RE: A comment from Wermuth regarding fertility drugs

[Guest guest]

Severe learning and physical disabilities nearly three times as high in this study, this commentary posted because the main researcher makes remarks of interest:Couples' Infertility Raises Autism Risk in Offsprings - SoftpediaPerhaps it's not due to the fertility drug itself? The woman was sub-fertile to begin with, the fertility drug boosts ovulation but doesn't necessarily address the underlying metabolic/endocrine problem that contributed to the infertility, which can have an impact on critical periods of a developing baby, and is often associated with nutrient deficiency or toxic exposure.(See studies listed at end) Most have an underlying insulin resistance and elevated stress hormones. Proper glucose oxidation, maintained by reduced stress hormones, and promoting thyroid health resolves most fertility issues.Stress hormones( cortisol, serotonin, estrogen, adrenaline, prolactin, histamine) are effectively reduced and normalized with diet. Some may need hormonal support such as thyroid, progesterone, bromocriptine, etc, for a short time. However, dietary support for these conditions is highly effective. The basal temps can be monitored, giving clues to subclinical hypothyroidism and can be used to watch return of the metabolism to within normal parameters. Although, the various stress hormones may raise temps interfering with accuracy, and other variables may be at play affecting the basal temp. Charting hormonal patterns gives clear clues as well for fertility disorders and the return to fertility can be accurately monitored. Their future health and that of their children may likely depend on correcting the underlying endocrine disorder.I work with couples from all over via phone, email, and Skype on diet and lifestyle. Recently had a 42 y.o. woman 10 years infertile, deliver a healthy baby. She made key dietary changes and conceived quickly. Our daughter has taught her college friends with irregular/anovulatory cycles, and all have returned to normal, regular cycling within a short time of 4-8 weeks. We experimented with 30+ chickens this winter. For the city folk on the list, chickens stop reproducing in winter and quit laying eggs when days are too short(daylight length) and the foraging food supply limited(key nutrients). All appeared to keep laying at the same daily summer rate for the entire winter with dietary change only, with no increase in light exposure. Neighboring chickens were not laying. We tried to mimic particular dietary changes our couples are making. It is not always so easy for people to make these changes, some just don't want to, but the chickens were very compliant and we enjoyed an abundance of fresh eggs through winter! It is also important to note that birds who continue to reproduce in winter, usually by flying south, extend their lifespans. Not unlike the situation with the drug companies and estrogens, the seed oil and fish oil companies have been effective at marketing and funding studies to make their(highly toxic and 'estrogenic') oils appear beneficial... which can lead to more grant money…. The problem as many are aware, seems to be in academia today. The 'low fat, low cholesterol ' mantra and veganism have also wreaked havoc.Putting together a website, otherwise am available for private consult.Have a joyful and holy Easter Week,Darcy Hemstad, RN, BSNNutrition and Fertility EducatorCertified instructor Billings Ovulation MethodRandom studies, related to stress hormones, low thyroid, insulin dysregulation:Psychiatry Res 1994 Jun;52(3):285-93. In vivo serotonin release and learned helplessness.Petty F, Kramer G, L, Jordan S Mental Health Clinic, Dallas Veterans Affairs Medical Center, TX. These data support the hypothesis that a cortical serotonergic excess(stress hormones) is causally related to the development of learned helplessness.Can J Psychiatry 1990 May;35(4):342-3. Increased detection of elevated TSH using immunoradiometric assay. Little KY, Kearfott KS, Castellanos X, Rinker A, Whitley R. Closer scrutiny of mood disorder patients with elevations found confirmatory evidence of thyroid dysfunction in most. Neuroscience 2000;100(4):749-68. Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome. Heidbreder CA, Weiss IC, Domeney AM, Pryce C, Homberg J, Hedou G, Feldon J, Moran MC, P. “Rearing rats in isolation has been shown to be a relevant paradigm for studying early life stress and understanding the genesis of depression and related affective disorders. Recent studies from our laboratory point to the relevance of studying the social isolation syndrome as a function of home caging conditions.”Am J Psychiatry 1981 Aug;138(8):1082-5. Tryptophan metabolism in children with attentional deficit disorder. Irwin M, Belendiuk K, McCloskey K, Freedman DX The authors present the first report, to their knowledge, of hyperserotonemia in children with attentional deficit disorder who had normal intelligence.J Neuropsychiatry Clin Neurosci 1990 Summer;2(3):268-74. Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence. Cook EH, Leventhal BL, Heller W, Metz J, Wainwright M, Freedman DX “Whole-blood serotonin (5-HT) and plasma norepinephrine (NE) were studied in 16 autistic children, 21 siblings of autistic children, and 53 parents of autistic children. Both plasma NE and whole-blood 5-HT were negatively correlated with vocabulary performance.” “Eighteen subjects were hyperserotonemic (whole-blood 5-HT greater than 270 ng/ml). For these subjects, plasma NE was significantly higher than for subjects without hyperserotonemia.”Eur Neuropsychopharmacol 1997 Oct;7 Suppl 3:S323-S328. Prevention of stress-induced morphological and cognitive consequences.. McEwen BS, Conrad CD, Kuroda Y, furt M, Magarinos AM, McKittrick C. There is reason to believe that adrenal glucocorticoids may contribute to these changes, since the elevations of glucocorticoids in Cushing's syndrome and during normal aging are associated with atrophy of the entire hippocampal formation in humans and are linked to deficits in short-term verbal memory. Because serotonin is released by stressors and may play a role in the actions of stress on nerve cells, we investigated the actions of agents that facilitate or inhibit serotonin reuptake. Med Hypotheses 1994 Dec;43(6):420-35 Schizophrenia is a diabetic brain state: an elucidation of impaired neurometabolism. Holden RJ, Mooney PA. Life Sci 1987 May 18;40(20):2031-9. Dysfunction in a prefrontal substrate of sustained attention in schizophrenia.Cohen RM, Semple WE, Gross M, Nordahl TE, DeLisi LE, Holcomb HH, King AC, Morihisa JM, Pickar D. Regional brain metabolism was measured in normal subjects and patients with schizophrenia while they performed an auditory discrimination task designed to emphasize sustained attention. A direct relationship was found in the normal subjects between metabolic rate in the middle prefrontal cortex and accuracy of performance. The metabolic rate in the middle prefrontal cortex of patients with schizophrenia, even those who performed as well as normals, was found to be significantly lower than normal and unrelated to performance. The findings point to a role of the mid-prefrontal region in sustained attention and to dysfunction of this region in schizophrenia. Zh Nevropatol Psikhiatr Im S S Korsakova 1991;91(1):122-3 [status of the thyroid gland in patients with schizophrenia]. Turianitsa IM, Lavkai IIu, Mishanich II, Margitich VM, Razhov KF. The rise of TTH concentration represents one of the mechanisms of correction, aimed at the attainment of the physiological content of T4 at the expense of its additional output for its level in the blood serum is appreciably reduced. Neuroendocrinology 1982 Jun; 34(6): 438-443. Sleep organization in hypo- and hyperthyroid rats. Carpenter AC, Timiras PS. The results show an increased number of awakenings during slow wave sleep (SWS) in hypothyroid animals, whereas total sleep time, levels of SWS, paradoxical sleep, and diurnal organization were unaffected by thyroid status. Our findings indicate that adequate levels of thyroid hormone are necessary to sustain extended periods of SWS in the adult rat while hyperthyroid animals show no disruption of sleep organization.Schizophr Res 1996 Oct 18;22(1):41-7. Are reduced head circumference at birth and increased obstetric complications associated only with schizophrenic psychosis? A comparison with schizo-affective and unspecified functional psychoses. McNeil TF, Cantor-Graae E, Nordstrom LG, Rosenlund T.

Based on anecdotal evidence, suspects that children conceived with help from infertility drugs are at greater risk of "birth defects" or other adverse lifetime health effects than children conceived without such drugs. Does anyone share her suspicions? Are there studies to confirm or refute?If I already asked, please forgive me.Blessings to all.Steve Koob> Subject: Re: A comment from Wermuth> Date: Sat, 7 Apr 2012 16:14:20 -0400> To: koob_8@...> > Thanks for getting back with me. I hope more is done to find out any effects on the babies conceived when the mother used infertility drugs.