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They do not have the action of Aldo correct. It should say in the presence of excess salt in the diet aldosterone increases the synthesis of ENaC channels on the luminal side of the distal renal tubular cells. These channels enable Na to diffuse into the cell. To maintain electrical neutrality in the urine as Na+ moves into the cell K+ and H+ move into the urine resulting in K loss from the body. When this exceeds intake hypokalemia results. As H+ is lost inthe urine the body H+ goes down. Aka causing alkalosis. Both low K and H result in changes in nerve and muscle irritability increases. Numbness and tingling and muscle cramps ensue. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

This looks like good information on what happnes when our PH changes.

http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

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Nerve and muscle irritability (or another way to put it is kinetic activity)

sounds very much like anxiety like SX. At least for me my feeling is to have a

true anxiety attack you also have to feel it in your mind. I have the kinetic

activity but don't feel sx in my mind.

>

> > This looks like good information on what happnes when our PH changes.

> >

> >

http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Redu\

ction_in_ECV.html

> >

> >

>

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Share on other sites

Would this also explain all the muscle twitching and stiffness, even if ones doesnt get cramps, numbness,etc? I still am thinking it has something to do with Ionized Calcium. It was always below normal range for me when I was twitching all over the place. Now it is just random, but i am still very low normal for Ionized Ca. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects:

Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Saturday, October 8, 2011 7:49 AMSubject: Re: PH Problems

Nerve and muscle irritability (or another way to put it is kinetic activity) sounds very much like anxiety like SX. At least for me my feeling is to have a true anxiety attack you also have to feel it in your mind. I have the kinetic activity but don't feel sx in my mind.

>

> > This looks like good information on what happnes when our PH changes.

> >

> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> >

> >

>

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I would think anxiety in the setting of PA though is more physical based, but leading to the mental and emotional point of dysfunction. The body senses something somewhere and the brain/body systems like the sympathetic start reacting, likely before we know it in the form of the aches/spasms/twitches etc, but it manifests as an anxiousness - and people sense anxiety different from person to person, plus our bodies react differently too. If it's brain first, then thats possibly a psych disorder (though even that can be pretty objective too) but really it's all related. I say it again and again that PA, and the low K (among other electrolytes), has long fingers and doesn't skip too many body systems.

Subject: Re: Re: PH ProblemsTo: "hyperaldosteronism " <hyperaldosteronism >Date: Saturday, October 8, 2011, 11:39 AM

Would this also explain all the muscle twitching and stiffness, even if ones doesnt get cramps, numbness,etc? I still am thinking it has something to do with Ionized Calcium. It was always below normal range for me when I was twitching all over the place. Now it is just random, but i am still very low normal for Ionized Ca.

============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank Pain

DASH: Started "sort of" DASHing 5/3/2011

Status: Last Urine K/Na ratio was 1.1. But total of Na high also

To: hyperaldosteronism Sent: Saturday, October 8, 2011 7:49 AMSubject: Re: PH Problems

Nerve and muscle irritability (or another way to put it is kinetic activity) sounds very much like anxiety like SX. At least for me my feeling is to have a true anxiety attack you also have to feel it in your mind. I have the kinetic activity but don't feel sx in my mind.> > > This looks like good information on what happnes when our PH changes.> > > > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html> > > >>

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Hyperventilation affects blood pH wHich affects ionized calcium. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

Would this also explain all the muscle twitching and stiffness, even if ones doesnt get cramps, numbness,etc? I still am thinking it has something to do with Ionized Calcium. It was always below normal range for me when I was twitching all over the place. Now it is just random, but i am still very low normal for Ionized Ca. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects:

Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Saturday, October 8, 2011 7:49 AMSubject: Re: PH Problems

Nerve and muscle irritability (or another way to put it is kinetic activity) sounds very much like anxiety like SX. At least for me my feeling is to have a true anxiety attack you also have to feel it in your mind. I have the kinetic activity but don't feel sx in my mind.

>

> > This looks like good information on what happnes when our PH changes.

> >

> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> >

> >

>

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What about breath holding?Thanks,AshleeSent via BlackBerry from T-MobileSender: hyperaldosteronism Date: Sat, 08 Oct 2011 13:06:06 -0500To: hyperaldosteronism <hyperaldosteronism >ReplyTo: hyperaldosteronism Subject: Re: Re: PH Problems Hyperventilation affects blood pH wHich affects ionized calcium. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension Would this also explain all the muscle twitching and stiffness, even if ones doesnt get cramps, numbness,etc? I still am thinking it has something to do with Ionized Calcium. It was always below normal range for me when I was twitching all over the place. Now it is just random, but i am still very low normal for Ionized Ca. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects:Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Saturday, October 8, 2011 7:49 AMSubject: Re: PH Problems Nerve and muscle irritability (or another way to put it is kinetic activity) sounds very much like anxiety like SX. At least for me my feeling is to have a true anxiety attack you also have to feel it in your mind. I have the kinetic activity but don't feel sx in my mind.> > > This looks like good information on what happnes when our PH changes.> > > > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html> > > >>

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All disorders are biochemical. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

I would think anxiety in the setting of PA though is more physical based, but leading to the mental and emotional point of dysfunction. The body senses something somewhere and the brain/body systems like the sympathetic start reacting, likely before we know it in the form of the aches/spasms/twitches etc, but it manifests as an anxiousness - and people sense anxiety different from person to person, plus our bodies react differently too. If it's brain first, then thats possibly a psych disorder (though even that can be pretty objective too) but really it's all related. I say it again and again that PA, and the low K (among other electrolytes), has long fingers and doesn't skip too many body systems.

Subject: Re: Re: PH ProblemsTo: "hyperaldosteronism " <hyperaldosteronism >Date: Saturday, October 8, 2011, 11:39 AM

Would this also explain all the muscle twitching and stiffness, even if ones doesnt get cramps, numbness,etc? I still am thinking it has something to do with Ionized Calcium. It was always below normal range for me when I was twitching all over the place. Now it is just random, but i am still very low normal for Ionized Ca.

============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank Pain

DASH: Started "sort of" DASHing 5/3/2011

Status: Last Urine K/Na ratio was 1.1. But total of Na high also

To: hyperaldosteronism Sent: Saturday, October 8, 2011 7:49 AMSubject: Re: PH Problems

Nerve and muscle irritability (or another way to put it is kinetic activity) sounds very much like anxiety like SX. At least for me my feeling is to have a true anxiety attack you also have to feel it in your mind. I have the kinetic activity but don't feel sx in my mind.> > > This looks like good information on what happnes when our PH changes.> > > > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html> > > >>

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Reverses hyperventilation Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

What about breath holding?Thanks,AshleeSent via BlackBerry from T-Mobile

Sender: hyperaldosteronism

Date: Sat, 08 Oct 2011 13:06:06 -0500To: hyperaldosteronism <hyperaldosteronism >ReplyTo: hyperaldosteronism

Subject: Re: Re: PH Problems

Hyperventilation affects blood pH wHich affects ionized calcium. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

Would this also explain all the muscle twitching and stiffness, even if ones doesnt get cramps, numbness,etc? I still am thinking it has something to do with Ionized Calcium. It was always below normal range for me when I was twitching all over the place. Now it is just random, but i am still very low normal for Ionized Ca. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects:

Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Saturday, October 8, 2011 7:49 AMSubject: Re: PH Problems

Nerve and muscle irritability (or another way to put it is kinetic activity) sounds very much like anxiety like SX. At least for me my feeling is to have a true anxiety attack you also have to feel it in your mind. I have the kinetic activity but don't feel sx in my mind.

>

> > This looks like good information on what happnes when our PH changes.

> >

> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> >

> >

>

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I never hyperventilate. If anything, I breath too shallow most of the time. I am anxious and edgy most of the time, often with a sense of dread that I cant quite put my finger on. Just about anything annoys me more than it should. I use to be a very relaxed and layed back person...always getting comments about that and handling enourmous amounts of stress without a flinch. Not anymore. I explode almost irrationally at times, and am more pissed off at the world than I have ever been in my life. If that is from PA (although I am not really convinced it is), why isnt Inspra/dashing, and all the suppliments fixing it? I am within arms length of simply quitting my job most days. I darn near feel like i qualify for disability, and that is not like me to even think that way. Most days I just want to escape the world and hide

it the northwoods someplace. It is maddening. I have built a great career and have a sweet family. This damn disease is robbing me of alot and I wish i could fix it before it does permanent damage to my everyday life. Grrrrrrrr. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: "hyperaldosteronism " <hyperaldosteronism >Sent: Saturday, October 8, 2011 1:06 PMSubject: Re: Re: PH Problems

Hyperventilation affects blood pH wHich affects ionized calcium. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

Would this also explain all the muscle twitching and stiffness, even if ones doesnt get cramps, numbness,etc? I still am thinking it has something to do with Ionized Calcium. It was always below normal range for me when I was twitching all over the place. Now it is just random, but i am still very low normal for Ionized Ca. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects:

Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Saturday, October 8, 2011 7:49

AMSubject: Re: PH Problems

Nerve and muscle irritability (or another way to put it is kinetic activity) sounds very much like anxiety like SX. At least for me my feeling is to have a true anxiety attack you also have to feel it in your mind. I have the kinetic activity but don't feel sx in my mind.

>

> > This looks like good information on what happnes when our PH changes.

> >

> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> >

> >

>

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I have posted about this before. In the mental health field there are studies

that link hyperaldosteronism to mental health disorders. Even though your B/P

may be under control Aldo still may not be blockd enough in the brain. Can find

some informating on PUBMED.

> >>>>

> >>>> > This looks like good information on what happnes when our PH changes.

> >>>> >

> >>>> >

http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Redu\

ction_in_ECV.html

> >>>> >

> >>>> >

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>

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If you have adrenal hyperplasia as a cause of PA then you are surely going to be

spewing out too much of all adrenal hormones as well as aldo, ones that affect

mood like adrenaline, noradrenaline etc so while dashing might be enough to

bring your bp down you could maybe do with other treatments options as

well...even if your catecholamines is 'normal' on a 24hr urine test - might

still be elevated enough to affect your mood..

> > >>>>

> > >>>> > This looks like good information on what happnes when our PH changes.

> > >>>> >

> > >>>> >

http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Redu\

ction_in_ECV.html

> > >>>> >

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So, just becuase me BP is "normal range" doesnt mean Aldo isnt having an impact in other ways? I feel much more viril on Inspra, but also way more irritable. I have been able to focus on my work much better than when I was taking Spiro, but it is almost like I am experincing a bit of "roid rage". Energy level is higher, less tired after mowing the lawn than even a few weeks ago. What a mess...How does one getit leveled out? I actually thought about taking spiro with inspra. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D

(weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Sunday, October 9, 2011 12:36 PMSubject: Re: PH Problems

If you have adrenal hyperplasia as a cause of PA then you are surely going to be spewing out too much of all adrenal hormones as well as aldo, ones that affect mood like adrenaline, noradrenaline etc so while dashing might be enough to bring your bp down you could maybe do with other treatments options as well...even if your catecholamines is 'normal' on a 24hr urine test - might still be elevated enough to affect your mood..

> > >>>>

> > >>>> > This looks like good information on what happnes when our PH changes.

> > >>>> >

> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> > >>>> >

> > >>>> >

> > >>>>

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> > >

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> > >

> >

>

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, the answer is simple - you don't have those female hormones flowing thru

your veins, you know " sugar and spice and everything nice! "

- 65 yo morb. ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank &

testicle pain. I have decided against an adrenalectomy at this time since

Meds. are working so well. Current BP(last week ave): 122/73

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2. and PTSD.

Meds: Duloxetine hcl 80 MG, Mirtazapine 7.5 MG, Metoprolol Tartrate 200 MG,

81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> >> > >>>>

> >> > >>>> > This looks like good information on what happnes when our PH

changes.

> >> > >>>> >

> >> > >>>> >

http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Redu\

ction_in_ECV.html

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On a more serious note, I think I have documented my case of BP under control

and other SX still out of control, in my case pain and peeing resolving 10 mos

later. I still have an exhaustion or lack of stamina and will be discussing

with PCP in a couple weeks.

You are also under corporate stress from the sound of things. I went through

much of that in 1997. I was one of the lucky ones who opted out when offered so

I missed the India invasion but they went through that too a couple years later.

Traded those stresors for driving a 45' tour bus through the likes of Boston,

New York and Montreal, never killed anybody but sure scared a few! (Of course

the last 6 years the biggest stresor has been to decide when to let the puppies

out, rainy days are best because they don't beg to go out!)

Keep working on that NA and you might find Inspra " has a second gear " like I did

with Spiro! Good Luck!

- 65 yo morb. ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank &

testicle pain. I have decided against an adrenalectomy at this time since

Meds. are working so well. Current BP(last week ave): 122/73

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2. and PTSD.

Meds: Duloxetine hcl 80 MG, Mirtazapine 7.5 MG, Metoprolol Tartrate 200 MG,

81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> >> > >>>>

> >> > >>>> > This looks like good information on what happnes when our PH

changes.

> >> > >>>> >

> >> > >>>> >

http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Redu\

ction_in_ECV.html

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LOL...but, if i were to be totally honest, I would say I preferred how i felt to a large degree when i was "kinder and gentler". ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank

PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Sunday, October 9, 2011 1:04 PMSubject: Re: PH Problems

, the answer is simple - you don't have those female hormones flowing thru your veins, you know "sugar and spice and everything nice!"

- 65 yo morb. ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank & testicle pain. I have decided against an adrenalectomy at this time since Meds. are working so well. Current BP(last week ave): 122/73

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2. and PTSD.

Meds: Duloxetine hcl 80 MG, Mirtazapine 7.5 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> >> > >>>>

> >> > >>>> > This looks like good information on what happnes when our PH changes.

> >> > >>>> >

> >> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> >> > >>>> >

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If you read our research on cats etc in PA you will note no detectable relationship of Cats to BP except in Pheo. Most PA ADENOMAS seem to produce only excess Aldo but rarely can also do cortisol Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

If you have adrenal hyperplasia as a cause of PA then you are surely going to be spewing out too much of all adrenal hormones as well as aldo, ones that affect mood like adrenaline, noradrenaline etc so while dashing might be enough to bring your bp down you could maybe do with other treatments options as well...even if your catecholamines is 'normal' on a 24hr urine test - might still be elevated enough to affect your mood..

> > >>>>

> > >>>> > This looks like good information on what happnes when our PH changes.

> > >>>> >

> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> > >>>> >

> > >>>> >

> > >>>>

> > >>>

> > >>>

> > >>>

> > >>>

> > >

> > >

> > >

> >

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Time for a urine check? IMHOTiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

So, just becuase me BP is "normal range" doesnt mean Aldo isnt having an impact in other ways? I feel much more viril on Inspra, but also way more irritable. I have been able to focus on my work much better than when I was taking Spiro, but it is almost like I am experincing a bit of "roid rage". Energy level is higher, less tired after mowing the lawn than even a few weeks ago. What a mess...How does one getit leveled out? I actually thought about taking spiro with inspra. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D

(weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Sunday, October 9, 2011 12:36 PMSubject: Re: PH Problems

If you have adrenal hyperplasia as a cause of PA then you are surely going to be spewing out too much of all adrenal hormones as well as aldo, ones that affect mood like adrenaline, noradrenaline etc so while dashing might be enough to bring your bp down you could maybe do with other treatments options as well...even if your catecholamines is 'normal' on a 24hr urine test - might still be elevated enough to affect your mood..

> > >>>>

> > >>>> > This looks like good information on what happnes when our PH changes.

> > >>>> >

> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> > >>>> >

> > >>>> >

> > >>>>

> > >>>

> > >>>

> > >>>

> > >>>

> > >

> > >

> > >

> >

>

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But what if you have Hyperplacia and no tumor? Can the whol adreanal be over reacting? What could cause that, stress? Is the change permanent at the cellular level, or can it be resolved wiht stress reduction? ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung

Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo:

"hyperaldosteronism " <hyperaldosteronism >Sent: Sunday, October 9, 2011 3:17 PMSubject: Re: Re: PH Problems

If you read our research on cats etc in PA you will note no detectable relationship of Cats to BP except in Pheo. Most PA ADENOMAS seem to produce only excess Aldo but rarely can also do cortisol Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

If you have adrenal hyperplasia as a cause of PA then you are surely going to be spewing out too much of all adrenal hormones as well as aldo, ones that affect mood like adrenaline, noradrenaline etc so while dashing might be enough to bring your bp down you could maybe do with other treatments options as well...even if your catecholamines is 'normal' on a 24hr urine test - might still be elevated enough to affect your mood..

> > >>>>

> > >>>> > This looks like good information on what happnes when our PH changes.

> > >>>> >

> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> > >>>> >

> > >>>> >

> > >>>>

> > >>>

> > >>>

> > >>>

> > >>>

> > >

> > >

> > >

> >

>

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Yup, it is about 6 weeks away form my next 24hr urine collection. That should give me the best picture of what is going on overall. I will move it up if I get feeling way out of whack. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules,

Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo:

"hyperaldosteronism " <hyperaldosteronism >Sent: Sunday, October 9, 2011 3:18 PMSubject: Re: Re: PH Problems

Time for a urine check? IMHOTiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

So, just becuase me BP is "normal range" doesnt mean Aldo isnt having an impact in other ways? I feel much more viril on Inspra, but also way more irritable. I have been able to focus on my work much better than when I was taking Spiro, but it is almost like I am experincing a bit of "roid rage". Energy level is higher, less tired after mowing the lawn than even a few weeks ago. What a mess...How does one getit leveled out? I actually thought about taking spiro with inspra. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg

Magnesium, 100,000UI Vit D

(weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Sunday, October 9, 2011 12:36 PMSubject: Re: PH Problems

If you have adrenal hyperplasia as a cause of PA then you are surely going to be spewing out too much of all adrenal hormones as well as aldo, ones that affect mood like adrenaline, noradrenaline etc so while dashing might be enough to bring your bp down you could maybe do with other treatments options as well...even if your catecholamines is 'normal' on a 24hr urine test - might still be elevated enough to affect your mood..

> > >>>>

> > >>>> > This looks like good information on what happnes when our PH changes.

> > >>>> >

> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> > >>>> >

> > >>>> >

> > >>>>

> > >>>

> > >>>

> > >>>

> > >>>

> > >

> > >

> > >

> >

>

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It is always at the cellular level. All disease is at cellular level-well except for bad luck. Microscopically hyperplasia looks like many small tumors through out both glands. Big tumors come from smaller tumors. In my experience if one looks carefully at the adrenal tissue in those with one large tumor you will see smaller tumors in the rest of the gland. Most pathologist ignore these as they are blNeed by the usually bright golden color or the biggest tumor. One can google adrenal hyperplasia and view images. I have a large collection of 35 mm slides of examples ESP in those with low renin and "normal" Aldo. Also in my papers with Longo D et al. BT Longo is a coeditor of the NEJM TODAY. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

But what if you have Hyperplacia and no tumor? Can the whol adreanal be over reacting? What could cause that, stress? Is the change permanent at the cellular level, or can it be resolved wiht stress reduction? ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung

Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo:

"hyperaldosteronism " <hyperaldosteronism >Sent: Sunday, October 9, 2011 3:17 PMSubject: Re: Re: PH Problems

If you read our research on cats etc in PA you will note no detectable relationship of Cats to BP except in Pheo. Most PA ADENOMAS seem to produce only excess Aldo but rarely can also do cortisol Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

If you have adrenal hyperplasia as a cause of PA then you are surely going to be spewing out too much of all adrenal hormones as well as aldo, ones that affect mood like adrenaline, noradrenaline etc so while dashing might be enough to bring your bp down you could maybe do with other treatments options as well...even if your catecholamines is 'normal' on a 24hr urine test - might still be elevated enough to affect your mood..

> > >>>>

> > >>>> > This looks like good information on what happnes when our PH changes.

> > >>>> >

> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> > >>>> >

> > >>>> >

> > >>>>

> > >>>

> > >>>

> > >>>

> > >>>

> > >

> > >

> > >

> >

>

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So...it is just a matter of time before one gets big enough to see on a CT? Mine have not in a 3 years span, so far. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank

PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: "hyperaldosteronism "

<hyperaldosteronism >Sent: Sunday, October 9, 2011 3:35 PMSubject: Re: Re: PH Problems

It is always at the cellular level. All disease is at cellular level-well except for bad luck. Microscopically hyperplasia looks like many small tumors through out both glands. Big tumors come from smaller tumors. In my experience if one looks carefully at the adrenal tissue in those with one large tumor you will see smaller tumors in the rest of the gland. Most pathologist ignore these as they are blNeed by the usually bright golden color or the biggest tumor. One can google adrenal hyperplasia and view images. I have a large collection of 35 mm slides of examples ESP in those with low renin and "normal" Aldo. Also in my papers with Longo D et al. BT Longo is a coeditor of the NEJM TODAY. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in

DifficultHypertension

But what if you have Hyperplacia and no tumor? Can the whol adreanal be over reacting? What could cause that, stress? Is the change permanent at the cellular level, or can it be resolved wiht stress reduction? ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head

and Pelvis. Benign Lung

Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo:

"hyperaldosteronism " <hyperaldosteronism >Sent: Sunday, October 9, 2011 3:17 PMSubject: Re: Re: PH Problems

If you read our research on cats etc in PA you will note no detectable relationship of Cats to BP except in Pheo. Most PA ADENOMAS seem to produce only excess Aldo but rarely can also do cortisol Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension

If you have adrenal hyperplasia as a cause of PA then you are surely going to be spewing out too much of all adrenal hormones as well as aldo, ones that affect mood like adrenaline, noradrenaline etc so while dashing might be enough to bring your bp down you could maybe do with other treatments options as well...even if your catecholamines is 'normal' on a 24hr urine test - might still be elevated enough to affect your mood..

> > >>>>

> > >>>> > This looks like good information on what happnes when our PH changes.

> > >>>> >

> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> > >>>> >

> > >>>> >

> > >>>>

> > >>>

> > >>>

> > >>>

> > >>>

> > >

> > >

> > >

> >

>

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, I believe you switched to Inspra not too long ago, Have they been

watching your K level. If 50mg of Inspra isn't quite enough you might be okay

in the BP department but low in the K department. When my PCP was adjusting my

meds she had me on 2-week cycle for blood test (I was on the high end of the

scale.) Just a thought.

- 65 yo morb. ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank &

testicle pain. I have decided against an adrenalectomy at this time since

Meds. are working so well. Current BP(last week ave): 122/73

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2. and PTSD.

Meds: Duloxetine hcl 80 MG, Mirtazapine 7.5 MG, Metoprolol Tartrate 200 MG,

81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> >>>> > >>>>

> >>>> > >>>> > This looks like good information on what happnes when our PH

changes.

> >>>> > >>>> >

> >>>> > >>>> >

http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Redu\

ction_in_ECV.html

> >>>> > >>>> >

> >>>> > >>>> >

> >>>> > >>>>

> >>>> > >>>

> >>>> > >>>

> >>>> > >>>

> >>>> > >>>

> >>>> > >

> >>>> > >

> >>>> > >

> >>>> >

> >>>>

> >>>

> >>>

> >>>

> >>>

> >>Reply to sender | Reply to group | Reply via web post | Start a New Topic

Messages in this topic (13)

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Yes. I had it tested 1 mo after starting it, it was 3.8(3.5-5.1 range). It was a bad draw, so i am not sure it was a good reading. I decided to experiment by adding back in 25mg of spiro this week and see how I feel. Adding more K has not really helped releive symptoms of low K. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism

caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoFrom:

To: hyperaldosteronism Sent: Sunday, October 9, 2011 6:34 PMSubject: Re: PH Problems

, I believe you switched to Inspra not too long ago, Have they been watching your K level. If 50mg of Inspra isn't quite enough you might be okay in the BP department but low in the K department. When my PCP was adjusting my meds she had me on 2-week cycle for blood test (I was on the high end of the scale.) Just a thought.

- 65 yo morb. ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank & testicle pain. I have decided against an adrenalectomy at this time since Meds. are working so well. Current BP(last week ave): 122/73

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2. and PTSD.

Meds: Duloxetine hcl 80 MG, Mirtazapine 7.5 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG.

> >>>> > >>>>

> >>>> > >>>> > This looks like good information on what happnes when our PH changes.

> >>>> > >>>> >

> >>>> > >>>> > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html

> >>>> > >>>> >

> >>>> > >>>> >

> >>>> > >>>>

> >>>> > >>>

> >>>> > >>>

> >>>> > >>>

> >>>> > >>>

> >>>> > >

> >>>> > >

> >>>> > >

> >>>> >

> >>>>

> >>>

> >>>

> >>>

> >>>

> >>Reply to sender | Reply to group | Reply via web post | Start a New Topic Messages in this topic (13)

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Re Hyperventilation. Can be either breathing too fast (but shallow) or too deep. Or both. So count how many times a minute you breath. Maybe each time you take your BP so we find out what is normal for you.CE Grim MD I never hyperventilate. If anything, I breath too shallow most of the time. I am anxious and edgy most of the time, often with a sense of dread that I cant quite put my finger on. Just about anything annoys me more than it should. I use to be a very relaxed and layed back person...always getting comments about that and handling enourmous amounts of stress without a flinch. Not anymore. I explode almost irrationally at times, and am more pissed off at the world than I have ever been in my life. If that is from PA (although I am not really convinced it is), why isnt Inspra/dashing, and all the suppliments fixing it? I am within arms length of simply quitting my job most days. I darn near feel like i qualify for disability, and that is not like me to even think that way. Most days I just want to escape the world and hide it the northwoods someplace. It is maddening. I have built a great career and have a sweet family. This damn disease is robbing me of alot and I wish i could fix it before it does permanent damage to my everyday life. Grrrrrrrr. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: "hyperaldosteronism " <hyperaldosteronism >Sent: Saturday, October 8, 2011 1:06 PMSubject: Re: Re: PH Problems Hyperventilation affects blood pH wHich affects ionized calcium. Tiped sad Send form miiPhone ;-)May your pressure be low!CE Grim MDSpecializing in DifficultHypertension Would this also explain all the muscle twitching and stiffness, even if ones doesnt get cramps, numbness,etc? I still am thinking it has something to do with Ionized Calcium. It was always below normal range for me when I was twitching all over the place. Now it is just random, but i am still very low normal for Ionized Ca. ============================================================================45-Male-Caucasian, 5'9"- 242lbs, PA Diagnosed 2007 Suspected Hyperplasia-No tumors on CT - No AVS.Meds: 50mg Inspra, 40meq Potassium, 1800mg Calcium, 1000mg Magnesium, 100,000UI Vit D (weekly), 20mg OmeprazoleSide effects: Gynecomastia, stomach inflammation (From Spiro)Other Diags: GERD, Hiatal Hernia, Metabolic Syndrome - PreDiabetic, Secondary Hyperparathyroidism caused by Renal calcium leak, Bone Cyct in left Femoral Head and Pelvis. Benign Lung Nodules, Fibromyalgia, Scarring on Right Kidney Lower Pole, Right Flank PainDASH: Started "sort of" DASHing 5/3/2011Status: Last Urine K/Na ratio was 1.1. But total of Na high alsoTo: hyperaldosteronism Sent: Saturday, October 8, 2011 7:49 AMSubject: Re: PH Problems Nerve and muscle irritability (or another way to put it is kinetic activity) sounds very much like anxiety like SX. At least for me my feeling is to have a true anxiety attack you also have to feel it in your mind. I have the kinetic activity but don't feel sx in my mind. > > > This looks like good information on what happnes when our PH changes. > > > > http://fitsweb.uchc.edu/student/selectives/TimurGraham/GI_Hydrogen_Loss_and_Reduction_in_ECV.html > > > > >

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