SPECT results

[Guest guest]

: Did you see this?

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_ui

ds=14675799 & dopt=Abstract

Levitt JG, O'Neill J, Blanton RE, Smalley S, Fadale D, McCracken JT, Guthrie

D, Toga AW, Alger JR.

Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric

Institute (JGL, JO, SS, DF, JTM, DG), Los Angeles, California, USA

Autism is a developmental disorder of unknown neurologic basis.

Based on prior work, we used proton magnetic resonance spectroscopic

imaging ((1)H- MRSI) to investigate brain structures, including cingulate

and caudate, that we hypothesized would reveal metabolic abnormalities in

subjects with autism.In 22 children with autism, 5 to 16 years old, and 20

age-matched healthy control subjects, (1)H-MRSI assessed levels of N-acetyl

compounds (NAA), choline compounds (Cho), and creatine plus phosphocreatine

(Cr) at 272 msec echo-time and 1.5 T.In subjects with autism compared with

control subjects, Cho was 27.2% lower in left inferior anterior cingulate

and 19.1% higher in the head of the right caudate nucleus; Cr was 21.1%

higher in the head of the right caudate nucleus, but lower in the body of

the left caudate nucleus (17.9%) and right occipital cortex (16.6%).Results

are consistent with altered membrane metabolism, altered energetic

metabolism, or both in the left anterior cingulate gyrus, both caudate

nuclei, and right occipital cortex in subjects with autism compared with

control subjects.

PMID: 14675799 [PubMed - in process]

* * *

[Guest guest]

The abstract describes metabolic findings that could reflect pathologies near to

or

distant from the brain locations evaluated.

Also, w/o the whole article, 'tis impossible to tell if there was overlap

between the

autistic kids (as a group) and the control kids (as a group), if so, then the

findings

would seem to apply to an autism subgroup.

If you call them, they'd probably send you a hard-copy or pdf of the article.

Jaquelyn McCandless wrote:

> : Did you see this?

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_ui

> ds=14675799 & dopt=Abstract

>

> 1: Biol Psychiatry. 2003 Dec 15;54(12):1355-66.

>

> Proton magnetic resonance spectroscopic imaging of the brain in childhood

> autism.

>

> Levitt JG, O'Neill J, Blanton RE, Smalley S, Fadale D, McCracken JT, Guthrie

D,

> Toga AW, Alger JR.

>

> Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric

Institute

> (JGL, JO, SS, DF, JTM, DG), Los Angeles, California, USA

>

> Autism is a developmental disorder of unknown neurologic basis. Based on prior

> work, we used proton magnetic resonance spectroscopic imaging ((1)H- MRSI) to

> investigate brain structures, including cingulate and caudate, that we

> hypothesized would reveal metabolic abnormalities in subjects with autism.In

22

> children with autism, 5 to 16 years old, and 20 age-matched healthy control

> subjects, (1)H-MRSI assessed levels of N-acetyl compounds (NAA), choline

> compounds (Cho), and creatine plus phosphocreatine (Cr) at 272 msec echo-time

> and 1.5 T.In subjects with autism compared with control subjects, Cho was

27.2%

> lower in left inferior anterior cingulate and 19.1% higher in the head of the

> right caudate nucleus; Cr was 21.1% higher in the head of the right caudate

> nucleus, but lower in the body of the left caudate nucleus (17.9%) and right

> occipital cortex (16.6%).Results are consistent with altered membrane

> metabolism, altered energetic metabolism, or both in the left anterior

cingulate

> gyrus, both caudate nuclei, and right occipital cortex in subjects with autism

> compared with control subjects.

> * * *

>