Re: Kutapressin and HHV6/Nexavir

[Guest guest]

Kutapressin has been re-branded as Nexavir ; I use it.http://www.nexcopharma.com/In Vivo. 1994 Jul-Aug;8(4):581-6. Antiviral activity in vitro of Kutapressin againsthuman herpesvirus-6.Ablashi DV, Berneman ZN, Lawyer C, Kramarsky B,Ferguson DM, Komaroff AL.National Cancer Institute, Bethesda, MD 20892.The recently discovered human herpesvirus-6 (HHV-6)is being associated with an increasing number of conditionsin which there is evidence of immunologic dysfunction. A number of widely available antiviral agents have shown littleor no activity against the virus. We found that Kutapressin (KU),a drug that has been available to practicing physicians for over50 years, has potent, previously unexpected antiviral effects. Cells known to allow replication of HHV-6 were infected withthe virus, under various conditions. Either pretreatment of thecells prior to infection or treatment shortly after infection, inhibited viral replication by > 90%. Indirect evidence suggests that KU may inhibit viral attachmentto cellular receptors, and inhibit intracellular maturation ofthe virus. Given these in vitro findings, and the low frequency of toxicityreported with the use of KU, clinical trials of this drug in patientswith evidence of reactivated HHV-6 infection would seem to be warranted.PMID: 7893985 [PubMed - indexed for MEDLINE] http://f4.grp.yahoofs.com/v1/wJm8Q_pjkrPfZ06qE5u4Hl6W3iQa2h-OvgIe-f6jcyUj-dcPNM98tKynMZVartGhb682zrJoUn_WPCi75x6kXw/Kutapressin%20Studies%20/Kuta_HHV-6%20

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>

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> Kutapressin has been re-branded as Nexavir ; I use it.

>

> http://www.nexcopharma.com/

>

> In Vivo. 1994 Jul-Aug;8(4):581-6.

>

> Antiviral activity in vitro of Kutapressin against

> human herpesvirus-6.

>

> Ablashi DV, Berneman ZN, Lawyer C, Kramarsky B,

> Ferguson DM, Komaroff AL.

>

> National Cancer Institute,

> Bethesda, MD 20892.

>

>

> The recently discovered human herpesvirus-6 (HHV-6)

> is being associated with an increasing number of conditions

> in which there is evidence of immunologic dysfunction.

>

> A number of widely available antiviral agents have shown little

> or no activity against the virus. We found that Kutapressin (KU),

> a drug that has been available to practicing physicians for over

> 50 years, has potent, previously unexpected antiviral effects.

>

> Cells known to allow replication of HHV-6 were infected with

> the virus, under various conditions. Either pretreatment of the

> cells prior to infection or treatment shortly after infection,

> inhibited viral replication by > 90%.

>

> Indirect evidence suggests that KU may inhibit viral attachment

> to cellular receptors, and inhibit intracellular maturation of

> the virus.

>

> Given these in vitro findings, and the low frequency of toxicity

> reported with the use of KU, clinical trials of this drug in

patients

> with evidence of reactivated HHV-6 infection would seem to be

warranted.

>

> PMID: 7893985 [PubMed - indexed for MEDLINE]

>

> http://f4.grp.yahoofs.com/v1/wJm8Q_pjkrPfZ06qE5u4Hl6W3iQa2h-OvgIe-

f6jcyUj-dcPNM98tKynMZVartGhb682zrJoUn_WPCi75x6kXw/Kutapressin%

20Studies%20/Kuta_HHV-6%20

>