Re: High FIGLU, low Methylmalonate

[Guest guest]

Hope,

I don't know if I am going to be of much help, but when we did an

OAT test on my son Nick in Nov. 2003 his FIGlu was 52.1 (ref. range

<=9.0). And his Methylmalonate was 22.9 (ref. range <=27.0)

At that time Dr. Usman said his FIGlu was the highest she had ever

seen, and that mb12 and folinic would help.

Are you seeing a DAN doctor? Hopefully your doctor or someone else

here will hava a better understanding of what this means. I just

wanted to relay what Dr. Usman had told me back then.

Good luck finding out what this means, it's so hard trying to

figuring some of these things out.

>

> We had my son on MB12 shots for about a year. I didn't see

anything

> and my son has not made any progress this year. He seemed ever so

> slightly angry with the shots and that did not go away with a

period

> of time but it was so slight I thought it could be my

imagination. We

> were encouraged to continue the shots because my son has the MTHFR

> genome. We tried him on the nasal spray about three times. Each

time

> his mood got really bad for the whole day so I stopped. I decided

to

> discontinue the shots too. I just got back a lab test. It says

that

> his Methylmalonate is on the low end of the reference range.

(There

> is no abnormal low for this marker.) I know that high

methylmalonate

> could indicate a need for MB12 but could low then not mean that he

> does not need it? And afterall, he did not respond positively.

>

> His Formiminoglutamate (FIGLU) is high in the yellow-red zone.

Does

> this mean he needs more Folinic Acid? He already gets 800 mcg from

> Kirkman's and he is about 40 pounds. Should I give more? He seems

> ever-so-slightly better with it.

>

> Any other insights into this?

>

> Hope

>

[Guest guest]

Thanks. Did she have you take more folinic than usual? My son is

already on folinic. Did the folinic and B12 bring improvements? We

do have a doctor's appointment in a few weeks but I was curious.

Hope

> >

> > We had my son on MB12 shots for about a year. I didn't see

> anything

> > and my son has not made any progress this year. He seemed ever so

> > slightly angry with the shots and that did not go away with a

> period

> > of time but it was so slight I thought it could be my

> imagination. We

> > were encouraged to continue the shots because my son has the MTHFR

> > genome. We tried him on the nasal spray about three times. Each

> time

> > his mood got really bad for the whole day so I stopped. I decided

> to

> > discontinue the shots too. I just got back a lab test. It says

> that

> > his Methylmalonate is on the low end of the reference range.

> (There

> > is no abnormal low for this marker.) I know that high

> methylmalonate

> > could indicate a need for MB12 but could low then not mean that he

> > does not need it? And afterall, he did not respond positively.

> >

> > His Formiminoglutamate (FIGLU) is high in the yellow-red zone.

> Does

> > this mean he needs more Folinic Acid? He already gets 800 mcg from

> > Kirkman's and he is about 40 pounds. Should I give more? He seems

> > ever-so-slightly better with it.

> >

> > Any other insights into this?

> >

> > Hope

> >

>

[Guest guest]

At the time I believe she recommended 400mg folinic. And we

started the mb12 shots every 3rd day as well.

We haven't done another OAT test since, we really should, but it's

just so expensive, and ins. won't pay for any of it.

> > >

> > > We had my son on MB12 shots for about a year. I didn't see

> > anything

> > > and my son has not made any progress this year. He seemed

ever so

> > > slightly angry with the shots and that did not go away with a

> > period

> > > of time but it was so slight I thought it could be my

> > imagination. We

> > > were encouraged to continue the shots because my son has the

MTHFR

> > > genome. We tried him on the nasal spray about three times.

Each

> > time

> > > his mood got really bad for the whole day so I stopped. I

decided

> > to

> > > discontinue the shots too. I just got back a lab test. It

says

> > that

> > > his Methylmalonate is on the low end of the reference range.

> > (There

> > > is no abnormal low for this marker.) I know that high

> > methylmalonate

> > > could indicate a need for MB12 but could low then not mean

that he

> > > does not need it? And afterall, he did not respond

positively.

> > >

> > > His Formiminoglutamate (FIGLU) is high in the yellow-red

zone.

> > Does

> > > this mean he needs more Folinic Acid? He already gets 800 mcg

from

> > > Kirkman's and he is about 40 pounds. Should I give more? He

seems

> > > ever-so-slightly better with it.

> > >

> > > Any other insights into this?

> > >

> > > Hope

> > >

> >

>

[Guest guest]

A very important question based on your test results. Was there folinic in the

spray?

- Stan

>

> We had my son on MB12 shots for about a year. I didn't see anything

> and my son has not made any progress this year. He seemed ever so

> slightly angry with the shots and that did not go away with a period

> of time but it was so slight I thought it could be my imagination. We

> were encouraged to continue the shots because my son has the MTHFR

> genome. We tried him on the nasal spray about three times. Each time

> his mood got really bad for the whole day so I stopped. I decided to

> discontinue the shots too. I just got back a lab test. It says that

> his Methylmalonate is on the low end of the reference range. (There

> is no abnormal low for this marker.) I know that high methylmalonate

> could indicate a need for MB12 but could low then not mean that he

> does not need it? And afterall, he did not respond positively.

>

> His Formiminoglutamate (FIGLU) is high in the yellow-red zone. Does

> this mean he needs more Folinic Acid? He already gets 800 mcg from

> Kirkman's and he is about 40 pounds. Should I give more? He seems

> ever-so-slightly better with it.

>

> Any other insights into this?

>

> Hope

>

[Guest guest]

Hi there

Im a male with mcs/cfs.

I have methylmalonic acid in low range(low end of green) 9,9 <= 19

I have Figlu on far red 17,9 <= 9

I did take a few B12 shots a few years ago.

I have tried folinic acid and tetrahydrofolate.

I seem to get OCD symptoms on the folic and tetrahydrofolate.

Dont like them at all, still I seem to be indicated for it according

to the tests.

I must add that in the beginning they didnt seem to create problems.

For me the SAM, TMG, B12, other bvitamins have given confusing

results.Initially good then wearing off or giving oposite results.

Any thoughts?

Per

> A very important question based on your test results. Was there

folinic in the spray?

>

> - Stan

>

>

> >

> > We had my son on MB12 shots for about a year. I didn't see anything

> > and my son has not made any progress this year. He seemed ever so

> > slightly angry with the shots and that did not go away with a period

> > of time but it was so slight I thought it could be my imagination. We

> > were encouraged to continue the shots because my son has the MTHFR

> > genome. We tried him on the nasal spray about three times. Each time

> > his mood got really bad for the whole day so I stopped. I decided to

> > discontinue the shots too. I just got back a lab test. It says that

> > his Methylmalonate is on the low end of the reference range. (There

> > is no abnormal low for this marker.) I know that high methylmalonate

> > could indicate a need for MB12 but could low then not mean that he

> > does not need it? And afterall, he did not respond positively.

> >

> > His Formiminoglutamate (FIGLU) is high in the yellow-red zone. Does

> > this mean he needs more Folinic Acid? He already gets 800 mcg from

> > Kirkman's and he is about 40 pounds. Should I give more? He seems

> > ever-so-slightly better with it.

> >

> > Any other insights into this?

> >

> > Hope

> >

>

[Guest guest]

Per,

Would you please post this on CFSFMExperimental also? It would be interesting to see what Rich had to say about it, too.

Thanks,Ellen

Re: High FIGLU, low Methylmalonate

Hi thereIm a male with mcs/cfs.I have methylmalonic acid in low range(low end of green) 9,9 <= 19I have Figlu on far red 17,9 <= 9I did take a few B12 shots a few years ago.I have tried folinic acid and tetrahydrofolate.I seem to get OCD symptoms on the folic and tetrahydrofolate.Dont like them at all, still I seem to be indicated for it accordingto the tests. I must add that in the beginning they didnt seem to create problems.For me the SAM, TMG, B12, other bvitamins have given confusingresults.Initially good then wearing off or giving oposite results.Any thoughts?Per

[Guest guest]

Was lab result in blood levels or urine? Low in blood is not always

relaible. We are a family with MTHFR 2 mutations and out of the 5 of

us blood was with in Quest " norma " l at high end. But Urine was very

high

MB12 has really helped whole family. The MTHFR we are finding in

surprising numbers at our center may be because it is now part of our

standard work up instead of " next step " since Quest is now doing.

Debbie

> >

> > We had my son on MB12 shots for about a year. I didn't see

anything

> > and my son has not made any progress this year. He seemed ever so

> > slightly angry with the shots and that did not go away with a

period

> > of time but it was so slight I thought it could be my

imagination. We

> > were encouraged to continue the shots because my son has the MTHFR

> > genome. We tried him on the nasal spray about three times. Each

time

> > his mood got really bad for the whole day so I stopped. I

decided to

> > discontinue the shots too. I just got back a lab test. It says

that

> > his Methylmalonate is on the low end of the reference range.

(There

> > is no abnormal low for this marker.) I know that high

methylmalonate

> > could indicate a need for MB12 but could low then not mean that he

> > does not need it? And afterall, he did not respond positively.

> >

> > His Formiminoglutamate (FIGLU) is high in the yellow-red zone.

Does

> > this mean he needs more Folinic Acid? He already gets 800 mcg

from

> > Kirkman's and he is about 40 pounds. Should I give more? He

seems

> > ever-so-slightly better with it.

> >

> > Any other insights into this?

> >

> > Hope

> >

>

[Guest guest]

Yes, there was folinic but he responds well to folinic.

Hope

> >

> > We had my son on MB12 shots for about a year. I didn't see anything

> > and my son has not made any progress this year. He seemed ever so

> > slightly angry with the shots and that did not go away with a period

> > of time but it was so slight I thought it could be my imagination. We

> > were encouraged to continue the shots because my son has the MTHFR

> > genome. We tried him on the nasal spray about three times. Each time

> > his mood got really bad for the whole day so I stopped. I decided to

> > discontinue the shots too. I just got back a lab test. It says that

> > his Methylmalonate is on the low end of the reference range. (There

> > is no abnormal low for this marker.) I know that high methylmalonate

> > could indicate a need for MB12 but could low then not mean that he

> > does not need it? And afterall, he did not respond positively.

> >

> > His Formiminoglutamate (FIGLU) is high in the yellow-red zone. Does

> > this mean he needs more Folinic Acid? He already gets 800 mcg from

> > Kirkman's and he is about 40 pounds. Should I give more? He seems

> > ever-so-slightly better with it.

> >

> > Any other insights into this?

> >

> > Hope

> >

>

[Guest guest]

My son has a really mixed response to TMG - a combination of

miraculous and scary. I wish we could keep the miraculous and trash

the scary.

Hope

> > >

> > > We had my son on MB12 shots for about a year. I didn't see anything

> > > and my son has not made any progress this year. He seemed ever so

> > > slightly angry with the shots and that did not go away with a period

> > > of time but it was so slight I thought it could be my

imagination. We

> > > were encouraged to continue the shots because my son has the MTHFR

> > > genome. We tried him on the nasal spray about three times.

Each time

> > > his mood got really bad for the whole day so I stopped. I

decided to

> > > discontinue the shots too. I just got back a lab test. It says

that

> > > his Methylmalonate is on the low end of the reference range. (There

> > > is no abnormal low for this marker.) I know that high

methylmalonate

> > > could indicate a need for MB12 but could low then not mean that he

> > > does not need it? And afterall, he did not respond positively.

> > >

> > > His Formiminoglutamate (FIGLU) is high in the yellow-red zone. Does

> > > this mean he needs more Folinic Acid? He already gets 800 mcg from

> > > Kirkman's and he is about 40 pounds. Should I give more? He seems

> > > ever-so-slightly better with it.

> > >

> > > Any other insights into this?

> > >

> > > Hope

> > >

> >

>

[Guest guest]

urine

> > >

> > > We had my son on MB12 shots for about a year. I didn't see

> anything

> > > and my son has not made any progress this year. He seemed ever so

> > > slightly angry with the shots and that did not go away with a

> period

> > > of time but it was so slight I thought it could be my

> imagination. We

> > > were encouraged to continue the shots because my son has the MTHFR

> > > genome. We tried him on the nasal spray about three times. Each

> time

> > > his mood got really bad for the whole day so I stopped. I

> decided to

> > > discontinue the shots too. I just got back a lab test. It says

> that

> > > his Methylmalonate is on the low end of the reference range.

> (There

> > > is no abnormal low for this marker.) I know that high

> methylmalonate

> > > could indicate a need for MB12 but could low then not mean that he

> > > does not need it? And afterall, he did not respond positively.

> > >

> > > His Formiminoglutamate (FIGLU) is high in the yellow-red zone.

> Does

> > > this mean he needs more Folinic Acid? He already gets 800 mcg

> from

> > > Kirkman's and he is about 40 pounds. Should I give more? He

> seems

> > > ever-so-slightly better with it.

> > >

> > > Any other insights into this?

> > >

> > > Hope

> > >

> >

>

[Guest guest]

Could this mean that the folinic is pooling in the body and there is

a blockage and he isn't processing the folinic? Maybe the Yasko

genetic tests might give you answers?

Gayatri

> > >

> > > We had my son on MB12 shots for about a year. I didn't see

anything

> > > and my son has not made any progress this year. He seemed

ever so

> > > slightly angry with the shots and that did not go away with a

period

> > > of time but it was so slight I thought it could be my

imagination. We

> > > were encouraged to continue the shots because my son has the

MTHFR

> > > genome. We tried him on the nasal spray about three times.

Each time

> > > his mood got really bad for the whole day so I stopped. I

decided to

> > > discontinue the shots too. I just got back a lab test. It

says that

> > > his Methylmalonate is on the low end of the reference range.

(There

> > > is no abnormal low for this marker.) I know that high

methylmalonate

> > > could indicate a need for MB12 but could low then not mean

that he

> > > does not need it? And afterall, he did not respond

positively.

> > >

> > > His Formiminoglutamate (FIGLU) is high in the yellow-red

zone. Does

> > > this mean he needs more Folinic Acid? He already gets 800 mcg

from

> > > Kirkman's and he is about 40 pounds. Should I give more? He

seems

> > > ever-so-slightly better with it.

> > >

> > > Any other insights into this?

> > >

> > > Hope

> > >

> >

>

[Guest guest]

The first thing I would try is Methylcobalamin. You said you tried B12 shots

which is

cynocobalamin and probably intramuscular. Try MB12 sub-q or MB12 Intranasal

from

Coastal Compounding (or other MB12 friendly pharmacy) and see what happens.

I would start there and report back.

- Stan

> > >

> > > We had my son on MB12 shots for about a year. I didn't see anything

> > > and my son has not made any progress this year. He seemed ever so

> > > slightly angry with the shots and that did not go away with a period

> > > of time but it was so slight I thought it could be my imagination. We

> > > were encouraged to continue the shots because my son has the MTHFR

> > > genome. We tried him on the nasal spray about three times. Each time

> > > his mood got really bad for the whole day so I stopped. I decided to

> > > discontinue the shots too. I just got back a lab test. It says that

> > > his Methylmalonate is on the low end of the reference range. (There

> > > is no abnormal low for this marker.) I know that high methylmalonate

> > > could indicate a need for MB12 but could low then not mean that he

> > > does not need it? And afterall, he did not respond positively.

> > >

> > > His Formiminoglutamate (FIGLU) is high in the yellow-red zone. Does

> > > this mean he needs more Folinic Acid? He already gets 800 mcg from

> > > Kirkman's and he is about 40 pounds. Should I give more? He seems

> > > ever-so-slightly better with it.

> > >

> > > Any other insights into this?

> > >

> > > Hope

> > >

> >

>

[Guest guest]

Nasal/sub-q folinic and oral folinic are two different animals. I would try it

without the

folinic in the spray just to rule that out.

- Stan

> > >

> > > We had my son on MB12 shots for about a year. I didn't see anything

> > > and my son has not made any progress this year. He seemed ever so

> > > slightly angry with the shots and that did not go away with a period

> > > of time but it was so slight I thought it could be my imagination. We

> > > were encouraged to continue the shots because my son has the MTHFR

> > > genome. We tried him on the nasal spray about three times. Each time

> > > his mood got really bad for the whole day so I stopped. I decided to

> > > discontinue the shots too. I just got back a lab test. It says that

> > > his Methylmalonate is on the low end of the reference range. (There

> > > is no abnormal low for this marker.) I know that high methylmalonate

> > > could indicate a need for MB12 but could low then not mean that he

> > > does not need it? And afterall, he did not respond positively.

> > >

> > > His Formiminoglutamate (FIGLU) is high in the yellow-red zone. Does

> > > this mean he needs more Folinic Acid? He already gets 800 mcg from

> > > Kirkman's and he is about 40 pounds. Should I give more? He seems

> > > ever-so-slightly better with it.

> > >

> > > Any other insights into this?

> > >

> > > Hope

> > >

> >

>

[Guest guest]

Would appreciate very much the information as to where to purchase TMG and

what is the full name spelled out. I had a folder for TMG and DMG and

cannot find it. Thanks, Sam.

Re: High FIGLU, low Methylmalonate

> My son has a really mixed response to TMG - a combination of

> miraculous and scary. I wish we could keep the miraculous and trash

> the scary.

>

> Hope

>

>

>>

>> Hi there

>> Im a male with mcs/cfs.

>>

>> I have methylmalonic acid in low range(low end of green) 9,9 <= 19

>> I have Figlu on far red 17,9 <= 9

>>

>> I did take a few B12 shots a few years ago.

>> I have tried folinic acid and tetrahydrofolate.

>> I seem to get OCD symptoms on the folic and tetrahydrofolate.

>> Dont like them at all, still I seem to be indicated for it according

>> to the tests.

>>

>> I must add that in the beginning they didnt seem to create problems.

>> For me the SAM, TMG, B12, other bvitamins have given confusing

>> results.Initially good then wearing off or giving oposite results.

>>

>> Any thoughts?

>>

>> Per

>>

>>

>> > A very important question based on your test results. Was there

>> folinic in the spray?

>> >

>> > - Stan

>> >

[Guest guest]

www.kirkmanlabs.com

--- Sam wrote:

> Would appreciate very much the information as to

> where to purchase TMG and

> what is the full name spelled out. I had a folder

> for TMG and DMG and

> cannot find it. Thanks, Sam.

>

>

> Re: High FIGLU, low

> Methylmalonate

>

>

> > My son has a really mixed response to TMG - a

> combination of

> > miraculous and scary. I wish we could keep the

> miraculous and trash

> > the scary.

> >

> > Hope

> >

> >

> >>

> >> Hi there

> >> Im a male with mcs/cfs.

> >>

> >> I have methylmalonic acid in low range(low end of

> green) 9,9 <= 19

> >> I have Figlu on far red 17,9 <= 9

> >>

> >> I did take a few B12 shots a few years ago.

> >> I have tried folinic acid and tetrahydrofolate.

> >> I seem to get OCD symptoms on the folic and

> tetrahydrofolate.

> >> Dont like them at all, still I seem to be

> indicated for it according

> >> to the tests.

> >>

> >> I must add that in the beginning they didnt seem

> to create problems.

> >> For me the SAM, TMG, B12, other bvitamins have

> given confusing

> >> results.Initially good then wearing off or giving

> oposite results.

> >>

> >> Any thoughts?

> >>

> >> Per

> >>

> >>

> >> > A very important question based on your test

> results. Was there

> >> folinic in the spray?

> >> >

> >> > - Stan

> >> >

>

>

>

__________________________________________________

[Guest guest]

Trimethylglycine and Dimethylglycine.

http://www.kirkmanlabs.com/products/dmg_tmg/dmg_tmg_index.html

Anne

> > >>

> > >> Hi there

> > >> Im a male with mcs/cfs.

> > >>

> > >> I have methylmalonic acid in low range(low end of

> > green) 9,9 <= 19

> > >> I have Figlu on far red 17,9 <= 9

> > >>

> > >> I did take a few B12 shots a few years ago.

> > >> I have tried folinic acid and tetrahydrofolate.

> > >> I seem to get OCD symptoms on the folic and

> > tetrahydrofolate.

> > >> Dont like them at all, still I seem to be

> > indicated for it according

> > >> to the tests.

> > >>

> > >> I must add that in the beginning they didnt seem

> > to create problems.

> > >> For me the SAM, TMG, B12, other bvitamins have

> > given confusing

> > >> results.Initially good then wearing off or giving

> > oposite results.

> > >>

> > >> Any thoughts?

> > >>

> > >> Per

> > >>

> > >>

> > >> > A very important question based on your test

> > results. Was there

> > >> folinic in the spray?

> > >> >

> > >> > - Stan

> > >> >

> >

> >

> >

>

>

> __________________________________________________

>

[Guest guest]

Anne, many thanks for your quick answer!!!! Have a good night, Sam.

Re: High FIGLU, low

>> > Methylmalonate

>> >

>> >

>> > > My son has a really mixed response to TMG - a

>> > combination of

>> > > miraculous and scary. I wish we could keep the

>> > miraculous and trash

>> > > the scary.

>> > >

>> > > Hope