Re: Adenosylcobalamin update

March 20, 2004

Hi Kim and thanks for sharing your new treatment! I have never heard

of this. Can you tell us more about it? What is it exactly?? Dumb

question but I've just never heard of it before. We've had luck with

B-12 too but it doesn't have the effect it did intially.. I saw huge

improvements inititally and we've only been on it about 3 months

now. I still think it definitely makes a difference.. just not as

much as initially. I love hearing about someone's progress with

something new.

Dr. McCandless.. is this something that you've used or had luck

with?? Could you share your thoughts on this??

Thanks Kim and glad you are seeing progress. Keep us posted.

> Listmates..my son was a tremendous B12 responder, in fact I rank

> daily B12 as the #1 thing we've done for Henry, and we've done

alot.

> We've been doing daily B12 for over a year and really notice if he

> misses even two days. In any event, a recent OAT test still

showed

> his MMA as elevated (although much lower than before). He was

> receiving 75mcg/kg of the Coastal prep. His doc recommended the

> addition of adenosylcobalamin and we started it 1:1 about two

weeks

> ago. Hard to believe, but again we saw dramatic, immediate

results.

> Within two or three days, his use of language became obviously

better

> and he became much more " relational " with his father and I. He

went

> from pointing out something and saying " what's this Mommy " , to

> saying " what's this little thing here called? " overnight.

>

> I just wanted to post this because I know some of you have kids

who

> were B12 responders and maybe have reached a plateau. This could

be

> something else to think about or talk with your doctors about. I

> haven't heard much about the use of the adenosyl version, but am

> grateful that we took a chance on something new. We will repeat

an

> OAT later, but wanted to share this before then. Kim

March 20, 2004

Dr. Jim Neubrander, our MB-12 guru, recently starting

adding a small amount of adenosylcobalamin (the form

that is in the mitochondria) to the compounded MB-12

mix for the kids who have an elevated MMA

(methylmalonate) and is reporting good results. I

have not done this yet, but will find out all about

it from my buddy Jim at the Think Tank in D.C. Dr. JM

--- Original Message ---

To: csb-autism-rx

Subject: Re: Adenosylcobalamin update

><html><body>

>

><tt>

>Hi Kim and thanks for sharing your new treatment! I

have never heard

>of this. Can you tell us more about it? What is it

exactly?? Dumb

>question but I've just never heard of it before.

We've had luck with

>B-12 too but it doesn't have the effect it did

intially.. I saw huge

>improvements inititally and we've only been on it

about 3 months

>now. I still think it definitely & nbsp; makes a

difference.. just not as

>much as initially. I love hearing about someone's

progress with

>something new.

>

>Dr. McCandless.. is this something that & nbsp; you've

used or had luck

>with?? Could you share your thoughts on this??

>

>Thanks Kim and glad you are seeing progress. Keep us

posted.

>

> & gt; Listmates..my son was a tremendous B12

responder, in fact I rank

> & gt; daily B12 as the #1 thing we've done for Henry,

and we've done

>alot. & nbsp;

> & gt; We've been doing daily B12 for over a year and

really notice if he

> & gt; misses even two days. & nbsp; In any event, a

recent OAT test still

>showed

> & gt; his MMA as elevated (although much lower than

before). & nbsp; He was

> & gt; receiving 75mcg/kg of the Coastal prep. His doc

recommended the

> & gt; addition of adenosylcobalamin and we started it

1:1 about two

>weeks

> & gt; ago. & nbsp; Hard to believe, but again we saw

dramatic, immediate

>results. & nbsp;

> & gt; Within two or three days, his use of language

became obviously

>better

> & gt; and he became much more & quot;relational & quot;

with his father and I. & nbsp; He

>went

> & gt; from pointing out something and saying

& quot;what's this Mommy & quot;, to

> & gt; saying & quot;what's this little thing here

called? & quot; overnight. & nbsp;

> & gt;

> & gt; I just wanted to post this because I know some

of you have kids

>who

> & gt; were B12 responders and maybe have reached a

plateau. & nbsp; This could

>be

> & gt; something else to think about or talk with your

doctors about. I

> & gt; haven't heard much about the use of the

adenosyl version, but am

> & gt; grateful that we took a chance on something

new. & nbsp; We will repeat

>an

> & gt; OAT later, but wanted to share this before

then. & nbsp; Kim

>

></tt>

>

>

><tt>

>Many frequently asked questions and answers can be

found at & lt;<a href= " http://www.autism-

rxguidebook.com/forums " >http://www.autism-

rxguidebook.com/forums</a> & gt;</tt>

>

>

>

>

>

>

><table border=0 cellspacing=0 cellpadding=2>

><tr bgcolor=#FFFFCC>

><td align=center><font size= " -1 "

color=#003399>

April 8, 2004

MMA (methylmalonate) is on the organic acid test, one of the " Methylation

Pathway Markers " . A vitamin B12-dependent enzyme, methylmalonyl CoA mutase

converts the amino acid valine into energy-yielding products, and in Vitamin B12

deficiency this conversion is impaired as well as the one in which methionine is

recovered from homocysteine, leading to accumulatoin of both homocysteine and

methymalonate. Dr. JN has found that adding a little adenosylcobalamine helps

move this cycle along better than methylcobalamin alone. I call it

" fine-tuning " and have not yet started doing this myself, but may if he can

convince me at the Think Tank that it really makes that much difference. Dr. JM

Re: Adenosylcobalamin update

><html><body>

>

><tt>

>Hi Kim and thanks for sharing your new treatment! I

have never heard

>of this. Can you tell us more about it? What is it

exactly?? Dumb

>question but I've just never heard of it before.

We've had luck with

>B-12 too but it doesn't have the effect it did

intially.. I saw huge

>improvements inititally and we've only been on it

about 3 months

>now. I still think it definitely & nbsp; makes a

difference.. just not as

>much as initially. I love hearing about someone's

progress with

>something new.

>

>Dr. McCandless.. is this something that & nbsp; you've

used or had luck

>with?? Could you share your thoughts on this??

>

>Thanks Kim and glad you are seeing progress. Keep us

posted.

>

> & gt; Listmates..my son was a tremendous B12

responder, in fact I rank

> & gt; daily B12 as the #1 thing we've done for Henry,

and we've done

>alot. & nbsp;

> & gt; We've been doing daily B12 for over a year and

really notice if he

> & gt; misses even two days. & nbsp; In any event, a

recent OAT test still

>showed

> & gt; his MMA as elevated (although much lower than

before). & nbsp; He was

> & gt; receiving 75mcg/kg of the Coastal prep. His doc

recommended the

> & gt; addition of adenosylcobalamin and we started it

1:1 about two

>weeks

> & gt; ago. & nbsp; Hard to believe, but again we saw

dramatic, immediate

>results. & nbsp;

> & gt; Within two or three days, his use of language

became obviously

>better

> & gt; and he became much more & quot;relational & quot;

with his father and I. & nbsp; He

>went

> & gt; from pointing out something and saying

& quot;what's this Mommy & quot;, to

> & gt; saying & quot;what's this little thing here

called? & quot; overnight. & nbsp;

> & gt;

> & gt; I just wanted to post this because I know some

of you have kids

>who

> & gt; were B12 responders and maybe have reached a

plateau. & nbsp; This could

>be

> & gt; something else to think about or talk with your

doctors about. I

> & gt; haven't heard much about the use of the

adenosyl version, but am

> & gt; grateful that we took a chance on something

new. & nbsp; We will repeat

>an

> & gt; OAT later, but wanted to share this before

then. & nbsp; Kim

>

></tt>

>

>

><tt>

>Many frequently asked questions and answers can be

found at & lt;<a href= " http://www.autism-

rxguidebook.com/forums " >http://www.autism-

rxguidebook.com/forums</a> & gt;</tt>

>

>

>

>

>

>

><table border=0 cellspacing=0 cellpadding=2>

><tr bgcolor=#FFFFCC>

><td align=center><font size= " -1 "

color=#003399>

April 8, 2004

Dr. McCandless,

I'm sorry to trouble you with a question with so much going on in your life

right now, but what is methylmalonate and on what test does it show up?

Many thanks and best wishes as always.

Abigail Floe

Re: Adenosylcobalamin update

><html><body>

>

><tt>

>Hi Kim and thanks for sharing your new treatment! I

have never heard

>of this. Can you tell us more about it? What is it

exactly?? Dumb

>question but I've just never heard of it before.

We've had luck with

>B-12 too but it doesn't have the effect it did

intially.. I saw huge

>improvements inititally and we've only been on it

about 3 months

>now. I still think it definitely & nbsp; makes a

difference.. just not as

>much as initially. I love hearing about someone's

progress with

>something new.

>

>Dr. McCandless.. is this something that & nbsp; you've

used or had luck

>with?? Could you share your thoughts on this??

>

>Thanks Kim and glad you are seeing progress. Keep us

posted.

>

> & gt; Listmates..my son was a tremendous B12

responder, in fact I rank

> & gt; daily B12 as the #1 thing we've done for Henry,

and we've done

>alot. & nbsp;

> & gt; We've been doing daily B12 for over a year and

really notice if he

> & gt; misses even two days. & nbsp; In any event, a

recent OAT test still

>showed

> & gt; his MMA as elevated (although much lower than

before). & nbsp; He was

> & gt; receiving 75mcg/kg of the Coastal prep. His doc

recommended the

> & gt; addition of adenosylcobalamin and we started it

1:1 about two

>weeks

> & gt; ago. & nbsp; Hard to believe, but again we saw

dramatic, immediate

>results. & nbsp;

> & gt; Within two or three days, his use of language

became obviously

>better

> & gt; and he became much more & quot;relational & quot;

with his father and I. & nbsp; He

>went

> & gt; from pointing out something and saying

& quot;what's this Mommy & quot;, to

> & gt; saying & quot;what's this little thing here

called? & quot; overnight. & nbsp;

> & gt;

> & gt; I just wanted to post this because I know some

of you have kids

>who

> & gt; were B12 responders and maybe have reached a

plateau. & nbsp; This could

>be

> & gt; something else to think about or talk with your

doctors about. I

> & gt; haven't heard much about the use of the

adenosyl version, but am

> & gt; grateful that we took a chance on something

new. & nbsp; We will repeat

>an

> & gt; OAT later, but wanted to share this before

then. & nbsp; Kim

>

></tt>

>

>

><tt>

>Many frequently asked questions and answers can be

found at & lt;<a href= " http://www.autism-

rxguidebook.com/forums " >http://www.autism-

rxguidebook.com/forums</a> & gt;</tt>

>

>

>

>

>

>

><table border=0 cellspacing=0 cellpadding=2>

><tr bgcolor=#FFFFCC>

><td align=center><font size= " -1 "

color=#003399>

April 9, 2004

I have always said that the #1 weapon in my arsenal for Henry is

B12. Well, despite daily shots his MMA remained somewhat elevated,

although less than before. About a month ago we added

adenosylcobalamin and again, it was like a miracle drug for him.

Within two days an explosion of functional language and imaginary

play. Have to say if I could only keep one supplement of all the

ones he gets, it would be the new B12. Can't tolerate many of the

methyl donors like TMG, etc, but B12 is a miracle for us.I am very

interested in what is said about it at the think tank...Kim

> > & gt; Listmates..my son was a tremendous B12

> responder, in fact I rank

> > & gt; daily B12 as the #1 thing we've done for Henry,

> and we've done

> >alot. & nbsp;

> > & gt; We've been doing daily B12 for over a year and

> really notice if he

> > & gt; misses even two days. & nbsp; In any event, a

> recent OAT test still

> >showed

> > & gt; his MMA as elevated (although much lower than

> before). & nbsp; He was

> > & gt; receiving 75mcg/kg of the Coastal prep. His doc

> recommended the

> > & gt; addition of adenosylcobalamin and we started it

> 1:1 about two

> >weeks

> > & gt; ago. & nbsp; Hard to believe, but again we saw

> dramatic, immediate

> >results. & nbsp;

> > & gt; Within two or three days, his use of language

> became obviously

> >better

> > & gt; and he became much more & quot;relational & quot;

> with his father and I. & nbsp; He

> >went

> > & gt; from pointing out something and saying

> & quot;what's this Mommy & quot;, to

> > & gt; saying & quot;what's this little thing here

> called? & quot; overnight. & nbsp;

> > & gt;

> > & gt; I just wanted to post this because I know some

> of you have kids

> >who

> > & gt; were B12 responders and maybe have reached a

> plateau. & nbsp; This could

> >be

> > & gt; something else to think about or talk with your

> doctors about. I

> > & gt; haven't heard much about the use of the

> adenosyl version, but am

> > & gt; grateful that we took a chance on something

> new. & nbsp; We will repeat

> >an

> > & gt; OAT later, but wanted to share this before

> then. & nbsp; Kim

> >

> ></tt>

> >

> >

> ><tt>

> >Many frequently asked questions and answers can be

> found at & lt;<a href= " http://www.autism-

> rxguidebook.com/forums " >http://www.autism-

> rxguidebook.com/forums</a> & gt;</tt>

> >

> >

> >

> >

> >

> >

> ><table border=0 cellspacing=0 cellpadding=2>

> ><tr bgcolor=#FFFFCC>

> ><td align=center><font size= " -1 "

> color=#003399>

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