Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 Wow , that is one that I will have to read a couple of times.Thanks for the breakdown on it. I am so glad that you are part of this group. You are able to break things down in a simple manner and help us understand. Pennie Abby's Mom Who's head hurts after all that information Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 i have been trying to understand neurotransmitters in the brain.. Yikes, I know, but has anyone done research on the autonomic nervous system? What interests me is the sympothetic nervous system - Norepinephirine, Dopamine and Seratonin.... My oldest daughter is 9 and has ADHD. We just started her on Strattera, which is a SNRI - selective norepinephirine reuptake inhibitor. We have seen DRAMATIC improvements in her behavior. My middle child Ally is 4 and has PDD-NOS and ADHD, and i have heard that it is not uncommon to have a child with ADHD and one with austim, as they are thought to be cousins of each other, which started my research journey!! There are some studies going on to see if Strattera helps with autism. As far as I know there are not any results yet, but I have a feeling that it will help. But, all of this led me to doing research on more natural medicines, and that is when I discovered B6 and magnesium. The double blinded placebo studies show that it works just as well and sometimes better to Ritalin. Ritalin a well known drug for ADHD stimulates the Dopamine response. Dopamine is the reward chemical in the brain. Dopamine then stimulates norepinephine which is the fight or flight response and the rest or digest chemical. So, I think, what Strattera does is stimulates the same response, but without using a stimulate to do it. And if b6 and magnesium can do this, which in my mind would be safer than the above drugs I think we should all give it a try and see how it works. Ofcourse consulting with a doctor or specialist to see what doses to give and monitoring, etc. Hopefully, this note makes sense. Thanks - Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 Neurotransmitters in the brain come from the food we put into our enteric nervous system. I " m still trying to read " The Second Brain, " and it's difficult. But 95% (maybe 98%) of the seratonin we make is made in the GUT, not the brain, so feeding the gut may indeed provide calming improvements in cognition and behavior. I haven't looked at the sympothetic nervouse system (yet) PennY > i have been trying to understand neurotransmitters in the brain.. > Yikes, I know, but has anyone done research on the autonomic nervous > system? What interests me is the sympothetic nervous system - > Norepinephirine, Dopamine and Seratonin.... > > My oldest daughter is 9 and has ADHD. We just started her on > Strattera, which is a SNRI - selective norepinephirine reuptake > inhibitor. We have seen DRAMATIC improvements in her behavior. My > middle child Ally is 4 and has PDD-NOS and ADHD, and i have heard > that it is not uncommon to have a child with ADHD and one with > austim, as they are thought to be cousins of each other, which > started my research journey!! There are some studies going on to see > if Strattera helps with autism. As far as I know there are not any > results yet, but I have a feeling that it will help. But, all of > this led me to doing research on more natural medicines, and that is > when I discovered B6 and magnesium. The double blinded placebo > studies show that it works just as well and sometimes better to > Ritalin. Ritalin a well known drug for ADHD stimulates the Dopamine > response. Dopamine is the reward chemical in the brain. Dopamine > then stimulates norepinephine which is the fight or flight response > and the rest or digest chemical. So, I think, what Strattera does is > stimulates the same response, but without using a stimulate to do > it. And if b6 and magnesium can do this, which in my mind would be > safer than the above drugs I think we should all give it a try and > see how it works. Ofcourse consulting with a doctor or specialist to > see what doses to give and monitoring, etc. Hopefully, this note > makes sense. Thanks - Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 , I know quite a bit about the autonomic nervous system since I teach neurobiology. Here are some key points for you. The activity of the nervous system is mediated by many kinds of interneurons releasing one or another neurotransmitter such as norepinephrine gamma aminobutyric acid (GABA ) dopamine glutamate (Glu ) acetylcholine (ACh ) serotonin Acetylcholine Widely used at synapses in the peripheral nervous system . Released at the terminals of : all motor neurons activating skeletal muscle. all preganglionic neurons of the autonomic nervous system. the postganglionic neurons of the parasympathetic branch of the autonomic nervous system. Also mediates transmission at some synapses in the brain. These include synapses involved in the acquisition of short-term memory . Drugs that enhance ACh release — acetylcholinesterase inhibitors — are now used in elderly patients with failing memory (e.g., Alzheimer's patients). Amino acids Glutamic acid (Glu); used at excitatory synapses in the central nervous system ( CNS ). Essential for long term potentiation (LTP ), a form of memory. Glycine (Gly ). Gamma aminobutyric acid (GABA ); used at inhibitory synapses in the CNS Catecholamines Synthesized from tyrosine (Tyr) Norepinephrine. Released by postganglionic neurons of the sympathetic branch of the autonomic nervous system . Dopamine . Used at certain synapses in the CNS. Other monoamines Serotonin (also known as 5-hydroxytryptamine or 5HT). Synthesized from tryptophan (Trp). Histamine Both of these neurotransmitters are confined to synapses in the brain. Peptides A selection of 8 of the 40 or more peptides that are suspected to serve as neurotransmitters in the brain. Five also serve as hormones . Antidepressants Antidepressants fall into four chemical categories. Most share a common property: they increase the amount of serotonin at synapses that use it as a neurotransmitter. Monoamine oxidase (MAO) inhibitors These drugs act on a mitochondrial enzyme that breaks down monoamines such as noradrenaline and serotonin . By inhibiting the enzyme in presynaptic serotonin-releasing neurons, more serotonin is deposited in the synapse. MAO inhibitors are not used much anymore. Tricyclics and tetracyclics These drugs block the reuptake of both noradrenaline and serotonin causing an increase in the level of these neurotransmitters in the synapse . Some examples: imipramine Tofranil clomiprimine Anafranil amitriptyline Elavil, Endep trimipramine Surmontil doxepin Adapin, Sinequan desipramine Norpramin nortriptyline Aventyl, Pamelor amoxapine Asendin mirtazapine Remeron Although tricyclics are still prescribed for pain relief, their role as antidepressants has largely been taken over by the selective serotonin reuptake inhibitors (SSRIs) Selective Serotonin Reuptake Inhibitors (SSRIs) As the name suggests, these drugs inhibit the reuptake of serotonin but not of noradrenaline. Examples: fluoxetine Prozac paroxetine Paxil sertraline Zoloft fluvoxamine Luvox Although all these drugs quickly increase the amount of serotonin in the brain, there is more to the story than that. Unlike most psychoactive drugs, antidepressants do not relieve the symptoms of depression until a week or more after dosing begins. During this period, the number of serotonin receptors on the postsynaptic membranes decreases. How this translates into relief of symptoms is not yet understood. Bupropion Bupropion (e.g., Wellbutrin®) is a novel drug that blocks the reuptake of noradrenaline and dopamine . Although it does not interfere with the uptake of serotonin, it also appears to be an effective antidepressant. Atomoxetine This drug (Strattera )selectively interferes with the reuptake of noradrenaline . It is used in children with attention deficit/hyperactivity disorder (ADHD). Hope that helps a bit, :-) > i have been trying to understand neurotransmitters in the brain.. > Yikes, I know, but has anyone done research on the autonomic nervous > system? What interests me is the sympothetic nervous system - > Norepinephirine, Dopamine and Seratonin.... > > My oldest daughter is 9 and has ADHD. We just started her on > Strattera, which is a SNRI - selective norepinephirine reuptake > inhibitor. We have seen DRAMATIC improvements in her behavior. My > middle child Ally is 4 and has PDD-NOS and ADHD, and i have heard > that it is not uncommon to have a child with ADHD and one with > austim, as they are thought to be cousins of each other, which > started my research journey!! There are some studies going on to see > if Strattera helps with autism. As far as I know there are not any > results yet, but I have a feeling that it will help. But, all of > this led me to doing research on more natural medicines, and that is > when I discovered B6 and magnesium. The double blinded placebo > studies show that it works just as well and sometimes better to > Ritalin. Ritalin a well known drug for ADHD stimulates the Dopamine > response. Dopamine is the reward chemical in the brain. Dopamine > then stimulates norepinephine which is the fight or flight response > and the rest or digest chemical. So, I think, what Strattera does is > stimulates the same response, but without using a stimulate to do > it. And if b6 and magnesium can do this, which in my mind would be > safer than the above drugs I think we should all give it a try and > see how it works. Ofcourse consulting with a doctor or specialist to > see what doses to give and monitoring, etc. Hopefully, this note > makes sense. Thanks - > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 My pleasure, Pennie, although after re-reading my post I can understand how your head hurts! Now I know how my students must feel :-) Mom to (who said her first three word sentence today!) On Thursday, April 8, 2004, at 10:23 AM, Ploveabby@... wrote: > Wow , that is one that I will have to read a couple of > times.Thanks for > the breakdown on it. I am so glad that you are part of this group. You > are > able to break things down in a simple manner and help us understand. > > Pennie > Abby's Mom > Who's head hurts after all that information > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 Thats great that she said a 3 word sentence!! Very cool! Pennie Abby's Mom Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 HOORAY FOR ERIN!!!!!!!!!!!!!!!!!!!!!!!!!!!! And you too Robin Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2004 Report Share Posted April 8, 2004 --- Hi I would be interested to hear if the b6/magnesium works for your dd. My dd is also pdd-nos/adhd and on dexadrine, which works wonderfully. But if there is another alternative to a stimulant which is " safer " , I would try . Strattera isn't available in Canada yet, or I would be giving that a try. In Autism_in_Girls , cathylynn2 <cathylynn2@m...> wrote: > , > > I know quite a bit about the autonomic nervous system since I teach > neurobiology. Here are some key points for you. > > The activity of the nervous system is mediated by many kinds of > interneurons releasing one or another neurotransmitter such as > norepinephrine > gamma aminobutyric acid (GABA ) > dopamine > glutamate (Glu ) > acetylcholine (ACh ) > serotonin > > Acetylcholine > Widely used at synapses in the peripheral nervous system . Released at > the terminals of : > all motor neurons activating skeletal muscle. > all preganglionic neurons of the autonomic nervous system. > the postganglionic neurons of the parasympathetic branch of the > autonomic nervous system. > Also mediates transmission at some synapses in the brain. These include > synapses involved in the acquisition of short-term memory . Drugs that > enhance ACh release — acetylcholinesterase inhibitors — are now used in > elderly patients with failing memory (e.g., Alzheimer's patients). > > Amino acids > Glutamic acid (Glu); used at excitatory synapses in the central nervous > system ( CNS ). Essential for long term potentiation (LTP ), a form of > memory. > > Glycine (Gly ). > Gamma aminobutyric acid (GABA ); used at inhibitory synapses in the CNS > > Catecholamines > Synthesized from tyrosine (Tyr) > Norepinephrine. Released by postganglionic neurons of the sympathetic > branch of the autonomic nervous system . > Dopamine . Used at certain synapses in the CNS. > > Other monoamines > Serotonin (also known as 5-hydroxytryptamine or 5HT). Synthesized from > tryptophan (Trp). > Histamine > > Both of these neurotransmitters are confined to synapses in the brain. > > Peptides > A selection of 8 of the 40 or more peptides that are suspected to serve > as neurotransmitters in the brain. Five also serve as hormones . > > > > > Antidepressants > Antidepressants fall into four chemical categories. Most share a common > property: they increase the amount of serotonin at synapses that use it > as a neurotransmitter. > > Monoamine oxidase (MAO) inhibitors > These drugs act on a mitochondrial enzyme that breaks down monoamines > such as noradrenaline and serotonin . By inhibiting the enzyme in > presynaptic serotonin-releasing neurons, more serotonin is deposited in > the synapse. MAO inhibitors are not used much anymore. > > Tricyclics and tetracyclics > These drugs block the reuptake of both noradrenaline and serotonin > causing an increase in the level of these neurotransmitters in the > synapse . Some examples: > > > imipramine > Tofranil > > clomiprimine > Anafranil > > amitriptyline > Elavil, Endep > > trimipramine > Surmontil > > doxepin > Adapin, Sinequan > > desipramine > Norpramin > > nortriptyline > Aventyl, Pamelor > > amoxapine > Asendin > > mirtazapine > Remeron > > Although tricyclics are still prescribed for pain relief, their role as > antidepressants has largely been taken over by the selective serotonin > reuptake inhibitors (SSRIs) > > Selective Serotonin Reuptake Inhibitors (SSRIs) > > As the name suggests, these drugs inhibit the reuptake of serotonin but > not of noradrenaline. > Examples: > > > fluoxetine > Prozac > > paroxetine > Paxil > > sertraline > Zoloft > > fluvoxamine > Luvox > > Although all these drugs quickly increase the amount of serotonin in > the brain, there is more to the story than that. Unlike most > psychoactive drugs, antidepressants do not relieve the symptoms of > depression until a week or more after dosing begins. During this > period, the number of serotonin receptors on the postsynaptic membranes > decreases. How this translates into relief of symptoms is not yet > understood. > > Bupropion > > Bupropion (e.g., Wellbutrin®) is a novel drug that blocks the reuptake > of noradrenaline and dopamine . Although it does not interfere with the > uptake of serotonin, it also appears to be an effective antidepressant. > > Atomoxetine > > This drug (Strattera )selectively interferes with the reuptake of > noradrenaline . It is used in children with attention > deficit/hyperactivity disorder (ADHD). > > Hope that helps a bit, > > :-) > > > > > > i have been trying to understand neurotransmitters in the brain.. > > Yikes, I know, but has anyone done research on the autonomic nervous > > system? What interests me is the sympothetic nervous system - > > Norepinephirine, Dopamine and Seratonin.... > > > > My oldest daughter is 9 and has ADHD. We just started her on > > Strattera, which is a SNRI - selective norepinephirine reuptake > > inhibitor. We have seen DRAMATIC improvements in her behavior. My > > middle child Ally is 4 and has PDD-NOS and ADHD, and i have heard > > that it is not uncommon to have a child with ADHD and one with > > austim, as they are thought to be cousins of each other, which > > started my research journey!! There are some studies going on to see > > if Strattera helps with autism. As far as I know there are not any > > results yet, but I have a feeling that it will help. But, all of > > this led me to doing research on more natural medicines, and that is > > when I discovered B6 and magnesium. The double blinded placebo > > studies show that it works just as well and sometimes better to > > Ritalin. Ritalin a well known drug for ADHD stimulates the Dopamine > > response. Dopamine is the reward chemical in the brain. Dopamine > > then stimulates norepinephine which is the fight or flight response > > and the rest or digest chemical. So, I think, what Strattera does is > > stimulates the same response, but without using a stimulate to do > > it. And if b6 and magnesium can do this, which in my mind would be > > safer than the above drugs I think we should all give it a try and > > see how it works. Ofcourse consulting with a doctor or specialist to > > see what doses to give and monitoring, etc. Hopefully, this note > > makes sense. Thanks - > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2004 Report Share Posted April 9, 2004 i am going to do some more research and do some consulting, as to the doses and such, and I will let you know. thanks - -- In Autism_in_Girls , " Diane " <dianeque@y...> wrote: > --- > > Hi > > I would be interested to hear if the b6/magnesium works for your dd. > My dd is also pdd-nos/adhd and on dexadrine, which works > wonderfully. But if there is another alternative to a stimulant > which is " safer " , I would try . Strattera isn't available in Canada > yet, or I would be giving that a try. > In Autism_in_Girls , cathylynn2 <cathylynn2@m...> > wrote: > > , > > > > I know quite a bit about the autonomic nervous system since I > teach > > neurobiology. Here are some key points for you. > > > > The activity of the nervous system is mediated by many kinds of > > interneurons releasing one or another neurotransmitter such as > > norepinephrine > > gamma aminobutyric acid (GABA ) > > dopamine > > glutamate (Glu ) > > acetylcholine (ACh ) > > serotonin > > > > Acetylcholine > > Widely used at synapses in the peripheral nervous system . > Released at > > the terminals of : > > all motor neurons activating skeletal muscle. > > all preganglionic neurons of the autonomic nervous system. > > the postganglionic neurons of the parasympathetic branch of the > > autonomic nervous system. > > Also mediates transmission at some synapses in the brain. These > include > > synapses involved in the acquisition of short-term memory . Drugs > that > > enhance ACh release — acetylcholinesterase inhibitors — are now > used in > > elderly patients with failing memory (e.g., Alzheimer's patients). > > > > Amino acids > > Glutamic acid (Glu); used at excitatory synapses in the central > nervous > > system ( CNS ). Essential for long term potentiation (LTP ), a > form of > > memory. > > > > Glycine (Gly ). > > Gamma aminobutyric acid (GABA ); used at inhibitory synapses in > the CNS > > > > Catecholamines > > Synthesized from tyrosine (Tyr) > > Norepinephrine. Released by postganglionic neurons of the > sympathetic > > branch of the autonomic nervous system . > > Dopamine . Used at certain synapses in the CNS. > > > > Other monoamines > > Serotonin (also known as 5-hydroxytryptamine or 5HT). Synthesized > from > > tryptophan (Trp). > > Histamine > > > > Both of these neurotransmitters are confined to synapses in the > brain. > > > > Peptides > > A selection of 8 of the 40 or more peptides that are suspected to > serve > > as neurotransmitters in the brain. Five also serve as hormones . > > > > > > > > > > Antidepressants > > Antidepressants fall into four chemical categories. Most share a > common > > property: they increase the amount of serotonin at synapses that > use it > > as a neurotransmitter. > > > > Monoamine oxidase (MAO) inhibitors > > These drugs act on a mitochondrial enzyme that breaks down > monoamines > > such as noradrenaline and serotonin . By inhibiting the enzyme in > > presynaptic serotonin-releasing neurons, more serotonin is > deposited in > > the synapse. MAO inhibitors are not used much anymore. > > > > Tricyclics and tetracyclics > > These drugs block the reuptake of both noradrenaline and > serotonin > > causing an increase in the level of these neurotransmitters in > the > > synapse . Some examples: > > > > > > imipramine > > Tofranil > > > > clomiprimine > > Anafranil > > > > amitriptyline > > Elavil, Endep > > > > trimipramine > > Surmontil > > > > doxepin > > Adapin, Sinequan > > > > desipramine > > Norpramin > > > > nortriptyline > > Aventyl, Pamelor > > > > amoxapine > > Asendin > > > > mirtazapine > > Remeron > > > > Although tricyclics are still prescribed for pain relief, their > role as > > antidepressants has largely been taken over by the selective > serotonin > > reuptake inhibitors (SSRIs) > > > > Selective Serotonin Reuptake Inhibitors (SSRIs) > > > > As the name suggests, these drugs inhibit the reuptake of > serotonin but > > not of noradrenaline. > > Examples: > > > > > > fluoxetine > > Prozac > > > > paroxetine > > Paxil > > > > sertraline > > Zoloft > > > > fluvoxamine > > Luvox > > > > Although all these drugs quickly increase the amount of serotonin > in > > the brain, there is more to the story than that. Unlike most > > psychoactive drugs, antidepressants do not relieve the symptoms > of > > depression until a week or more after dosing begins. During this > > period, the number of serotonin receptors on the postsynaptic > membranes > > decreases. How this translates into relief of symptoms is not yet > > understood. > > > > Bupropion > > > > Bupropion (e.g., Wellbutrin®) is a novel drug that blocks the > reuptake > > of noradrenaline and dopamine . Although it does not interfere > with the > > uptake of serotonin, it also appears to be an effective > antidepressant. > > > > Atomoxetine > > > > This drug (Strattera )selectively interferes with the reuptake of > > noradrenaline . It is used in children with attention > > deficit/hyperactivity disorder (ADHD). > > > > Hope that helps a bit, > > > > :-) > > > > > > > > > > > i have been trying to understand neurotransmitters in the brain.. > > > Yikes, I know, but has anyone done research on the autonomic > nervous > > > system? What interests me is the sympothetic nervous system - > > > Norepinephirine, Dopamine and Seratonin.... > > > > > > My oldest daughter is 9 and has ADHD. We just started her on > > > Strattera, which is a SNRI - selective norepinephirine reuptake > > > inhibitor. We have seen DRAMATIC improvements in her behavior. > My > > > middle child Ally is 4 and has PDD-NOS and ADHD, and i have heard > > > that it is not uncommon to have a child with ADHD and one with > > > austim, as they are thought to be cousins of each other, which > > > started my research journey!! There are some studies going on > to see > > > if Strattera helps with autism. As far as I know there are not > any > > > results yet, but I have a feeling that it will help. But, all of > > > this led me to doing research on more natural medicines, and > that is > > > when I discovered B6 and magnesium. The double blinded placebo > > > studies show that it works just as well and sometimes better to > > > Ritalin. Ritalin a well known drug for ADHD stimulates the > Dopamine > > > response. Dopamine is the reward chemical in the brain. > Dopamine > > > then stimulates norepinephine which is the fight or flight > response > > > and the rest or digest chemical. So, I think, what Strattera > does is > > > stimulates the same response, but without using a stimulate to do > > > it. And if b6 and magnesium can do this, which in my mind would > be > > > safer than the above drugs I think we should all give it a try > and > > > see how it works. Ofcourse consulting with a doctor or > specialist to > > > see what doses to give and monitoring, etc. Hopefully, this note > > > makes sense. Thanks - > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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