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----- Forwarded Message ----To: pwatsonascc@...Sent: Wednesday, May 13, 2009 8:51:01 AMSubject: study

Dear ,

We just need a few more participants to finish the mitochondrial/carnitine study. I was hoping that you would be willing to send the information out again. It is attached.

Thank you so much,

Janet

Janet K. Kern, PhDDirectorGenetic Consultants of Dallas/ASD Centers, LLC408 N. Dr., Texas 75013

Autism-Mitochondrial Study: Participants Needed

May 12, 2009

DALLAS, TX – ASD Centers, LLC has started a clinical study in the Dallas, Texas area. This study is designed to examine mitochondrial dysfunction and how L-carnitine supplementation affects behavior, cognition, muscle strength, and health/physical traits in those with a diagnosed autism spectrum disorder (ASD). The study is also being conducted out of Woodinville,

Washington.

Study Background

L-carnitine is a naturally occurring amino acid required in energy metabolism. Carnitine is essential for the utilization of fatty acids to produce the energy needed to sustain cell function. Carnitine deficiency is commonly found in children who have a diagnosis in the autism spectrum.

Mitochondrial dysfunction is also often found in those diagnosed with autism. And carnitine has been used to treat mitochondrial dysfunction.

Design of This Study

Participants: Thirty children 3-10 years of age (they can be older than ten if they weigh less than 100 pounds), who have a diagnosis of autism, PDD-NOS, or other ASD or pervasive developmental disorder. They cannot have had carnitine-based therapy, or methionine or lysine supplementation.

Study: Two-thirds of the children that participate in the study will receive treatment and one-third will receive a placebo. The study period is 3 months. Blood work and muscle strength testing will be done before and after treatment. The product is citrus flavored and taken orally.

There will be no costs to the participants.

For more information or if you would like to participate, please contact Dr. Janet Kern at: or jkern@..., Janet Kern, PhD, RN, Genetic Consultants of Dallas: 408 N. Dr., , Texas 75013-2500.

The Autism Research Institute (ARI) and CoMeD are supporting this study.

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