RE: newbie/test results

[Guest guest]

I have the test results from when I was still

on synthroid .075, so I’ll be curious to see how they differ after a month

off of it (plus the antibody tests, which I didn’t have before):

Blood test:

Estradiol 60 reference range 0-400 (Follicular

Phase ND-160) I was day 7

Free T4 1.57 (range 0.8 – 1.9) (was taking .075

synthroid at the time of the test)

Free T3 2.3 (ref range 2.3 - 4.2)

" normal "

TSH was 1.13 a month or so prior to the above test, but

it may be skewed because I had been off synthroid for a month, and then back on

for 3 days at the time of that test.

Progesterone 0.84 (Follicular .41 – 1.0)

Saliva Test:

Adrenal Stress Index:

Free Cortisol Rhythm:

7-8 am 9 Depressed

(13.24)

11-12 9 Normal (5-10)

4-5 pm 5 Normal (3-8)

11-midnight 5 Elevated (1-4)

Remarks: depressed morning cortisol <13 nM, is suggestive

of marginal HPA performance. Normal rhythms exhibit highest cortisol for the

day at 7-8 am….may be associated with insomnia, and caused by a stress

response to an emotional or mental situation, nocturnal hypoglycemia or chronic

pain and overt/hidden inflammation.

Consider dietary modifications and glycemic control,

initiating a mild-to-moderate aerobic exercise program, use of ACTH dampening

Phosphorylated serine supplement with 1-2 hours of time(s) of high cortisol,

the palliative use of a natural or pharmaceutical anti-histamine or

anti-inflammatory, balancing the parasympathetic/sympathetic systems using

established techniques such as meditation or Tai Chai.

If above changes to not yield the desired clinical and

follow up test results, look for low grade or hidden inflammation &

infections. Ex: food intolerances, chronic gastrointestinal & other

infections.

DHEA Pooled Value 3

borderline Adults 3-10 ng/ml

Your hormone values are in Zone 4 (cortisol-DHEA correlation

zone – Maladapted Phase II)

This zone represents marginal cortisol output with reduced

DHEA levels reflecting a minimal adrenal reserve. The production of the

precursor pregnenolone is usually limited and the adrenal cortex may show

hypertrophic changes. Under stress the cortisol response is either suboptimal or

at best low normal. This condition is usually the outcome of chronic and

protracted stress exposure.

Insulin Post-prandial 5 Normal

(optimal: 5-20 uIU/mL)

Why measure insulin?

Insulin Resistance is defined as reduced insulin effects on

target issues. Elevated cortisol levels antagonize insulin activity at almost

every level. Cortisol inhibits insulin post-receptor glucose utilization in

muscle and fat cells leading to reduced insulin activity (Functional Insulin

Resistance). Cortisol also increases pancreatic Insulin release. Chronically

elevated Cortisol is Diabetogenic. It renders insulin ineffective leading to

overproduction. Insulin resistance eventually leads to exhaustion of the

pancreatic capacity to produce Insulin. Please note that Growth Hormone

elevation is antagonistic to insulin activity.

17-OH Progesterone 143 Elevated

(Optional 22-100 pg/ml – Elevated: >130 pg/ml)

Adrenal Steroid Synthesis Pathway

17-OH Progesterone elevation may result from intake/buildup

of exogenous progesterone, or reduced 21-Hydroxylase enzyme activity. This may

limit the amount and capacity of cortisol synthesis. In this condition,

supplementation with the cortisol precursors, pregnenolone, or progesterone may

not guarantee full restoration of cortisol production.

Total Salivary SIgA 7

Depressed Normal 25-60

mg/dl Borderline 20-25 mg/dl

A depressed SIgA may be attributed to one or more of the

following:

1 – excessive chronic cortisol output causes a

reduction in the number of SIgA producing immunocytes. Appropriate restorative

treatments have been shown to produce incremental improvements in SIgA.

2 – excessive sympathetic activity causes inhibition

of SIgA release from the mucosal immunocytes.

3 – Chronic deficits in cortisol and/or DHEA levels.

4 – possible systemic deficit in capacity to produce

IgA – an inherited problem. Rule out possibility with a serum IgA test. A

normal finding rules out this possibility.

Basic Facts About SigA

1 – Secretory IgA (SIgA) is secreted by the various

mucosal surfaces. It is mostly a dimeric molecule. Less than 2% of saliva is of

serum origin. The secretory component of SIgA stabilizes it against enzymatic

and bacterial degradation.

2 – The main functions of SIgA include Immune

Exclusion, Viral and Toxin Neutralization, Plasmid Elimination, and Inhibition

of Bacterial Colonization. SIgA immune complexes are not inflammatory to the

mucosal surfaces.

3 – Production of SIgA is adversely affected by stress

which is mediated by increased cortisol and/or catecholamine levels.

Gliadin Ab, SIgA 1

Negative Borderline: 13-15 U/ml Positive: >15 U/ml

Gliadins are polypeptides found in wheat, rye, oat, barley

and other grain glutens, and are toxic to the intestinal mucosa in susceptible

individuals. Healthy adults and children may have a positive andigliadin test

because of subclinical gliadin intolerance. Some of their symptoms include mild

enteritis, occasional loose stools, fat intolerance, marginal vitamin and

mineral status, fatigue or accelerated osteoporosis.

From:

Sent: Saturday, July 31, 2004

10:13 AM

To:

Texas_Thyroid_Groups

Subject: Re:

newbie

I have a feeling that there will be something on your thyroid tests,

when

you get them

back, and maybe the ferritin. I will tell you that it is many

peoples'

opinion, mine as well, that chronic fatigue and fibromyalgia are

not diseases

to themselves, but are symptoms of low thyroid instead. If

the thyroid

is treated properly, funny thing is that these two symptoms seem

to

disappear. Your thyroid panel---I hope you ran the panel with the Free

T3 and Free

T4. Those are the two that count t'wd what's really going on in

there.

Some people seem to do fine on $ynthroid, though I don't know many

who do, and

I certainly didn't for all those yrs. The Armour provides more

T3 that

evidently just didn't happen with the synthetic meds. Besides, as

you can see

by the posted recalls today, both $ynthroid and Levoxyl have not

been that

stable, repeatedly, over many yrs. When you get your results,

post them

here with the lab reference ranges.