Re: Are Some Genotypes Worse than Others?

[Guest guest]

I'm sorry....What group do you mean?

I'm a nurse and Hepatitis C Speaker/Consultant ....I have worked with

hepatitis C patients for 6 years now and have had many many patients who remain

clear. As a matter of fact very few relapse.

From the last group of ten that I'm helping online....all genotype

1....including 1 post transplant, 1 co-infected and 1 decompensating....so far 4

obtained SVR, 2 have 3 more months to go. 2 are at week 24 and 1 is on

Infergen at

16 weeks of treatment. Only one had to stop treatment because of a

hypersensitivity reaction.....and she had cleared at week 12.

But you definetly need to have a positive attitude....which you seem to be

lacking.

Silvia

[Guest guest]

I'm sorry....What group do you mean?

I'm a nurse and Hepatitis C Speaker/Consultant ....I have worked with

hepatitis C patients for 6 years now and have had many many patients who remain

clear. As a matter of fact very few relapse.

From the last group of ten that I'm helping online....all genotype

1....including 1 post transplant, 1 co-infected and 1 decompensating....so far 4

obtained SVR, 2 have 3 more months to go. 2 are at week 24 and 1 is on

Infergen at

16 weeks of treatment. Only one had to stop treatment because of a

hypersensitivity reaction.....and she had cleared at week 12.

But you definetly need to have a positive attitude....which you seem to be

lacking.

Silvia

[Guest guest]

I'm sorry....What group do you mean?

I'm a nurse and Hepatitis C Speaker/Consultant ....I have worked with

hepatitis C patients for 6 years now and have had many many patients who remain

clear. As a matter of fact very few relapse.

From the last group of ten that I'm helping online....all genotype

1....including 1 post transplant, 1 co-infected and 1 decompensating....so far 4

obtained SVR, 2 have 3 more months to go. 2 are at week 24 and 1 is on

Infergen at

16 weeks of treatment. Only one had to stop treatment because of a

hypersensitivity reaction.....and she had cleared at week 12.

But you definetly need to have a positive attitude....which you seem to be

lacking.

Silvia

[Guest guest]

There are no experts in HCV.

There are only doctors who care and know more about

the body and how the liver works. These are

specialists.

If there were experts, there would be a way to clear

most bodies of the virus.

The guy who turned me onto this 'group' remissed after

10 years.

Is this a big group? Who here has been 'treated' and

is now in remission longer than 1 year?

--- Bhprice425@... wrote:

> Look in www.projectsinknowledge.com it's the site

> with all the experts.

>

>

> If you are clear 6 months after treatment then you

> have a 97% chance of

> remauining clear......the NIH says so.

>

> After 2 years ...yes I have heard of a few

> case....rare but they do exist.

> There's is one case on recent news that turned out

> positive after 8 and half

> years....

>

> Reemergence of hepatitis C virus after 8.5 years in

> a patient with

> hypogammaglobulinemia: evidence for an occult viral

> reservoir.

> Lee WM, Polson JE, Carney DS, Sahin B, Gale M Jr.

> Department of Internal Medicine, Division of

> Digestive and Liver

> Diseases, University of Texas Southwestern Medical

> Center, Dallas, USA.

> The question of whether viruses persist after

> apparent clearance of

> infection remains unanswered. Here, we describe a

> patient with

> hypogammaglobulinemia whose acute hepatitis C virus

> (HCV) infection

> appeared to resolve after receipt of interferon

> therapy, relapse immediately,

> and then clear spontaneously--only to relapse after

> receipt of corticosteroid

> therapy, and clear again, 8.5 years later.

> Sequencing indicated that the

> viruses detected during each relapse were virtually

> identical, with the

> hypervariable region 1 of E2 appearing to be

> monoclonal, which is typical of patients

> with hypogammaglobulinemia. Nonstructural 5A

> sequences exhibited quasispecies

> diversity initially but, after 8.5 years, had become

> monoclonal. The prolonged period of negativity for

> HCV RNA followed by

> relapse suggests that HCV may persist in apparent

> sustained viral responders.

> PMID: 16107964 [PubMed - in process]

>

>

> [Non-text portions of this message have been

> removed]

>

>

>

>

[Guest guest]

There are no experts in HCV.

There are only doctors who care and know more about

the body and how the liver works. These are

specialists.

If there were experts, there would be a way to clear

most bodies of the virus.

The guy who turned me onto this 'group' remissed after

10 years.

Is this a big group? Who here has been 'treated' and

is now in remission longer than 1 year?

--- Bhprice425@... wrote:

> Look in www.projectsinknowledge.com it's the site

> with all the experts.

>

>

> If you are clear 6 months after treatment then you

> have a 97% chance of

> remauining clear......the NIH says so.

>

> After 2 years ...yes I have heard of a few

> case....rare but they do exist.

> There's is one case on recent news that turned out

> positive after 8 and half

> years....

>

> Reemergence of hepatitis C virus after 8.5 years in

> a patient with

> hypogammaglobulinemia: evidence for an occult viral

> reservoir.

> Lee WM, Polson JE, Carney DS, Sahin B, Gale M Jr.

> Department of Internal Medicine, Division of

> Digestive and Liver

> Diseases, University of Texas Southwestern Medical

> Center, Dallas, USA.

> The question of whether viruses persist after

> apparent clearance of

> infection remains unanswered. Here, we describe a

> patient with

> hypogammaglobulinemia whose acute hepatitis C virus

> (HCV) infection

> appeared to resolve after receipt of interferon

> therapy, relapse immediately,

> and then clear spontaneously--only to relapse after

> receipt of corticosteroid

> therapy, and clear again, 8.5 years later.

> Sequencing indicated that the

> viruses detected during each relapse were virtually

> identical, with the

> hypervariable region 1 of E2 appearing to be

> monoclonal, which is typical of patients

> with hypogammaglobulinemia. Nonstructural 5A

> sequences exhibited quasispecies

> diversity initially but, after 8.5 years, had become

> monoclonal. The prolonged period of negativity for

> HCV RNA followed by

> relapse suggests that HCV may persist in apparent

> sustained viral responders.

> PMID: 16107964 [PubMed - in process]

>

>

> [Non-text portions of this message have been

> removed]

>

>

>

>

[Guest guest]

LOL...I totally agree with you

Silvia

[Guest guest]

THAT IS BS....i don't know where you got youir stats ....according to you

nobody clears.....ridiculous!

Silvia

[Guest guest]

LOL.....two friends and that gives you info on how many relapse?

Silvia

[Guest guest]

Hi Sandy

Im still clear and I finished tx 2 1/2 years ago, with genotype 1a, vl about

600,000 with stage 3-4 damage with early cirrhosis,, and now am stage 0-1 with

NO activity. Im counting my self lucky because my liver has regressed in damage

but I know that it could come back at any time while Im hoping to be in that 97%

who it never shows up again!

welcome to the group

jax

sandy katt wrote:

There are no experts in HCV.

There are only doctors who care and know more about

the body and how the liver works. These are

specialists.

If there were experts, there would be a way to clear

most bodies of the virus.

The guy who turned me onto this 'group' remissed after

10 years.

Is this a big group? Who here has been 'treated' and

is now in remission longer than 1 year?

--- Bhprice425@... wrote:

> Look in www.projectsinknowledge.com it's the site

> with all the experts.

>

>

> If you are clear 6 months after treatment then you

> have a 97% chance of

> remauining clear......the NIH says so.

>

> After 2 years ...yes I have heard of a few

> case....rare but they do exist.

> There's is one case on recent news that turned out

> positive after 8 and half

> years....

>

> Reemergence of hepatitis C virus after 8.5 years in

> a patient with

> hypogammaglobulinemia: evidence for an occult viral

> reservoir.

> Lee WM, Polson JE, Carney DS, Sahin B, Gale M Jr.

> Department of Internal Medicine, Division of

> Digestive and Liver

> Diseases, University of Texas Southwestern Medical

> Center, Dallas, USA.

> The question of whether viruses persist after

> apparent clearance of

> infection remains unanswered. Here, we describe a

> patient with

> hypogammaglobulinemia whose acute hepatitis C virus

> (HCV) infection

> appeared to resolve after receipt of interferon

> therapy, relapse immediately,

> and then clear spontaneously--only to relapse after

> receipt of corticosteroid

> therapy, and clear again, 8.5 years later.

> Sequencing indicated that the

> viruses detected during each relapse were virtually

> identical, with the

> hypervariable region 1 of E2 appearing to be

> monoclonal, which is typical of patients

> with hypogammaglobulinemia. Nonstructural 5A

> sequences exhibited quasispecies

> diversity initially but, after 8.5 years, had become

> monoclonal. The prolonged period of negativity for

> HCV RNA followed by

> relapse suggests that HCV may persist in apparent

> sustained viral responders.

> PMID: 16107964 [PubMed - in process]

>

>

> [Non-text portions of this message have been

> removed]

>

>

>

>

[Guest guest]

Hi Sandy

Im still clear and I finished tx 2 1/2 years ago, with genotype 1a, vl about

600,000 with stage 3-4 damage with early cirrhosis,, and now am stage 0-1 with

NO activity. Im counting my self lucky because my liver has regressed in damage

but I know that it could come back at any time while Im hoping to be in that 97%

who it never shows up again!

welcome to the group

jax

sandy katt wrote:

There are no experts in HCV.

There are only doctors who care and know more about

the body and how the liver works. These are

specialists.

If there were experts, there would be a way to clear

most bodies of the virus.

The guy who turned me onto this 'group' remissed after

10 years.

Is this a big group? Who here has been 'treated' and

is now in remission longer than 1 year?

--- Bhprice425@... wrote:

> Look in www.projectsinknowledge.com it's the site

> with all the experts.

>

>

> If you are clear 6 months after treatment then you

> have a 97% chance of

> remauining clear......the NIH says so.

>

> After 2 years ...yes I have heard of a few

> case....rare but they do exist.

> There's is one case on recent news that turned out

> positive after 8 and half

> years....

>

> Reemergence of hepatitis C virus after 8.5 years in

> a patient with

> hypogammaglobulinemia: evidence for an occult viral

> reservoir.

> Lee WM, Polson JE, Carney DS, Sahin B, Gale M Jr.

> Department of Internal Medicine, Division of

> Digestive and Liver

> Diseases, University of Texas Southwestern Medical

> Center, Dallas, USA.

> The question of whether viruses persist after

> apparent clearance of

> infection remains unanswered. Here, we describe a

> patient with

> hypogammaglobulinemia whose acute hepatitis C virus

> (HCV) infection

> appeared to resolve after receipt of interferon

> therapy, relapse immediately,

> and then clear spontaneously--only to relapse after

> receipt of corticosteroid

> therapy, and clear again, 8.5 years later.

> Sequencing indicated that the

> viruses detected during each relapse were virtually

> identical, with the

> hypervariable region 1 of E2 appearing to be

> monoclonal, which is typical of patients

> with hypogammaglobulinemia. Nonstructural 5A

> sequences exhibited quasispecies

> diversity initially but, after 8.5 years, had become

> monoclonal. The prolonged period of negativity for

> HCV RNA followed by

> relapse suggests that HCV may persist in apparent

> sustained viral responders.

> PMID: 16107964 [PubMed - in process]

>

>

> [Non-text portions of this message have been

> removed]

>

>

>

>

[Guest guest]

Sandy

Im sorry to say but I TOTALLY agree with you regarding the Drug companies,, its

much to their advantage to have us sick CHRONICALLY so we can continue to use

their poisons,,

Well its probably NOT in MY best interest to get started on this subject,, lol

sandy katt wrote:

I need more.

<<If there is no detectable amount of HCV in your

blood six months after you have finished a full course

of treatment, you have a sustained virological

response (SVR).>>

Why don't you research further and find out the stats

for two years after treatment?

Unless, of course, 6 months is all the health duration

you are after.

Selected information is being put out by a company in

who's interest it is to sell a drug treatment. In my

humble opinion, a person who believes that the R & I

companies want to find a cure is naive. A chronic

disease is preferrable to their pockets.

Has anyone heard anything new about VERTEX?

--- Bhprice425@... wrote:

> Let me know if you need more.

>

> Research has shown that it is more effective to

> treat HCV using a combination

> of pegylated interferon and ribavirin than treating

> without ribavirin. For

> people infected with HCV only, SVR is achieved in

> about 45-50% with genotype 1,

> and over 80% with genotype 2 or 3 when treated with

> the combination.

> http://www.atdn.org/simple/pifn.html

>

> The currently acceptable therapy for HCV is a

> combination of interferon and

> ribavirin. Conjugation of polyethylene glycol (PEG)

> to interferon--pegylated

> interferon--is the newest advance in the treatment

> of HCV patients. Pegylation

> increases the elimination half-life of interferon,

> providing improved efficacy

> with once-weekly dosing. SVR rates in patients

> infected with genotype 1 HCV

> have increased from 10-15% with interferon

> monotherapy to over 50% using the

> pegylated interferon-ribavirin combination. Patients

> infected with genotype 2 or

> 3 achieve SVR rates of 80% and more.

>

http://www.vh.org/adult/provider/internalmedicine/hepatitisc/

> Pipeline Innovations in Hepatitis C Treatments

> However, approximately 50% of patients infected with

> HCV genotype 1 do not

> achieve

> a sustained virologic response (SVR) with initial

> interferon-based ...

> www.projectsinknowledge.com/Init/G/1708/ - 83k

> May I recommend the Clinicians Guide Volume

> VII........it's a guide for

> doctors to treat Hepatitis C .....all the latest by

> the best hepatologists in the

> nation.

> Silvia

> www.projectsinknowledge.com/

> init/g/1688/1688_Monograph.pdf

>

>

> [Non-text portions of this message have been

> removed]

>

>

>

>

[Guest guest]

Sandy

Im sorry to say but I TOTALLY agree with you regarding the Drug companies,, its

much to their advantage to have us sick CHRONICALLY so we can continue to use

their poisons,,

Well its probably NOT in MY best interest to get started on this subject,, lol

sandy katt wrote:

I need more.

<<If there is no detectable amount of HCV in your

blood six months after you have finished a full course

of treatment, you have a sustained virological

response (SVR).>>

Why don't you research further and find out the stats

for two years after treatment?

Unless, of course, 6 months is all the health duration

you are after.

Selected information is being put out by a company in

who's interest it is to sell a drug treatment. In my

humble opinion, a person who believes that the R & I

companies want to find a cure is naive. A chronic

disease is preferrable to their pockets.

Has anyone heard anything new about VERTEX?

--- Bhprice425@... wrote:

> Let me know if you need more.

>

> Research has shown that it is more effective to

> treat HCV using a combination

> of pegylated interferon and ribavirin than treating

> without ribavirin. For

> people infected with HCV only, SVR is achieved in

> about 45-50% with genotype 1,

> and over 80% with genotype 2 or 3 when treated with

> the combination.

> http://www.atdn.org/simple/pifn.html

>

> The currently acceptable therapy for HCV is a

> combination of interferon and

> ribavirin. Conjugation of polyethylene glycol (PEG)

> to interferon--pegylated

> interferon--is the newest advance in the treatment

> of HCV patients. Pegylation

> increases the elimination half-life of interferon,

> providing improved efficacy

> with once-weekly dosing. SVR rates in patients

> infected with genotype 1 HCV

> have increased from 10-15% with interferon

> monotherapy to over 50% using the

> pegylated interferon-ribavirin combination. Patients

> infected with genotype 2 or

> 3 achieve SVR rates of 80% and more.

>

http://www.vh.org/adult/provider/internalmedicine/hepatitisc/

> Pipeline Innovations in Hepatitis C Treatments

> However, approximately 50% of patients infected with

> HCV genotype 1 do not

> achieve

> a sustained virologic response (SVR) with initial

> interferon-based ...

> www.projectsinknowledge.com/Init/G/1708/ - 83k

> May I recommend the Clinicians Guide Volume

> VII........it's a guide for

> doctors to treat Hepatitis C .....all the latest by

> the best hepatologists in the

> nation.

> Silvia

> www.projectsinknowledge.com/

> init/g/1688/1688_Monograph.pdf

>

>

> [Non-text portions of this message have been

> removed]

>

>

>

>

[Guest guest]

Sandy

Im sorry to say but I TOTALLY agree with you regarding the Drug companies,, its

much to their advantage to have us sick CHRONICALLY so we can continue to use

their poisons,,

Well its probably NOT in MY best interest to get started on this subject,, lol

sandy katt wrote:

I need more.

<<If there is no detectable amount of HCV in your

blood six months after you have finished a full course

of treatment, you have a sustained virological

response (SVR).>>

Why don't you research further and find out the stats

for two years after treatment?

Unless, of course, 6 months is all the health duration

you are after.

Selected information is being put out by a company in

who's interest it is to sell a drug treatment. In my

humble opinion, a person who believes that the R & I

companies want to find a cure is naive. A chronic

disease is preferrable to their pockets.

Has anyone heard anything new about VERTEX?

--- Bhprice425@... wrote:

> Let me know if you need more.

>

> Research has shown that it is more effective to

> treat HCV using a combination

> of pegylated interferon and ribavirin than treating

> without ribavirin. For

> people infected with HCV only, SVR is achieved in

> about 45-50% with genotype 1,

> and over 80% with genotype 2 or 3 when treated with

> the combination.

> http://www.atdn.org/simple/pifn.html

>

> The currently acceptable therapy for HCV is a

> combination of interferon and

> ribavirin. Conjugation of polyethylene glycol (PEG)

> to interferon--pegylated

> interferon--is the newest advance in the treatment

> of HCV patients. Pegylation

> increases the elimination half-life of interferon,

> providing improved efficacy

> with once-weekly dosing. SVR rates in patients

> infected with genotype 1 HCV

> have increased from 10-15% with interferon

> monotherapy to over 50% using the

> pegylated interferon-ribavirin combination. Patients

> infected with genotype 2 or

> 3 achieve SVR rates of 80% and more.

>

http://www.vh.org/adult/provider/internalmedicine/hepatitisc/

> Pipeline Innovations in Hepatitis C Treatments

> However, approximately 50% of patients infected with

> HCV genotype 1 do not

> achieve

> a sustained virologic response (SVR) with initial

> interferon-based ...

> www.projectsinknowledge.com/Init/G/1708/ - 83k

> May I recommend the Clinicians Guide Volume

> VII........it's a guide for

> doctors to treat Hepatitis C .....all the latest by

> the best hepatologists in the

> nation.

> Silvia

> www.projectsinknowledge.com/

> init/g/1688/1688_Monograph.pdf

>

>

> [Non-text portions of this message have been

> removed]

>

>

>

>

[Guest guest]

Let me know how to unenroll from this site. Incredibly negative jerks have

been allowed on this site and it's getting from bad to worse. This is what

your newbies will see. A bitter person who has seen two people fail and thinks

he knows it all. They must have forgotten that it was a support forum.

Silvia

[Guest guest]

Let me know how to unenroll from this site. Incredibly negative jerks have

been allowed on this site and it's getting from bad to worse. This is what

your newbies will see. A bitter person who has seen two people fail and thinks

he knows it all. They must have forgotten that it was a support forum.

Silvia

[Guest guest]

Let me know how to unenroll from this site. Incredibly negative jerks have

been allowed on this site and it's getting from bad to worse. This is what

your newbies will see. A bitter person who has seen two people fail and thinks

he knows it all. They must have forgotten that it was a support forum.

Silvia

[Guest guest]

Congrats, Jax;

I am very happy for you. From what I have read, you

are in a lucky 13%.

May I ask you questions please? If not, just don't

reply.

1. Do you feel well?

2. Has your energy returned? Are the joint aches gone?

3. Have you been able to get yourself stronger? Did

the spiderveins disappear?

4. Do you still have after effects from your

'treatment'? Which drug combo did you take?

5. How tough was it? Really.

Blessings

--- Jackie on wrote:

> Hi Sandy

> Im still clear and I finished tx 2 1/2 years ago,

> with genotype 1a, vl about 600,000 with stage 3-4

> damage with early cirrhosis,, and now am stage 0-1

> with NO activity. Im counting my self lucky because

> my liver has regressed in damage but I know that it

> could come back at any time while Im hoping to be in

> that 97% who it never shows up again!

> welcome to the group

> jax

>

> sandy katt wrote:

> There are no experts in HCV.

>

> There are only doctors who care and know more about

> the body and how the liver works. These are

> specialists.

>

> If there were experts, there would be a way to clear

> most bodies of the virus.

>

> The guy who turned me onto this 'group' remissed

> after

> 10 years.

>

> Is this a big group? Who here has been 'treated' and

> is now in remission longer than 1 year?

>

> --- Bhprice425@... wrote:

>

> > Look in www.projectsinknowledge.com it's the

> site

> > with all the experts.

> >

> >

> > If you are clear 6 months after treatment then you

> > have a 97% chance of

> > remauining clear......the NIH says so.

> >

> > After 2 years ...yes I have heard of a few

> > case....rare but they do exist.

> > There's is one case on recent news that turned out

> > positive after 8 and half

> > years....

> >

> > Reemergence of hepatitis C virus after 8.5 years

> in

> > a patient with

> > hypogammaglobulinemia: evidence for an occult

> viral

> > reservoir.

> > Lee WM, Polson JE, Carney DS, Sahin B, Gale M Jr.

> > Department of Internal Medicine, Division of

> > Digestive and Liver

> > Diseases, University of Texas Southwestern Medical

> > Center, Dallas, USA.

> > The question of whether viruses persist after

> > apparent clearance of

> > infection remains unanswered. Here, we describe a

> > patient with

> > hypogammaglobulinemia whose acute hepatitis C

> virus

> > (HCV) infection

> > appeared to resolve after receipt of interferon

> > therapy, relapse immediately,

> > and then clear spontaneously--only to relapse

> after

> > receipt of corticosteroid

> > therapy, and clear again, 8.5 years later.

> > Sequencing indicated that the

> > viruses detected during each relapse were

> virtually

> > identical, with the

> > hypervariable region 1 of E2 appearing to be

> > monoclonal, which is typical of patients

> > with hypogammaglobulinemia. Nonstructural 5A

> > sequences exhibited quasispecies

> > diversity initially but, after 8.5 years, had

> become

> > monoclonal. The prolonged period of negativity for

> > HCV RNA followed by

> > relapse suggests that HCV may persist in apparent

> > sustained viral responders.

> > PMID: 16107964 [PubMed - in process]

> >

> >

> > [Non-text portions of this message have been

> > removed]

> >

> >

> >

> >

[Guest guest]

Of course I will answer your questions,, thats what we are here for!!!

1. no I dont feel well,,

2.no , my energy has not returned, no joint aches are still there, infact I now

have to take Morphine to control my body aches.

3. I am trying to get stronger, bought a bowflex, am trying to get up the nerve

and strength to use it, lol,,, I only had one spider angioma and yes that is

gone but the rest of the spider veins are still there on my legs, but my mom has

them as do all the women in my family, so I think the chance to have those is

just high in my family and dont have much to do with the hep,

4.I took the Peg-intron and Riba,, I ended tx having to have another blood

transfusion which is how I got the hep to begin with,, but my anemia has totally

resolved and all labs are in the normal range.

Would I do tx again? IF needed, YES I would.. even tho I now have osteo,

probably RA, sarcoidosis,and cataracts in my eyes and fibro from tx,, I would

still do it because all of these problems are not fatal in and of themselves,

but the hep was gonna kill me, it was moving along rather quickly,, my grade of

inflammation was 3 so it was eatin my liver, lol,,,

Im very surprised that you have read that only 13%,, I have read that geno1's

are about 40-50%,, and most of the geno 1's that I know have cleared and have

remained so,,

Feel free to ask any other questions,,

hugs

jax

sandy katt wrote:

Congrats, Jax;

I am very happy for you. From what I have read, you

are in a lucky 13%.

May I ask you questions please? If not, just don't

reply.

1. Do you feel well?

2. Has your energy returned? Are the joint aches gone?

3. Have you been able to get yourself stronger? Did

the spiderveins disappear?

4. Do you still have after effects from your

'treatment'? Which drug combo did you take?

5. How tough was it? Really.

Blessings

--- Jackie on wrote:

> Hi Sandy

> Im still clear and I finished tx 2 1/2 years ago,

> with genotype 1a, vl about 600,000 with stage 3-4

> damage with early cirrhosis,, and now am stage 0-1

> with NO activity. Im counting my self lucky because

> my liver has regressed in damage but I know that it

> could come back at any time while Im hoping to be in

> that 97% who it never shows up again!

> welcome to the group

> jax

>

> sandy katt wrote:

> There are no experts in HCV.

>

> There are only doctors who care and know more about

> the body and how the liver works. These are

> specialists.

>

> If there were experts, there would be a way to clear

> most bodies of the virus.

>

> The guy who turned me onto this 'group' remissed

> after

> 10 years.

>

> Is this a big group? Who here has been 'treated' and

> is now in remission longer than 1 year?

>

> --- Bhprice425@... wrote:

>

> > Look in www.projectsinknowledge.com it's the

> site

> > with all the experts.

> >

> >

> > If you are clear 6 months after treatment then you

> > have a 97% chance of

> > remauining clear......the NIH says so.

> >

> > After 2 years ...yes I have heard of a few

> > case....rare but they do exist.

> > There's is one case on recent news that turned out

> > positive after 8 and half

> > years....

> >

> > Reemergence of hepatitis C virus after 8.5 years

> in

> > a patient with

> > hypogammaglobulinemia: evidence for an occult

> viral

> > reservoir.

> > Lee WM, Polson JE, Carney DS, Sahin B, Gale M Jr.

> > Department of Internal Medicine, Division of

> > Digestive and Liver

> > Diseases, University of Texas Southwestern Medical

> > Center, Dallas, USA.

> > The question of whether viruses persist after

> > apparent clearance of

> > infection remains unanswered. Here, we describe a

> > patient with

> > hypogammaglobulinemia whose acute hepatitis C

> virus

> > (HCV) infection

> > appeared to resolve after receipt of interferon

> > therapy, relapse immediately,

> > and then clear spontaneously--only to relapse

> after

> > receipt of corticosteroid

> > therapy, and clear again, 8.5 years later.

> > Sequencing indicated that the

> > viruses detected during each relapse were

> virtually

> > identical, with the

> > hypervariable region 1 of E2 appearing to be

> > monoclonal, which is typical of patients

> > with hypogammaglobulinemia. Nonstructural 5A

> > sequences exhibited quasispecies

> > diversity initially but, after 8.5 years, had

> become

> > monoclonal. The prolonged period of negativity for

> > HCV RNA followed by

> > relapse suggests that HCV may persist in apparent

> > sustained viral responders.

> > PMID: 16107964 [PubMed - in process]

> >

> >

> > [Non-text portions of this message have been

> > removed]

> >

> >

> >

> >

[Guest guest]

I'm sorry, but are you seriously suggesting that the drug companies " want "

or view your sickness in only a profitable light?

Johanna Koskinen, Outreach Coordinator

Hepatitic C Multicultural Outreach(HepC-Missouri)

http://www.hepcmo.org Email: johanna@...

Toll-free/24-Hour Hotline: 1.888.436.HEPC(4372)

Phone#: 1.(Business)

On Sat, September 3, 2005 10:58 pm, Jackie on said:

> Sandy

> Im sorry to say but I TOTALLY agree with you regarding the Drug

> companies,, its much to their advantage to have us sick CHRONICALLY so we

> can continue to use their poisons,,

> Well its probably NOT in MY best interest to get started on this

> subject,, lol

>

> sandy katt wrote:

> I need more.

>

>

>

> Why don't you research further and find out the stats

> for two years after treatment?

>

> Unless, of course, 6 months is all the health duration

> you are after.

>

> Selected information is being put out by a company in

> who's interest it is to sell a drug treatment. In my

> humble opinion, a person who believes that the R & amp; I

> companies want to find a cure is naive. A chronic

> disease is preferrable to their pockets.

>

> Has anyone heard anything new about VERTEX?

>

> --- Bhprice425@... wrote:

>

> > Let me know if you need more.

> >

> > Research has shown that it is more effective to

> > treat HCV using a combination

> > of pegylated interferon and ribavirin than treating

> > without ribavirin. For

> > people infected with HCV only, SVR is achieved in

> > about 45-50% with genotype 1,

> > and over 80% with genotype 2 or 3 when treated with

> > the combination.

> > http://www.atdn.org/simple/pifn.html

> >

> > The currently acceptable therapy for HCV is a

> > combination of interferon and

> > ribavirin. Conjugation of polyethylene glycol (PEG)

> > to interferon--pegylated

> > interferon--is the newest advance in the treatment

> > of HCV patients. Pegylation

> > increases the elimination half-life of interferon,

> > providing improved efficacy

> > with once-weekly dosing. SVR rates in patients

> > infected with genotype 1 HCV

> > have increased from 10-15% with interferon

> > monotherapy to over 50% using the

> > pegylated interferon-ribavirin combination. Patients

> > infected with genotype 2 or

> > 3 achieve SVR rates of 80% and more.

> >

> http://www.vh.org/adult/provider/internalmedicine/hepatitisc/

> > Pipeline Innovations in Hepatitis C Treatments

> > However, approximately 50% of patients infected with

> > HCV genotype 1 do not

> > achieve

> > a sustained virologic response (SVR) with initial

> > interferon-based ...

> > www.projectsinknowledge.com/Init/G/1708/ - 83k

> > May I recommend the Clinicians Guide Volume

> > VII........it's a guide for

> > doctors to treat Hepatitis C .....all the latest by

> > the best hepatologists in the

> > nation.

> > Silvia

> > www.projectsinknowledge.com/

> > init/g/1688/1688_Monograph.pdf

> >

> >

> > [Non-text portions of this message have been

> > removed]

> >

> >

> >

> >

[Guest guest]

IN MY PERSONAL opinion,, YES! Not everyone feels that way, but I DO ,, and that

is why Im not going out of my way to start down THAT road of discussion. I DO

have a right to my own opinion,, dont I???

" Johanna (Hep C - MO) " wrote:I'm sorry, but are you

seriously suggesting that the drug companies " want "

or view your sickness in only a profitable light?

Johanna Koskinen, Outreach Coordinator

Hepatitic C Multicultural Outreach(HepC-Missouri)

http://www.hepcmo.org Email: johanna@...

Toll-free/24-Hour Hotline: 1.888.436.HEPC(4372)

Phone#: 1.(Business)

On Sat, September 3, 2005 10:58 pm, Jackie on said:

> Sandy

> Im sorry to say but I TOTALLY agree with you regarding the Drug

> companies,, its much to their advantage to have us sick CHRONICALLY so we

> can continue to use their poisons,,

> Well its probably NOT in MY best interest to get started on this

> subject,, lol

>

> sandy katt wrote:

> I need more.

>

>

>

> Why don't you research further and find out the stats

> for two years after treatment?

>

> Unless, of course, 6 months is all the health duration

> you are after.

>

> Selected information is being put out by a company in

> who's interest it is to sell a drug treatment. In my

> humble opinion, a person who believes that the R & amp; I

> companies want to find a cure is naive. A chronic

> disease is preferrable to their pockets.

>

> Has anyone heard anything new about VERTEX?

>

> --- Bhprice425@... wrote:

>

> > Let me know if you need more.

> >

> > Research has shown that it is more effective to

> > treat HCV using a combination

> > of pegylated interferon and ribavirin than treating

> > without ribavirin. For

> > people infected with HCV only, SVR is achieved in

> > about 45-50% with genotype 1,

> > and over 80% with genotype 2 or 3 when treated with

> > the combination.

> > http://www.atdn.org/simple/pifn.html

> >

> > The currently acceptable therapy for HCV is a

> > combination of interferon and

> > ribavirin. Conjugation of polyethylene glycol (PEG)

> > to interferon--pegylated

> > interferon--is the newest advance in the treatment

> > of HCV patients. Pegylation

> > increases the elimination half-life of interferon,

> > providing improved efficacy

> > with once-weekly dosing. SVR rates in patients

> > infected with genotype 1 HCV

> > have increased from 10-15% with interferon

> > monotherapy to over 50% using the

> > pegylated interferon-ribavirin combination. Patients

> > infected with genotype 2 or

> > 3 achieve SVR rates of 80% and more.

> >

> http://www.vh.org/adult/provider/internalmedicine/hepatitisc/

> > Pipeline Innovations in Hepatitis C Treatments

> > However, approximately 50% of patients infected with

> > HCV genotype 1 do not

> > achieve

> > a sustained virologic response (SVR) with initial

> > interferon-based ...

> > www.projectsinknowledge.com/Init/G/1708/ - 83k

> > May I recommend the Clinicians Guide Volume

> > VII........it's a guide for

> > doctors to treat Hepatitis C .....all the latest by

> > the best hepatologists in the

> > nation.

> > Silvia

> > www.projectsinknowledge.com/

> > init/g/1688/1688_Monograph.pdf

> >

> >

> > [Non-text portions of this message have been

> > removed]

> >

> >

> >

> >

[Guest guest]

Not only are the drug co's. #1 priority money. but so are the

doctors (most). The F.D.A. Congress, to the stockholders and on

and on. The concern for your personal health and a CURE is WAY

down on the list. But I don't want to talk about it either.

[Guest guest]

THANK YOU RIC! I couldnt agree more,, its ALL about the MONEY!

Ric wrote:Not only are the drug co's. #1 priority money.

but so are the

doctors (most). The F.D.A. Congress, to the stockholders and on

and on. The concern for your personal health and a CURE is WAY

down on the list. But I don't want to talk about it either.

It's a pleasure having you join in our conversations. We hope you have found the

support you need with us.

If you are using email for your posts, for easy access to our group, just click

the link-- http://groups.yahoo.com/group/Hepatitis_C_Central/

Happy Posting

[Guest guest]

THANK YOU RIC! I couldnt agree more,, its ALL about the MONEY!

Ric wrote:Not only are the drug co's. #1 priority money.

but so are the

doctors (most). The F.D.A. Congress, to the stockholders and on

and on. The concern for your personal health and a CURE is WAY

down on the list. But I don't want to talk about it either.

It's a pleasure having you join in our conversations. We hope you have found the

support you need with us.

If you are using email for your posts, for easy access to our group, just click

the link-- http://groups.yahoo.com/group/Hepatitis_C_Central/

Happy Posting

[Guest guest]

And as far as the doctors are concerned, their biggest fear is about

money, but not to line their pockets, but to pay their bills just like

everyone else.

Doctors have the same fears about their jobs like everyone else. Don't put

them up on a pedestal just because they've got the title. If you saw their

credit rating, and how they're trying hard to stay a step ahead, you'd be

pretty happy that you weren't in their shoes.

Johanna Koskinen, Outreach Coordinator

Hepatitic C Multicultural Outreach(HepC-Missouri)

http://www.hepcmo.org Email: johanna@...

Toll-free/24-Hour Hotline: 1.888.436.HEPC(4372)

Phone#: 1.(Business)

Not only are the drug co's. #1 priority money. but so are

the

> doctors (most). The F.D.A. Congress, to the stockholders and on

> and on. The concern for your personal health and a CURE is WAY

> down on the list. But I don't want to talk about it either.

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

> It's a pleasure having you join in our conversations. We hope you have

> found the support you need with us.

>

> If you are using email for your posts, for easy access to our group, just

> click the link-- http://groups.yahoo.com/group/Hepatitis_C_Central/

>

> Happy Posting

>

>

>

>

[Guest guest]

And as far as the doctors are concerned, their biggest fear is about

money, but not to line their pockets, but to pay their bills just like

everyone else.

Doctors have the same fears about their jobs like everyone else. Don't put

them up on a pedestal just because they've got the title. If you saw their

credit rating, and how they're trying hard to stay a step ahead, you'd be

pretty happy that you weren't in their shoes.

Johanna Koskinen, Outreach Coordinator

Hepatitic C Multicultural Outreach(HepC-Missouri)

http://www.hepcmo.org Email: johanna@...

Toll-free/24-Hour Hotline: 1.888.436.HEPC(4372)

Phone#: 1.(Business)

Not only are the drug co's. #1 priority money. but so are

the

> doctors (most). The F.D.A. Congress, to the stockholders and on

> and on. The concern for your personal health and a CURE is WAY

> down on the list. But I don't want to talk about it either.

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

>

> It's a pleasure having you join in our conversations. We hope you have

> found the support you need with us.

>

> If you are using email for your posts, for easy access to our group, just

> click the link-- http://groups.yahoo.com/group/Hepatitis_C_Central/

>

> Happy Posting

>

>

>

>