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Understanding Your Biopsy Results

The following terms are often used to

describe the changes in liver tissue associated with HCV infection:

Portal

Inflammation. The portal areas are tiny tracts of connective tissue

within the liver that contain branches of the portal vein, the hepatic artery

and bile ducts.

Piecemeal Necrosis.

This term describes necrosis (cellular death) and inflammation around the

portal areas.

Fibrosis.

Fibrosis is the deposition of specialized fibers in the cell structure of

the liver, forming scar tissue. The early stages of fibrosis are confined

to the portal tracts.

The intermediate stages of

fibrosis are characterized by expansion of fibrous tissue to the portal

tracts and bridging between portal areas (known as bridging fibrosis).

Cirrhosis. A

term used to describe significant deformation of the structure of the

liver due to scarring.

Grade. Grading

describes the degree of inflammation and necrosis that has occurred in the

liver.

Stage. Staging describes the degree of fibrosis

(scarring) that has occurred.

There are several systems for describing the amount

and type of inflammation and fibrosis you may have. When receiving biopsy

results, the physician should specify which system is being used for grading

and staging.

Source

Flora, K. Diagnostic Liver Biopsy.

eMedicine.com.

Liver Biopsy. National Digestive

Diseases Information Clearinghouse (NDDIC).

Liver Biopsy. British Liver Trust,

2002.

Chronic Hepatitis C: Current Disease

Management. National Digestive Diseases Information Clearinghouse, National

Institutes of Health.

Reviewed 7/13/05 by V. J. , RN, BSN, MA.

http://www.hepatitisneighborhood.com/content/understanding_hepatitis/diagnosing_hepatitisc_133.aspx

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