Re: Ursula and

February 2, 2001

Ursula,

If I recall correctly, the way it was explained to me is that Cd19 is term

for a mature B-cell component of your immune system. Dr. Hans Ochs is the

man that termed and named it Cd5-Cd19 PID. The Cd5 is for the high

expression of Cd5+ Bcells and the Cd19 is for the lack of mature Bcells

all 3 boys had less then 2% Cd19, mature functioning bcells).

, to answer your question the Cd5+ involves the humoral part of the

immune system. On another note, and I failed to mention this in my long

previous email....Cd5+ bcells are responsible for making autoantibodies

against the body. All three of the boys in the US with the Cd5-Cd19 PID

have developed autoantibodies that have shown up in various degrees. Mark

has autoimmune LCV, IBD, and autoimmune thyroid disease. Each of the other

two also have autoimmune diseases that have developed.

Autumn (Mom to Mark Cd5-Cd19 PID and )

RE: Autumn

> Autumn - what is the CD19 part of it? what influence does a CD19 amount

> have on the diagnosis? I'm curious what these cells do because when Macey

> was diagnosed in 97 they ran a CD19 count (along with several others) and

it

> was high.

>

> Ursula Holleman uahollem@...

> and Macey's mom (5 yr. old with CVID, asthma, sinus disease, GERD,

> kidney reflux, Sensory Integration Disorder, Diabetes Insipidus)

>

>

>

> This forum is open to parents and caregivers of children diagnosed with a

Primary Immune Deficiency. Opinions or medical advice stated here are the

sole responsibility of the poster and should not be taken as professional

advice.

>

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