Re: Spironlactone - Are you Crazy?

December 18, 2011

In all seriousness it does make me wonder why they only studied men... I will

say that during my three weeks on spiro last summer, I felt like my anxiety

levels were out of control and I was incredibly unfocused (I even took a week

off from work because I was afraid of screwing something up big-time). I

attributed it to being uncomfortable about being on meds in the first place but

who knows, maybe there was more to it.

-msmith1928

Nulliparous female, 46, 5'3 " , 115 lbs, CT showed 1cm left adrenal nodule, AVS

determined disease is unilateral, had left laparoscopic adrenalectomy on

10/13/2011. Low sodium, fructose- and grain-free diet due to hereditary fructose

intolerance, lactose intolerance, gluten intolerance (probable celiac).

>

> We have had some discussions regarding doctors treating us for psychological

problems or at least considering it an issue for us. I was preparing for an

Endocrinology discussion tomorrow, no med change in another week. I did a

search on " spironolactone and pituitary " (for my month+ long headache) and came

across this article/study. Thought it might be interesting to some.

>

> I plan to send to my psyco docs for their impression also.

>

> Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

>

> Original Article

> Neuropsychopharmacology (2007) 32, 232–238. doi:10.1038/sj.npp.1301217;

published online 11 October 2006

> Clinical Research

>

> Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on

Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

>

> Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana

Madrischewski1, Klaus Wiedemann1 and Kellner1

> 1Department of Psychiatry and Psychotherapy, University Hospital

Hamburg-Eppendorf, Hamburg, Germany

> 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich,

Germany

>

> " In summary, we found that blockade of MR with spironolactone in healthy men

impairs several aspects of cognition, particularly selective attention,

visuospatial memory, and set shifting/mental flexibility but did not affect

symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

>

> Wonder if they only tested men because they felt women were too psyco

normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

>

> - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt.

flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76

HR 60

> Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin,

Metformin 2000MG and Spironolactone 50 MG.

>

December 18, 2011

I suspect that pts usually feel less anxiety etc on Spiro and DASH. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

In all seriousness it does make me wonder why they only studied men... I will say that during my three weeks on spiro last summer, I felt like my anxiety levels were out of control and I was incredibly unfocused (I even took a week off from work because I was afraid of screwing something up big-time). I attributed it to being uncomfortable about being on meds in the first place but who knows, maybe there was more to it.

-msmith1928

Nulliparous female, 46, 5'3", 115 lbs, CT showed 1cm left adrenal nodule, AVS determined disease is unilateral, had left laparoscopic adrenalectomy on 10/13/2011. Low sodium, fructose- and grain-free diet due to hereditary fructose intolerance, lactose intolerance, gluten intolerance (probable celiac).

>

> We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.

>

> I plan to send to my psyco docs for their impression also.

>

> Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

>

> Original Article

> Neuropsychopharmacology (2007) 32, 232â€“238. doi:10.1038/sj.npp.1301217; published online 11 October 2006

> Clinical Research

>

> Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

>

> Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

> 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany

>

> "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."

>

> Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

>

> - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

> Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

>

December 18, 2011

Walk mile in my shoes and then we will talk about it! I'm beginning to think

PTNs feel a lot less anxiety ect. after a sucessful adrenalectomy!

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

> > >

> > > We have had some discussions regarding doctors treating us for

psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting to

some.

> > >

> > > I plan to send to my psyco docs for their impression also.

> > >

> > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > Original Article

> > > Neuropsychopharmacology (2007) 32, 232â€ " 238. doi:10.1038/sj.npp.1301217;

published online 11 October 2006

> > > Clinical Research

> > >

> > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on

Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana

Madrischewski1, Klaus Wiedemann1 and Kellner1

> > > 1Department of Psychiatry and Psychotherapy, University Hospital

Hamburg-Eppendorf, Hamburg, Germany

> > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich,

Germany

> > >

> > > " In summary, we found that blockade of MR with spironolactone in healthy

men impairs several aspects of cognition, particularly selective attention,

visuospatial memory, and set shifting/mental flexibility but did not affect

symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

> > >

> > > Wonder if they only tested men because they felt women were too psyco

normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> > >

> > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt.

flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR

60

> > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin,

Metformin 2000MG and Spironolactone 50 MG.

> > >

> >

>

December 18, 2011

And you thought I wasn't being serious? I'll ask my doctors if they can think

of any reason for a gender difference, they are both female so they may be more

serious! ;>)

My therapist has started a Cognitative Processing Theory series so she might

have some insight. (I was actually enrolled but had to back out when I needed

to deal with gynecomastia needed my attention.)

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

> >

> > We have had some discussions regarding doctors treating us for psychological

problems or at least considering it an issue for us. I was preparing for an

Endocrinology discussion tomorrow, no med change in another week. I did a

search on " spironolactone and pituitary " (for my month+ long headache) and came

across this article/study. Thought it might be interesting to some.

> >

> > I plan to send to my psyco docs for their impression also.

> >

> > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> >

> > Original Article

> > Neuropsychopharmacology (2007) 32, 232–238. doi:10.1038/sj.npp.1301217;

published online 11 October 2006

> > Clinical Research

> >

> > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on

Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> >

> > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana

Madrischewski1, Klaus Wiedemann1 and Kellner1

> > 1Department of Psychiatry and Psychotherapy, University Hospital

Hamburg-Eppendorf, Hamburg, Germany

> > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich,

Germany

> >

> > " In summary, we found that blockade of MR with spironolactone in healthy men

impairs several aspects of cognition, particularly selective attention,

visuospatial memory, and set shifting/mental flexibility but did not affect

symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

> >

> > Wonder if they only tested men because they felt women were too psyco

normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> >

> > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt.

flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76

HR 60

> > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin,

Metformin 2000MG and Spironolactone 50 MG.

> >

>

December 18, 2011

They were studying the males apsect of MR blockade, but not the exact things intially that were found in the studies at the end. Good research means we sometimes find other things we weren't looking for, that may have surprised us, but are important nonetheless.

Sadly, it seems that in research circles we are uncovering more and more data in this age that was hidden, manipulated, or simply lied about, like the Tobacco companies did for years, and the global warming people, auto industry, and in a more famous incident that was simply downright lying that got people - who still believe it no matter what - is the false research on autism and vaccines the English researcher made his name on.

Who do you believe anymore..........

Subject: Re: Spironlactone - Are you Crazy?To: hyperaldosteronism Date: Sunday, December 18, 2011, 5:02 PM

And you thought I wasn't being serious? I'll ask my doctors if they can think of any reason for a gender difference, they are both female so they may be more serious! ;>)My therapist has started a Cognitative Processing Theory series so she might have some insight. (I was actually enrolled but had to back out when I needed to deal with gynecomastia needed my attention.) - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. > >> > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.> > > > I plan to send to my psyco docs for their impression also.> > > > > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html> > >

> Original Article> > Neuropsychopharmacology (2007) 32, 232â€“238. doi:10.1038/sj.npp.1301217; published online 11 October 2006> > Clinical Research> > > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition> > > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1> > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany> > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany> > > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect

symptoms of panic, anxiety and arousal after a challenge with CCK-4."> > > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))> > > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60> > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.> > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.> >>

December 18, 2011

, with all your comorbid conditions, what or which do you attribute to PA and what do you not? For instance if the treatment of PA for you doesn't work on your anxiety, but you have PTSD and chronic pain issues then we couldn't say in your case whether anxiety has anything to do with PA at all...it might of course, but how do YOU mentally/emotionally/ etc sort what is what? Sent from my Palm Pre on the Now Network from Sprint

Walk mile in my shoes and then we will talk about it! I'm beginning to think PTNs feel a lot less anxiety ect. after a sucessful adrenalectomy!

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> > > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.

> > >

> > > I plan to send to my psyco docs for their impression also.

> > >

> > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > Original Article

> > > Neuropsychopharmacology (2007) 32, 232Ã¢Â€"238. doi:10.1038/sj.npp.1301217; published online 11 October 2006

> > > Clinical Research

> > >

> > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> > > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

> > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany

> > >

> > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."

> > >

> > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> > >

> > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

> > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> >

>

December 18, 2011

BUT if the reports we keep getting from patients, and some are short term results so far, are any indication then adrenalectomy sure seems like aVERY valid and good option as they seem to feel better. Now, I never ask nor hear from someone years out, but on the short term end I wonder if any is the euphoria due to pain meds and post surgical opiates (euphoria can mean just feeling better not just on cloud nine). They still seem better.Sent from my Palm Pre on the Now Network from Sprint

Walk mile in my shoes and then we will talk about it! I'm beginning to think PTNs feel a lot less anxiety ect. after a sucessful adrenalectomy!

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> > > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.

> > >

> > > I plan to send to my psyco docs for their impression also.

> > >

> > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > Original Article

> > > Neuropsychopharmacology (2007) 32, 232Ã¢Â€"238. doi:10.1038/sj.npp.1301217; published online 11 October 2006

> > > Clinical Research

> > >

> > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> > > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

> > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany

> > >

> > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."

> > >

> > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> > >

> > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

> > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> >

>

December 18, 2011

Just to prove I don't discriminte, here - we can drive the ladies crazy too!

Mineralocorticoid Receptor Function in Major Depression

A. Young, MD; F. , MD; Virginia -Weinberg, MS, RN;

Stanley J. , MD, PhD; Huda Akil, PhD

Arch Gen Psychiatry. 2003;60:24-28.

source:

http://archpsyc.ama-assn.org/cgi/reprint/60/1/24

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

> > >

> > > We have had some discussions regarding doctors treating us for

psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting

to some.

> > >

> > > I plan to send to my psyco docs for their impression also.

> > >

> > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > Original Article

> > > Neuropsychopharmacology (2007) 32, 232–238. doi:10.1038/sj.npp.1301217;

published online 11 October 2006

> > > Clinical Research

> > >

> > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on

Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana

Madrischewski1, Klaus Wiedemann1 and Kellner1

> > > 1Department of Psychiatry and Psychotherapy, University Hospital

Hamburg-Eppendorf, Hamburg, Germany

> > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich,

Germany

> > >

> > > " In summary, we found that blockade of MR with spironolactone in healthy

men impairs several aspects of cognition, particularly selective attention,

visuospatial memory, and set shifting/mental flexibility but did not affect

symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

> > >

> > > Wonder if they only tested men because they felt women were too psyco

normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> > >

> > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt.

flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76

HR 60

> > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin,

Metformin 2000MG and Spironolactone 50 MG.

> > >

> >

>

December 18, 2011

One way is to only believe what is in reputable journals and then always be a skeptic.The next is that the study was one that asked in a random design was x doing y?Third one always likes to see someone else be able to repeat the experiment and get the same result more or less.One needs to understand that one can never prove anything. One can only disprove something. At least some philosophers of science say (Bonner? but am not sure of name at this time).CE Grim MD They were studying the males apsect of MR blockade, but not the exact things intially that were found in the studies at the end. Good research means we sometimes find other things we weren't looking for, that may have surprised us, but are important nonetheless. Sadly, it seems that in research circles we are uncovering more and more data in this age that was hidden, manipulated, or simply lied about, like the Tobacco companies did for years, and the global warming people, auto industry, and in a more famous incident that was simply downright lying that got people - who still believe it no matter what - is the false research on autism and vaccines the English researcher made his name on. Who do you believe anymore.......... Subject: Re: Spironlactone - Are you Crazy?To: hyperaldosteronism Date: Sunday, December 18, 2011, 5:02 PM And you thought I wasn't being serious? I'll ask my doctors if they can think of any reason for a gender difference, they are both female so they may be more serious! ;>)My therapist has started a Cognitative Processing Theory series so she might have some insight. (I was actually enrolled but had to back out when I needed to deal with gynecomastia needed my attention.) - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. > >> > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.> > > > I plan to send to my psyco docs for their impression also.> > > > > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html> > > > Original Article> > Neuropsychopharmacology (2007) 32, 232–238. doi:10.1038/sj.npp.1301217; published online 11 October 2006> > Clinical Research> > > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition> > > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1> > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany> > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany> > > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."> > > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))> > > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60> > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.> > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.> >>

December 18, 2011

Now it would be much better to do this with Inspra as it is a much more selective blocker. They only measured cortisol as far as I can tell but should have measured others as well. CE Grim MD Just to prove I don't discriminte, here - we can drive the ladies crazy too! Mineralocorticoid Receptor Function in Major Depression A. Young, MD; F. , MD; Virginia -Weinberg, MS, RN; Stanley J. , MD, PhD; Huda Akil, PhD Arch Gen Psychiatry. 2003;60:24-28. source: http://archpsyc.ama-assn.org/cgi/reprint/60/1/24 - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60 Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD. Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. > > > > > > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some. > > > > > > I plan to send to my psyco docs for their impression also. > > > > > > > > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html > > > > > > Original Article > > > Neuropsychopharmacology (2007) 32, 232–238. doi:10.1038/sj.npp.1301217; published online 11 October 2006 > > > Clinical Research > > > > > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition > > > > > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1 > > > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany > > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany > > > > > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4." > > > > > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>)) > > > > > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60 > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD. > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. > > > > > >

December 18, 2011

Of course everyone is different and an interaction of other drugs may be a factor as well.CE Grim MD Walk mile in my shoes and then we will talk about it! I'm beginning to think PTNs feel a lot less anxiety ect. after a sucessful adrenalectomy! - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60 Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD. Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. > > > > > > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some. > > > > > > I plan to send to my psyco docs for their impression also. > > > > > > > > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html > > > > > > Original Article > > > Neuropsychopharmacology (2007) 32, 232â€"238. doi:10.1038/sj.npp.1301217; published online 11 October 2006 > > > Clinical Research > > > > > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition > > > > > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1 > > > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany > > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany > > > > > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4." > > > > > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>)) > > > > > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60 > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD. > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. > > > > > > > >

December 19, 2011

They were looking at men. Some of the results were not exactly what they were looking for, but were found in the studies, and were listed. One aspect of a good study is it gives us more to study....ie...women in this case.

It would be awonderful world if all research in each study covered men/women/children/ and cats and dogs, but tis not so.

In all seriousness it does make me wonder why they only studied men... I will say that during my three weeks on spiro last summer, I felt like my anxiety levels were out of control and I was incredibly unfocused (I even took a week off from work because I was afraid of screwing something up big-time). I attributed it to being uncomfortable about being on meds in the first place but who knows, maybe there was more to it.-msmith1928Nulliparous female, 46, 5'3", 115 lbs, CT showed 1cm left adrenal nodule, AVS determined disease is unilateral, had left laparoscopic adrenalectomy on 10/13/2011. Low sodium, fructose- and grain-free diet due to hereditary fructose intolerance, lactose intolerance, gluten intolerance (probable celiac).>> We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.> > I plan to send to my psyco docs for their impression also.> > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html> > Original Article> Neuropsychopharmacology (2007) 32, 232â€“238. doi:10.1038/sj.npp.1301217; published online 11 October 2006> Clinical

Research> > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition> > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1> 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany> 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany> > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."> > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate

mail anywy! ;>))> > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60> Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.> Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.>

December 19, 2011

To me the scary thing is when studies focused on a single subset of people leads

to an across-the-board belief that becomes accepted as good for everybody.

After I got really sick when my last doctor ( " the one that I fired " ) put me on

Vit D supplements, I did some research. The study that led to the widespread

practice of testing Vit D levels and prescribing massive OTC supplements was

IIRC based on benefits shown in Northern European males over age 50 who had a

history of cardiovascular events. Being neither Northern European, male, or over

50, I decided I should discontinue the Vit D

Unfortunately I doubt that there will ever be any studies focused on 40something

women of mixed Eastern European/Middle Eastern/Asian ancestry, so I will

continue to be my experiment of one!

> >

> > We have had some discussions regarding doctors treating us for psychological

problems or at least considering it an issue for us. I was preparing for an

Endocrinology discussion tomorrow, no med change in another week. I did a search

on " spironolactone and pituitary " (for my month+ long headache) and came across

this article/study. Thought it might be interesting to some.

> >

> > I plan to send to my psyco docs for their impression also.

> >

> > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> >

> > Original Article

> > Neuropsychopharmacology (2007) 32, 232â€ " 238. doi:10.1038/sj.npp.1301217;

published online 11 October 2006

> > Clinical Research

> >

> > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on

Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> >

> > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana

Madrischewski1, Klaus Wiedemann1 and Kellner1

> > 1Department of Psychiatry and Psychotherapy, University Hospital

Hamburg-Eppendorf, Hamburg, Germany

> > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich,

Germany

> >

> > " In summary, we found that blockade of MR with spironolactone in healthy men

impairs several aspects of cognition, particularly selective attention,

visuospatial memory, and set shifting/mental flexibility but did not affect

symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

> >

> > Wonder if they only tested men because they felt women were too psyco

normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> >

> > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt.

flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR

60

> > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin,

Metformin 2000MG and Spironolactone 50 MG.

> >

>

December 19, 2011

I agree. And my views on vitamin D I have written about over and over and just that I have a "feeling" something isn't quite right about how we look at it or diagnose the deficiency. That's a good example though. Many of the SSRI studies are like that too - applied to everyone when the study was limited in scope.

Subject: Re: Spironlactone - Are you Crazy?To: hyperaldosteronism Date: Monday, December 19, 2011, 10:39 AM

To me the scary thing is when studies focused on a single subset of people leads to an across-the-board belief that becomes accepted as good for everybody. After I got really sick when my last doctor ("the one that I fired") put me on Vit D supplements, I did some research. The study that led to the widespread practice of testing Vit D levels and prescribing massive OTC supplements was IIRC based on benefits shown in Northern European males over age 50 who had a history of cardiovascular events. Being neither Northern European, male, or over 50, I decided I should discontinue the Vit D :)Unfortunately I doubt that there will ever be any studies focused on 40something women of mixed Eastern European/Middle Eastern/Asian ancestry, so I will continue to be my experiment of one!> >> > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.> > > > I plan to send to my psyco docs for their impression also.> > > > > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html> > > > Original Article> > Neuropsychopharmacology (2007) 32, 232Ã¢â‚¬"238. doi:10.1038/sj.npp.1301217; published online 11 October 2006> > Clinical Research> > > > Blockade of the Mineralocorticoid

Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition> > > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1> > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany> > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany> > > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."> > > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy!

;>))> > > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60> > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.> > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.> >>

December 19, 2011

As well as the statin studies - again, they originally focused on focused on

males over 50. But as with SSRIs, big profits in statins...

> > >

> > > We have had some discussions regarding doctors treating us for

psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting to

some.

> > >

> > > I plan to send to my psyco docs for their impression also.

> > >

> > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > Original Article

> > > Neuropsychopharmacology (2007) 32, 232Ã¢â‚¬ " 238.

doi:10.1038/sj.npp.1301217; published online 11 October 2006

> > > Clinical Research

> > >

> > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on

Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana

Madrischewski1, Klaus Wiedemann1 and Kellner1

> > > 1Department of Psychiatry and Psychotherapy, University Hospital

Hamburg-Eppendorf, Hamburg, Germany

> > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich,

Germany

> > >

> > > " In summary, we found that blockade of MR with spironolactone in healthy

men impairs several aspects of cognition, particularly selective attention,

visuospatial memory, and set shifting/mental flexibility but did not affect

symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

> > >

> > > Wonder if they only tested men because they felt women were too psyco

normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> > >

> > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt.

flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR

60

> > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin,

Metformin 2000MG and Spironolactone 50 MG.

> > >

> >

>

December 19, 2011

Of course all studies only apply to folks like were in the study. But often generalized to "Everyman" well and "Everywoman"May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

As well as the statin studies - again, they originally focused on focused on males over 50. But as with SSRIs, big profits in statins...

> > >

> > > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.

> > >

> > > I plan to send to my psyco docs for their impression also.

> > >

> > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > Original Article

> > > Neuropsychopharmacology (2007) 32, 232ÃƒÂ¢Ã¢â€šÂ¬"238. doi:10.1038/sj.npp.1301217; published online 11 October 2006

> > > Clinical Research

> > >

> > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> > > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

> > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany

> > >

> > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."

> > >

> > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> > >

> > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

> > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> >

>

December 19, 2011

I can say with certainty that my post-surgical lack of anxiety wasn't due to

euphoria from opiates - I stopped those and switched to ibuprofen as soon as

they allowed me, I think within 72 hours after surgery. Opiates and I do not

play well together at all!

In the interest of presenting all perspectives - a woman who used to post here

but stopped still posts on her blog now and again about how she is doing

post-surgery: http://hyperaldosteronism.blogspot.com. She seems to be struggling

quite a bit with ongoing anxiety and other issues.

As for myself - it's been just over two months since the surgery and even though

I've had some pain issues develop (for which I only blame myself and doing too

much too soon), I'm still feeling much better than I have in years. Anxiety is

almost nonexistent and along with that, so is insomnia - which had been an issue

for me since childhood.

--msmith1928

Nulliparous female, 46, 5'3 " , 115 lbs, CT showed 1cm left adrenal nodule, AVS

determined disease is unilateral, had left laparoscopic adrenalectomy on

10/13/2011. Low sodium, fructose- and grain-free diet due to hereditary fructose

intolerance, lactose intolerance, gluten intolerance (probable celiac).

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; We have had some discussions regarding doctors treating us for

psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting to

some.

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; I plan to send to my psyco docs for their impression also.

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Source:

http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Original Article

>

> & gt; & gt; & gt; Neuropsychopharmacology (2007) 32, 232Ã¢Â€ " 238.

doi:10.1038/sj.npp.1301217; published online 11 October 2006

>

> & gt; & gt; & gt; Clinical Research

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Blockade of the Mineralocorticoid Receptor in Healthy Men:

Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Christian Otte1, Steffen Moritz1, Yassouridis2, Maike

Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

>

> & gt; & gt; & gt; 1Department of Psychiatry and Psychotherapy, University

Hospital Hamburg-Eppendorf, Hamburg, Germany

>

> & gt; & gt; & gt; 2Department of Biostatistics, Max Planck Institute of

Psychiatry, Munich, Germany

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; " In summary, we found that blockade of MR with spironolactone

in healthy men impairs several aspects of cognition, particularly selective

attention, visuospatial memory, and set shifting/mental flexibility but did not

affect symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Wonder if they only tested men because they felt women were too

psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ; & gt;))

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with

previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week

ave): 131/76 HR 60

>

> & gt; & gt; & gt; Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2,

and PTSD.

>

> & gt; & gt; & gt; Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg

asprin, Metformin 2000MG and Spironolactone 50 MG.

>

> & gt; & gt; & gt;

>

> & gt; & gt;

>

> & gt; & gt;

>

> & gt;

>

December 19, 2011

When I refer or quote a study, it comes with no recommendation or guarantee. I

have reviewed it and understood maybe 48% of it. I saw something, even if I

don't totally understand it, that either may apply to me or may be of interest

to someone else that has posed a question. LET THE BUYER BEWARE! I may be

unique because in addition to a very open minded PCP I have a Neperologist,

Endocronologist, Pulmonologist, Psychitrist, Theraistis, Poditrist and maybe

others at my disposal so they can validate it for me and often do!

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

> > > > >

> > > > > We have had some discussions regarding doctors treating us for

psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting to

some.

> > > > >

> > > > > I plan to send to my psyco docs for their impression also.

> > > > >

> > > > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > > > >

> > > > > Original Article

> > > > > Neuropsychopharmacology (2007) 32, 232ÃƒÂ¢Ã¢â€šÂ¬ " 238.

doi:10.1038/sj.npp.1301217; published online 11 October 2006

> > > > > Clinical Research

> > > > >

> > > > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on

Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > > > >

> > > > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1,

Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> > > > > 1Department of Psychiatry and Psychotherapy, University Hospital

Hamburg-Eppendorf, Hamburg, Germany

> > > > > 2Department of Biostatistics, Max Planck Institute of Psychiatry,

Munich, Germany

> > > > >

> > > > > " In summary, we found that blockade of MR with spironolactone in

healthy men impairs several aspects of cognition, particularly selective

attention, visuospatial memory, and set shifting/mental flexibility but did not

affect symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

> > > > >

> > > > > Wonder if they only tested men because they felt women were too psyco

normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> > > > >

> > > > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous

rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave):

131/76 HR 60

> > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and

PTSD.

> > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin,

Metformin 2000MG and Spironolactone 50 MG.

> > > > >

> > > >

> > >

> >

>

December 19, 2011

And we have not done a sham surgery study. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

BUT if the reports we keep getting from patients, and some are short term results so far, are any indication then adrenalectomy sure seems like aVERY valid and good option as they seem to feel better. Now, I never ask nor hear from someone years out, but on the short term end I wonder if any is the euphoria due to pain meds and post surgical opiates (euphoria can mean just feeling better not just on cloud nine). They still seem better.Sent from my Palm Pre on the Now Network from Sprint

Walk mile in my shoes and then we will talk about it! I'm beginning to think PTNs feel a lot less anxiety ect. after a sucessful adrenalectomy!

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> > > We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.

> > >

> > > I plan to send to my psyco docs for their impression also.

> > >

> > > Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > Original Article

> > > Neuropsychopharmacology (2007) 32, 232Ã¢Â€"238. doi:10.1038/sj.npp.1301217; published online 11 October 2006

> > > Clinical Research

> > >

> > > Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> > > 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

> > > 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany

> > >

> > > "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."

> > >

> > > Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ;>))

> > >

> > > - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

> > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> >

>

December 19, 2011

And you cannot dash or tolerate MCBS as I recall. Recall that long term cure is likely in under 50%. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

I can say with certainty that my post-surgical lack of anxiety wasn't due to euphoria from opiates - I stopped those and switched to ibuprofen as soon as they allowed me, I think within 72 hours after surgery. Opiates and I do not play well together at all!

In the interest of presenting all perspectives - a woman who used to post here but stopped still posts on her blog now and again about how she is doing post-surgery: http://hyperaldosteronism.blogspot.com. She seems to be struggling quite a bit with ongoing anxiety and other issues.

As for myself - it's been just over two months since the surgery and even though I've had some pain issues develop (for which I only blame myself and doing too much too soon), I'm still feeling much better than I have in years. Anxiety is almost nonexistent and along with that, so is insomnia - which had been an issue for me since childhood.

--msmith1928

Nulliparous female, 46, 5'3", 115 lbs, CT showed 1cm left adrenal nodule, AVS determined disease is unilateral, had left laparoscopic adrenalectomy on 10/13/2011. Low sodium, fructose- and grain-free diet due to hereditary fructose intolerance, lactose intolerance, gluten intolerance (probable celiac).

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; I plan to send to my psyco docs for their impression also.

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Original Article

>

> & gt; & gt; & gt; Neuropsychopharmacology (2007) 32, 232ÃƒÂ¢Ã‚â‚¬"238. doi:10.1038/sj.npp.1301217; published online 11 October 2006

>

> & gt; & gt; & gt; Clinical Research

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

>

> & gt; & gt; & gt; 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

>

> & gt; & gt; & gt; 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ; & gt;))

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

>

> & gt; & gt; & gt; Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

>

> & gt; & gt; & gt; Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

>

> & gt; & gt; & gt;

>

> & gt; & gt;

>

> & gt; & gt;

>

> & gt;

>

December 19, 2011

, you ask a good question and that is one of the issues I'll be looking at

in the next couple months. I'll give you a knee-jerk reaction with the

understanding that it might change as I look into it in more detail. I also

have had HTN for at least 30 years so it is difficult to determine when PA

started but I know I had the tumor in 2005 and have great documentation from

then on.

HTN - Yes, may have started with essential HTN. Probably exacerbated by

incorrect taking of BP measurements!

LVH - Yes

COPD- Yes, previous long term smoking a major factor. PA kicked it " over the

threshold " .

Oxygen - Yes, caused by LVH

OSA - No but worsened by PA. (Settings went from 11/17 to 13/19 w/ft/oxygen.

Gynecomstia - Yes from treatment. Still question if testosterone was low to

start, especially w/previous long term testis pain.

Weight - I charge 40# to PA, 40# to joint problem (over active rt. Elbow), 40#

to lack of exercise and 40# to occupational hazards!

Okay, that's the easy part, let's look at depression:

PTSD - No, that is condition I have had for > 42 years. It came to the

forefront when I went to the VA for PA treatment, association issues. I had

always used the " avoidance method " to deal with it. (Not recommended by Psyco

Docs, probably because they don't make any money!) It worked for me and

probably would have never needed to be treated if PA had continued another year

- I would have been Dead! PA and the VA did cause me to seek treatment and the

jury is still out!

MDD (Clinical Depression) - Yes. Many meds, frustrated and doubting doctors.

Emotional issues, there were times I just broke down, was on a suicide watch,

you probably know the drill. Medications may have done some good, I didn't kill

anybody, but wonder how much. May have more info after I get off the last one,

Cymbalta, but it will be difficult to tell with the time lapse. My recent

postings regarding Spironolactone's effect on Cortisol makes me wonder how much

that contributed. I didn't even know how to spell it couple days ago, when I

looked it up I found this: (God, I don't see anything there I need!)

Higher and more prolonged levels of cortisol in the bloodstream (like those

associated with chronic stress) have been shown to have negative effects, such

as:

Impaired cognitive performance

Suppressed thyroid function

Blood sugar imbalances such as hyperglycemia

Decreased bone density

Decrease in muscle tissue

Higher blood pressure

Lowered immunity and inflammatory responses in the body, slowed wound healing,

and other health consequences

Increased abdominal fat, which is associated with a greater amount of health

problems than fat deposited in other areas of the body. Some of the health

problems associated with increased stomach fat are heart attacks, strokes, the

development of metabolic syndrome, higher levels of " bad " cholesterol (LDL) and

lower levels of " good " cholesterol (HDL), which can lead to other health

problems!

You didn't ask but I tell you anyway. I have call in to the head of

Endocrology to investigate my future direction. We will be discussing whether

now is the time to wash out Spironolactone and head toward an AVS. I am

convinced MCBs are not as benign as I was led to believe and don't want to spend

another year confirming that!

Questions/comments? Bring them on!

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg aspirin,

Metformin 2000MG and Spironolactone 50 MG.

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; We have had some discussions regarding doctors treating us for

psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting to

some.

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; I plan to send to my psyco docs for their impression also.

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Source:

http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Original Article

>

> & gt; & gt; & gt; Neuropsychopharmacology (2007) 32, 232Ã¢Â€ " 238.

doi:10.1038/sj.npp.1301217; published online 11 October 2006

>

> & gt; & gt; & gt; Clinical Research

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Blockade of the Mineralocorticoid Receptor in Healthy Men:

Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Christian Otte1, Steffen Moritz1, Yassouridis2, Maike

Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

>

> & gt; & gt; & gt; 1Department of Psychiatry and Psychotherapy, University

Hospital Hamburg-Eppendorf, Hamburg, Germany

>

> & gt; & gt; & gt; 2Department of Biostatistics, Max Planck Institute of

Psychiatry, Munich, Germany

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; " In summary, we found that blockade of MR with spironolactone

in healthy men impairs several aspects of cognition, particularly selective

attention, visuospatial memory, and set shifting/mental flexibility but did not

affect symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; Wonder if they only tested men because they felt women were too

psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ; & gt;))

>

> & gt; & gt; & gt;

>

> & gt; & gt; & gt; - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with

previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week

ave): 131/76 HR 60

>

> & gt; & gt; & gt; Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2,

and PTSD.

>

> & gt; & gt; & gt; Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg

asprin, Metformin 2000MG and Spironolactone 50 MG.

>

> & gt; & gt; & gt;

>

> & gt; & gt;

>

> & gt; & gt;

>

> & gt;

>

December 19, 2011

What is the " long term cure " with MCBs and DASH?

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; We have had some discussions regarding doctors treating us

for psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting to

some.

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; I plan to send to my psyco docs for their impression also.

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Source:

http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Original Article

> > >

> > > & gt; & gt; & gt; Neuropsychopharmacology (2007) 32, 232ÃƒÂ¢Ã‚â‚¬ " 238.

doi:10.1038/sj.npp.1301217; published online 11 October 2006

> > >

> > > & gt; & gt; & gt; Clinical Research

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Blockade of the Mineralocorticoid Receptor in Healthy Men:

Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Christian Otte1, Steffen Moritz1, Yassouridis2,

Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> > >

> > > & gt; & gt; & gt; 1Department of Psychiatry and Psychotherapy, University

Hospital Hamburg-Eppendorf, Hamburg, Germany

> > >

> > > & gt; & gt; & gt; 2Department of Biostatistics, Max Planck Institute of

Psychiatry, Munich, Germany

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; " In summary, we found that blockade of MR with

spironolactone in healthy men impairs several aspects of cognition, particularly

selective attention, visuospatial memory, and set shifting/mental flexibility

but did not affect symptoms of panic, anxiety and arousal after a challenge with

CCK-4. "

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Wonder if they only tested men because they felt women were

too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy!

; & gt;))

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with

previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week

ave): 131/76 HR 60

> > >

> > > & gt; & gt; & gt; Other Issues/Opportunities: OSA w Bi-Pap settings 13/19,

DM2, and PTSD.

> > >

> > > & gt; & gt; & gt; Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG,

81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt;

> > >

> > > & gt; & gt;

> > >

> > > & gt;

> > >

> >

>

December 19, 2011

Long term control with MCBs and DASH is a better word. I would say at least 75% do well. But really no good study yet properly comparing surgery vs medical management. But suspect as we accumulate more long term followup after surgery a cure is going to be found to be less and less common. The sheer number and cost is going to lead to a proper study I would hope. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

What is the "long term cure" with MCBs and DASH?

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; We have had some discussions regarding doctors treating us for psychological problems or at least considering it an issue for us. I was preparing for an Endocrinology discussion tomorrow, no med change in another week. I did a search on "spironolactone and pituitary" (for my month+ long headache) and came across this article/study. Thought it might be interesting to some.

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; I plan to send to my psyco docs for their impression also.

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Source: http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Original Article

> > >

> > > & gt; & gt; & gt; Neuropsychopharmacology (2007) 32, 232ÃƒÆ’Ã‚Â¢Ãƒâ€šÃ¢â€šÂ¬"238. doi:10.1038/sj.npp.1301217; published online 11 October 2006

> > >

> > > & gt; & gt; & gt; Clinical Research

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Blockade of the Mineralocorticoid Receptor in Healthy Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Christian Otte1, Steffen Moritz1, Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> > >

> > > & gt; & gt; & gt; 1Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf, Hamburg, Germany

> > >

> > > & gt; & gt; & gt; 2Department of Biostatistics, Max Planck Institute of Psychiatry, Munich, Germany

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; "In summary, we found that blockade of MR with spironolactone in healthy men impairs several aspects of cognition, particularly selective attention, visuospatial memory, and set shifting/mental flexibility but did not affect symptoms of panic, anxiety and arousal after a challenge with CCK-4."

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; Wonder if they only tested men because they felt women were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy! ; & gt;))

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt; & gt; - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

> > >

> > > & gt; & gt; & gt; Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

> > >

> > > & gt; & gt; & gt; Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > >

> > > & gt; & gt; & gt;

> > >

> > > & gt; & gt;

> > >

> > > & gt; & gt;

> > >

> > > & gt;

> > >

> >

>

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December 19, 2011

Since your requirement for a " cure " with surgery is no meds shouldn't that

parameter also hold true with MCB's? How many people that choose MCBs and DASH

end up only DASHing? And the time frame?

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; We have had some discussions regarding doctors treating

us for psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting to

some.

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; I plan to send to my psyco docs for their impression

also.

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; Source:

http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; Original Article

> > > > >

> > > > > & gt; & gt; & gt; Neuropsychopharmacology (2007) 32,

232ÃƒÆ'Ã‚Â¢Ãƒâ€šÃ¢â€šÂ¬ " 238. doi:10.1038/sj.npp.1301217; published online 11

October 2006

> > > > >

> > > > > & gt; & gt; & gt; Clinical Research

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; Blockade of the Mineralocorticoid Receptor in Healthy

Men: Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and

Cognition

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; Christian Otte1, Steffen Moritz1,

Yassouridis2, Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and

Kellner1

> > > > >

> > > > > & gt; & gt; & gt; 1Department of Psychiatry and Psychotherapy, University

Hospital Hamburg-Eppendorf, Hamburg, Germany

> > > > >

> > > > > & gt; & gt; & gt; 2Department of Biostatistics, Max Planck Institute of

Psychiatry, Munich, Germany

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; " In summary, we found that blockade of MR with

spironolactone in healthy men impairs several aspects of cognition, particularly

selective attention, visuospatial memory, and set shifting/mental flexibility

but did not affect symptoms of panic, anxiety and arousal after a challenge with

CCK-4. "

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; Wonder if they only tested men because they felt women

were too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy!

; & gt;))

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt; & gt; - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma

with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last

week ave): 131/76 HR 60

> > > > >

> > > > > & gt; & gt; & gt; Other Issues/Opportunities: OSA w Bi-Pap settings

13/19, DM2, and PTSD.

> > > > >

> > > > > & gt; & gt; & gt; Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG,

81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> > > > >

> > > > > & gt; & gt; & gt;

> > > > >

> > > > > & gt; & gt;

> > > > >

> > > > > & gt; & gt;

> > > > >

> > > > > & gt;

> > > > >

> > > >

> > >

> >

> > Reply to sender | Reply to group | Reply via web post | Start a New Topic

> > Messages in this topic (23)

> > RECENT ACTIVITY: New Members 7

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the Yahoo! Toolbar now.

> >

>

December 21, 2011

, I realized this morning as I was installing my teeth that I missed a

couple:

T2DM - This is under discussion and I may never know. In talking w/Dr. Grim it

could very well have exaserbated the problem. Agent Orange is also an issue. I

was labeled pre-diabetic after starting with the VA and got the full DX a couple

years later.

Oral Health - Dry Mouth and side effects of all the unnecesary meds caused my

mouth to get so bad that I had to have all my teeth extracted last June. My

dentist had never seen such a bad case, I always had a bottle of water and

tongue often looked like piece of dry leather! I used the Biotene products and

chewed alot of Trident gum (anything with xylitol which she contends fights

dental disease.)

, I'm looking for your reaction. Even if you disgree, you can't hurt my

feelings! Thanks....

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; We have had some discussions regarding doctors treating us

for psychological problems or at least considering it an issue for us. I was

preparing for an Endocrinology discussion tomorrow, no med change in another

week. I did a search on " spironolactone and pituitary " (for my month+ long

headache) and came across this article/study. Thought it might be interesting to

some.

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; I plan to send to my psyco docs for their impression also.

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; Source:

http://www.nature.com/npp/journal/v32/n1/abs/1301217a.html

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; Original Article

> >

> > & gt; & gt; & gt; Neuropsychopharmacology (2007) 32, 232Ã¢Â€ " 238.

doi:10.1038/sj.npp.1301217; published online 11 October 2006

> >

> > & gt; & gt; & gt; Clinical Research

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; Blockade of the Mineralocorticoid Receptor in Healthy Men:

Effects on Experimentally Induced Panic Symptoms, Stress Hormones, and Cognition

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; Christian Otte1, Steffen Moritz1, Yassouridis2,

Maike Koop1, Ana Madrischewski1, Klaus Wiedemann1 and Kellner1

> >

> > & gt; & gt; & gt; 1Department of Psychiatry and Psychotherapy, University

Hospital Hamburg-Eppendorf, Hamburg, Germany

> >

> > & gt; & gt; & gt; 2Department of Biostatistics, Max Planck Institute of

Psychiatry, Munich, Germany

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; " In summary, we found that blockade of MR with spironolactone

in healthy men impairs several aspects of cognition, particularly selective

attention, visuospatial memory, and set shifting/mental flexibility but did not

affect symptoms of panic, anxiety and arousal after a challenge with CCK-4. "

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; Wonder if they only tested men because they felt women were

too psyco normaly!!!! (Just kidding ladies but send your hate mail anywy!

; & gt;))

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt; & gt; - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with

previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week

ave): 131/76 HR 60

> >

> > & gt; & gt; & gt; Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2,

and PTSD.

> >

> > & gt; & gt; & gt; Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg

asprin, Metformin 2000MG and Spironolactone 50 MG.

> >

> > & gt; & gt; & gt;

> >

> > & gt; & gt;

> >

> > & gt; & gt;

> >

> > & gt;

> >

>

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Re: Spironlactone - Are you Crazy?

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