Spironlactone - Are you Crazy?

[Guest guest]

We have had some discussions regarding doctors treating us for psychological

problems or at least considering it an issue for us. I was preparing for an

Endocrinology discussion tomorrow, no med change in another week. I did a

search on " spironolactone and pituitary " (for my month+ long headache) and came

across this article/study. Thought it might be interesting to some.

I plan to send to my psyco docs for their impression also.

Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

Original Article

Neuropsychopharmacology (2007) 32, 232–238. doi:10.1038/sj.npp.1301217;

published online 11 October 2006

Clinical Research

Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on

Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana

Madrischewski1, Klaus Wiedemann1 and Kellner1

1Department of Psychiatry and Psychotherapy, University Hospital

Hamburg-Eppendorf, Hamburg, Germany

2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich,

Germany

" In summary, we found that blockade of MR with spironolactone in healthy men

impairs several aspects of cognition, particularly selective attention,

visuospatial memory, and set shifting/mental flexibility but did not affect

symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

Wonder if they only tested men because they felt women were too psyco

normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.