Re: Niacin

[Guest guest]

Pat,

I thoroughly enjoyed reading about the roles of the various cholesterol factors and I believe he is right. How else do they explain people who have low cholesterol, low trig, and low blood pressure having sudden heart attacks (like my brother when he just turned 40). His arteries were calcified and heart twice enlarged, but never had one high reading in his life. My mom was the same with her heart disease, but she did have diabetes which presented itself first. His article about how "research conclusions" get passed around the block without a lot of proof is very right on and his assumptions about where they will go with CRP and any other factor that coincides with disease as being "the villian".

The nicotinic acid and niacinamide might be risky for me with the possibility of elevated blood sugars (diabetic). For years, they did not recommend taking B Vitamins outside of a B Complex, with the B Vitamins in balance with each other. In recent years, there seems to be a lot of isolating B Vitamins to supplement for this and that. Perhaps the old standbys like Brewers Yeast or that Red Rice Yeast may be the way to go. I did read a very interesting article from the Linus ing Institute about a study in regards to comparing supplementation of B3 vs B6 and another B Vitamin separately, vs people who took nothing or took all 3 (being more prone to supposed CV events).

It certainly gets confusing, but I'm rather excited to keep reading the rest of what he has to say and research from there.

Thanks,

Lor

The flushing is caused by the release of histamine. It happens when

a large dose is taken. The same histamine released in allergic

reactions. I also read that the vitamin niacin that comes in the

form of niacinamide doen not cause flushing. The following websites

have a lot of information about niacin. My interest in reading about

niacin was as a vitamin, only, since I don't believe all that

mainstream business about cholesterol.

Another interesting site by Malcom Kendrick, MD is:

http://www.thincs.org/Malcolm.htm#CRP

His two essays, "Why Atkins diet is healthy" and "Liquid Drano"

explains how cholesterol, LDL, HDL and other DLs work.

http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/nia_018

4.shtml

(Niacin and reactions with other medications)

http://www.physiciansselect.com/niacin-vitamin-b3-information.htm

(Niacin)

Pat

[Guest guest]

Lor wrote:

Perhaps the old standbys like Brewers Yeast or that Red Rice

Yeast may be the way to go.

Hi Lor,

Red Rice Yeast is actually Red Yeast Rice. The concept of

statins started with Red Yeast Rice, which is a natual statin

and has all the same side effects as statins.

Please read Colpo's article titled:

" Natural " Cholesterol-Lowering Supplement Depletes

Coenzyme Q(10) Levels "

http://www.theomnivore.com/RYR_versus_CoQ10.html

Fran

[Guest guest]

> The flushing is caused by the release of histamine. It happens when

> a large dose is taken. The same histamine released in allergic

> reactions. I also read that the vitamin niacin that comes in the

> form of niacinamide doen not cause flushing.

Personally, I would not use niacinamide. If you want to take a chance with

no-flush niacin, Inositol Hexanicotinate is the form to use. Studies that

show Niacin has benefits to cholesterol, heart attack risk, etc., have not

been done on no-flush versions of niacin. Compare the research referenced on

the next two web pages.

Niacin

http://qualitycounts.com/fpniacin.html

Inositol Hexanicotinate/Hexaniacinate (no-flush niacin)

http://qualitycounts.com/fpinositolhexanicotinate.html

Niacinamide might block the lfespan-extending effects of calorie restriction.

http://groups.google.com/group/sci.life-extension/browse_thread/thread/7c3ad4273\

224ffb6/1e92557188d762be?lnk=st & q=niacinamide & rnum=9 & hl=en#1e92557188d762be

--

Steve - dudescholar2@...

" What luck for rulers, that men do not think. "

--Adolph Hitler

[Guest guest]

> Pat,

>

> I thoroughly enjoyed reading about the roles of the various cholesterol

> factors and I believe he is right. How else do they explain people who have

> low cholesterol, low trig, and low blood pressure having sudden heart

> attacks (like my brother when he just turned 40). His arteries were

> calcified and heart twice enlarged, but never had one high reading in his

> life. My mom was the same with her heart disease, but she did have diabetes

> which presented itself first. His article about how " research conclusions "

> get passed around the block without a lot of proof is very right on and his

> assumptions about where they will go with CRP and any other factor that

> coincides with disease as being " the villian " .

>

> The nicotinic acid and niacinamide might be risky for me with the

> possibility of elevated blood sugars (diabetic). For years, they did not

> recommend taking B Vitamins outside of a B Complex, with the B Vitamins in

> balance with each other. In recent years, there seems to be a lot of

> isolating B Vitamins to supplement for this and that. Perhaps the old

> standbys like Brewers Yeast or that Red Rice Yeast may be the way to go. I

> did read a very interesting article from the Linus ing Institute about

> a study in regards to comparing supplementation of B3 vs B6 and another B

> Vitamin separately, vs people who took nothing or took all 3 (being more

> prone to supposed CV events).

>

> It certainly gets confusing, but I'm rather excited to keep reading the

> rest of what he has to say and research from there.

>

> Thanks,

> Lor

See the study below. Also, click on the like here and choose " related

articles " on the web page for more similar research. This is from the

National Institutes of Health web site.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15969866 & query_hl=2 & itool=pubmed_docsum

--

Nicotinic acid in the management of dyslipidaemia associated with diabetes and

metabolic syndrome: a position paper developed by a European Consensus Panel.

Shepherd J, Betteridge J, Van Gaal L; European Consensus Panel.

Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, UK.

jsheperd@...

Individuals with type 2 diabetes and metabolic syndrome are at markedly

increased risk of cardiovascular morbidity and mortality. The increasing

prevalence of both conditions poses a major challenge for clinicians in the

21st century. Both diabetes and metabolic syndrome are associated with a

clustering of cardiovascular risk factors. In particular, dyslipidaemia

characterised by low plasma levels of high-density lipoprotein cholesterol

(HDL-C), elevated triglycerides and an increase in small, dense low-density

lipoprotein (LDL) particles (the lipid triad), has been established as the

most important modifiable risk factor for coronary heart disease (CHD).

Current treatment guidelines recognise the increased CHD risk associated with

diabetes and metabolic syndrome and focus on LDL-C lowering with statin

treatment, in addition to dietary and lifestyle modification, as the primary

lipid-modifying therapy. However, while there is no doubt that statin therapy

significantly reduces CHD risk in these patients, their residual absolute

risk remains higher than in individuals without diabetes or metabolic

syndrome. Thus, there is a clear need to target other aspects of lipoprotein

metabolism, notably low HDL-C and hypertriglyceridaemia, to further reduce

CHD risk. Combining statin therapy (targeting LDL-C) with interventions that

also modify low HDL-C and elevated triglycerides could be a useful strategy

to optimise CHD risk reduction. Cautious combination of a fibrate or

nicotinic acid with a statin is useful for the management of combined

dyslipidaemia. Nicotinic acid is the more potent agent for raising HDL-C (by

up to 29% at clinically recommended doses). It also substantially reduces

triglycerides and LDL-C, and promotes a shift from small, dense LDL to

larger, more buoyant LDL particles. Preliminary clinical data suggest that

combining nicotinic acid with a statin will produce a greater reduction in

cardiovascular risk in patients with diabetes and metabolic syndrome than

statin monotherapy alone. Nicotinic acid is also safe for use in patients

with diabetes, with no evidence of clinically relevant deterioration in

glycaemic control at recommended doses (< or = 2 g/day). On review of the

available evidence, this European Consensus Panel recommends the combination

of nicotinic acid and a statin, together with lifestyle modification, as a

useful strategy to lower CHD risk in patients with diabetes and metabolic

syndrome. Prolonged-release nicotinic acid with improved tolerability

compared with previous formulations may have obvious advantages for use in

this setting.

Publication Types:

* Consensus Development Conference

* Review

PMID: 15969866 [PubMed - indexed for MEDLINE]

--

Steve - dudescholar2@...

" We will either find a way, or make one. "

--Hannibal Barca

[Guest guest]

Fran,

Oops, that was a typo on the Red Yeast Rice. Thank you for sending

the article. I surely will be staying away from that product. Enjoyed

the whole site also, by the way.

Lor

Hi Lor,

Red Rice Yeast is actually Red Yeast Rice. The concept of

statins started with Red Yeast Rice, which is a natual statin

and has all the same side effects as statins.

Please read Colpo's article titled:

"Natural" Cholesterol-Lowering Supplement Depletes

Coenzyme Q(10) Levels"

http://www.theomnivore.com/RYR_versus_CoQ10.html

Fran