Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 I am referring to an old (1996) American PDR, and find a proprietary product called Nebcin, which is Tobramycin Sulfate Injection, USP, an aminoglycoside, but nothing for " nebramine " . Medline and RxList also didn't give any results for " nebra* " . Sorry, Fran ~~~~~~~~~~~~~~~~~~~ Fran Spielberg PhD Medical & Academic Translating and Editing Hebrew <=> English writing@... ~~~~~~~~~~~~~~~~~~~ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 Hi Rod: I see you are still struggling with this term - I do remember your earlier request in December :-) ------- Dear List Members, You have always been so helpful to me before so I would like to pose another question. I have just started a translation that discusses a product called (in Spanish) " tobramicina " (tobramycin) and its degradation by-product " nebramina " . The only references I can find are to nebramycin (nebramicina?) but not nebramine(?). It does not seem to be a typo as it is repeated at least 12 times in the same document. Any ideas to enlighten me? -------- I think the reason why it is so hard to find " nebramin(e) " anywhere is because it is a degradation product. I couldn't find the term in any of my reference materials (all paper, no URLs, as I am hopelessly old-fashioned...). Perhaps a biochemist, pharmacologist, toxicologist might be able to help --- are there any on this list??? The following information could help getting on the right tract: Dorland's (29th ed.): nebramycin - an aminoglycoside antibacterial complex produced by Streptomyces tenebrarius, consistimg of 8 components; factor 6 (tobramycine) is used clinically as an antibiotic and factor 2 (apramycin) is used as an antibiotic in veterinary medicine. Nebcin, Nebicina, Obracine, Tobra, Tobracin are all brand names for tobramycin sulfate. Unfortunately, the pharmacology section in my old Canadian Compendium of Pharmaceuticals does not name the degradation products. Did you try a search for " tobramycine (or nebramycine) + degredation " ? HTH, Ursula _________________________________________ Ursula Vielkind, Ph.D. German/English Translation in Biological Sciences Dundas, Ontario L9H 3L8, Canada Tel: +1 Fax: +1 e-mail: uvielk@... http://hpcaonline.com/urvi.html ________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 Hi Rod: I see you are still struggling with this term - I do remember your earlier request in December :-) ------- Dear List Members, You have always been so helpful to me before so I would like to pose another question. I have just started a translation that discusses a product called (in Spanish) " tobramicina " (tobramycin) and its degradation by-product " nebramina " . The only references I can find are to nebramycin (nebramicina?) but not nebramine(?). It does not seem to be a typo as it is repeated at least 12 times in the same document. Any ideas to enlighten me? -------- I think the reason why it is so hard to find " nebramin(e) " anywhere is because it is a degradation product. I couldn't find the term in any of my reference materials (all paper, no URLs, as I am hopelessly old-fashioned...). Perhaps a biochemist, pharmacologist, toxicologist might be able to help --- are there any on this list??? The following information could help getting on the right tract: Dorland's (29th ed.): nebramycin - an aminoglycoside antibacterial complex produced by Streptomyces tenebrarius, consistimg of 8 components; factor 6 (tobramycine) is used clinically as an antibiotic and factor 2 (apramycin) is used as an antibiotic in veterinary medicine. Nebcin, Nebicina, Obracine, Tobra, Tobracin are all brand names for tobramycin sulfate. Unfortunately, the pharmacology section in my old Canadian Compendium of Pharmaceuticals does not name the degradation products. Did you try a search for " tobramycine (or nebramycine) + degredation " ? HTH, Ursula _________________________________________ Ursula Vielkind, Ph.D. German/English Translation in Biological Sciences Dundas, Ontario L9H 3L8, Canada Tel: +1 Fax: +1 e-mail: uvielk@... http://hpcaonline.com/urvi.html ________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 Dear Rod Nebcin is sulfato de tobramicina according to guía profesional de medicamentos, and according to the sigma catalog it is CAS Reg No 79645-27-5; C18H37N5O9 Also according to Sigma and Fluka catalogs Apramycin sulfate = Nebramycin II; CAS Reg No 65710-07-8 C21H41N5O11 Perzynsky, S. et al Eur J. Biochem 99, 623 (1979) Now, they are bot aminoglycosides so it is not unthinkable that one hydrolysis product is nebramine I am sending the formula for nebramycin II directly because it will not show on egroups Gerardo Ferrer Sueta M. Sc. Chemistry Scientific and Technical Translator -----Mensaje original----- De: Rod & Gemma Enviado el: domingo 7 de enero de 2001 8:47 Para: medical_translationegroups Asunto: Does nebramine exist? Dear List Members, You have always been so helpful to me before so I would like to pose another question. I have just started a translation that discusses a product called (in Spanish) " tobramicina " (tobramycin) and its degradation by-product " nebramina " . The only references I can find are to nebramycin (nebramicina?) but not nebramine(?). It does not seem to be a typo as it is repeated at least 12 times in the same document. Any ideas to enlighten me? Rod Bowman URL: www./group/medical_translation To unsubscribe, please send an *empty* message to medical_translation-UNSUBSCRIBEegroups Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 Dear Rod Nebcin is sulfato de tobramicina according to guía profesional de medicamentos, and according to the sigma catalog it is CAS Reg No 79645-27-5; C18H37N5O9 Also according to Sigma and Fluka catalogs Apramycin sulfate = Nebramycin II; CAS Reg No 65710-07-8 C21H41N5O11 Perzynsky, S. et al Eur J. Biochem 99, 623 (1979) Now, they are bot aminoglycosides so it is not unthinkable that one hydrolysis product is nebramine I am sending the formula for nebramycin II directly because it will not show on egroups Gerardo Ferrer Sueta M. Sc. Chemistry Scientific and Technical Translator -----Mensaje original----- De: Rod & Gemma Enviado el: domingo 7 de enero de 2001 8:47 Para: medical_translationegroups Asunto: Does nebramine exist? Dear List Members, You have always been so helpful to me before so I would like to pose another question. I have just started a translation that discusses a product called (in Spanish) " tobramicina " (tobramycin) and its degradation by-product " nebramina " . The only references I can find are to nebramycin (nebramicina?) but not nebramine(?). It does not seem to be a typo as it is repeated at least 12 times in the same document. Any ideas to enlighten me? Rod Bowman URL: www./group/medical_translation To unsubscribe, please send an *empty* message to medical_translation-UNSUBSCRIBEegroups Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 Subject: RE: Does nebramine exist? Dear Rod, yes, it exists, Gerardo is quite right, and here's what I found out so far: [u.S. Pat. 4,032,404] Nebramycin complex is a known complex of eight different aminoglycoside antibiotic components (nebramycin factors I, I', II, III, IV, V', VI and VII) which has been prepared by fermentation of Streptomyces tenebrarius (American Type Culture Collection-- A.T.C.C. 17920 and 17921). The complex and its preparation using the above organism is described in Antimicrob. Agents and Chemother., 1967, pg. 314-348 and in U.S. Pat. No. 3,691,279 (see also U.S. Pat. No. 3,853,709 disclosing preparation of nebramycin factors II and VII by fermentation of Streptomyces tenebrarius NRRL 3816, a mutant strain of Streptomyces tenebrarius A.T.C.C. 17920. Nebramycin factor VI, now named tobramycin, is reported in Antimicrob. Agents and Chemother., 1970, pg. 309-313 to have the structure ##STR1## Tobramycin is a commercially available antibiotic which possesses a broad spectrum of antimicrobial activity, including activity against Pseudomonas and Proteus microorganisms. K. F. Koch, et al. in J. Antibiotics, 1973, pg. 745-751 state that tobramycin is not produced directly by fermentation of Streptomyces tenebrarius but arises from the acid or base catalyzed hydrolysis of nebramycin factor V' (6 " -O-carbamoyltobramycin). Nebramycin factor II, now named apramycin, is reported in Annual Reports in Medicinal Chemistry, Vol. 9, 1974, pg. 99 to have the structure ##STR2## Apramycin is described as being useful as an antimicrobial agent in treating various plant and animal diseases (see U.S. Pat. Nos. 3,691,279, 3,853,709 and 3,876,767). Nebramine (also called 3'-deoxyneamine or 3'-deoxyneomycin-A) is an aminoglycoside antibiotic which has been prepared by hydrolysis of tobramycin (Antimicrob. Agents and Chemother., 1970, pg. 309-313). The physical and biological properties of nebramine are disclosed in Belgian Patent 808,393 and in J. Amer. Chem. Soc., Vol. 96, 1974, pg. 3,300-3,305. Neamine, an aminoglycoside antibiotic degradation product of neomycin, is disclosed in J. Amer. Chem. Soc., Vol. 73, 1951, pg. 2794-2797. Nebramycin factors IV and V' have been identified as 6 " -O-carbamoylkanamycin B and 6 " -O-carbamoyltobramycin, respectively. J. Antibiotics, Vol. 26, 1973, pg. 745-751. Wondrous things are to be found in patents... HTH, Cheers, F De: Rod & Gemma Enviado el: domingo 7 de enero de 2001 8:47 Para: medical_translationegroups Asunto: Does nebramine exist? Dear List Members, You have always been so helpful to me before so I would like to pose another question. I have just started a translation that discusses a product called (in Spanish) " tobramicina " (tobramycin) and its degradation by-product " nebramina " . The only references I can find are to nebramycin (nebramicina?) but not nebramine(?). It does not seem to be a typo as it is repeated at least 12 times in the same document. Any ideas to enlighten me? Rod Bowman URL: www./group/medical_translation To unsubscribe, please send an *empty* message to medical_translation-UNSUBSCRIBEegroups Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 Subject: RE: Does nebramine exist? Dear Rod, yes, it exists, Gerardo is quite right, and here's what I found out so far: [u.S. Pat. 4,032,404] Nebramycin complex is a known complex of eight different aminoglycoside antibiotic components (nebramycin factors I, I', II, III, IV, V', VI and VII) which has been prepared by fermentation of Streptomyces tenebrarius (American Type Culture Collection-- A.T.C.C. 17920 and 17921). The complex and its preparation using the above organism is described in Antimicrob. Agents and Chemother., 1967, pg. 314-348 and in U.S. Pat. No. 3,691,279 (see also U.S. Pat. No. 3,853,709 disclosing preparation of nebramycin factors II and VII by fermentation of Streptomyces tenebrarius NRRL 3816, a mutant strain of Streptomyces tenebrarius A.T.C.C. 17920. Nebramycin factor VI, now named tobramycin, is reported in Antimicrob. Agents and Chemother., 1970, pg. 309-313 to have the structure ##STR1## Tobramycin is a commercially available antibiotic which possesses a broad spectrum of antimicrobial activity, including activity against Pseudomonas and Proteus microorganisms. K. F. Koch, et al. in J. Antibiotics, 1973, pg. 745-751 state that tobramycin is not produced directly by fermentation of Streptomyces tenebrarius but arises from the acid or base catalyzed hydrolysis of nebramycin factor V' (6 " -O-carbamoyltobramycin). Nebramycin factor II, now named apramycin, is reported in Annual Reports in Medicinal Chemistry, Vol. 9, 1974, pg. 99 to have the structure ##STR2## Apramycin is described as being useful as an antimicrobial agent in treating various plant and animal diseases (see U.S. Pat. Nos. 3,691,279, 3,853,709 and 3,876,767). Nebramine (also called 3'-deoxyneamine or 3'-deoxyneomycin-A) is an aminoglycoside antibiotic which has been prepared by hydrolysis of tobramycin (Antimicrob. Agents and Chemother., 1970, pg. 309-313). The physical and biological properties of nebramine are disclosed in Belgian Patent 808,393 and in J. Amer. Chem. Soc., Vol. 96, 1974, pg. 3,300-3,305. Neamine, an aminoglycoside antibiotic degradation product of neomycin, is disclosed in J. Amer. Chem. Soc., Vol. 73, 1951, pg. 2794-2797. Nebramycin factors IV and V' have been identified as 6 " -O-carbamoylkanamycin B and 6 " -O-carbamoyltobramycin, respectively. J. Antibiotics, Vol. 26, 1973, pg. 745-751. Wondrous things are to be found in patents... HTH, Cheers, F De: Rod & Gemma Enviado el: domingo 7 de enero de 2001 8:47 Para: medical_translationegroups Asunto: Does nebramine exist? Dear List Members, You have always been so helpful to me before so I would like to pose another question. I have just started a translation that discusses a product called (in Spanish) " tobramicina " (tobramycin) and its degradation by-product " nebramina " . The only references I can find are to nebramycin (nebramicina?) but not nebramine(?). It does not seem to be a typo as it is repeated at least 12 times in the same document. Any ideas to enlighten me? Rod Bowman URL: www./group/medical_translation To unsubscribe, please send an *empty* message to medical_translation-UNSUBSCRIBEegroups Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 1,000,000 thanks to all of you who replied regarding nebramin. Rod Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2001 Report Share Posted January 7, 2001 1,000,000 thanks to all of you who replied regarding nebramin. Rod Quote Link to comment Share on other sites More sharing options...
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