FW: DPT vaccine pdf and other information regading enviornmental insult and autism

[Guest guest]

Please make informed decisions regarding

your children’s health and vaccinations.

This gives a very comprehensive

picture of what is happening to our kids, thanks to Sofia Hohnholt for

compiling the following data:

Please note that most of the published science deals with

autism, which we feel is equally relevant for a child with ADD/ADHD. What can

parents learn from the existing science today? Generation Rescue believes the

following has been proven to be true:

1.

The prevalence of neurological disorders amongst children

is growing, which means the environment must be playing a role (because

genetic conditions can only grow at the rate of population growth).

We cite four published studies that support this

position:

Report to the Legislature on the Principle Findings from The

Epidemiology of Autism in California: A Comprehensive Pilot Study

MIND Institute, UC , Oct 2002.

Byrd

Using data from California, the state perceived to

maintain the best data on autism, this report demonstrates clearly that the

rise in autism is not due to improved diagnosis and expanded diagnostic

criteria, but is rather a REAL rise for which some external factor must be

playing a role. Excerpt:

" There is no evidence that a loosening in the

diagnostic criteria has contributed to increased number of autism

clients...we conclude that some, if not all, of the observed increase represents

a true increase in cases of autism in California...a purely genetic basis

for autism does not fully explain the increasing autism prevalence. Other

theories that attempt to better explain the observed increase in autism

cases include environmental exposures to substances such as mercury; viral

exposures; autoimmune disorders; and childhood vaccinations. "

National

Autism Prevalence Trends From United States Special Education Data.

Pediatrics, March 2005.

Craig J. Newschaffer, PhD [s Hopkins University].

This study shows that the rise in the incidence of

autism is real and that the greatest increase took place between 1987 and 1992,

which matches the timing of the near-tripling of vaccines given to our

children and the tripling of mercury within those vaccines.

The Changing

Prevalence of Autism In California

Journal of Autism and Developmental Disorders, April 2003

Mark Blaxill, MBA

This study helps to refute the supposition made by some

researchers that autism's epidemic may only be due to " diagnostic substitution " .

Excerpt:

" They have suggested that 'diagnostic

substitution' accounts for an apparent increase in the incidence of autism

in California that is not real. This hypothesized substitution is not supported

by proper and detailed analyses of the California data. "

What's Going On? The Question of Time Trends in Autism.

Public Health Reports, Nov-Dec 2004.

Mark F. Blaxill, MBA.

This detailed analysis of reported rates of autism in

the United States and United Kingdom serves to further refute the assertion

made by some that the " epidemic " of autism is nothing more than

better diagnosis.

2.

When environmental toxicity in children with

neurological disorders is measured, it is meaningfully higher than

neurotypical (normal) children.

We cite five published studies that support this

position:

Porphyrinuria

in Childhood Autistic Disorder: Implications for Environmental Toxicity

Toxicology and Applied Pharmacology, 2006.

Nataf, Corinne Skorupka, Lorene Amet

This new study from France utilizes a new and

sophisticated measurement for environmental toxicity by assessing porphyrin

levels in autistic children. It provides clear and unequivocal evidence that

children with autism spectrum disorders are more toxic than their

neurotypical peers. Excerpt:

" Coproporphyrin levels were elevated in children

with autistic disorder relative to control groups...the elevation was

significant. These data implicate environmental toxicity in childhood

autistic disorder. "

A Case

Control Study of Mercury Burden in Children with Autism Spectrum Disorder.

Journal of American Physicians and Surgeon, 2003.

, PhD [Arizona State University].

This recent study shows, through active chelation with

DMSA, that autistic children excrete significantly higher levels of mercury

than their neurotypical peers, leading to the conclusion that autistic

children bear a much higher load of mercury in their bodies and that

chelation may be an effective treatment for removing the mercury. Excerpt:

" The data from this study, along with emerging epidemiological

data showing a link between increasing mercury doses from childhood

vaccines and childhood neurodevelopmental disorders, increases the

likelihood that mercury is one of the main factors leading to the large

increase in the rate of autism and other neurodevelopmental disorders. It

is hoped that removing thimerosal from all childhood vaccines will

contribute to a decline in the numbers of new cases of autistic spectrum

disorders. "

A

Case Series of Children with Apparent Mercury Toxic Encephalopathies

Manifesting with Clinical Symptoms of Regressive Autistic Disorder

Journal of Toxicology and Environmental Health, 2007

A. Geier, Mark R. Geier

This study reviewed the case histories and medical

profiles of nine autistic children and concluded that eight of the nine

children were mercury toxic and this toxicity manifested itself in a manner

consistent with Autism Spectrum Disorders. Excerpt:

" ...these previously normally developing

children suffered mercury toxic encephalopathies that manifested with

clinical symptoms consistent with regressive ASDs. Evidence for mercury

intoxication should be considered in the differential diagnosis as

contributing to some regressive ASDs. "

Attention-deficit hyperactivity disorder and blood mercury

level: a case-control study in chinese children

Neuropediatrics, August 2006

P.R. Kong [Department of Pediatrics and Adolescent Medicine, The University

of Hong Kong].

This study demonstrates that blood mercury levels are

higher for children with ADHD. Excerpt:

" There was significant difference in blood

mercury levels between cases and controls, which persists after adjustment

for age, gender and parental occupational status. The geometric mean blood

mercury level was also significantly higher in children with inattentive

and combined subtypes of ADHD. CONCLUSION: High blood mercury level was

associated with ADHD. Whether the relationship is causal requires further

studies. "

Reduced Levels of Mercury in First Baby Haircuts of Autistic

Children

International Journal of Toxicology

Dr. Amy S. Holmes, Mark F. Blaxill, Boyd E. Haley, Ph.D.

March 14, 2003

This recent study demonstrates that the levels of

mercury in the birth hair of autistic children were significantly lower

than their control peers. While this may at first appear contradictory, it

highlights one of the critical insights to understanding mercury poisoning

and autistic children: many autistic children are non-excretors of mercury.

This means their capacity to excrete mercury is significantly lower than

their neurotypical peers and contributes to their condition.

3.

The brains of children with neurological disorders are

experiencing severe oxidative stress and inflammation, suggesting an

environmental cause.

We cite four published studies that support this

position:

Large Brains in Autism: The Challenge of Pervasive Abnormality.

The Neuroscientist, Volume 11, Number 5, 2005.

Martha Herbert, MD, PhD [Harvard University].

This study helps refute the notion that the brains of

autistic children are simply wired differently and notes,

" neuroinflammation appears to be present in autistic brain tissue from

childhood through adulthood. " Dr. Herbert suggests that chronic

disease or an external environmental source (like heavy metals) may be

causing the inflammation. Excerpt:

" Oxidative stress, brain inflammation, and

microgliosis have been much documented in association with toxic exposures

including various heavy metals...the awareness that the brain as well as

medical conditions of children with autism may be conditioned by chronic

biomedical abnormalities such as inflammation opens the possibility that

meaningful biomedical interventions may be possible well past the window of

maximal neuroplasticity in early childhood because the basis for assuming

that all deficits can be attributed to fixed early developmental

alterations in neural architecture has now been undermined. "

Neuroglial Activation and Neuroinflammation in the Brain of

Patients with Autism.

ls of Neurology, Feb 2005.

L. Vargas, MD [s Hopkins University].

This study, performed independently and using a

different methodology than Dr. Herbert (see above) reached the same

conclusion: the brains of autistic children are suffering from

inflammation. Excerpt:

" Because this neuroinflammatory process appears

to be associated with an ongoing and chronic mechanism of CNS dysfunction, potential

therapeutic interventions should focus on the control of its detrimental

effects and thereby eventually modify the clinical course of autism. "

Evidence

of Toxicity, Oxidative Stress, and Neuronal Insult in Autism

Journal of Toxicology and Environmental Health, Nov-Dec 2006.

Janet Kern, Anne

" This article discusses the evidence for the case

that some children with autism may become autistic from neuronal cell death

or brain damage sometime after birth as result of insult; and addresses the

hypotheses that toxicity and oxidative stress may be a cause of neuronal

insult in autism..the article discusses what may be happening over the

course of development and the multiple factors that may interplay and make

these children more vulnerable to toxicity, oxidative stress, and neuronal

insult. "

Oxidative

Stress in Autism

Pathophysiology, 2006.

Abha Chauhan, Ved Chauhan

This study provides a helpful overview of the growing

evidence supporting the link between oxidative stress and autism. Excerpt:

" Upon completion of this article, participants

should be able to: 1. Be aware of laboratory and clinical evidence of

greater oxidative stress in autism. 2. Understand how gut, brain,

nutritional, and toxic status in autism are consistent with greater oxidative

stress. 3. Describe how anti-oxidant nutrients are used in the contemporary

treatment of autism. "

4.

Children with neurological disorders are often

suffering from severe gastrointestinal distress and inflammation. A trigger

of this inflammation and the resultant behaviors is the MMR vaccine.

We cite four published studies that support this

position:

Ileal-lymphoid-nodular

hyperplasia, non-specific colitis, and pervasive developmental disorder in

children

Lancet 1998 Feb 28

Wakefield AJ, Murch SH, A, Linnell J, Casson DM, [university

Department of Medicine, Royal Free Hospital and School of Medicine, London,

UK]

This study demonstrates that the MMR vaccine triggered

autistic behaviors and inflammatory bowel disease in autistic children.

Excerpt:

" Onset of behavioral symptoms was associated, by

the parents, with measles, mumps, and rubella vaccination [MMR] in eight of

the 12 children, with measles infection in one child, and otitis media in

another� We identified

associated gastrointestinal disease and developmental regression in a group

of previously normal children, which was generally associated in time with

possible environmental triggers. "

The

Significance of Ileo-Colonic Lymphoid Nodular Hyperplasia in Children With

Autism Spectrum Disorder.

European Journal of Gastroenterology & Hepatology, August 2005.

J. Wakefield, MD [Royal Free & University College Medical

School, London].

This study demonstrates that, to a much higher degree,

children with an autism spectrum disorder suffer from Ileo-Colonic Lymphoid

Nodular Hyperplasia (LNH) a serious disorder of the intestinal tract.

Excerpt:

" Both ileal and colonic LNH are significantly

more prevalent, and of greater severity, in ASD children compared with developmentally

normal controls. "

Detection and Sequencing of Measles Virus from Peripheral

Mononuclear Cells from Patients with Inflammatory Bowel Disease and Autism

Digestive Diseases and Sciences, 2000

Hisashi Kawashima, Takayuki Mori, Yasuyo Kashiwagi, Kouji Takekuma

This study shows that the measles in the bowels of

autistic children is from the MMR vaccine. Excerpt:

" Additionally, a new syndrome has been reported

in children with autism who exhibited developmental regression and

gastrointestinal symptoms (autistic enterocolitis), in some cases soon

after MMR vaccine. It is not known whether the virus, if confirmed to be

present in these patients, derives from either wild strains or vaccine

strains. ...The sequences obtained from the patients with ulcerative

colitis and children with autism were consistent with being vaccine

strains. The results were concordant with the exposure history of the

patients. Persistence of measles virus was confirmed in PBMC in some

patients with chronic intestinal inflammation. "

Dysregulated

Innate Immune Responses in Young Children with Autism Spectrum Disorders:

Their Relationship to Gastrointestinal Symptoms and Dietary Intervention.

Neuropsychobiology, 2005.

Harumi Jyonouchi, MD [New Jersey Medical School].

This study examines the link between autistic behaviors

and gastrointestinal disorders and notes a possible link " between GI

and behavioral symptoms mediated by innate immune abnormalities. "

5.

One preservative used in vaccines, Thimerosal

(mercury), enters the bloodstream of the child and ends up in the brain

after being administered.

We cite two published studies that support this

position:

Iatrogenic Exposure to Mercury After Hepatitis B Vaccination in

Preterm Infants.

Journal of Pediatrics, May 2000.

V. Stajich, PharmD [Mercer University].

This study measured mercury levels in infants before and

after the administration of a Hepatitis B vaccine containing Thimerosal and

found that a " comparison of pre and post-vaccination mercury levels

showed a significant increase in both preterm and term infants after

vaccination. "

Comparison

of Blood and Brain Mercury Levels in Infant Monkeys Exposed to

Methylmercury or Vaccines Containing Thimerosal.

Environmental Health Perspectives, Aug 2005.

Burbacher, PhD [university of Washington].

This study demonstrates clearly and unequivocally that

ethyl mercury, the kind of mercury found in vaccines, not only ends up in

the brain, but leaves double the amount of inorganic mercury as methyl mercury,

the kind of mercury found in fish. This work is groundbreaking because

little is known about ethyl mercury, and many health authorities have

asserted that the mercury found in vaccines is the " safe kind. "

This study also delivers a strong rebuke of the Institute of Medicine's

recommendation in 2004 to no longer pursue the mercury-autism connection.

Excerpt:

" A recently published IOM review (IOM 2004)

appears to have abandoned the earlier recommendation [of studying mercury

and autism] as well as back away from the American Academy of Pediatrics

goal [of removing mercury from vaccines]. This approach is difficult to

understand, given our current limited knowledge of the toxicokinetics and

developmental neurotoxicity of thimerosal, a compound that has been (and

will continue to be) injected in millions of newborns and infants. "

6.

Higher levels of environmental mercury has been shown

to produce higher rates of autism.

We cite one published study that supports this position:

Environmental mercury release, special education rates, and

autism disorder: an ecological study of Texas.

Health & Place, 2006

F. Palmer, University of Texas Health Science Center

This study demonstrated the correlation between

environmental mercury and autism rates in Texas. Excerpt:

" On average, for each 1,000 lb of

environmentally released mercury, there was a 43% increase in the rate of

special education services and a 61% increase in the rate of autism. The

association between environmentally released mercury and special education

rates were fully mediated by increased autism rates. This ecological study

suggests the need for further research regarding the association between

environmentally released mercury and developmental disorders such as

autism. "

7.

The preservatives in vaccines, most notably

Thimerosal (mercury) and aluminum, are highly toxic and damaging to the

nervous system and immune system of a developing child, and reactions to

these toxins may vary greatly by child.

We cite nine published studies that support this

position:

Thimerosal Neurotoxicity is Associated with Glutathione

Depletion: Protection with Glutathione Precursors.

Neurotoxicology, Jan 2005.

S. Jill , PhD [university of Arkansas].

This recent study demonstrates that Thimerosal lowers or

inhibits the body's ability to produce Glutathione, an antioxidant and the

body's primary cellular-level defense against mercury. Excerpt:

" Thimerosal-induced cytotoxicity was associated

with depletion of intracellular Glutathione in both cell lines...The

potential effect of Glutathione or N-acetylcysteine against mercury

toxicity warrants further research as possible adjunct therapy to individuals

still receiving Thimerosal-containing vaccines. "

Uncoupling of ATP-mediated Calcium Signaling and Dysregulated

IL-6 Secretion in Dendritic Cells by Nanomolar Thimerosal

Environmental Health Perspectives, July 2006.

R. Goth, Ruth A. Chu P. Gregg

This study demonstrates that very low-levels of

Thimerosal can contribute to immune system disregulation. Excerpt:

" Our findings that DCs primarily express the

RyR1 channel complex and that this complex is uncoupled by very low levels

of THI with dysregulated IL-6 secretion raise intriguing questions about a

molecular basis for immune dyregulation and the possible role of the RyR1

complex in genetic susceptibility of the immune system to mercury. "

Aluminum

adjuvant linked to gulf war illness induces motor neuron death in mice

Neuromolecular Medicine, 2007

Shaw, Ph.D. [Department of Ophthalmology and Program in

Neuroscience, University of British Columbia, Vancouver, British Columbia,

Canada]

This study demonstrates the extreme toxicity of the

aluminum adjuvant used as a preservative in vaccines. Excerpt:

" testing showed motor deficits in the aluminum

treatment group that expressed as a progressive decrease in strength

measured...Significant cognitive deficits in water-maze learning were

observed in the combined aluminum and squalene group...Apoptotic neurons

were identified in aluminum-injected animals that showed significantly

increased activated caspase-3 labeling in lumbar spinal cord (255%) and

primary motor cortex (192%) compared with the controls. Aluminum-treated

groups also showed significant motor neuron loss (35%) and increased

numbers of astrocytes (350%) in the lumbar spinal cord.

Activation of Methionine Synthase by Insulin-like Growth

Factor-1 and Dopamine: a Target for Neurodevelopmental Toxins and

Thimerosal.

Molecular Psychiatry, July 2004.

C. Deth, PhD [Northeastern University].

This study demonstrates how Thimerosal inhibits

methylation, a central driver of cellular communication and development.

Excerpt:

" The potent inhibition of this pathway

[methylation] by ethanol, lead, mercury, aluminum, and thimerosal suggests

it may be an important target of neurodevelopmental toxins. "

Neurotoxic Effects of Postnatal Thimerosal are Mouse Strain

Dependent.

Molecular Psychiatry, Sep 2004.

Mady Hornig, MD [Columbia University].

This recent work by Columbia University Doctors explores

whether genes are important in determining if mercury exposures akin to those

in childhood immunizations can disrupt brain development and function. It

is the first known scientific study done specifically on ethlymercury

administered in a way similar to the vaccine schedule. Dr. Hornig discussed

the study before Congress in September 2004. Excerpt:

" The premise of our research is that if mercury

in vaccines creates risk for neurodevelopmental disorders such as autism,

genetic differences are likely to contribute to that risk. Earlier studies,

however, did not use the form of mercury present in vaccines, known as

thimerosal, and did not consider whether intramuscular, repetitive

administration during early postnatal development, when the brain and

immune systems are still maturing, might intensify toxicity. Our predictions

were confirmed. Using thimerosal dosages and timing that approximated the

childhood immunization schedule, our model of postnatal thimerosal

neurotoxicity demonstrated that the genes in mice that predict

mercury-related immunotoxicity also predicted nuerodevelopmental damage.

Features reminiscent of those observed in autism occurred in the mice of

the genetically sensitive strain. "

Thimerosal induces DNA breaks, Caspase-3 Activation, Membrane

Damage, and Cell Death in Cultured Human Neurons and Fibroblasts.

Toxicological Science, 2003.

S. Baskin, MD [baylor College of Medicine].

This study demonstrates the potent toxicity of

Thimerosal on brain cells.

Organic

Mercury Compounds and Autoimmunity.

Autoimmunity Review, 2005.

Said Havarinasab, MD [Linkoping University].

This study demonstrates the clear link between

ethylmercury [from Thimerosal] and autoimmune responses.

Mercury and autism: Accelerating Evidence?

Neuroendocrinology Letters, Oct 2005.

Joachim Mutter, M.D. [Freiburg University, Germany].

This recent study from Germany summarizes many of the

recent scientific advances. Excerpt:

" The causes of autism and neurodevelopmental disorders

are unknown. Genetic and environmental risk factors seem to be

involved...Repetitive doses of thimerosal leads to neurobehavioral

deteriorations in autoimmune susceptible mice, increased oxidative stress

and decreased intracellular levels of glutathione in vitro. Subsequently,

autistic children have significantly decreased level of reduced

glutathione. Promising treatments of autism involve detoxification of

mercury, and supplementation of deficient metabolites. "

Retrograde Degeneration of Neurite Membrane Structural Integrity

of Nerve Growth In Vitro Exposure to Mercury.

NeuroReport, 2001.

Leong, MD [university of Calgary].

This study shows how mercury damages brain cells.

8.

The symptoms of autism and the symptoms of mercury

poisoning appear to be very similar.

We cite one published study that support this position:

Autism: A Novel Form of Mercury Poisoning.

Medical Hypothesis, 2001.

Sallie Bernard, Albert Enyati, Lynn Redwood, RN, Binstock, PhD.

This simple but groundbreaking work spelled it out for

the layperson by demonstrating that the symptoms of autism and the symptoms

of mercury poisoning are identical. Excerpt:

" Due to the extensive parallels between autism and

mercury poisoning, the likelihood of a causal relationship is great. Given

that possibility, Thimerosal should be removed from all childhood vaccines

and the mechanisms of mercury toxicity in autism should be thoroughly

investigated. "

9.

The Government Reform Committee of the U.S. Congress

has published reports on the relationship between mercury and autism and on

the conflicts in policy-making for the national immunization schedule.

We cite two studies by the Committee on Government

Reform of the U.S. Congress:

Mercury in Medicine - Taking Unnecessary Risks

Congressional Record - Extensions of Remarks

Congressman Dan Burton (R-IN), Committee on Government Reform

May 21, 2003

This extensive report was prepared by the staff of the

Subcommittee on Human Rights and Wellness and was the result of a

three-year investigation. The Committee on Government Reform, chaired by

Congressman Dan Burton, initiated the investigation and compiled the

testimony of hundreds of researchers and physicians, as well as

representatives from the FDA and CDC, who presented to the committee.

Excerpt:

" Mercury is hazardous to humans. Its use in

medicinal products is undesirable, unnecessary and should be minimized or

eliminated entirely. Manufacturers of vaccines and thimerosal, (an

ethlymercury compound used in vaccines), have never conducted adequate testing

on the safety of thimerosal. The FDA has never required manufacturers to

conduct adequate safety testing on thimerosal and ethlymercury

compounds...Thimerosal used as a preservative in vaccines is likely related

to the autism epidemic. This epidemic in all probability may have been

prevented or curtailed had the FDA not been asleep at the switch regarding

injected thimerosal and the sharp rise of infant exposure to this known

neurotoxin. Our public health agencies' failure to act is indicative of institutional

malfeasance for self-protection and misplaced protectionism of the

pharmaceutical industry. "

Conflicts of Interest in Vaccine Policy Making

Majority Staff Report, Committee on Government Reform, U.S. House of

Representatives

June 15, 2000

" Members of the advisory committees are required

to disclose any financial conflicts of interest and recuse themselves from participating

in decisions in which they have an interest. The Committee�s investigation has

determined that conflict of interest rules employed by the FDA and the CDC

have been weak, enforcement has been lax, and committee members with

substantial ties to pharmaceutical companies have been given waivers to

participate in committee proceedings. "

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