Re: Spironolactone Side Effects, Is It Right For You?

[Guest guest]

You are missing my point. To the best of my knowledge every person who you have

recommended " Spiro and DASH " to are NOT knowingly seeking a sex change so a

Transgender Specialist is not appropriate! I say it needs to be looked at by

every speciality using it and the proper proactive testing established. (I used

the transgender site because they had the most complete " cause and effect " I

have seen.) It's important that we know what side effects to watch and when to

call a halt to the lab test (Us).

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> > > > > > But all anti-androgens are far from a panacea. One should

> > realize that the bulk of these preparations used in transgender

> > medicine are comprised of drugs that produce an anti-androgenic

> > effect incidental to their designed purpose. The anti-androgens that

> > some transgender patients are taking, are being taken by many others

> > for a variety of very different medical conditions that include anti-

> > hypertensive treatment (reducing high blood pressure), treating

> > prostactic cancer, prostatic enlargement, and fungal conditions,

> > amongst others. And as common sense would dictate, these drugs with

> > their wide scope of uses may also produce a wide variety of

> > potentially serious side effects. For example, a particular drug

> > when used in treating cancer may work within acceptable limits of

> > overall risk, even though it produces a certain stain on the liver.

> > But when the same drug is used to add a mild anti-androgenic (de-

> > masculinizing) effect to an otherwise healthy individual, are the

> > mild feminizing effects of this mediation worth the potentially

> > serious health risks associated with its use? This is the question

> > the transgender patient should consider, and naturally, the

> > physician entrusted with the care of that individual is also

> > considering.

> > > > > >

> > > > > > Looks like at the minimum we should decide if we want to go

> > the transgender route. I know at one point it was asked if

> > spironolactone was used for sex changes and the answer was " Not that

> > I am aware of " if memory serves me right. I can now say it is the

> > medicine of choice dosed at 100 to 200 mg along with a supplemental

> > estrogen medicine according to atleast one support site!

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[Guest guest]

I know, I know but how does that tell us if eplere works as well as spiro? Also

if you keep the " easy to treat " cases on Spiro aren't you biasing the result? I

say reverse it and switch to spiro if eplere and documented DASH doesn't work!

How many PTNs need to switch after say 4 or more years?

I'm also wondering how many that are affected by lack of testosterone develop

CHF and is it identified as such or is it just charged off as previous HTN.

Might be an interesting project! How about a random study treating half w/spiro

and the other half w/elpere?

- 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank

pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin

2000MG and Spironolactone 50 MG.

> > > > > > > >

> > > > > > > > > I'm quite convinced that Inspra (prior spiro) is binding

> > > > my progesterone reception. Progesterone is simply not working for me

> > > > like it's supposed to.

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> > > > > > > > > Val

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> > > > > > > > > From: hyperaldosteronism

[mailto:hyperaldosteronism

> > > > ] On Behalf Of

> > > > > > > > >

> > > > > > > > >

> > > > > > > > > I believe we are in agreement that Spiro, as an

> > > > Antiandrogens, or androgen antagonists will bind to testosterone and

> > > > reduce the amount in one's system. Everything I've read says this

> > > > allows for more circulating estrogen which has no apparent effect on

> > > > most men, the operative word may be apparent! I feel we should be

> > > > looking to see what may be happening that may not be readily visible.

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