Re: TERM: binary restenosis definition

[Guest guest]

KASTRATI ET AL., PREDICTORS OF RESTENOSIS AFTER STENTING JACC Vol. 30, No. 6, November 15, 1997:1428-36 --------------------------------------------------------------------------------

Predictive Factors of Restenosis After Coronary Stent Placement Adnan Kastrati, MD, Albert Schömig, MD, Shpend Elezi, MD, Helmut Schühlen, MD, f Dirschinger, MD, Hadamitzky, MD, Anne Wehinger, MD, Jörg Hausleiter, MD, Hanna Walter, MD, Franz-f Neumann, MD Munich, Germany AbstractObjectives. The objective of this study was to identify clinical, lesional and procedural factors that can predict restenosis after coronary stent placement. Background. Coronary stent placement reduces the restenosis rate compared with that after percutaneous transluminal coronary angioplasty (PTCA). However, restenosis remains an unresolved issue, and identification of its predictive factors may allow further insight into the underlying process. Methods. All patients with successful coronary stent placement were eligible for this study unless they had had a major adverse cardiac event during the 1st 30 days after the procedure. Of the 1,349 eligible patients (1,753 lesions), follow-up angiography at 6 months was performed in 80.4% (1,084 patients, 1,399 lesions). Demographic, clinical, lesional and procedural data were prospectively recorded and analyzed for any predictive power for the occurrence of late restenosis after stenting. Restenosis was evaluated by using three outcomes at follow-up: binary restenosis as a diameter stenosis >=50%, late lumen loss as lumen diameter reduction and target lesion revascularization (TLR) as any repeat PTCA or coronary artery bypass surgery involving the stented lesion. Results. Multivariate analysis demonstrated that diabetes mellitus, placement of multiple stents and minimal lumen diameter (MLD) immediately after stenting were the strongest predictors of restenosis. Diabetes increased the risk of binary restenosis with an odds ratio (OR) [95% confidence interval] of 1.86 [1.56 to 2.16] and the risk of TLR with an OR of 1.45 [1.11 to 1.80]. Multiple stents increased the risk of binary restenosis with an OR of 1.81 [1.55 to 2.06] and that of TLR with an OR of 1.94 [1.66 to 2.22]. An MLD <3 mm at the end of the procedure augmented the risk of binary restenosis with an OR of 1.81 [1.55 to 2.06] and that of TLR with an OR of 2.05 [1.77 to 2.34]. Classification and regression tree analysis demonstrated that the incidence of restenosis may be as low as 16% for a lesion without any of these risk factors and as high as 59% for a lesion with a combination of these risk factors. Conclusions. Diabetes, multiple stents and smaller final MLD are strong predictors of restenosis after coronary stent placement. Achieving an optimal result with a minimal number of stents during the procedure may significantly reduce this risk even in patients with adverse clinical characteristics such as diabetes. (J Am Coll Cardiol 1997;30:1428-36) ______________________________François Malaise, DMVEN>FR Biomedical Translations172-A, rue Henri DunantB-7000 MonsBelgiumPhone: +32-(0)65.84.33.98Fax: +32-(0)65.84.29.57Mob. phone: +32-(0)75.53.75.73E-mail: fmalaise@...______________________________ Well, binary is related to the restenosis and not to the rate!

[Guest guest]

>>Well, binary is related to the restenosis and not to the rate!<<

I do not agree, binary related to the way the stenosis is classified, (stenosed-yes or stenosed-no) regardless of whether it is a stenosis or a re-stenosis. I have also found examples where 'binary stenosis' is used.

Hartelijke groeten * Bart *

[Guest guest]

It's a misunderstanding. In the text I translated, the " rate " (in " binary

restenosis rate " ) is not the degree of restenosis but actually the

percentage of patients with (binary) restenosis.

A+,

F

>>Well, binary is related to the restenosis and not to the rate!<<

I do not agree, binary related to the way the stenosis is classified,

(stenosed-yes or stenosed-no) regardless of whether it is a stenosis or a

re-stenosis. I have also found examples where 'binary stenosis' is used.

Hartelijke groeten * Bart *

eGroups.com Home: /group/medical_translation

www. - Simplifying group communications

[Guest guest]

>>Well, binary is related to the restenosis and not to the rate!<<

I do not agree, binary related to the way the stenosis is classified,

(stenosed-yes or stenosed-no) regardless of whether it is a stenosis or a

re-stenosis. I have also found examples where 'binary stenosis' is used.

Hartelijke groeten * Bart *

------------------------------

Well, ..... I think this is an excellent example of how important clear

scientific/medical writing is. If even the medical people on the list

cannot agree on the meaning of this term, how are the rest of us supposed

to know??

Anyway, I am happy to see this list coming to live!

Ursula

Ursula Vielkind, Ph.D.

German/English Translation in Biological Sciences

http://home.istar.ca/~hpca/urvi.html

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[Guest guest]

Hi Folks,

I think there was a misunderstanding here.

At the beggining we were talking only about binary stenosis and this was

wonderfully clarified by susan and Bart.

Later François added his thoughts about something else: binary stenosis

rate.

Binary stenosis rate is the percentage of individuals in a given

population/ sample that presents stenosis defined by the binary concept

( which is a stenosis >50% in an individual, at follow-up angiography).

In guess now we clarified everything... huh?

Have a nice eve !

Lúcia

Ursula Vielkind gravada:

>

>

>

> >>Well, binary is related to the restenosis and not to the rate!<<

>

> I do not agree, binary related to the way the stenosis is classified,

> (stenosed-yes or stenosed-no) regardless of whether it is a stenosis or a

> re-stenosis. I have also found examples where 'binary stenosis' is used.

>

> Hartelijke groeten * Bart *

> ------------------------------

> Well, ..... I think this is an excellent example of how important clear

> scientific/medical writing is. If even the medical people on the list

> cannot agree on the meaning of this term, how are the rest of us supposed

> to know??

>

> Anyway, I am happy to see this list coming to live!

> Ursula

>

> Ursula Vielkind, Ph.D.

> German/English Translation in Biological Sciences

> http://home.istar.ca/~hpca/urvi.html

> ----------

>

> ------------------------------------------------------------------------

> Love. Relationships? E - Commerce!

> http://click./1/1145/2/_/98296/_/950133479/

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> eGroups.com Home: /group/medical_translation/

> - Simplifying group communications

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Lúcia

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