Re: Re: Links between Spironolactone and gastric problems

[Guest guest]

Maybe we need to put this in perspective. Taking one 81 mg low-dose Aspirin (baby Asprin) per day, like so many doctors now recommend, increases the risk of gastric ulcer 2% - 4%. Gastritis and hiatal hernia are quite common and gastritis can be cause by many factors.

To: hyperaldosteronism Sent: Thursday, November 3, 2011 2:22 PMSubject: Re: Links between Spironolactone and gastric problemsThanks for this article. Is this another good reason for an andrelectomy over long term medicines? Is this part of the med. control the same in Elperenone so the effect would be the same? - 65 yo

super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. >> I have had an endoscopy today which indicates some erosion of the first part of the duodenun, gastritis and a small hiatus hernia.> > I have done some research on possible links to taking spiro (now 150mg daily)which I have done since diagnosed with conn's in 2004. My conn's is stable and I am currently discharged from King's College Hospital (London) endo dept.

BP is fine (115/78 today at hospital). The stomach stuff has been going on since January.> > Found this online:> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539051/?tool=pmcentrez - main point: > > Conclusion The risk of gastroduodenal ulcers or upper gastrointestinal bleeding is significantly increased in patients using spironolactone.> > > Has anyone else experienced stomach problems from taking spiro long term?>------------------------------------

[Guest guest]

I have never recognized an ulcer directly related to spiro only. Have seen GI bleeds thought to be due to K tablets. BTW once BP is controlled I recommend all of my patients take the 81 mg a day of ASA.I was part of the original Dr Study (as a research subject) that demonstrated a reduction in CVD in the 1/2 of the Drs assigned to ASA. I was in the placebo group for 5 years but as soon as the study results were available and began real ASA.CE Grim MD Maybe we need to put this in perspective. Taking one 81 mg low-dose Aspirin (baby Asprin) per day, like so many doctors now recommend, increases the risk of gastric ulcer 2% - 4%. Gastritis and hiatal hernia are quite common and gastritis can be cause by many factors. To: hyperaldosteronism Sent: Thursday, November 3, 2011 2:22 PMSubject: Re: Links between Spironolactone and gastric problemsThanks for this article. Is this another good reason for an andrelectomy over long term medicines? Is this part of the med. control the same in Elperenone so the effect would be the same? - 65 yo super ob. male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with Meds. And DASH. . Current BP(last week ave): 131/76 HR 60Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, and PTSD.Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, 81mg asprin, Metformin 2000MG and Spironolactone 50 MG. >> I have had an endoscopy today which indicates some erosion of the first part of the duodenun, gastritis and a small hiatus hernia.> > I have done some research on possible links to taking spiro (now 150mg daily)which I have done since diagnosed with conn's in 2004. My conn's is stable and I am currently discharged from King's College Hospital (London) endo dept. BP is fine (115/78 today at hospital). The stomach stuff has been going on since January.> > Found this online:> http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539051/?tool=pmcentrez - main point: > > Conclusion The risk of gastroduodenal ulcers or upper gastrointestinal bleeding is significantly increased in patients using spironolactone.> > > Has anyone else experienced stomach problems from taking spiro long term?>------------------------------------

[Guest guest]

GI prob can be controlled in most by reducing dose or dividing dose. Our longest Spiro person here is 35 years on it as I recall. If you DASH YOU can reduce dose needed markedly. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

Interestingly the NHS drug info pages give gastrointestinal problems as a possible side effect of aking Spiro long term.

http://www.nhs.uk/medicine-guides/pages/MedicineSideEffects.aspx?condition=Blood%20pressure & medicine=spironolactone & preparation=Spironolactone%20100mg%20tablets

I also now have a very irregular if at all menstrual cycle for the past 2 years although hormones fine after blood tests.

Which makes me wonder re a possible common causal factor. 7 years of taking a drug is a long time.

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> > > I have had an endoscopy today which indicates some erosion of the first part of the duodenun, gastritis and a small hiatus hernia.

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> > > I have done some research on possible links to taking spiro (now 150mg daily)which I have done since diagnosed with conn's in 2004. My conn's is stable and I am currently discharged from King's College Hospital (London) endo dept. BP is fine (115/78 today at hospital). The stomach stuff has been going on since January.

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> > > Found this online:

> > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539051/?tool=pmcentrez - main point:

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> > > Conclusion The risk of gastroduodenal ulcers or upper gastrointestinal bleeding is significantly increased in patients using spironolactone.

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> > > Has anyone else experienced stomach problems from taking spiro long term?

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[Guest guest]

We have about 650 folks here so best to look in our data base for an answer unless you want to read 650 replies.You can also search all of our emails since founding nearly 10 years ago for say ulcer and see what you find. CE Grim MD Thanks for the comment, be reassured my world is perfectly in perspective... I just wanted to see if this is something anyone else has had happen that has been linked to Spiro use. > > > > I have had an endoscopy today which indicates some erosion of the first part of the duodenun, gastritis and a small hiatus hernia. > > > > I have done some research on possible links to taking spiro (now 150mg daily)which I have done since diagnosed with conn's in 2004. My conn's is stable and I am currently discharged from King's College Hospital (London) endo dept. BP is fine (115/78 today at hospital). The stomach stuff has been going on since January. > > > > Found this online: > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539051/?tool=pmcentrez - main point: > > > > Conclusion The risk of gastroduodenal ulcers or upper gastrointestinal bleeding is significantly increased in patients using spironolactone. > > > > > > Has anyone else experienced stomach problems from taking spiro long term? > > > > > > > ------------------------------------ > >

[Guest guest]

And start to DASH now. But tell them you are doing it as BP may plummet.CE Grim MD Thanks. Will talk to my GP. > > > > > > > > > > I have had an endoscopy today which indicates some erosion of the first part of the duodenun, gastritis and a small hiatus hernia. > > > > > > > > > > I have done some research on possible links to taking spiro (now 150mg daily)which I have done since diagnosed with conn's in 2004. My conn's is stable and I am currently discharged from King's College Hospital (London) endo dept. BP is fine (115/78 today at hospital). The stomach stuff has been going on since January. > > > > > > > > > > Found this online: > > > > > http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1539051/?tool=pmcentrez - main point: > > > > > > > > > > Conclusion The risk of gastroduodenal ulcers or upper gastrointestinal bleeding is significantly increased in patients using spironolactone. > > > > > > > > > > > > > > > Has anyone else experienced stomach problems from taking spiro long term? > > > > > > > > > > > > > > > > > > > > > > > > > ------------------------------------ > > > > > > > >