Vitamins and Supplements That MAY be Helpful in treating Metabolic syndrome

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from The United Mitochondrial Disease Foundation web site:

http://www.umdf.org/mitodisease/treatment.html

Consult your physician before starting any of the following possible

treatments

First Tier Supplements

CoQ10

5 – 15 mg/kg/day

Levo-carnitine

(Carnitor)

Variable, starting dose of 30 mg/kg/day, typical maximum of 100

mg/kg/day

Riboflavin (B2)

100 – 400 mg a day

Second Tier Supplement

Acetyl-L-Carnitine

250 – 1000 mg per day

Thiamine (B1)

50 – 100 mg a day

Nicotinamide (B3)

50 – 100 mg a day

Vitamin E

200 – 400 IU; 1 – 3 times a day

Vitamin C

100 – 500 mg; 1 – 3 times a day

Lipoic Acid

(a -lipoate)

60 – 200 mg; 3 times a day

Selenium

25 – 50 micrograms a day

b -carotene

10,000 IU; every other day to daily

Biotin

2.5 – 10 mg a day

Folic Acid

1 – 10 mg a day

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Medication, Minerals, Vitamins and Substrates that May be Helpful

Any use of the following medications, minerals, vitamins and

substrates MUST BE made only under a physician's direction

Supplement

Dose Range

Calcium

Variable

Magnesium

Variable

Phosphorus

Variable

Succinate

6 gm per day

Creatine

5 gm bid after initial load (adults)

Uridine

To be determined

Citrates

Variable

Prednisone

Variable

Vitamin K3 5-30 mg per day

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Avoidance of Physiologic " Stress "

Physiologic stress is triggered by external factors that may result

in worsening the metabolic situation, which may result in

temporary , or in sometimes, permanent worsening of the condition.

It is impossible to avoid all physiologic stressful conditions, so

one should not attempt to do so. However, recognizing what may be

stressful for patients allows one to adjust the lifestyle. Many

patients and their parents have already identified these stresses,

despite not knowing why the stresses were important, and avoid them.

Cold Stress is extremely important. Thermal regulation (temperature

control) is not always normal in people with mitochondrial diseases

and exposure to cold can result in severe heat loss and trigger an

energy crisis. When going out into the cold, all exposed body parts

should be covered, and exposure to extreme cold should be avoided

for anything more than a short period. Over bundling can be a

problem too (see below).

Heat Stress can be a problem in some people. This is especially true

of those with an inability to sweat normally. Heat exhaustion and

heat stroke may occur on hot days. It is typical for parents to

describe that their child seems to " wilt " in situations like hot

classrooms or direct sunlight, whereas the other children function

normally. Light clothing is important. Patients should avoid direct

sunlight on hot days and stay indoors if it is too warm outside. An

air-conditioned environment may be needed.

Starvation – avoid fasting.

Lack of sleep may possibly be harmful