Robin.. Help for Seizures and ASD in general.....

[Guest guest]

Hi Robin and others from Sue,

The cut and paste below.. of 2 Carnosine links.. may be helpful info regarding seizures ..as well as for helping other ASD behaviors..as discussed in the double blind study below on Carnosine.

(Many including myself and husband find the LW Carnosine booster patches that are sold with the Glutathione boosters..called Y-age.. extremely effective for our spectrum conditions.. )

(The link for that is www.lifewave.com/fundingASDresearch ..a non profit site that I manage for my son on the Spectrum.

Proceeds go to the Autism Research Insitute.

You'll now find Both non transdermal patches under OTHER products called Yage-- on the REVISED website.

When placed on specific meridians...the patches activate the body to produce more glutathione or carnosine in these two cases.

Research on them is also found on the website.)

(As you know...Glutathione is also highly beneficial for Spectrum disorders (and for general health of all.). since it is a major chelator of heavy metals, toxins as well as viral issues......and helps normalize testosterone...often problematic in both girls and boys on the spectrum. =(precocious puberty)...and most of all.. helps build immunity... My husband's early stage of Shingles.( herpes virus)...went away after 2 days of wearing these patches..last Jan... I used to be sick a lot ..and am so much healthier now ...having worn them for over a year.. some warts are disappearing..as well as brown spots..too..etc.

A doctors family members test scores went from 550 to 700 while wearing the Glutathione patch for about 5 months......as well as others have seen smoother and clearer skin..and increased immunity... which is the result of heavy metals chelated and increased anitoxidant activities..since Glutathione has been called the MASTER antioxidant. etc... )

GETTING BACK TO CARNOSINE--- Those wearing the LW non transdermal Carnosine patch... have also seen improvements in speech...and other things listed as in the summary of the studies below.

Hope that helps,

Sue

L - C A R N O S I N E

What is Carnosine?

The supplement that you are interested in learning more

about contains 200mg powdered carnosine, as well as powdered Vitamin E (25IU) and powdered Zinc (2.5 mg). The exact dosage that is correct for your child should be established by your doctor in coordination with Dr. Chez, who pioneered the use of this supplement in children with developmental delays. L-carnosine, or "carnosine" is an amino acid dipeptidemade up of histidine and alanine. The naturally-occurring amino acid is found

within the human body, a by-product of proteins digested within the body. The deep frontal part of the brain (entorhinal cortex) is believed to be a site where carnosine tends to accumulate. It may interact with zinc in that area, as well as having effects on GABA, a brain neurotransmitter, which by a complex chemical reaction forms homo-carnosine.

What Studies Have Been Done with Carnosine?

Rat and animal studies have been done with carnosine looking at

"neuroprotection." These investigations aimed to examine protective

action since carnosine may be protective of muscle and nerve

function. There have been no studies that have shown any evidence of toxicity or teratogenicity in animals where carnosine has been studied. Few scientifically-validated human studies have been conducted, however, and most of the information one finds about carnosine's claims are of the quality found on the intenet. Claims have been made for generic carnosine/carnosine formulations aiding in combating a range of maladies from Alzheimer's to body building.

Why Carnosine, then?

Recent MRI studies by Petroff and colleagues (2001) examining levels of brain chemistry showed a relationship between homo-carnosine and GABA in temporal lobe and generalized myoclonic epilepsies. These authors described homo-carnosine levels that may correlate with seizure control even when GABA response is defective in human studies. Dr. Chez was intrigued by the results of this study, and thus began a study in June, 2001 that aimed to test if supplementing carnosine orally could enhance seizure protection in children

who were already on anticonvulsants and who had recurrent seizures despite being on standard drug therapy. He hypothesized that the addition of carnosine could decrease seizure frequency and so began an open-label study of carnosine which he acquired via an industrial chemical company.

The Open-Label Study

A total of 75 children, who had "failed" multiple

antiepilepticmedications in an effort to stop their seizures (including

steroids and the Ketogenic diet) with histories of partial or

generalized epilepsy entered the open-label study. The majority had

fronto-temporal lobe seizures, or generalized epilepsy. Approximately 25% had EEGs to directly compare before and after starting the carnosine. Many patients had reductions in seizure frequency, but without EEG correlation. Two sisters with hypsarrythmia/Lennox-Gastaut variant both showed dramatic improvements in EEG amplitude, spike frequency, and background activity. In

three other patients with primary or secondary generalized spike and wave patterns or Lennox-Gastaut type patterns, EEG amplitude and spike frequency improved with carnosine in dosages of 800-2,000 mg. per day. Dosage was titrated upward depending upon bodyweight. No side effects were reported.Unexpectedly, parental diaries showed a pattern of comments related to gains in cognitive domains including language, alertness, energy levels, and even gross motor ability. Dr. Chez was motivated by such reports in addition to comments from other professionals that worked simultaneously with the children (e.g., speech therapists) who, unaware that children were

on the new supplement, spontaneously stated that individual children were showing incremental gains not previously seen. Expressive language was described as more fluent, eye contact more frequent, and interest in the environment was more prominent. Dr. Chez thought that this supplement could be of benefit to children with autism or PDD and so began to give it to children with such diagnoses in an open-label trial. Indeed, parents reported benefits in their children after as few as 2 weeks, in the areas of socialization, expressive language, alertness level, energy level, adaptation to change, and curiously, gross motor planning.

The Double-Blind Study

Because of the remarkable cognitive improvements in language, speech production and school performance as well as social alertness, Dr. Chez felt it important to study the effect of the supplement in children with Autistic Spectrum Disorders. Children were included in this study if they had histories of abnormal EEG, and had previously responded to cognitive-enhancing dementia medications (as part of a controlled study at the office) or to anti-convulsants. A double-blind placebo controlled stud with carnosine was begun. Children were randomly placed on either active

carnosine or placebo.Expressive and receptive language measures, two autism rating scales, and parent rating analog scales were administered at the start and completion of the study. Results of this study indicated clinically meaningful changes in many aspects of autistic features, and also showed that the carnosine supplement improved children's expressive and receptive language significantly. This is the only dietary supplement to date studied in a double-blind fashion in autism.

Who Benefits and What are the Side Effects?

The majority of children with either epilepsy or autism treated in open label studies by Dr. Chez benefited from carnosine supplementation. Dr. Chez estimates that approximately 10% of children who have been on the carnosine supplement have had reports of no improvement. A very small percentage (less than 5% of children with epilepsy or autistic spectrum disorders) have shown increased physical hyperactivity or verbal hyperactivity, but we are unable to

ascertain if these reports are directly related to the carnosine supplement. No sleep disturbances were reported as a result of carnosine therapy even in dosages up to 3,000 mg. a day. No abdominal side effects, skin rashes, or any changes in anticonvulsant blood levels, liver functions or hematological studies. No patients had any urinary changes or bowel habit changes from the

carnosine.Many children on the autistic spectrum were reported to

increase their range of food choices with an improved range of

appetite.Responses have been seen in generalized epilepsies, focal

seizure disorders, autism, PDD, and head injury to date. Because of its effect on entorhinal cortex, improvements in Alzheimer's disease or other frontal lobe encephalopathy may be possible. Any syndrome that involves apraxia or expressive language delay may benefit from this. Concurrent studies are currently being run or planned in areas of attention disorder, Tourette's syndrome, and various learning disability syndromes of the nonverbal type.

PS...ANOTHER WONDERFUL comprehesive link (27 pages )for the muti- use's of carnosine is

http://www.ethosplan.com/l-carnosine-information.asp

or

http://tinyurl.com/22ufmd

Table 1. Carnosine as complementary therapy (Disorder/disease and year of commence)

1. Arthritis (polyarthritis)

1935

2. Gastric and duodenal ulcers

1936

3. Wound healing

1940

4. Hypertension (blood pressure)

1941

5. Antibiotic effect

1969

6. Adrenal cortex effect

1976

7. Alleviation of sleep

1977

8. Treatment of trauma

1980

9. Prevention of seizures

1989

10. Coronary heart disease

1989

11. Anti-inflammatory effect

1971, 1986

12. Cataracts

1989

13. Anti-carcinogenic effect

1989

14. Immunologic effects

1986,1989

15. Prevention of radiation damage

1990

16. ADHD, Autistic Spectrum Disorder, epilepsy, other neurological & psychiatric

2001

Summary: dramatical effect in Autistic Spectrum Disordersprotects brain cells from excitotoxicity protects brain proteins (proteasomes) and biochemistry preserves brain biochemical functions functions as neurotransmittersafeguards brain chemistry in disorders overproducing free radicals rejuvenates senescent human cells in cultureincreases cell life span restores youthful appearance and growth patterns to cells approaching senescence protects against metal toxicity chelates copper and zinc naturally protects against copper-zinc toxicity in the brain copper-zinc chelators dissolve Alzheimer’s disease plaques inhibits cross-linking of amyloid-beta into Alzheimer’s disease plaques

Carnosine - references

Re: Valtrex and yeast +adrenal problems

Posted by: "" Ladyshrink111@... ladyshrink222

Thu Aug 9, 2007 4:31 am (PST)

I do know other people whose children exhibited seizures with any viral treatment, Virastop included. IMO, get an eeg and get him on some anticonvulsants. Repeated seizures, even the ones you can't see, are damaging. Valtrex and yeast +adrenal problemsHello group: 2 moths ago I started valtrex with my 13yo son, he had subclinical seizures in the past, which I controlled with diet. When I started valtrex (250mg 1xday at first,)He started to show seizure actitvity, his eyes where doing the "movements" that I know means subclinical seizures, he showed a mild rush in his face, under the mouth(chin), He took Nizoral 2 weeks before and during the Valtrex treatment plus B-12 shots. Recently he shows in OAT (great plains) high markers for yeast, also I found out he has adrenal problems, so he started taking Cortef (1/4 pill of 15mg/day)and adrenal cortex. I stop the valtrex and our DAN Dr. started him on Nystatin, (2000 units/day), My questions are, 1. When is he gona be able to re-start the valtrex treatment? 2. Does the yeast means he has viral load?(he shows High adenosine) 3. Can I do all this treatments at the same time? I know valtrex side effects is seizures,4. but How can I know when is to much and when to stop?He is having bad die-off reaction from the Nystatin (even more then with Nizoral)Stan? Anyone please?Thanks a lot!Have a good day..

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