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Re: Fatigue and malaise

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> By the way, i quit taking my Abacavir last Friday to see if this or

the other

> meds could be the culprit.

>

Did you discuss your experiment with your doctor? It's not generally

advisable to stop just one med. You could quickly become resistant

to the others.

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Hi Rob,

I can tell you that I was on the same triple combo as you, for as

many years, and then switched out the Zerit for Viread about a year

and a half ago, also due to lipodystrophy. And since then have also

steadily grown more tired and irritable and fatigued and experience

malaise much more. Lab values, liver and lactic acid are all

normal, CD4's and vl remain good and stable, but definitely feel

different, for me, from the Viread.

Hope this is helpful, even if it isn't hopeful.

> Date: Mon, 24 May 2004 11:04:20 EDT

> From: robjob4u@...

>Subject: Fatigue and malaise

>

>Good morning everyone!

>

>I have been on Crix/Epivir/Zerit since November 1998. My t-cells remained

>near 600 with my vl<50 non-detectable. Due to lipodystrophy, I switched my

>Zerit to Abacavir this past February. Since that time, I have steadily grown

>more tired, irritable and anxious.

>

>I am constantly in this fog that effects my memory, I'm fatigued the moment I

>get up and have trouble just focusing on the simple day to day tasks.

>

>Has anyone else had these symptons and if so, what was done to remedy the

>situation.

>

>I just had my labs completed last Wednesday to rule out anemia, thyroid,

>testosterone etc. Results back later this week.

>

>By the way, i quit taking my Abacavir last Friday to see if this or the other

>meds could be the culprit.

>

>Any thoughts or insights would be greatly appreciated.

>

>Rob

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Rob said:

>>I am constantly in this fog that effects my memory, I'm fatigued the moment I get up and have trouble just focusing on the simple day to day tasks. >>Has anyone else had these symptons and if so, what was done to remedy the situation.

Rob, I get terrible fatigue from time to time. For me, I have found out how to remedy it.

I go to an acupuncturist regularly who also has a masters degree in Chinese Medicine.

In Chinese Medicine, they say that my blood is not moving enough. She has me take

Dong Quai Formula 18 for this and as long as I take it. I feel great. It takes a few days to about

a week before I start feeling better. If I go off of it, I start feeling crappy again so I continuously

take it these days. It helps build up the blood too even though I am not anemic.

I'm not sure if this is the specific formula for you. But have you tried seeing someone who has this

background? They have done wonders for me.

Pobi

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Hello,

I have had memory problems, which were a symptom of dysthymia, a

mild-to-moderate form of depression. From what I understand, dysthmia is

often associated with chronic fatigue syndrome. I found this little

descriptiom, which I feel fits me to a " T " (just as when I read a

description of homosexuality when I was 15, I thought " OK, that's me " ).

There could be other reasons for your memory troubles, I am sure, so I'd

suggest discussing this with your doctor.

Cheers,

.Mtl

Dysthymia, as defined in the American Psychiatric Association and

International Classification of Mental Disorders, refers to a prevalent form

of subthreshold depressive pathology with gloominess, anhedonia, low drive

and energy, low self-esteem and pessimistic outlook. Although comorbidity

with panic, social phobic, and alcohol use disorders has been described, the

most significant association is with major depressive episodes. Family

history is loaded with affective, including bipolar, disorders. The latter

finding explains why dysthymia, especially when onset is in childhood, can

lead to hypomanic switches, both spontaneously and upon pharmacologic

challenge in as many as 30%. Indeed, antidepressants from different classes

-tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs),

reversible inhibitors of monoamine oxidase A (RIMAs), selective

serotonin-reuptake inhibitors (SSRIs) and, more recently, amisulpride, and

spanning noradrenergic, serotonergic as well as dopaminergic mechanisms of

action - have been shown to be effective against dysthymia in an average of

65% of cases. This is a promising development because social and

characterologic disturbances so pervasive in dysthymia often, though not

always, recede with continued pharmacotherapy beyond acute treatment.

Despite symptomatic overlap of dysthymia with chronic fatigue syndrome -

especially with respect to the cluster of symptoms consisting of low drive,

lethargy, lassitude and poor concentration - neither the psychopathologic

status, nor the pharmacologic response profile of the latter syndrome is

presently understood. Chronic fatigue today is where dysthymia was two

decades ago. We submit that the basic science - clinical paradigm that has

proven so successful in dysthymia could, before too long, crack down the

conundrum of chronic fatigue as well. At a more practical level, we raise

the possibility that a subgroup within the chronic fatigue group represents

a variant of dysthymia.

----Original Message Follows----

To: <lipodystrophy >

Subject: re: fatigue and malaise

Date: Tue, 25 May 2004 09:07:09 -0700

Rob said:

>>I am constantly in this fog that effects my memory, I'm fatigued the

moment I

get up and have trouble just focusing on the simple day to day tasks.

>>Has anyone else had these symptons and if so, what was done to remedy the

situation.

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