Maternal neuronal antibodies associated with autism and a language disorder

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Ann Neurol 2003 Apr;53(4):533-7 Related Articles, Links

Maternal neuronal antibodies associated with autism and a language disorder.

Dalton P, Deacon R, Blamire A, Pike M, McKinlay I, Stein J, Styles P,

A.

Neurosciences Group, Department of Clinical Neurology, University of Oxford,

Oxford, United Kingdom.

Neurodevelopmental disorders could be caused by maternal antibodies or other

serum factors. We detected serum antibodies binding to rodent Purkinje cells

and other neurons in a mother of three children: the first normal, the

second with autism, and the third with a severe specific language disorder.

We injected the serum (0.5-1.0 ml/day) into pregnant mice during gestation

and found altered exploration and motor coordination and changes in

cerebellar magnetic resonance spectroscopy in the mouse offspring, comparing

with offspring of mice injected with sera from mothers of healthy children.

This evidence supports a role for maternal antibodies in some forms of

neurodevelopmental disorder.

PMID: 12666123 [PubMed - indexed for MEDLINE]

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Maternal antibodies to what?? Is this the entire abstract? It's

awful vague..........

Thanks for sharing! Becky

Maternal neuronal antibodies associated with autism and a

language disorder

> Ann Neurol 2003 Apr;53(4):533-7 Related Articles, Links

>

>

> Maternal neuronal antibodies associated with autism and a language

disorder.

>

> Dalton P, Deacon R, Blamire A, Pike M, McKinlay I, Stein J, Styles P,

> A.

>

> Neurosciences Group, Department of Clinical Neurology, University of

Oxford,

> Oxford, United Kingdom.

>

> Neurodevelopmental disorders could be caused by maternal antibodies or

other

> serum factors. We detected serum antibodies binding to rodent Purkinje

cells

> and other neurons in a mother of three children: the first normal, the

> second with autism, and the third with a severe specific language

disorder.

>

> We injected the serum (0.5-1.0 ml/day) into pregnant mice during gestation

> and found altered exploration and motor coordination and changes in

> cerebellar magnetic resonance spectroscopy in the mouse offspring,

comparing

> with offspring of mice injected with sera from mothers of healthy

children.

>

> This evidence supports a role for maternal antibodies in some forms of

> neurodevelopmental disorder.

>

> PMID: 12666123 [PubMed - indexed for MEDLINE]

>

>

>

>

>

> _________________________________________________________________

> Protect your PC - get McAfee.com VirusScan Online

> http://clinic.mcafee.com/clinic/ibuy/campaign.asp?cid=3963

>

>

>

>

> Responsibility for the content of this message lies strictly with

> the original author, and is not necessarily endorsed by or the

> opinion of the Research Institute.

>

>

>

[Guest guest]

----Original Message Follows----

From: " & Becky " <beckeric@...>

Maternal antibodies to what?? Is this the entire abstract? It's

awful vague..........

> Purkinje cells and other neurons in a mother of three children

------------------------------------------------------------------------

Purkinje cell

<neurology, pathology> A class of output neurons in the cerebellum, which

are the only neurons that convey signals away from the cerebellum. They form

a layer of large ganglion cells near the surface of the cerebellum.

neurons

Any of the conducting cells of the nervous system. A typical neuron consists

of a cell body, containing the nucleus and the surrounding cytoplasm

(perikaryon); several short radiating processes (dendrites); and one long

process (the axon), which terminates in twiglike branches (telodendrons) and

may have branches (collaterals) projecting along its course.

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[Guest guest]

So the maternal antibodies are to the neurons? Sort of like the ANA titer

our kids can have? (Sorry if I'm completely dense here, LOL)

Becky

Re: Maternal neuronal antibodies associated with autism and

a language disorder

> ----Original Message Follows----

> From: " & Becky " <beckeric@...>

>

> Maternal antibodies to what?? Is this the entire abstract? It's

> awful vague..........

>

>

> > Purkinje cells and other neurons in a mother of three children

> ------------------------------------------------------------------------

> Purkinje cell

> <neurology, pathology> A class of output neurons in the cerebellum, which

> are the only neurons that convey signals away from the cerebellum. They

form

> a layer of large ganglion cells near the surface of the cerebellum.

>

> neurons

> Any of the conducting cells of the nervous system. A typical neuron

consists

> of a cell body, containing the nucleus and the surrounding cytoplasm

> (perikaryon); several short radiating processes (dendrites); and one long

> process (the axon), which terminates in twiglike branches (telodendrons)

and

> may have branches (collaterals) projecting along its course.

>

>

>

>

>

>

> _________________________________________________________________

> The new MSN 8: smart spam protection and 2 months FREE*

> http://join.msn.com/?page=features/junkmail

>

>

>

>

> Responsibility for the content of this message lies strictly with

> the original author, and is not necessarily endorsed by or the

> opinion of the Research Institute.

>

>

>

[Guest guest]

> Maternal antibodies to what?? Is this the entire abstract?

It's awful vague..........

Another thing to look at in this " study " is... one woman. If I read

this abstract correctly, they tested *ONE* woman. What I would

like to see is them test more than *one* person and see if the same

holds true.- A.C.

[Guest guest]

What is the ana titer? Barb

--- & Becky <beckeric@...> wrote:

> So the maternal antibodies are to the neurons? Sort

> of like the ANA titer

> our kids can have? (Sorry if I'm completely dense

> here, LOL)

>

> Becky

[Guest guest]

----Original Message Follows----

From: Barb Katsaros <barbkatsaros@...>

What is the ana titer? Barb

Hi Barb,

Here's the medical description.

Cheryl

Antinuclear antibody is an antibody that react against components of the

cell nucleus such as DNA, RNA, histone or non-histone proteins.

These antibodies are present in a variety of immunologic or autoimmune

diseases including systemic lupus erythematosus, systemic sclerosis,

scleroderma, Sjogren's syndrome, rheumatoid arthritis, polymyositis,

dermatomyositis and in persons taking hydralazine, procainamide or

isoniazid.

A serologic measurement for antinuclear antibodies can aid in the diagnosis

of unexplained arthritis, rashes or chest pains.

Acronym: ANA

(12 Jan 1998)

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Auto-Nuclear Antibodies titre. A measure of autoimmune antibodies produced

in the body.

Re: Maternal neuronal antibodies associated with autism

and a language disorder

What is the ana titer? Barb