Re: fyi.....Captopril-induced bone marrow suppression in two cardiac patients with trisomy 21

[Guest guest]

WOW! Thank you for sending this in. My son is currently on Captopril for his

heart. I will take this article to his Dr. for sure! Scarry!!

Debbie

>

> http://www.springerlink.com/content/v0712l7326355746/

>

> Summary Neutropenia is an infrequent complication following administration

> of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most

> reports have been in adult patients, with rare reports in the pediatric

> population. We report two cases of neutropenia following captopril use in

> cardiac patients, with trisomy 21. As this was not seen in patients without

> Down''s syndrome, we postulate that patients with trisomy 21 have bone

> marrow which is [image: ldquo]at risk[image: rdquo] for suppression, and

> thus warrant close evaluation while on such medications.

>

[Guest guest]

I just want to give the person who sent in the original post on Captopril a

heartfelt " THANK YOU " . We called our cardiologist and he ordered another CBC.

's WBC dropped 30% in 12 weeks. The doctor has taken him off Captopril

and put him on another cardiac med. Hopefully, we caught this soon enough and

his counts will go back up. We retest his CBC in 4 weeks.

Debbie

> >

> > http://www.springerlink.com/content/v0712l7326355746/

> >

> > Summary Neutropenia is an infrequent complication following administration

> > of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most

> > reports have been in adult patients, with rare reports in the pediatric

> > population. We report two cases of neutropenia following captopril use in

> > cardiac patients, with trisomy 21. As this was not seen in patients without

> > Down''s syndrome, we postulate that patients with trisomy 21 have bone

> > marrow which is [image: ldquo]at risk[image: rdquo] for suppression, and

> > thus warrant close evaluation while on such medications.

> >

>

[Guest guest]

good! glad that it helped. a mom on anther listserv said that her son had a problem with Captopril, and his counts returned to normal after he was taken off of it.KathyR

 

I just want to give the person who sent in the original post on Captopril a heartfelt " THANK YOU " . We called our cardiologist and he ordered another CBC. 's WBC dropped 30% in 12 weeks. The doctor has taken him off Captopril and put him on another cardiac med. Hopefully, we caught this soon enough and his counts will go back up. We retest his CBC in 4 weeks.

Debbie

> >

> > http://www.springerlink.com/content/v0712l7326355746/

> >

> > Summary Neutropenia is an infrequent complication following administration

> > of the angiotensin-converting enzyme (ACE) inhibitor, captopril. Most

> > reports have been in adult patients, with rare reports in the pediatric

> > population. We report two cases of neutropenia following captopril use in

> > cardiac patients, with trisomy 21. As this was not seen in patients without

> > Down''s syndrome, we postulate that patients with trisomy 21 have bone

> > marrow which is [image: ldquo]at risk[image: rdquo] for suppression, and

> > thus warrant close evaluation while on such medications.

> >

>