Secretin Study to begin in San

[Guest guest]

Hi List,

A few of you may know that one of the places I volunteer is at TCART

(Texas Center for Autism Research & Treatment)here in San . I

do their web page at http://www.tcart.org and Dr. just gave me

the Repligen Secretin Study information to place on the web site. I

am also the " lucky person " who will get to return the phone calls,

schedule appointments and give out information on this study. I

thought I would let " my favorite group " know first that the study has

opened and they/we are taking calls to be returned for initial

screening.

Repligen will be publicizing this across Texas. San already

has TV airing time set up to get the word out. They are only taking a

limited number of children at this site. This is the phase 3 study

for Repligen http://www.repligen.com (their web site has information

too). I heard Dr. Schneider talk about their phase 2 study

results at the Feb. Medical Conference. There are alot of places to

research this potential treatment on the Internet and I would

encourage parents to make informed decisions.

This is what is now on the web site:

Secretin Study - TCART & Repligen Corporation are now accepting

children to participate in a FDA approved double-blinded, placebo

controlled study, to evaluate the effectiveness and safety of the man-

made hormone Secretin, for treatment of autism in young children.

Your child may be eligible to participate in this research study if

he/she is at least 2 years, 8 months but less than 5 years, and has

been diagnosed with autism. This study will take place at the Texas

Center for Autism Research & Treatment, and the University Health

Center-Downtown in San .

The duration of the study is about 5-6 months and will require 11

study visits in San . If you would be interested in

participating in this study, or would like more information, please

contact: Theresa Madore, Study Coordinator at , 1-888-338-

2278, or e-mail: secretinstudy@... . We will be returning

calls Monday-Thursday 9:00am - 12:00 noon and returning e-mails

intermittently.

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There is no financial cost to patients admitted to this study. Study

medications, laboratory tests, psychological evaluations and the

limited medical examinations are paid for by the program. There will

be six intravenous doses of RG1068 or placebo at three-week

intervals. In the phase 2 studies, Repligen allowed those children

that were a part of the study to continue receiving the secretin when

the study ended if they wanted (with no charge for the secretin only

a charge if the facility charged for the IV push), and for those that

received the placebo, they could begin the real secretin and continue

also. This would hopefully be the case here if there is no problem

with re-approval for TCART - which they are not anticipating.

If you would like a flyer sent out to your organization to inform

parents of this study, just e-mail me or call TCART, and I will mail,

fax, e-mail attach a informational flyer. Feel free to contact me if

you have more questions. Hopefully I have everything correct here but

I may have missed some points that you would like addressed. I will

be in at TCART Wednesday April 17th from 9-12+ if you want to talk to

me personally at the above phone numbers.

Theresa, SA