Health: CFIDS & Animals with CFIDS

[Guest guest]

Many of us have animals in our homes. They are loved and treated as our

children in many cases... This article is not to scare you but for

information about animals and CFIDS. It is noted that no formal scientific

studies were done in the articles text.

Mij

AUTHORS NOTE: This article is the first of three articles on my experiences

with Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS; aka CFS). The

first article deals with the interaction between CFIDS patients and their

animals. The second article will deal with the actual autopsy findings of

sick animals owned by CFIDS patients, the transmission of the CFIDS

infectious agent to healthy animals, and the autopsy results of these

animals. The third article will deal with the oral and head and neck

manifestations of CFIDS, a lip biopsy of minor salivary glands for the

confirmation of CFIDS, and some interesting therapy for the head and neck

pain so often experienced by CFIDS patients [The second and third articles

by Dr. Glass will he published in the next two consecutive issues of MPWC

News - Ed. note.] In the early 1990's, the following studies were conducted

on CFIDS patients and their animals. The articles were sent to a number of

both medical joumals and veterinary medical journals. The response from the

editor of the medical journals was that while the articles were

well-written, thorough and timely, they were better placed in veterinary

medical journals. The veterinary medical joumal editors agreed with the

medical journal editors in terms of the validity of the studies; however,

they felt that if they published the articles, they might jeopardize the

entire practice of veterinary medicine as small animals comprise the largest

segments of such practices.

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Throughout the recognized existence of Chronic Fatigue and Immune

Dysfunction Syndrome, anecdotal reports have linked domestic animals with

CFIDS, but no formal scientiflc studies were reported (1,2). Cats and dogs

were implicated by their owners most frequently. The usual association with

the presence of the animal in the household of a CFIDS patient, followed by

the development of strange diseases or dysfunctions in the animal, many of

which mimic CFIDS. The severity of the diseases often necessitated

euthanasia. In a fewer number of cases, the onset of CFIDS in the patient

was associated with an exposure to a domestic animal which was later found

to show signs of CFIDS.

Observations from my animal biopsy service demonstrate two interesting

findings in animals of CFIDS patients (unpublished findings). Gingival

biopsies from cats demonstrated an unusual epithelial viral vesicle

associated with an equally unusual submucosal inflammatory response. Several

melanomas were found in dogs of CFIDS patients which had the unique feature

of a striking progression of the tumor in the absence of an inflammatory

response.

Both dogs and cats are known to be susceptible to a wide range of viruses.

With the exception of rabies, no zoonotic (animal to human or human to

animal) viral infection transmission has been demonstrated between typical

domestic animals and humans (3).

These observations and recognitions prompted the following questions:

Do CFIDS patients have domestic animals (pets)?

What is the interaction between CFIDS patients and their pets?

Do the domestic animals have any clinical signs of CFIDS?

What type of signs or manifestations of CFIDS do animals of CFIDS patients

demonstrate?

What is the relationship between the interaction of CFIDS patients and their

animals and the onset and course of CFIDS?

and resulted in a series of studies to answer the questions.

The first study was a retrospective study of Center for Disease Control and

Prevention (CDC) criteria-met CFIDS patient: using a standardized

questionnaire which included patient comments. The study subjects came from

a university medical center and CFIDS support groups throughout the United

States. Appropriate statistical tests, including mean, median, Z test,

multivariant analysis, and Chi-square test, were used. This information was

compared to national statistical Information on animal interaction compiled

by the American Veterinary Medical Association.

One hundred twenty-seven (127) criteria-met CFIDS patients completed

questionnaires on their animal Interactions- There were 114 females and 13

males in the study. All respondents were Caucasian with the exception of one

Native American. The mean age of the CFIDS patients was 42.4 years with a

median age of 43 years. 61.4% of the respondents were married; 311.6% were

either single, divorced, or widowed.

The most striking result of this study was the association between CFIDS

patients and animals (usually indoor pets) and the number of animals per

CFIDS patient. 97% of the CFIDS patients had animal contact [expected normal

contact: 57.9% (4)], with only 2 males and 2 females not reporting animal

contact. Reported dog ownership per household for CFIDS males was 9.5 and

for CFIDS females was 7.9 (expected national average: 1.52). Reported cat

ownership per household for CFIDS males was 6.1 and for CFIDS females was

8.7 (expected national average: 1.95). 106 of the respondents (83.5%)

reported that their animals (pets) had atypical diseases with signs and

symptoms which mimicked CFIDS in humans. Of these 106 CFIDS patients 100

(94.3%) either were the primary caregiver for the sick animals or had

intimate contact (sleeping with, being bitten or scratched by, or kissing

the animal). The next most common animal contact was birds (parakeets and

ducks were mentioned most often), followed by horses, cows, rabbits, goats,

and guinea pigs. Two (2) CFIDS patients had contact with primates. The

reported mean age of the dogs was 6 years (median = 6 years); of the cats

was 6.2 years (median = 5 years); and of other types of animals was 3.2

years (median = 0.4 years).

All of these differences between expected and observed values were found to

be statistically significant (p>001) including a statistically significant

higher (.02<p£ 05) possession of cats by single, divorced, and widowed

persons than married people. Statistical analysis (Chi-square) of the

relationship between intimate contact by CFIDS patients and the presence of

CFIDS like signs in their animals was highly significant (p£ 001). 67% of

the respondents that had such contact stated that the animal showed

CFIDS-like signs prior to the human and 33% of the respondents felt that the

otherwise healthy animal contracted its CFIDS signs from the CFDS patient.

The place where the pet was obtained was as follows: Friends (35%),

Commercial (26%), Stray (21%), Pound (15%), Self-bred (3%), 41% of the CFIDS

patients had animals that were still alive while 69% of the CFIDS patients

had animals that had either died or were moribund at the time of the survey.

Finally, of equal importance were the CFIDS patient's comments. These

comments were often voluminous and detailed the interaction between the

animals and the CFIDS patient. It is very clear that the CFIDS patients, in

general, are " animal lovers " even though frquently the patient comments

spoke of allergies to animals. Simliarly, the respondents gave excellent

descriptions of their animal's(s') CFIDS-like signs from time of onset to

ultimate temination.Respondents also noted that the animals were often the

" living being " most consistently in close contact with the CFIDS patient.

The conclusion of this study was that CFIDS patients not only have pets, but

that there is a significant animal interaction and that a large number of

these animals have atypical or unusual diseases which at least mimic CFIDS.

In the second study, the CFIDS patients reported on a total of 463 animals:

115 healthy animals (which served as a control group for the study) and 348

animals which showed signs of either dysfunction or disease. The control

group was comprised of 51 dogs (44%), 39 cats (34%), and 25 animals that

were grouped together as " others " . The " others " group was predominantly

large animals: horses, cows, goats, and pigs. All the control animals were

still living and well at the time of the survey or had died of either

traumatic or natural causes.

The group of animals which showed signs of either dysfunction or disease

were made up of 189 dogs (54%), 144 cats (41%), and 15 animals that were

grouped together as " others " . This " others " group was predominantly small

domestic pets: birds, hamsters, and guinea pigs. The mean age of the dogs in

this study was 6.5 years (median 6 years); of the cats was 6.2 years (median

= 5 years); and of other types of animals was 3.2 years (median = 0.4

years).

The distribution of signs of the animals showing either dysfunction or

disease are as follows: 137 animals (59 cats; 64 dogs; 14 others) were

classified as having " General Signs. " 36 animals (15 cats; 14 dogs; 7

others) of the general signs category were classified as being " Sick NOS "

because the animals were clearly Ill, but no diagnosis could be or had been

rendered by a veterinarian. The " Sick NOS " animals were often described as

having the same types of clinical signs as their owner. 26 animals (9 cats;

9 dogs; 7 others) in the general signs category died suddenly of unexplained

causes. 26 animals (11 cats; 15 dogs) of the general signs category had a

variety of altered immune conditions. including allergies, skin rashes, hair

loss, systemic lupus erythematosus, and sneezing. 20 animals (3 cats; 17

dogs) developed Parvo or other viral Infections. 11 animals (9 cats; 2 dogs)

transmitted their conditions to other animals either by birth or direct

contact. 10 animals (9 cats; 1 dog) were listed as having eaten mice, rats,

or other wild animals. 9 animals (3 cats; 6 dogs) had non-viral infections.

122 animals (41 cats; 81 dogs) had " Neurological " signs. 32 animals (17

cat.; 15 dogs) of the neurological category had lethargy, weakness, or sleep

disorders. 30 animals (9 cats; 21 dogs) in the neurological category had

seizures, tremors, or tail twitching. 19 animals (4 cat:; 15 dogs)

demonstrated hind limb dragging, myalgia, arthralgia, or Bell's palsy. 16

animals (6 cats; 10 dogs) were anxious, depressed, moody, or demonstrated

inappropriate behavior, including urination and defecation outside their

litterbox. 15 animals (4 cats; 11 dogs) had photophobia, ocular discharge,

or blindness. 10 animals (1 cat; 9 dogs) had deafness, ear sensitivity, or

loss of balance.

36 animals (21 cat.; 15 dogs) demonstrated " Gastrointestinal " signs. 13

animals (9 cats; 4 dogs) in the gastrointestinal category had inflamed

gingiva, mouth odor, tooth loss, or drooling. 10 animal, (4 cats; 6 dogs) in

the gastrointestinal category had diarrhea or abdominal distention. 9

animals (5 cat.; 4 dogs) demonstrated anorexia. 3 animals (2 cats; I dog)

had increased appetite without weight gain. 1 cat had hard stools.

33 animals (18 cats; 14 dogs; 1 other) showed " Reticuloendothelial or Blood

Disorders " . 12 animals (3 cats; 8 dogs; 1 other) of this category

demonstrated bleeding or blood disorders. 10 animals (9 cats; I dog) in this

category developed leukemia. While all of the leukemic cats were positive

for feline leukemia virus [FLV], 5 of the cats had been vaccinated against

FLV prior to the onset of their feline leukemia. 7 animals (5 cat.; 2 dogs)

died of either feline AIDS or canine immune defidency (AIDS). 2 dogs showed

massive and generalized lymphadenopathy. 1 cat and 1 dog died of lymphoma

(lymphosarcoma).

Excluding leukemia and lymphoma, 15 animals (3 cats;12 dogs) developed

tumors ( " Neoplasia " ). 8 animals (2 cats; 6 dogs) in this category had either

fatal and/or multiple tumors which were not further classified, but which

resulted in euthanasia of the animal. 4 dogs of this category died from

malignant tumors of epithelial origin (3 squamous cell carcinomas and 1

transitional cell carcinoma), while 1 cat developed perianal adenomas, but

was still living at the time of the survey. 1 dog died of a functional

pituitary tumor and 1 dog died of melanoma.

Only 5 animals (2 cats; 3 dogs) were reported to have " Endocrine Disorders " .

2 cats and 2 dogs in this category had thyroid hyperplasia or thyroid

nodules and 1 dog has pituitary hyperplasia.

Of equal importance, 113 of the 127 patients 89%) stated that their own

CFIDS symptoms directly related their interaction with animals.

Specifically, 79 of the respondents (71%) stated that they either had

contact with multiple animals, were farmers, or were caretakers of multiple

animals. 18 of these CFIDS patients (16%) note that the onset of their CFIDS

symptoms were temporarily associated with the obtaining of a new pet, while

2 CFID patients (1%) noted that their CFIDS symptoms improved after the pet

left or died. 9 respondents (8%) stated the other family members also

contracted CFIDS in such manner as to implicate the pet as being possibly a

common link in etiology. 3 CFIDS patients noted that the onset their CFIDS

symptoms directly followed a flea bite episode and 2 CFDS patients reported

that the prior owner of the home in which they contracted their CFIDS was

inhabited by both CFIDS patients and sick animals.

As was noted in the first study, CFIDS patients care deeply for their

animals. This observation can be understood by the detail and thoroughness

with which the CFIDS patients filled out the information concerning the

symptoms, laboratory results (such as blood count., blood chemistries,

biopsy reports, etc.) and the courses of the animal's(s') condition. For the

most part, it was the CF1DS patient who filled out the questionnaire. It

must be remembered that these patients usually have severe fatigue and for

them to have given such attention to detail was a major task.

Both studies also noted what an important role the pet plays in the CFIDS

patient's life. An analysis of the comments by the CFDS patients

demonstrates unequivocally that the pet was often the CFIDS patient's major

contact with a living being. While it is imperative to consider the results

of this study, it is equally imperative not to isolate CFIDS patients from

their pets Rather, prevention of intimate contact, such as sharing food or

kissing between the CFIDS patient and the pet, should be encouraged.

While the results of this study have certain subjective elements, such as

reliance upon CFIDS patient and fault observations or the possibility of

" symptom transference " (e.g., arthralgia in a pet is more likely to be noted

by an arthralgic patient than a person free of joint pain), the recurrent

finding of certain symptoms that may be common to both the CFIDS patient and

the animal warrant attention It is important to consider the possibility

that CFIDS may be transmitted from human to animal and/or from animal to

human. If one considers the symptom of lethargy in the animals, the 32 CFIDS

patients who observed this symptom all noted that the lack of energy was

different than they had observed before in either the affected animal or in

other animals in the same household who did not demonstrate the symptom. The

seizure disorders and sudden unexplained deaths were more dramatic and

objective signs of possible transmission of an agent that affects the

nervous system. While seizure disorders and sudden unexplained deaths are

not accepted features of CFIDS in humans, others have noted anecdotally a

higher than usual number of seizure disorders and even sudden unexplained

deaths in CFIDS patients.

While this study demonstrates the multiplicity of CFIDS-like signs in the

animals, it is this same multi-organ involvement in the CFIDS patients that

makes CFIDS so difficult to diagnose in humans. As with CFIDS in humans, the

animals usually showed no laboratory evidence of a specific disease entity.

There was, however, a predominance of neumlogic, neuromuscular, and

rheumatologic symptoms in the animals just as there are in CFIDS patients.

The result of these studies need to alert the veterinary profession of the

need to inquire as to the health of the animal owner and their family.

Conversations with a number of clinical veterinarians have pointed out that

they are commonly confronted with conditions in domestic animals which do

not fall into well established disease patterns. The most common of these

deal with neurological and infectious diseases. These two areas were the

most often reported as the pet signs found by CFIDS patients. Somewhat

confounding was the low number of animals demonstrating endocrine disease.

This under-reporting may be more of a lack of testing than a lack of disease

as these tests are expensive and CFIDS patients are often financially unable

to afford their own diagnostic tests., much less their animal's(s').

The results of these studies also need to alert the veterinaray profession

that should there be a possibility of animal to human transmission of CFIDS,

veterinarians might want to consider the wearing of protective clothing,

gloves, eyewear, and masks when examining animals. We have received a number

of reports from veterinarians around the country, especially from female

veterinarians, that they have had to substantially limit their practices due

to fatigue and other CFIDS-like symptoms. Similarly, precautions need to be

taken to prevent CFIDS from being transmitted from one animal to another.

The conclusions of the second study were that animals of CFIDS patient.

demonstrated a wide range of disease and dysfunctional signs, similar to

their CFIDS owners. The interactions between the animal and the CFIDS

patients was often intimate. The study showed that the course of CFIDS in

the animals varied widely, but after more thorough analyses of the data and

of subsequent data, it appears that the animals have two distinct courses:

1. Their CFIDS signs produce progressive deterioration and the animal dies

or 2. The animals appear to completely recover, usually after about five

years.

In closing, both of the above studies had one common conclusion: animal

interaction is a very important part of CFIDS patients' lives'. I am often

asked by CFIDS patients, knowing what I do about the CFIDS patient/animal

interaction, if I would recommend that CFIDS patients have pets. While there

is no way for me to survey animals, from my interaction with my own pet. and

with the way CFIDS patients love their pets' I would say that any pet would

willingly run the risk of contracting CFIDS for the love, care and attention

they will receive from CFIDS patients.

REFERENCES:

1. Ostrom, N. 50 Things You Should Know About the Chronic Fatigue Syndrome:

New York: That New Magazine, 1992: pp 25, 26, 36, 37

2. Ostrom, N. What Really Killed Gilda Radner? New York: That New Magazine,

Inc., 1991 pp. 159-164, 345-352

3. Cotran, RS., Kumar, V., Robbins, SL. Robbins Pathological Basis of

Disease, 4th ed. Philadelphia: W. B. Saunders Co., 1989; pp. 309-310

4. Wise, JK. The Veterinary Sevice Market for Companion Animals. Schaumburg,

IL; American Veterinary Association, 1992; pp. 5-65.