonal tic exacerbations. PMID: 14706426 [PubMed - in process] Arch Pediatr Adolesc Med. 2002 Apr;156(4):356-61. Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS). ML, Pichichero ME. Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA. BACKGROUND: The current diagnostic criteria for pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS) are pediatric onset, neuropsychiatric disorder (obsessive-compulsive disorder [OCD]) and/or tic disorder; abrupt onset and/or episodic course of symptoms; association with group A beta-hemolytic streptococcal (GABHS) infection; and association with neurological abnormalities (motoric hyperactivity or adventitious movements, including choreiform movements or tics). OBJECTIVE: To assess new-onset PANDAS cases in relation to acute GABHS tonsillopharyngitis. DESIGN: Prospective PANDAS case identification and follow-up. RESULTS: Over a 3-year period (1998-2000), we identified 12 school-aged children with new-onset PANDAS. Each patient had the abrupt appearance of severe OCD behaviors, accompanied by mild symptoms and signs of acute GABHS tonsillopharyngitis. Throat swabs tested positive for GABHS by rapid antigen detection and/or were culture positive. The GABHS serologic tests, when performed (n = 3), showed very high antideoxyribonuclease antibody titers. Mean age at presentation was 7 years (age range, 5-11 years). In children treated with antibiotics effective in eradicating GABHS infection at the sentinel episode, OCD symptoms promptly disappeared. Follow-up throat cultures negative for GABHS were obtained prospectively after the first PANDAS episode. Recurrence of OCD symptoms was seen in 6 patients; each recurrence was associated with evidence of acute GABHS infection and responded to antibiotic therapy, supporting the premise that these patients were not GABHS carriers. The OCD behaviors exhibited included hand washing and preoccupation with germs, but daytime urinary urgency and frequency without dysuria, fever, or incontinence were the most notable symptoms in our series (58% of patients). Symptoms disappeared at night, and urinalysis and urine cultures were negative. CONCLUSION: To our knowledge, this is the first prospective study to confirm that PANDAS is associated with acute GABHS tonsillopharyngitis and responds to appropriate antibiotic therapy at the sentinel episode. Publication Types: Case Reports PMID: 11929370 [PubMed - indexed for MEDLINE] Am J Psychiatry. 1998 Feb;155(2):264-71. Related Articles, Links Erratum in: Am J Psychiatry 1998 Apr;155(4):578. Comment in: Am J Psychiatry. 2002 Feb;159(2):320. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Swedo SE, Leonard HL, Garvey M, Mittleman B, AJ, Perlmutter S, Lougee L, Dow S, Zamkoff J, Dubbert BK. Section on Behavioral Pediatrics, NIMH, Rockville Pike, Bethesda, MD 20892-1381, USA. swedos@... OBJECTIVE: The purpose of this study was to describe the clinical characteristics of a novel group of patients with obsessive-compulsive disorder (OCD) and tic disorders, designated as pediatric autoimmune neuropsychiatric disorders associated with streptococcal (group A beta-hemolytic streptococcal [GABHS]) infections (PANDAS). METHOD: The authors conducted a systematic clinical evaluation of 50 children who met all of the following five working diagnostic criteria: presence of OCD and/or a tic disorder, prepubertal symptom onset, episodic course of symptom severity, association with GABHS infections, and association with neurological abnormalities. RESULTS: The children's symptom onset was acute and dramatic, typically triggered by GABHS infections at a very early age (mean = 6.3 years, SD = 2.7, for tics; mean = 7.4 years, SD = 2.7, for OCD). The PANDAS clinical course was characterized by a relapsing-remitting symptom pattern with significant psychiatric comorbidity accompanying the exacerbations; emotional lability, separation anxiety, nighttime fears and bedtime rituals, cognitive deficits, oppositional behaviors, and motoric hyperactivity were particularly common. Symptom onset was triggered by GABHS infection for 22 (44%) of the children and by pharyngitis (no throat culture obtained) for 14 others (28%). Among the 50 children; there were 144 separate episodes of symptom exacerbation; 45 (31%) were associated with documented GABHS infection, 60 (42%) with symptoms of pharyngitis or upper respiratory infection (no throat culture obtained), and six (4%) with GABHS exposure. CONCLUSIONS: The working diagnostic criteria appear to accurately characterize a homogeneous patient group in which symptom exacerbations are triggered by GABHS infections. The identification of such a subgroup will allow for testing of models of pathogenesis, as well as the development of novel treatment and prevention strategies. PMID: 9464208 [PubMed - indexed for MEDLINE] http://ajp.psychiatryonline.org/cgi/content/full/155/2/264?ijkey=f7c9d21d2fa707b\ e78c56a5702d3323ff8a21835 _________________________________________________________________ Get a FREE online computer virus scan from McAfee when you click here. http://clinic.mcafee.com/clinic/ibuy/campaign.asp?cid=3963 Quote Link to comment Share on other sites More sharing options...
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