Re: Reference Values for Aldosterone-Renin Ratios

[Guest guest]

One of the problems with renin and aldo assays is that there is no international reference standard (as there is for cholesterol for example) for either analyte that permits labs to compare values. So never used published values unless that is the lab that did your measurement. Most have not done the extensive work needed to be able to provide values based on age, gender, ethnicity, medications and sodium intake. As these authors note without a 24 hr urine Na one cannot interpret a renin or an aldo. Ever.CE Grim MD Reference Values for Aldosterone–Renin Ratios in Normotensive Individuals and Effect of Changes in Dietary Sodium ConsumptionMichiel N. Kerstens, Anneke C. Muller Kobold, Marcel Volmer, Jan Koerts, Wim J. Sluiter, and Robin P.F. DullaartClin. Chem. 2011; 57:1607-1611. [Abstract] [Full Text] [PDF]

[Guest guest]

One problem with renin and Aldo assays is that there is no universal reference standard so it is impossible to use one labs values to compare to another. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertension

Reference Values for Aldosterone–Renin Ratios in Normotensive Individuals and Effect of Changes in Dietary Sodium ConsumptionMichiel N. Kerstens, Anneke C. Muller Kobold, Marcel Volmer, Jan Koerts, Wim J. Sluiter, and Robin P.F. DullaartClin. Chem. 2011; 57:1607-1611. [Abstract] [Full Text] [PDF]

[Guest guest]

So, it means that even for healthy individuals renin gets lower after sodium consumptions? Natalia Kamneva To: hyperaldosteronism Sent: Saturday, October 29, 2011 5:46 PMSubject: Reference Values for Aldosterone-Renin Ratios

Reference Values for Aldosterone–Renin Ratios in Normotensive Individuals and Effect of Changes in Dietary Sodium ConsumptionMichiel N. Kerstens, Anneke C. Muller Kobold, Marcel Volmer, Jan Koerts, Wim J. Sluiter, and Robin P.F. DullaartClin. Chem. 2011; 57:1607-1611. [Abstract] [Full Text] [PDF]

[Guest guest]

Yes. Both renin and aldo should go down on a high salt diet and up on a low sodium diet. However if we consider a normal human Na intake of say 250 mg a day until perhaps 10,000 years ago we should call today's "normal intake" as a toxic salt intake level for what you physiology was fine tuned for over hundreds of thousands of years. And what we consider a low sodium intake should be called a normal human intake.CE Grim MD So, it means that even for healthy individuals renin gets lower after sodium consumptions? Natalia Kamneva To: hyperaldosteronism Sent: Saturday, October 29, 2011 5:46 PMSubject: Reference Values for Aldosterone-Renin Ratios Reference Values for Aldosterone–Renin Ratios in Normotensive Individuals and Effect of Changes in Dietary Sodium ConsumptionMichiel N. Kerstens, Anneke C. Muller Kobold, Marcel Volmer, Jan Koerts, Wim J. Sluiter, and Robin P.F. DullaartClin. Chem. 2011; 57:1607-1611. [Abstract] [Full Text] [PDF]

[Guest guest]

So, when we are Dashing, we increase our aldo? But it's not a goal!!!! Natalia Kamneva To: hyperaldosteronism Sent: Monday, October 31, 2011 11:18 PMSubject: Re: Reference Values for Aldosterone-Renin Ratios

Yes. Both renin and aldo should go down on a high salt diet and up on a low sodium diet. However if we consider a normal human Na intake of say 250 mg a day until perhaps 10,000 years ago we should call today's "normal intake" as a toxic salt intake level for what you physiology was fine tuned for over hundreds of thousands of years. And what we consider a low sodium intake should be called a normal human intake.CE Grim MD So, it means that

even for healthy individuals renin gets lower after sodium consumptions? Natalia Kamneva To: hyperaldosteronism Sent: Saturday, October 29, 2011 5:46 PMSubject: Reference Values for

Aldosterone-Renin Ratios Reference Values for Aldosterone–Renin Ratios in Normotensive Individuals and Effect of Changes in Dietary Sodium ConsumptionMichiel N. Kerstens, Anneke C. Muller Kobold, Marcel Volmer, Jan Koerts, Wim J. Sluiter, and Robin P.F. DullaartClin. Chem. 2011; 57:1607-1611. [Abstract] [Full Text] [PDF]

[Guest guest]

I am confused. So, when we are dashing, our aldo goes up? Natalia To: hyperaldosteronism Sent: Monday, October 31, 2011 11:18 PMSubject: Re: Reference Values for Aldosterone-Renin Ratios

Yes. Both renin and aldo should go down on a high salt diet and up on a low sodium diet. However if we consider a normal human Na intake of say 250 mg a day until perhaps 10,000 years ago we should call today's "normal intake" as a toxic salt intake level for what you physiology was fine tuned for over hundreds of thousands of years. And what we consider a low sodium intake should be called a normal human intake.CE Grim MD So, it means that

even for healthy individuals renin gets lower after sodium consumptions? Natalia Kamneva To: hyperaldosteronism Sent: Saturday, October 29, 2011 5:46 PMSubject: Reference Values for

Aldosterone-Renin Ratios Reference Values for Aldosterone–Renin Ratios in Normotensive Individuals and Effect of Changes in Dietary Sodium ConsumptionMichiel N. Kerstens, Anneke C. Muller Kobold, Marcel Volmer, Jan Koerts, Wim J. Sluiter, and Robin P.F. DullaartClin. Chem. 2011; 57:1607-1611. [Abstract] [Full Text] [PDF]